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    Ella Jones, PhD

    SchoolUCSF School of Medicine
    Address1600 Divisadero Mt. Zion Bldg
    San Francisco CA 94115

      Cancer development is a multi-step process with well-defined pathological characteristics. It undergoes sequential stages from normal tissues to proliferative benign lesions and finally carcinomas and invasive carcinomas. These stages can be broadly defined as premalignancy, malignancy and metastasis. Study of the underlying cellular and molecular signaling pathways at different stages of cancer not only will advance our understanding of the disease itself, it will also help us to develop new tools for early detection, personalized treatment and ultimately strategies of disease prevention. Dr. Jones' research is to fully integrate cell biology, protein engineering and synthetic chemistry to develop new reporter systems for in vivo imaging of biomarkers that are important to all stages of cancer development. Her interests include in vivo characterization of variant human mammary epithelial cells (vHMECs) in breast premalignancy, targeted imaging of malignant prostate cancer with prostate specific membrane antigen (PSMA) inhibitors and molecular imaging of metastatic lymph nodes in breast cancer using dendrimer based protease sensing probes. As an enabling technology, nanoparticles in forms of dendritic polymer, liposomes and quantum dots are also being explored to advance cancer imaging in Jones' laboratory.

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Aliu SO, Jones EF, Azziz A, Kornak J, Wilmes LJ, Newitt DC, Suzuki SA, Klifa C, Gibbs J, Proctor EC, Joe BN, Hylton NM. Repeatability of quantitative MRI measurements in normal breast tissue. Transl Oncol. 2014 Feb; 7(1):130-7.
        View in: PubMed PMC3998684
      2. McLaughlin RL, Newitt DC, Wilmes LJ, Jones EF, Wisner DJ, Kornak J, Proctor E, Joe BN, Hylton NM. High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging. J Magn Reson Imaging. 2014 May; 39(5):1308-13.
        View in: PubMed PMC3983569
      3. Jones EF, Sinha SP, Newitt DC, Klifa C, Kornak J, Park CC, Hylton NM. MRI enhancement in stromal tissue surrounding breast tumors: association with recurrence free survival following neoadjuvant chemotherapy. PLoS One. 2013; 8(5):e61969.
        View in: PubMed PMC3646993
      4. Wilmes LJ, McLaughlin RL, Newitt DC, Singer L, Sinha SP, Proctor E, Wisner DJ, Saritas EU, Kornak J, Shankaranarayanan A, Banerjee S, Jones EF, Joe BN, Hylton NM. High-resolution diffusion-weighted imaging for monitoring breast cancer treatment response. Acad Radiol. 2013 May; 20(5):581-9.
        View in: PubMed
      5. Mongan J, Rathnayake S, Fu Y, Wang R, Jones EF, Gao DW, Yeh BM. In vivo differentiation of complementary contrast media at dual-energy CT. Radiology. 2012 Oct; 265(1):267-72.
        View in: PubMed PMC3447173
      6. Tucker RM, Parcher BW, Jones EF, Desai TA. Single-injection HPLC method for rapid analysis of a combination drug delivery system. AAPS PharmSciTech. 2012 Jun; 13(2):605-10.
        View in: PubMed PMC3364377
      7. Jones EF, Schooler J, Miller DC, Drake CR, Wahnishe H, Siddiqui S, Li X, Majumdar S. Characterization of human osteoarthritic cartilage using optical and magnetic resonance imaging. Mol Imaging Biol. 2012 Feb; 14(1):32-9.
        View in: PubMed PMC3258397
      8. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9.
        View in: PubMed PMC3245868
      9. Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology. 2011 Nov; 141(5):1864-74.e1-3.
        View in: PubMed PMC4041343
      10. Drake CR, Miller D and Jones EF. Activatable Optical Probes for the Detection of Enzymes. Current Organic Synthesis. 2011; 8(4):498-520.
      11. Meier R, Krug C, Golovko D, Boddington S, Piontek G, Rudelius M, Sutton EJ, Baur-Melnyk A, Jones EF, Daldrup-Link HE. Indocyanine green-enhanced imaging of antigen-induced arthritis with an integrated optical imaging/radiography system. Arthritis Rheum. 2010 Aug; 62(8):2322-7.
        View in: PubMed PMC2921028
      12. Lapi SE, Wahnishe H, Pham D, Wu LY, Nedrow-Byers JR, Liu T, Vejdani K, VanBrocklin HF, Berkman CE, Jones EF. Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. J Nucl Med. 2009 Dec; 50(12):2042-8.
        View in: PubMed PMC3575752
      13. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem. 2009 Jan 15; 17(2):653-9.
        View in: PubMed PMC2639212
      14. Boddington S, Sutton EJ, Jones E, Purcell DD, Henning TD, Tavri S, Meier R, Sista A, Fu Y, Daldrup-Link H. Improved fluorescence of indocyanine green in vitro and in vivo after simple cooling procedures. Contrast Media Mol Imaging. 2008 Sep-Oct; 3(5):191-7.
        View in: PubMed
      15. He J, VanBrocklin HF, Franc BL, Seo Y, Jones EF . Nanoprobes for Medical Diagnosis and Management: Current Status of Nanotechnology in Molecular Imaging. Current NanoScience. 2008; 4(1):17-29.
      16. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92.
        View in: PubMed
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