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    Ella Jones, PhD

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address1600 Divisadero Mt. Zion Bldg
    San Francisco CA 94115
    Phone415-885-7299
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      Collapse Biography 
      Collapse Awards and Honors
      American Chemical Society1986Undergraduate Award in Analytical Chemistry
      American Chemical Society1987Student Award
      University of California, Davis1987 - 1991Non-resident Tuition Fellowship
      University of California, Davis1991Outstanding Graduate Student Nominee
      University of Oxford1991 - 1993Assoicated Member of Balliol College
      Mallinckrodt Medical, Inc.19942 Outstanding Patent Awards
      Monsanto Chemical Company1997 - 2001Chair of the Monsanto Technical Community, Phosphorus Chapter
      Solutia, Inc.2001Chair of the Solution Science and Engineering Network
      Department of Defense, Breast Cancer2009Peer Reviewer
      National Institute of Health, Challenge grants2009Peer Reviewer
      Department of Defense, Breast Cancer2010Peer Reviewer
      National Institute of Health, NIBIB Training SEP2010Peer Reviewer
      National Institute of Health, NIBIB Quantum Projects2010Peer Reviewer
      World Molecular Imaging Congress Meeting2013Section Chair and Moderator
      World Molecular Imaging Congress Meeting2013Poster Award Recipient
      Department of Defense, Breast Cancer2015Peer Reviewer

      Collapse Overview 
      Collapse Overview
      Cancer development is a multi-step process with well-defined pathological characteristics. It undergoes sequential stages from normal tissues to proliferative benign lesions and finally carcinomas and invasive carcinomas. These stages can be broadly defined as premalignancy, malignancy and metastasis. Study of the underlying cellular and molecular signaling pathways at different stages of cancer not only will advance our understanding of the disease itself, it will also help us to develop new tools for early detection, personalized treatment and ultimately strategies of disease prevention. Dr. Jones' research is to fully integrate cell biology, protein engineering and synthetic chemistry to develop new reporter systems for in vivo imaging of biomarkers that are important to all stages of cancer development. Her interests include in vivo characterization of variant human mammary epithelial cells (vHMECs) in breast premalignancy, targeted imaging of malignant prostate cancer with prostate specific membrane antigen (PSMA) inhibitors and molecular imaging of metastatic lymph nodes in breast cancer using dendrimer based protease sensing probes. As an enabling technology, nanoparticles in forms of dendritic polymer, liposomes and quantum dots are also being explored to advance cancer imaging in Jones' laboratory.


      Collapse ORNG Applications 
      Collapse NIH Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Aliu SO, Jones EF, Azziz A, Kornak J, Wilmes LJ, Newitt DC, Suzuki SA, Klifa C, Gibbs J, Proctor EC, Joe BN, Hylton NM. Repeatability of quantitative MRI measurements in normal breast tissue. Transl Oncol. 2014 Feb; 7(1):130-7.
        View in: PubMed
      2. McLaughlin RL, Newitt DC, Wilmes LJ, Jones EF, Wisner DJ, Kornak J, Proctor E, Joe BN, Hylton NM. High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging. J Magn Reson Imaging. 2014 May; 39(5):1308-13.
        View in: PubMed
      3. Jones EF, Sinha SP, Newitt DC, Klifa C, Kornak J, Park CC, Hylton NM. MRI enhancement in stromal tissue surrounding breast tumors: association with recurrence free survival following neoadjuvant chemotherapy. PLoS One. 2013; 8(5):e61969.
        View in: PubMed
      4. Wilmes LJ, McLaughlin RL, Newitt DC, Singer L, Sinha SP, Proctor E, Wisner DJ, Saritas EU, Kornak J, Shankaranarayanan A, Banerjee S, Jones EF, Joe BN, Hylton NM. High-resolution diffusion-weighted imaging for monitoring breast cancer treatment response. Acad Radiol. 2013 May; 20(5):581-9.
        View in: PubMed
      5. Mongan J, Rathnayake S, Fu Y, Wang R, Jones EF, Gao DW, Yeh BM. In vivo differentiation of complementary contrast media at dual-energy CT. Radiology. 2012 Oct; 265(1):267-72.
        View in: PubMed
      6. Tucker RM, Parcher BW, Jones EF, Desai TA. Single-injection HPLC method for rapid analysis of a combination drug delivery system. AAPS PharmSciTech. 2012 Jun; 13(2):605-10.
        View in: PubMed
      7. Jones EF, Schooler J, Miller DC, Drake CR, Wahnishe H, Siddiqui S, Li X, Majumdar S. Characterization of human osteoarthritic cartilage using optical and magnetic resonance imaging. Mol Imaging Biol. 2012 Feb; 14(1):32-9.
        View in: PubMed
      8. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem. 2011 Dec 21; 22(12):2593-9.
        View in: PubMed
      9. Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology. 2011 Nov; 141(5):1864-74.e1-3.
        View in: PubMed
      10. Drake CR, Miller D and Jones EF. Activatable Optical Probes for the Detection of Enzymes. Current Organic Synthesis. 2011; 8(4):498-520.
      11. Noey, S.; Tam., S.; Pham, D. M.; Curtis, J.; Jones, E.F. . Tungsten Cluster Synthesis and Subsequent Ligand-Exchange Reactions. J. Chem. Ed. 2011; 88(6):793-797.
      12. Pham, D; Zhang, L; Jones, E. F. . Nanoplatform Based Molecular Imaging. Dendrimer, "Liposomes and Biopolymer Based Nano-platofrms for Optical Imaging". 2011; 183.
      13. Meier R, Krug C, Golovko D, Boddington S, Piontek G, Rudelius M, Sutton EJ, Baur-Melnyk A, Jones EF, Daldrup-Link HE. Indocyanine green-enhanced imaging of antigen-induced arthritis with an integrated optical imaging/radiography system. Arthritis Rheum. 2010 Aug; 62(8):2322-7.
        View in: PubMed
      14. Lapi SE, Wahnishe H, Pham D, Wu LY, Nedrow-Byers JR, Liu T, Vejdani K, VanBrocklin HF, Berkman CE, Jones EF. Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. J Nucl Med. 2009 Dec; 50(12):2042-8.
        View in: PubMed
      15. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem. 2009 Jan 15; 17(2):653-9.
        View in: PubMed
      16. Boddington S, Sutton EJ, Jones E, Purcell DD, Henning TD, Tavri S, Meier R, Sista A, Fu Y, Daldrup-Link H. Improved fluorescence of indocyanine green in vitro and in vivo after simple cooling procedures. Contrast Media Mol Imaging. 2008 Sep-Oct; 3(5):191-7.
        View in: PubMed
      17. He J, VanBrocklin HF, Franc BL, Seo Y, Jones EF . Nanoprobes for Medical Diagnosis and Management: Current Status of Nanotechnology in Molecular Imaging. Current NanoScience. 2008; 4(1):17-29.
      18. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92.
        View in: PubMed
      19. Fung EY, Olmstead MM, Vickery JC, Balch AL . Glowing gold rings: Solvoluminescence from Planar Trigold(I) Complexes. Coord. Chem. Rev. 1998; 171:151.
      20. Vickery JC, Olmstead MM, Fung EY, Balch AL. Solvent-Stimulated Luminescence from the Supramolecular Aggregation of a Trinuclear Gold(I) Complex that Displays Extensive Intermolecular Au…Au Interactions. Angew. Chem., Int. Ed. Engl. 1997; 36:1179.
      21. Lau KW, Hu NM, Yen MH, Fung EY, Grzybicki S, Matamoros R, Curtis JC . Solvent, Electrolyte and Solute Shape Effects on Optical Electron Transfer in Mixed-Valence Ruthenium Ammine Dimers. Inorg. Chim. Acta. 1994; 226:137.
      22. Balch AL, Fung EY, Nagle JK, Olmstead MM, Rowley SP . Lead(II)/Platinum(II) Complexes with and without Pb-Pt Interactions. Inorg. Chem. 1993; 32:3295.
      23. Salaymeh F, Berhane S, Yusof R, de la Rosa R, Fung EY, Matamoros R, Lau KW, Zheng Q, Kober EM, Curtis JC . Electronic Coupling in Mixed-Valence Binuclear Ruthenium Ammine Complexes as Probed by an Electrochemical Method and an Extension of R. S. Mulliken's Theory of Donor-Acceptor Interactions. Inorg. Chem. 1993; 32:3895.
      24. Balch AL, Davis BJ, Fung EY, Olmstead MM . Palladium-thallium Interactions in Dinuclear Complexes with Structural Components that Place the Two Metal Centers in Close Proximity. Inorg. Chim. Acta. 1993; 212:149.
      25. Balch AL, Fung EY, Olmstead MM . Preparation and Structure of Two Polynuclear Aggregate Obtained Using the Metalloligand {ClAuPPh2CH2}2AsPh. Inorg. Chem. 1990; 29:3203.
      26. Balch AL, Fung EY, Olmstead MM . Polynuclear ((Diphenylphosphino)-methyl)-phenylarsine Bridged Complexes of Gold(I). Bent Chains of Gold(I) and a Role for Au(I)-Au(I) Interactions in Guiding a Reaction. J. Am. Chem. Soc. 1990; 112:5181.
      27. Balch AL, Fung EY . Two- and Four-Coordinate Gold(I) Complexes of Tris(2-diphenylphosphinoethyl)phosphine. Inorg. Chem. 1990; 29:4764.
      28. Fung EY, Chua A, Curtis JC . Evidence for a Specific Solvent-Solute Interaction as a Major Contributor to the Excited-State Distortion of the Emitting Charge-Transfer State in the Complex (bpy)2RuII(CN)2. Inorg. Chem. 1988; 27:1294.
      29. Chang JP, Fung EY, Curtis JC . Evidence for Specific Solvent-Solute Interactions as a Major Contributor to the Franck-Condon Energy in Intervalence-Transfer Absorptions of Ruthenium Amine Complexes. Inorg. Chem. 1986; 25:4233.
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