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    Elliott Vichinsky, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address401 Parnassus Ave.
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      University of Wisconsin, MadisonB.S. Biology1970
      State University of New York DownstateM.D.School of Medicine1974
      Children's Orthopedic Hospital and Medical Center, Seattle, WAInternshipPediatrics1975
      Children's Orthopedic Hospital and Medical Center, Seattle, WAFellowshipPediatrics1978
      University of Washington, Seattle, WASenior Research FellowDept of Pediatrics and Medicine1979
      Collapse Awards and Honors
      Sickle Cell Disease Association of America (SCDAA)2013Pioneer Award
      Cooley's Anemia Foundation2009Distinguished Leadership as Chair of the Medical Advisory Board
      Sickle Cell Disease Foundation of California2007Lifetime Achievement Award
      Children's Hospital & Research Center Oakland2005Bronze Bambino Lifetime Achievement Award
      Children's Miracle Network1995Miracle Maker Award
      Alpha Omega Alpha Honor Society1974Alpha Omega Award
      State University of New York Downstate1974Cum Laude
      University of Wisconsin1970Cum Laude

      Collapse Overview 
      Collapse Overview
      I am the Director of Hematology/Oncology at UCSF Benioff Children's Hospital Oakland, Adjunct Professor at University of California San Francisco, as well as the Director of the Northern California Sickle Cell and Thalassemia Centers. I am a board-certified pediatric hematologist/oncologist with a major interest in understanding and improving the care of patients with hemoglobinopathies. My career has focused on translational research in hemoglobinopathies to answer therapeutic questions in hematologic and iron overload disorders, including iron metabolism and its consequences in multiple diseases, alloimmunization, transfusion efficacy and risks in hematology.

      Over 30 years ago, I established the hemoglobinopathy center at Children's Hospital Oakland to provide primary through tertiary care to pediatric and adult patients. I have been a federally-funded research investigator for over 30 years and national principal investigator for many successful trials -- including transfusion therapy and chelation therapy in hemoglobinopathies. I have been principal investigator or co-investigator on many of the key translational studies, including understanding the mechanism and treatment of neurologic injury in sickle cell disease; iron trafficking and iron overload in hemoglobinopathies, and new therapies to change the pathophysiology of sickle cell biology.

      I have served as Editor-in-Chief of Pediatric Hematology and Oncology; Chairman of the Thalassemia Clinical Research Network, and Director of the Cooley’s Medical Board.


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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E. Favorable Outcomes After In Utero Transfusion in Fetuses with Alpha Thalassemia Major - A Case Series and Review of the Literature. Prenat Diagn. 2016 Nov 9. PMID: 27862048.
        View in: PubMed
      2. Neumayr L, Vichinsky E. Stroke recurrence in adult sickle cell patients: it is time for action! Transfusion. 2016 May; 56(5):1001-4. PMID: 27167352.
        View in: PubMed
      3. Vichinsky E. Non-transfusion-dependent thalassemia and thalassemia intermedia: epidemiology, complications, and management. Curr Med Res Opin. 2016 Jan; 32(1):191-204. PMID: 26479125.
        View in: PubMed
      4. Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA. Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia. Br J Haematol. 2015 Jun; 169(6):887-98. PMID: 25907665; PMCID: PMC4452408 [Available on 06/01/16].
      5. Ballas SK, Vichinsky EP. Is the medical home for adult patients with sickle cell disease a reality or an illusion? Hemoglobin. 2015; 39(2):130-3. PMID: 25806421.
        View in: PubMed
      6. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. In utero hematopoietic cell transplantation for hemoglobinopathies. Front Pharmacol. 2014; 5:278. PMID: 25628564; PMCID: PMC4290536.
      7. Porter JB, Walter PB, Neumayr LD, Evans P, Bansal S, Garbowski M, Weyhmiller MG, Harmatz PR, Wood JC, Miller JL, Byrnes C, Weiss G, Seifert M, Grosse R, Grabowski D, Schmidt A, Fischer R, Nielsen P, Niemeyer C, Vichinsky E. Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients. Br J Haematol. 2014 Dec; 167(5):692-6. PMID: 25209728; PMCID: PMC4577015.
      8. Paulukonis ST, Harris WT, Coates TD, Neumayr L, Treadwell M, Vichinsky E, Feuchtbaum LB. Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH). Pediatr Blood Cancer. 2014 Dec; 61(12):2271-6. PMID: 25176145.
        View in: PubMed
      9. Vichinsky, Elliott P., ed. . Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease. Hematology/Oncology Clinics of North America. 2014; 155-414.
      10. Trachtenberg FL, Gerstenberger E, Xu Y, Mednick L, Sobota A, Ware H, Thompson AA, Neufeld EJ, Yamashita R. Relationship among chelator adherence, change in chelators, and quality of life in thalassemia. Qual Life Res. 2014 Oct; 23(8):2277-88. PMID: 24682717; PMCID: PMC4315322.
      11. Singer ST, Kuypers F, Fineman J, Gildengorin G, Larkin S, Sweeters N, Rosenfeld H, Kurio G, Higa A, Jeng M, Huang J, Vichinsky EP. Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy. Ann Hematol. 2014 Jul; 93(7):1139-48. PMID: 24577514; PMCID: PMC4467727.
      12. Mackin RS, Insel P, Truran D, Vichinsky EP, Neumayr LD, Armstrong FD, Gold JI, Kesler K, Brewer J, Weiner MW. Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology. 2014 Mar 11; 82(10):835-41. PMID: 24523480; PMCID: PMC3959758.
      13. Klings ES, Vichinsky EP, Morris CR. Response to "efficacy and safety of sildenafil for the treatment of severe pulmonary hypertension in patients with hemoglobinopathies: results from a long-term follow up " Haematologica 2014;99(2):e17-18. Haematologica. 2014 Feb; 99(2):e19. PMID: 24497564; PMCID: PMC3912978.
      14. Vichinsky EP. Emerging therapy in hemoglobinopathies: lessons from the past and optimism for the future. Hematol Oncol Clin North Am. 2014 Apr; 28(2):xiii-xviii. PMID: 24589274.
        View in: PubMed
      15. Klaassen RJ, Barrowman N, Merelles-Pulcini M, Vichinsky EP, Sweeters N, Kirby-Allen M, Neufeld EJ, Kwiatkowski JL, Wu J, Vickars L, Blanchette VS, Forgie M, Yamashita R, Wong-Rieger D, Young NL. Validation and reliability of a disease-specific quality of life measure (the TranQol) in adults and children with thalassaemia major. Br J Haematol. 2014 Feb; 164(3):431-7. PMID: 24180641.
        View in: PubMed
      16. Oliveros O, Trachtenberg F, Haines D, Gerstenberger E, Martin M, Carson S, Green S, Calamaras D, Hess P, Yamashita R, Vichinsky E. Pain over time and its effects on life in thalassemia. Am J Hematol. 2013 Nov; 88(11):939-43. PMID: 23918696; PMCID: PMC3872488.
      17. Marsh A, Golden C, Hoppe C, Quirolo K, Vichinsky E. Renal medullary carcinoma in an adolescent with sickle cell anemia. Pediatr Blood Cancer. 2014 Mar; 61(3):567. PMID: 24108577.
        View in: PubMed
      18. Vichinsky E, Torres M, Minniti CP, Barrette S, Habr D, Zhang Y, Files B. Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: two-year results including pharmacokinetics and concomitant hydroxyurea. Am J Hematol. 2013 Dec; 88(12):1068-73. PMID: 23946212.
        View in: PubMed
      19. Fung EB, Kwiatkowski JL, Huang JN, Gildengorin G, King JC, Vichinsky EP. Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2013 Oct; 98(4):960-71. PMID: 23945720; PMCID: PMC3778866.
      20. Pratini NR, Sweeters N, Vichinsky E, Neufeld JA. Treatment of classic pantothenate kinase-associated neurodegeneration with deferiprone and intrathecal baclofen. Am J Phys Med Rehabil. 2013 Aug; 92(8):728-33. PMID: 23370589; PMCID: PMC3707939.
      21. Vichinsky E, Neumayr L, Trimble S, Giardina PJ, Cohen AR, Coates T, Boudreaux J, Neufeld EJ, Kenney K, Grant A, Thompson AA. Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME). Transfusion. 2014 Apr; 54(4):972-81; quiz 971. PMID: 23889533; PMCID: PMC4410835.
      22. Thompson AA, Kim HY, Singer ST, Vichinsky E, Eile J, Yamashita R, Giardina PJ, Olivieri N, Parmar N, Trachtenberg F, Neufeld EJ, Kwiatkowski JL. Pregnancy outcomes in women with thalassemia in North America and the United Kingdom. Am J Hematol. 2013 Sep; 88(9):771-3. PMID: 23757266; PMCID: PMC4106126.
      23. Musallam KM, Rivella S, Vichinsky E, Rachmilewitz EA. Non-transfusion-dependent thalassemias. Haematologica. 2013 Jun; 98(6):833-44. PMID: 23729725; PMCID: PMC3669437.
      24. Porter JB, Wood J, Olivieri N, Vichinsky EP, Taher A, Neufeld E, Giardina P, Thompson A, Moore B, Evans P, Kim HY, Macklin EA, Trachtenberg F. Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone. J Cardiovasc Magn Reson. 2013; 15:38. PMID: 23688265; PMCID: PMC3669105.
      25. Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP. A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica. 2013 Sep; 98(9):1375-82. PMID: 23645695; PMCID: PMC3762093.
      26. Vichinsky EP. Clinical manifestations of a-thalassemia. Cold Spring Harb Perspect Med. 2013 May; 3(5):a011742. PMID: 23543077; PMCID: PMC3633183.
      27. Goldberg SL, Giardina PJ, Chirnomas D, Esposito J, Paley C, Vichinsky E. The palatability and tolerability of deferasirox taken with different beverages or foods. Pediatr Blood Cancer. 2013 Sep; 60(9):1507-12. PMID: 23637051.
        View in: PubMed
      28. Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA, Vichinsky EP. Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension. Haematologica. 2013 Sep; 98(9):1359-67. PMID: 23585527; PMCID: PMC3762091.
      29. Cui J, Azimi M, Baysdorfer C, Vichinsky EP, Hoppe CC. Application of multiplex ligation-dependent probe amplification to screen for ß-globin cluster deletions: detection of two novel deletions in a multi ethnic population. Hemoglobin. 2013; 37(3):241-56. PMID: 23577918.
        View in: PubMed
      30. Switzer WM, Shankar A, Trimble SR, Thompson AA, Giardina PJ, Cohen AR, Coates TD, Vichinsky E, Neufeld EJ, Boudreaux JM, Heneine W. Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients. AIDS Res Hum Retroviruses. 2013 Jul; 29(7):1006-9. PMID: 23409829.
        View in: PubMed
      31. Haines D, Martin M, Carson S, Oliveros O, Green S, Coates T, Eile J, Schilling L, Dinu B, Mendoza T, Gerstenberger E, Trachtenberg F, Vichinsky E. Pain in thalassaemia: the effects of age on pain frequency and severity. Br J Haematol. 2013 Mar; 160(5):680-7. PMID: 23278768.
        View in: PubMed
      32. Walter PB, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Grady RW, Vichinsky E, Olivieri N, Trachtenberg F, Alberti D, Fung E, Ames B, Higa A, Harmatz P. Increased leucocyte apoptosis in transfused ß-thalassaemia patients. Br J Haematol. 2013 Feb; 160(3):399-403. PMID: 23216540; PMCID: PMC4597914.
      33. Lal A, Porter J, Sweeters N, Ng V, Evans P, Neumayr L, Kurio G, Harmatz P, Vichinsky E. Combined chelation therapy with deferasirox and deferoxamine in thalassemia. Blood Cells Mol Dis. 2013 Feb; 50(2):99-104. PMID: 23151373; PMCID: PMC3592978.
      34. Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L, Labotka R, Glass J, Keefer JR, Wargin WA, Berenson R, Perrine SP. A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. Am J Hematol. 2012 Nov; 87(11):1017-21. PMID: 22887019; PMCID: PMC3904792.
      35. Fung EB, Gariepy CA, Sawyer AJ, Higa A, Vichinsky EP. The effect of whole body vibration therapy on bone density in patients with thalassemia: a pilot study. Am J Hematol. 2012 Oct; 87(10):E76-9. PMID: 22886910; PMCID: PMC3845963.
      36. Fung EB, Xu Y, Trachtenberg F, Odame I, Kwiatkowski JL, Neufeld EJ, Thompson AA, Boudreaux J, Quinn CT, Vichinsky EP. Inadequate dietary intake in patients with thalassemia. J Acad Nutr Diet. 2012 Jul; 112(7):980-90. PMID: 22551675; PMCID: PMC3419338.
      37. Wahl SK, Garcia A, Hagar W, Gildengorin G, Quirolo K, Vichinsky E. Lower alloimmunization rates in pediatric sickle cell patients on chronic erythrocytapheresis compared to chronic simple transfusions. Transfusion. 2012 Dec; 52(12):2671-6. PMID: 22519830.
        View in: PubMed
      38. Kutlar A, Ataga KI, McMahon L, Howard J, Galacteros F, Hagar W, Vichinsky E, Cheung AT, Matsui N, Embury SH. A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease. Am J Hematol. 2012 May; 87(5):536-9. PMID: 22488107.
        View in: PubMed
      39. Vichinsky E. Advances in the treatment of alpha-thalassemia. Blood Rev. 2012 Apr; 26 Suppl 1:S31-4. PMID: 22631041.
        View in: PubMed
      40. Cui J, Baysdorfer C, Azimi M, Vichinsky EP, Hoppe CC. Identification of three novel Hb F variants: Hb F-Hayward [G?1(NA1)Gly?Asp, GGT>GAT], Hb F-Chori-I [A?T16(A13)Gly?Asp, GGC>GAC] and Hb F-Chori-II [A?I29(B11)Gly?Glu, GGA>GAA]. Hemoglobin. 2012; 36(3):305-9. PMID: 22384921.
        View in: PubMed
      41. DeBaun MR, Armstrong FD, McKinstry RC, Ware RE, Vichinsky E, Kirkham FJ. Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia. Blood. 2012 May 17; 119(20):4587-96. PMID: 22354000; PMCID: PMC3367871.
      42. Vichinsky E. . British Journal of Haematology. Safety of deferasirox in sickle cell disease patients with co-existing liver impairment – response to Sinakos et al. 2012; 157(4):506–507.
      43. Kwiatkowski JL, Kim HY, Thompson AA, Quinn CT, Mueller BU, Odame I, Giardina PJ, Vichinsky EP, Boudreaux JM, Cohen AR, Porter JB, Coates T, Olivieri NF, Neufeld EJ. Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort. Blood. 2012 Mar 22; 119(12):2746-53. PMID: 22279056; PMCID: PMC3327453.
      44. Vichinsky EP. The prevention and management of alloimmunization in sickle cell disease: the benefit of extended phenotypic matching of red blood cells. Immunohematology. 2012; 28(1):20-3. PMID: 22646146.
        View in: PubMed
      45. Vichinsky E. Emerging 'A' therapies in hemoglobinopathies: agonists, antagonists, antioxidants, and arginine. Hematology Am Soc Hematol Educ Program. 2012; 2012:271-5. PMID: 23233591.
        View in: PubMed
      46. Olivieri NF, Pakbaz Z, Vichinsky E. Hb E/beta-thalassaemia: a common & clinically diverse disorder. Indian J Med Res. 2011 Oct; 134:522-31. PMID: 22089616; PMCID: PMC3237252.
      47. Morris CR, Kim HY, Trachtenberg F, Wood J, Quinn CT, Sweeters N, Kwiatkowski JL, Thompson AA, Giardina PJ, Boudreaux J, Olivieri NF, Porter JB, Neufeld EJ, Vichinsky EP. Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report. Blood. 2011 Oct 6; 118(14):3794-802. PMID: 21772051; PMCID: PMC3193260.
      48. Singer ST, Vichinsky EP, Gildengorin G, van Disseldorp J, Rosen M, Cedars MI. Reproductive capacity in iron overloaded women with thalassemia major. Blood. 2011 Sep 8; 118(10):2878-81. PMID: 21757620; PMCID: PMC3172803.
      49. Olivieri NF, Saunthararajah Y, Thayalasuthan V, Kwiatkowski J, Ware RE, Kuypers FA, Kim HY, Trachtenberg FL, Vichinsky EP. A pilot study of subcutaneous decitabine in ß-thalassemia intermedia. Blood. 2011 Sep 8; 118(10):2708-11. PMID: 21700776; PMCID: PMC3172790.
      50. Vichinsky E, Bernaudin F, Forni GL, Gardner R, Hassell K, Heeney MM, Inusa B, Kutlar A, Lane P, Mathias L, Porter J, Tebbi C, Wilson F, Griffel L, Deng W, Giannone V, Coates T. Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease. Br J Haematol. 2011 Aug; 154(3):387-97. PMID: 21592110; PMCID: PMC3170481.
      51. Trachtenberg F, Vichinsky E, Haines D, Pakbaz Z, Mednick L, Sobota A, Kwiatkowski J, Thompson AA, Porter J, Coates T, Giardina PJ, Olivieri N, Yamashita R, Neufeld EJ. Iron chelation adherence to deferoxamine and deferasirox in thalassemia. Am J Hematol. 2011 May; 86(5):433-6. PMID: 21523808; PMCID: PMC4599708.
      52. Singer ST, Vichinsky EP, Sweeters N, Rachmilewitz E. Darbepoetin alfa for the treatment of anaemia in alpha- or beta- thalassaemia intermedia syndromes. Br J Haematol. 2011 Jul; 154(2):281-4. PMID: 21496003.
        View in: PubMed
      53. Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L. A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction. Br J Haematol. 2011 Jun; 153(5):655-63. PMID: 21477202; PMCID: PMC3601917.
      54. Fung EB, Vichinsky EP, Kwiatkowski JL, Huang J, Bachrach LK, Sawyer AJ, Zemel BS. Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover. Bone. 2011 Jun 1; 48(6):1305-12. PMID: 21443975; PMCID: PMC3095710.
      55. Gold JI, Treadwell M, Weissman L, Vichinsky E. The mediating effects of family functioning on psychosocial outcomes in healthy siblings of children with sickle cell disease. Pediatr Blood Cancer. 2011 Dec 1; 57(6):1055-61. PMID: 21360652.
        View in: PubMed
      56. Lal A, Goldrich ML, Haines DA, Azimi M, Singer ST, Vichinsky EP. Heterogeneity of hemoglobin H disease in childhood. N Engl J Med. 2011 Feb 24; 364(8):710-8. PMID: 21345100.
        View in: PubMed
      57. Thompson AA, Cunningham MJ, Singer ST, Neufeld EJ, Vichinsky E, Yamashita R, Giardina P, Kim HY, Trachtenberg F, Kwiatkowski JL. Red cell alloimmunization in a diverse population of transfused patients with thalassaemia. Br J Haematol. 2011 Apr; 153(1):121-8. PMID: 21323889.
        View in: PubMed
      58. Wang, W., Brugnara, C., Snyder, C., Wynn, L., Rogers, Z., Kalinyak, K., Brown, C., Qureshi, A., Bigelow, C., Neumayr, L., Smith-Whitley, K., Chui, D. H. K., Delahunty, M., Woolson, R., Steinberg, M., Telen, M. and Kesler, K. . The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial. British Journal of Haematology. 2011; 152(6):771–776.
      59. Jacobs JE, Quirolo K, Vichinsky E. Novel influenza A (H1N1) viral infection in pediatric patients with sickle-cell disease. Pediatr Blood Cancer. 2011 Jan; 56(1):95-8. PMID: 20973097.
        View in: PubMed
      60. Rienhoff HY, Viprakasit V, Tay L, Harmatz P, Vichinsky E, Chirnomas D, Kwiatkowski JL, Tapper A, Kramer W, Porter JB, Neufeld EJ. A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload. Haematologica. 2011 Apr; 96(4):521-5. PMID: 21173101; PMCID: PMC3069228.
      61. Olivieri NF, Pakbaz Z, Vichinsky E. HbE/ß-thalassemia: basis of marked clinical diversity. Hematol Oncol Clin North Am. 2010 Dec; 24(6):1055-70. PMID: 21075280.
        View in: PubMed
      62. Neumayr L, Pringle S, Giles S, Quirolo KC, Paulukonis S, Vichinsky EP, Treadwell MJ. Chart Card: feasibility of a tool for improving emergency department care in sickle cell disease. J Natl Med Assoc. 2010 Nov; 102(11):1017-23. PMID: 21141289.
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      63. Pakbaz Z, Treadwell M, Kim HY, Trachtenberg F, Parmar N, Kwiatkowski JL, Cunningham MJ, Martin M, Sweeters N, Neufeld EJ, Giardina PJ, Olivieri N, Yamashita RC, Vichinsky E. Education and employment status of children and adults with thalassemia in North America. Pediatr Blood Cancer. 2010 Oct; 55(4):678-83. PMID: 20535817; PMCID: PMC2932798.
      64. Gladwin MT, Barst RJ, Castro OL, Gordeuk VR, Hillery CA, Kato GJ, Kim-Shapiro DB, Machado R, Morris CR, Steinberg MH, Vichinsky EP. Pulmonary hypertension and NO in sickle cell. Blood. 2010 Aug 5; 116(5):852-4. PMID: 20688967; PMCID: PMC2918336.
      65. Vichinsky E. Complexity of alpha thalassemia: growing health problem with new approaches to screening, diagnosis, and therapy. Ann N Y Acad Sci. 2010 Aug; 1202:180-7. PMID: 20712791.
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      66. Vichinsky EP, Neufeld EJ. Preface to Cooley's Anemia: Ninth Symposium. Ann N Y Acad Sci. 2010 Aug; 1202:ix-x. PMID: 20712763.
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      67. Singer ST, Sweeters N, Vega O, Higa A, Vichinsky E, Cedars M. Fertility potential in thalassemia major women: current findings and future diagnostic tools. Ann N Y Acad Sci. 2010 Aug; 1202:226-30. PMID: 20712797.
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      68. Morris CR, Vichinsky EP. Pulmonary hypertension in thalassemia. Ann N Y Acad Sci. 2010 Aug; 1202:205-13. PMID: 20712794.
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      69. Vichinsky EP, Ohene-Frempong K. Approaches to transfusion therapy and iron overload in patients with sickle cell disease: results of an international survey. Pediatr Hematol Oncol. 2011 Feb; 28(1):37-42. PMID: 20673029.
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      70. Vichinsky EP, Ohene-Frempong K, Thein SL, Lobo CL, Inati A, Thompson AA, Smith-Whitley K, Kwiatkowski JL, Swerdlow PS, Porter JB, Marks PW. Transfusion and chelation practices in sickle cell disease: a regional perspective. Pediatr Hematol Oncol. 2011 Mar; 28(2):124-33. PMID: 20673030.
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      71. Fung EB, Xu Y, Kwiatkowski JL, Vogiatzi MG, Neufeld E, Olivieri N, Vichinsky EP, Giardina PJ. Relationship between chronic transfusion therapy and body composition in subjects with thalassemia. J Pediatr. 2010 Oct; 157(4):641-7, 647.e1-2. PMID: 20547400; PMCID: PMC2936667.
      72. Vichinsky EP, Neumayr LD, Gold JI, Weiner MW, Rule RR, Truran D, Kasten J, Eggleston B, Kesler K, McMahon L, Orringer EP, Harrington T, Kalinyak K, De Castro LM, Kutlar A, Rutherford CJ, Johnson C, Bessman JD, Jordan LB, Armstrong FD. Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA. 2010 May 12; 303(18):1823-31. PMID: 20460621; PMCID: PMC2892214.
      73. James EB, Vreman HJ, Wong RJ, Stevenson DK, Vichinsky E, Schumacher L, Hall JY, Simon J, Golden DW, Harmatz P. Elevated exhaled carbon monoxide concentration in hemoglobinopathies and its relation to red blood cell transfusion therapy. Pediatr Hematol Oncol. 2010 Mar; 27(2):112-21. PMID: 20201692.
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      74. Wahl S, Vichinsky E. Pulmonary hypertension in hemolytic anemias. F1000 Med Rep. 2010; 2. PMID: 20948876; PMCID: PMC2948405.
      75. Kanathezhath B, Hazard FK, Guo H, Kidd J, Azimi M, Kuypers FA, Vichinsky EP, Lal A. Hemoglobin Hakkari: an autosomal dominant form of beta thalassemia with inclusion bodies arising from de novo mutation in exon 2 of beta globin gene. Pediatr Blood Cancer. 2010 Feb; 54(2):332-5. PMID: 19852066.
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      76. Wang ZJ, Fischer R, Chu Z, Mahoney DH, Mueller BU, Muthupillai R, James EB, Krishnamurthy R, Chung T, Padua E, Vichinsky E, Harmatz P. Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia. Magn Reson Imaging. 2010 Apr; 28(3):363-71. PMID: 20061110; PMCID: PMC2839041.
      77. Gabrovsky A, Aderinto A, Aderinto A, Spevak M, Vichinsky E, Resar LM. Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease. Pediatr Blood Cancer. 2010 Jan; 54(1):148-50. PMID: 19785026.
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      78. Kidd JL, Azimi M, Lubin B, Vichinsky E, Hoppe C. Application of an expanded multiplex genotyping assay for the simultaneous detection of Hemoglobin Constant Spring and common deletional alpha-thalassemia mutations. Int J Lab Hematol. 2010 Aug 1; 32(4):373-80. PMID: 19919622.
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      79. Walter PB, Harmatz P, Vichinsky E. Iron metabolism and iron chelation in sickle cell disease. Acta Haematol. 2009; 122(2-3):174-83. PMID: 19907155.
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      80. Singer ST, Kim HY, Olivieri NF, Kwiatkowski JL, Coates TD, Carson S, Neufeld E, Cunningham MJ, Giardina PJ, Mueller BU, Quinn CT, Fung E, Vichinsky E. Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications. Am J Hematol. 2009 Nov; 84(11):759-61. PMID: 19787795; PMCID: PMC4254706.
      81. Buchanan G, Vichinsky E, Krishnamurti L, Shenoy S. Severe sickle cell disease--pathophysiology and therapy. Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl):S64-7. PMID: 19819341; PMCID: PMC2832723.
      82. Taher A, Cappellini MD, Vichinsky E, Galanello R, Piga A, Lawniczek T, Clark J, Habr D, Porter JB. Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload. Br J Haematol. 2009 Dec; 147(5):752-9. PMID: 19764988; PMCID: PMC2779992.
      83. Adamkiewicz TV, Abboud MR, Paley C, Olivieri N, Kirby-Allen M, Vichinsky E, Casella JF, Alvarez OA, Barredo JC, Lee MT, Iyer RV, Kutlar A, McKie KM, McKie V, Odo N, Gee B, Kwiatkowski JL, Woods GM, Coates T, Wang W, Adams RJ. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury. Blood. 2009 Nov 19; 114(21):4632-8. PMID: 19721013; PMCID: PMC2780299.
      84. Vogiatzi MG, Macklin EA, Trachtenberg FL, Fung EB, Cheung AM, Vichinsky E, Olivieri N, Kirby M, Kwiatkowski JL, Cunningham M, Holm IA, Fleisher M, Grady RW, Peterson CM, Giardina PJ. Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br J Haematol. 2009 Sep; 146(5):546-56. PMID: 19604241; PMCID: PMC2798591.
      85. Hoppe C, Klitz W, Vichinsky E, Styles L. HLA type and risk of alloimmunization in sickle cell disease. Am J Hematol. 2009 Jul; 84(7):462-4. PMID: 19484735.
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      86. Michlitsch J, Azimi M, Hoppe C, Walters MC, Lubin B, Lorey F, Vichinsky E. Newborn screening for hemoglobinopathies in California. Pediatr Blood Cancer. 2009 Apr; 52(4):486-90. PMID: 19061217.
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      87. Vogiatzi MG, Macklin EA, Fung EB, Cheung AM, Vichinsky E, Olivieri N, Kirby M, Kwiatkowski JL, Cunningham M, Holm IA, Lane J, Schneider R, Fleisher M, Grady RW, Peterson CC, Giardina PJ. Bone disease in thalassemia: a frequent and still unresolved problem. J Bone Miner Res. 2009 Mar; 24(3):543-57. PMID: 18505376; PMCID: PMC3276604.
      88. Vichinsky EP. Alpha thalassemia major--new mutations, intrauterine management, and outcomes. Hematology Am Soc Hematol Educ Program. 2009; 35-41. PMID: 20008180.
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      89. Gladwin MT, Vichinsky E. Pulmonary complications of sickle cell disease. N Engl J Med. 2008 Nov 20; 359(21):2254-65. PMID: 19020327.
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      90. Vichinsky E, Rodgers GP, Rachmilewitz E. Hemoglobinopathies. Curr Mol Med. 2008 Nov; 8(7):591. PMID: 18991644.
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      91. Singer ST, Vichinsky EP, Larkin S, Olivieri N, Sweeters N, Kuypers FA. Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells. Am J Hematol. 2008 Nov; 83(11):842-5. PMID: 18821710; PMCID: PMC2881160.
      92. Gold JI, Mahrer NE, Treadwell M, Weissman L, Vichinsky E. Psychosocial and behavioral outcomes in children with sickle cell disease and their healthy siblings. J Behav Med. 2008 Dec; 31(6):506-16. PMID: 18784995.
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      93. Harmatz P, Jonas MM, Kwiatkowski JL, Wright EC, Fischer R, Vichinsky E, Giardina PJ, Neufeld EJ, Porter J, Olivieri N. Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia. Haematologica. 2008 Aug; 93(8):1247-51. PMID: 18556414.
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      94. Gold JI, Johnson CB, Treadwell MJ, Hans N, Vichinsky E. Detection and assessment of stroke in patients with sickle cell disease: neuropsychological functioning and magnetic resonance imaging. Pediatr Hematol Oncol. 2008 Jun; 25(5):409-21. PMID: 18569843.
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      95. Vichinsky E. Oral iron chelators and the treatment of iron overload in pediatric patients with chronic anemia. Pediatrics. 2008 Jun; 121(6):1253-6. PMID: 18519495.
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      96. Fung EB, Harmatz PR, Milet M, Balasa V, Ballas SK, Casella JF, Hilliard L, Kutlar A, McClain KL, Olivieri NF, Porter JB, Vichinsky EP. Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. Transfusion. 2008 Sep; 48(9):1971-80. PMID: 18513257; PMCID: PMC4613769.
      97. Gold JI, Treadwell M, Weissman L, Vichinsky E. An expanded Transactional Stress and Coping Model for siblings of children with sickle cell disease: family functioning and sibling coping, self-efficacy and perceived social support. Child Care Health Dev. 2008 Jul; 34(4):491-502. PMID: 18485027.
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      98. Walter PB, Macklin EA, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Vichinsky E, Olivieri N, Alberti D, Holland J, Harmatz P. Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial. Haematologica. 2008 Jun; 93(6):817-25. PMID: 18469351.
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      99. Vichinsky E. Clinical application of deferasirox: practical patient management. Am J Hematol. 2008 May; 83(5):398-402. PMID: 18058997.
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      100. Vichinsky E, Pakbaz Z, Onyekwere O, Porter J, Swerdlow P, Coates T, Lane P, Files B, Mueller BU, Coïc L, Forni GL, Fischer R, Marks P, Rofail D, Abetz L, Baladi JF. Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial. Acta Haematol. 2008; 119(3):133-41. PMID: 18408362.
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      101. Fung EB, Harmatz PR, Milet M, Coates TD, Thompson AA, Ranalli M, Mignaca R, Scher C, Giardina P, Robertson S, Neumayr L, Vichinsky EP. Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia. Bone. 2008 Jul; 43(1):162-8. PMID: 18430624; PMCID: PMC2500183.
      102. Hagar W, Vichinsky E. Advances in clinical research in sickle cell disease. Br J Haematol. 2008 May; 141(3):346-56. PMID: 18341629.
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      103. Jastaniah W, Harmatz P, Pakbaz Z, Fischer R, Vichinsky E, Walters MC. Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies. Pediatr Blood Cancer. 2008 Feb; 50(2):319-24. PMID: 17557314.
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      104. Ataga KI, Smith WR, De Castro LM, Swerdlow P, Saunthararajah Y, Castro O, Vichinsky E, Kutlar A, Orringer EP, Rigdon GC, Stocker JW. Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Blood. 2008 Apr 15; 111(8):3991-7. PMID: 18192510.
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      105. Porter JB, Taher AT, Cappellini MD, Vichinsky EP. Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox [Kontoghiorghes GJ, Hemoglobin 2008; 32(1-2):1-15.]. Hemoglobin. 2008; 32(6):601-7. PMID: 19065340.
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      106. Porter J, Galanello R, Saglio G, Neufeld EJ, Vichinsky E, Cappellini MD, Olivieri N, Piga A, Cunningham MJ, Soulières D, Gattermann N, Tchernia G, Maertens J, Giardina P, Kwiatkowski J, Quarta G, Jeng M, Forni GL, Stadler M, Cario H, Debusscher L, Della Porta M, Cazzola M, Greenberg P, Alimena G, Rabault B, Gathmann I, Ford JM, Alberti D, Rose C. Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. Eur J Haematol. 2008 Feb; 80(2):168-76. PMID: 18028431; PMCID: PMC2268958.
      107. Hagar RW, Michlitsch JG, Gardner J, Vichinsky EP, Morris CR. Clinical differences between children and adults with pulmonary hypertension and sickle cell disease. Br J Haematol. 2008 Jan; 140(1):104-12. PMID: 17916102.
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      108. Morris CR, Suh JH, Hagar W, Larkin S, Bland DA, Steinberg MH, Vichinsky EP, Shigenaga M, Ames B, Kuypers FA, Klings ES. Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood. 2008 Jan 1; 111(1):402-10. PMID: 17848621; PMCID: PMC2200820.
      109. Pakbaz Z, Fischer R, Fung E, Nielsen P, Harmatz P, Vichinsky E. Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients. Pediatr Blood Cancer. 2007 Sep; 49(3):329-32. PMID: 17554789.
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      110. Harmatz P, Grady RW, Dragsten P, Vichinsky E, Giardina P, Madden J, Jeng M, Miller B, Hanson G, Hedlund B. Phase Ib clinical trial of starch-conjugated deferoxamine (40SD02): a novel long-acting iron chelator. Br J Haematol. 2007 Aug; 138(3):374-81. PMID: 17614825.
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      111. Jenkins ZA, Hagar W, Bowlus CL, Johansson HE, Harmatz P, Vichinsky EP, Theil EC. Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression. Pediatr Hematol Oncol. 2007 Jun; 24(4):237-43. PMID: 17613866.
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      112. Cappellini MD, Bejaoui M, Agaoglu L, Porter J, Coates T, Jeng M, Lai ME, Mangiagli A, Strauss G, Girot R, Watman N, Ferster A, Loggetto S, Abish S, Cario H, Zoumbos N, Vichinsky E, Opitz H, Ressayre-Djaffer C, Abetz L, Rofail D, Baladi JF. Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia. Clin Ther. 2007 May; 29(5):909-17. PMID: 17697909.
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      113. Fung EB, Harmatz P, Milet M, Ballas SK, De Castro L, Hagar W, Owen W, Olivieri N, Smith-Whitley K, Darbari D, Wang W, Vichinsky E. Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. Am J Hematol. 2007 Apr; 82(4):255-65. PMID: 17094096.
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      114. Vichinsky E, Onyekwere O, Porter J, Swerdlow P, Eckman J, Lane P, Files B, Hassell K, Kelly P, Wilson F, Bernaudin F, Forni GL, Okpala I, Ressayre-Djaffer C, Alberti D, Holland J, Marks P, Fung E, Fischer R, Mueller BU, Coates T. A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haematol. 2007 Feb; 136(3):501-8. PMID: 17233848; PMCID: PMC1974786.
      115. Vichinsky E. Hemoglobin e syndromes. Hematology Am Soc Hematol Educ Program. 2007; 79-83. PMID: 18024613.
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      116. Moskowitz JT, Butensky E, Harmatz P, Vichinsky E, Heyman MB, Acree M, Wrubel J, Wilson L, Folkman S. Caregiving time in sickle cell disease: psychological effects in maternal caregivers. Pediatr Blood Cancer. 2007 Jan; 48(1):64-71. PMID: 16622841.
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      117. Neumayr LD, Aguilar C, Earles AN, Jergesen HE, Haberkern CM, Kammen BF, Nancarrow PA, Padua E, Milet M, Stulberg BN, Williams RA, Orringer EP, Graber N, Robertson SM, Vichinsky EP. Physical therapy alone compared with core decompression and physical therapy for femoral head osteonecrosis in sickle cell disease. Results of a multicenter study at a mean of three years after treatment. J Bone Joint Surg Am. 2006 Dec; 88(12):2573-82. PMID: 17142406.
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      118. Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP. Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer. 2006 Dec; 47(7):901-6. PMID: 16317761.
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      119. Ataga KI, Orringer EP, Styles L, Vichinsky EP, Swerdlow P, Davis GA, Desimone PA, Stocker JW. Dose-escalation study of ICA-17043 in patients with sickle cell disease. Pharmacotherapy. 2006 Nov; 26(11):1557-64. PMID: 17064199.
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      120. Fung EB, Harmatz PR, Lee PD, Milet M, Bellevue R, Jeng MR, Kalinyak KA, Hudes M, Bhatia S, Vichinsky EP. Increased prevalence of iron-overload associated endocrinopathy in thalassaemia versus sickle-cell disease. Br J Haematol. 2006 Nov; 135(4):574-82. PMID: 17054676.
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      121. Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, Harmatz P. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol. 2006 Oct; 135(2):254-63. PMID: 17010049; PMCID: PMC2185791.
      122. Hoppe C, Watson RM, Long CM, Lorey F, Robles L, Klitz W, Styles L, Vichinsky E. Prevalence of HFE mutations in California newborns. Pediatr Hematol Oncol. 2006 Sep; 23(6):507-16. PMID: 16849282.
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      123. Singer ST, Kuypers FA, Styles L, Vichinsky EP, Foote D, Rosenfeld H. Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state. Am J Hematol. 2006 Sep; 81(9):670-5. PMID: 16795058.
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      124. Hagar RW, Morris CR, Vichinsky EP. Pulmonary hypertension in thalassaemia major patients with normal left ventricular systolic function. Br J Haematol. 2006 May; 133(4):433-5. PMID: 16643452.
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      125. Treadwell MJ, McClough L, Vichinsky E. Using qualitative and quantitative strategies to evaluate knowledge and perceptions about sickle cell disease and sickle cell trait. J Natl Med Assoc. 2006 May; 98(5):704-10. PMID: 16749645; PMCID: PMC2569269.
      126. Vogiatzi MG, Macklin EA, Fung EB, Vichinsky E, Olivieri N, Kwiatkowski J, Cohen A, Neufeld E, Giardina PJ. Prevalence of fractures among the Thalassemia syndromes in North America. Bone. 2006 Apr; 38(4):571-5. PMID: 16298178; PMCID: PMC4594870.
      127. Vichinsky EP, MacKlin EA, Waye JS, Lorey F, Olivieri NF. Changes in the epidemiology of thalassemia in North America: a new minority disease. Pediatrics. 2005 Dec; 116(6):e818-25. PMID: 16291734.
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      128. Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP. Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome. Br J Haematol. 2005 Nov; 131(3):378-88. PMID: 16225658.
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      129. Aguilar C, Vichinsky E, Neumayr L. Bone and joint disease in sickle cell disease. Hematol Oncol Clin North Am. 2005 Oct; 19(5):929-41, viii. PMID: 16214653.
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      130. Vichinsky E, Butensky E, Fung E, Hudes M, Theil E, Ferrell L, Williams R, Louie L, Lee PD, Harmatz P. Comparison of organ dysfunction in transfused patients with SCD or beta thalassemia. Am J Hematol. 2005 Sep; 80(1):70-4. PMID: 16138345.
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      131. Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA. 2005 Jul 6; 294(1):81-90. PMID: 15998894; PMCID: PMC2065861.
      132. Aguilar CM, Neumayr LD, Eggleston BE, Earles AN, Robertson SM, Jergesen HE, Stulberg BN, Vichinsky EP. Clinical evaluation of avascular necrosis in patients with sickle cell disease: Children's Hospital Oakland Hip Evaluation Scale--a modification of the Harris Hip Score. Arch Phys Med Rehabil. 2005 Jul; 86(7):1369-75. PMID: 16003666.
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      133. Treadwell MJ, Law AW, Sung J, Hackney-Stephens E, Quirolo K, Murray E, Glendenning GA, Vichinsky E. Barriers to adherence of deferoxamine usage in sickle cell disease. Pediatr Blood Cancer. 2005 May; 44(5):500-7. PMID: 15602707.
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      134. Pakbaz Z, Fischer R, Treadwell M, Yamashita R, Fung EB, Calvelli L, Quirolo K, Foote D, Harmatz P, Vichinsky EP. A simple model to assess and improve adherence to iron chelation therapy with deferoxamine in patients with thalassemia. Ann N Y Acad Sci. 2005; 1054:486-91. PMID: 16339703.
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      135. Pakbaz Z, Treadwell M, Yamashita R, Quirolo K, Foote D, Quill L, Singer T, Vichinsky EP. Quality of life in patients with thalassemia intermedia compared to thalassemia major. Ann N Y Acad Sci. 2005; 1054:457-61. PMID: 16339697.
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      136. Premawardhena A, De Silver S, Arambepola M, Olivieri NF, Vichinsky EP, Merson L, Muraco G, Allen A, Fisher C, Peto T, Weatherall DJ. Hemoglobin E-beta-thalassemia: Progress report from the International Study Group. Ann N Y Acad Sci. 2005; 1054:33-9. PMID: 16339649.
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      137. Qureshi N, Foote D, Walters MC, Singer ST, Quirolo K, Vichinsky EP. Outcomes of preimplantation genetic diagnosis therapy in treatment of beta-thalassemia: A retrospective analysis. Ann N Y Acad Sci. 2005; 1054:500-3. PMID: 16339706.
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      138. Butensky E, Fischer R, Hudes M, Schumacher L, Williams R, Moyer TP, Vichinsky E, Harmatz P. Variability in hepatic iron concentration in percutaneous needle biopsy specimens from patients with transfusional hemosiderosis. Am J Clin Pathol. 2005 Jan; 123(1):146-52. PMID: 15762291.
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      139. Qureshi N, Avasarala K, Foote D, Vichinsky EP. Utility of Holter electrocardiogram in iron-overloaded hemoglobinopathies. Ann N Y Acad Sci. 2005; 1054:476-80. PMID: 16339701.
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      140. Butensky E, Pakbaz Z, Foote D, Walters MC, Vichinsky EP, Harmatz P. Treatment of hepatitis C virus infection in thalassemia. Ann N Y Acad Sci. 2005; 1054:290-9. PMID: 16339677.
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      141. Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP. Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment. Ann N Y Acad Sci. 2005; 1054:250-6. PMID: 16339672.
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      142. Vichinsky EP. Changing patterns of thalassemia worldwide. Ann N Y Acad Sci. 2005; 1054:18-24. PMID: 16339647.
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      143. Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN. Measuring chromosome breaks in patients with thalassemia. Ann N Y Acad Sci. 2005; 1054:439-44. PMID: 16339694.
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      144. Morris CR, Kuypers FA, Kato GJ, Lavrisha L, Larkin S, Singer T, Vichinsky EP. Hemolysis-associated pulmonary hypertension in thalassemia. Ann N Y Acad Sci. 2005; 1054:481-5. PMID: 16339702; PMCID: PMC3217300.
      145. Jeng MR, Vichinsky E. Hematologic problems in immigrants from Southeast Asia. Hematol Oncol Clin North Am. 2004 Dec; 18(6):1405-22, x. PMID: 15511622.
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      146. Fung EB, Fischer R, Pakbaz Z, Fagaly RL, Vichinsky E, Starr TN, Ewing T, Paulson DN, Hassenzahl WV, Harmatz P. The new SQUID biosusceptometer at Oakland: first year of experience. Neurol Clin Neurophysiol. 2004; 2004:5. PMID: 16012600.
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      147. Jones A, Granger S, Brambilla D, Gallagher D, Vichinsky E, Woods G, Berman B, Roach S, Nichols F, Adams RJ. Can peak systolic velocities be used for prediction of stroke in sickle cell anemia? Pediatr Radiol. 2005 Jan; 35(1):66-72. PMID: 15517239.
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      148. Premawardhena A, De Silva S, Arambepola M, Olivieri N, Merson L, Muraco J, Allen A, Fisher C, Peto T, Vichinsky E, Weatherall D. Thalassemia in Sri Lanka: a progress report. Hum Mol Genet. 2004 Oct 1; 13 Spec No 2:R203-6. PMID: 15358726.
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      149. Lal A, Vichinsky E. The role of fetal hemoglobin-enhancing agents in thalassemia. Semin Hematol. 2004 Oct; 41(4 Suppl 6):17-22. PMID: 15534853.
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      150. Vichinsky EP. Pulmonary hypertension in sickle cell disease. N Engl J Med. 2004 Feb 26; 350(9):857-9. PMID: 14985481.
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      151. Adams RJ, Brambilla DJ, Granger S, Gallagher D, Vichinsky E, Abboud MR, Pegelow CH, Woods G, Rohde EM, Nichols FT, Jones A, Luden JP, Bowman L, Hagner S, Morales KH, Roach ES. Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study. Blood. 2004 May 15; 103(10):3689-94. PMID: 14751925.
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      152. Cohen AR, Galanello R, Pennell DJ, Cunningham MJ, Vichinsky E. Thalassemia. Hematology Am Soc Hematol Educ Program. 2004; 14-34. PMID: 15561674.
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      153. Claster S, Vichinsky EP. Managing sickle cell disease. BMJ. 2003 Nov 15; 327(7424):1151-5. PMID: 14615343; PMCID: PMC261819.
      154. Hoppe C, Klitz W, Cheng S, Apple R, Steiner L, Robles L, Girard T, Vichinsky E, Styles L. Gene interactions and stroke risk in children with sickle cell anemia. Blood. 2004 Mar 15; 103(6):2391-6. PMID: 14615367.
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      155. Adamkiewicz TV, Sarnaik S, Buchanan GR, Iyer RV, Miller ST, Pegelow CH, Rogers ZR, Vichinsky E, Elliott J, Facklam RR, O'Brien KL, Schwartz B, Van Beneden CA, Cannon MJ, Eckman JR, Keyserling H, Sullivan K, Wong WY, Wang WC. Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination. J Pediatr. 2003 Oct; 143(4):438-44. PMID: 14571216.
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      156. Morris CR, Vichinsky EP, van Warmerdam J, Machado L, Kepka-Lenhart D, Morris SM, Kuypers FA. Hydroxyurea and arginine therapy: impact on nitric oxide production in sickle cell disease. J Pediatr Hematol Oncol. 2003 Aug; 25(8):629-34. PMID: 12902916.
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      157. Neumayr L, Lennette E, Kelly D, Earles A, Embury S, Groncy P, Grossi M, Grover R, McMahon L, Swerdlow P, Waldron P, Vichinsky E. Mycoplasma disease and acute chest syndrome in sickle cell disease. Pediatrics. 2003 Jul; 112(1 Pt 1):87-95. PMID: 12837872.
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      158. Brittenham GM, Nathan DG, Olivieri NF, Porter JB, Pippard M, Vichinsky EP, Weatherall DJ. Deferiprone and hepatic fibrosis. Blood. 2003 Jun 15; 101(12):5089-90; author reply 5090-1. PMID: 12788794.
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      159. Steinberg MH, Barton F, Castro O, Pegelow CH, Ballas SK, Kutlar A, Orringer E, Bellevue R, Olivieri N, Eckman J, Varma M, Ramirez G, Adler B, Smith W, Carlos T, Ataga K, DeCastro L, Bigelow C, Saunthararajah Y, Telfer M, Vichinsky E, Claster S, Shurin S, Bridges K, Waclawiw M, Bonds D, Terrin M. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. JAMA. 2003 Apr 2; 289(13):1645-51. PMID: 12672732.
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      160. Hagar W, Vichinsky EP, Theil EC. Liver ferritin subunit ratios in neonatal hemochromatosis. Pediatr Hematol Oncol. 2003 Apr-May; 20(3):229-35. PMID: 12637219.
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      161. Morris CR, Morris SM, Hagar W, Van Warmerdam J, Claster S, Kepka-Lenhart D, Machado L, Kuypers FA, Vichinsky EP. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med. 2003 Jul 1; 168(1):63-9. PMID: 12626350.
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      162. Dean D, Neumayr L, Kelly DM, Ballas SK, Kleman K, Robertson S, Iyer RV, Ware RE, Koshy M, Rackoff WR, Pegelow CH, Waldron P, Benjamin L, Vichinsky E. Chlamydia pneumoniae and acute chest syndrome in patients with sickle cell disease. J Pediatr Hematol Oncol. 2003 Jan; 25(1):46-55. PMID: 12544773.
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      163. Hoppe C, Klitz W, Noble J, Vigil L, Vichinsky E, Styles L. Distinct HLA associations by stroke subtype in children with sickle cell anemia. Blood. 2003 Apr 1; 101(7):2865-9. PMID: 12517810.
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      164. Lo L, Singer ST, Vichinsky E. Pancytopenia induced by hypothermia. J Pediatr Hematol Oncol. 2002 Nov; 24(8):681-4. PMID: 12439045.
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      165. Hagar W, Theil EC, Vichinsky EP. Diseases of iron metabolism. Pediatr Clin North Am. 2002 Oct; 49(5):893-909. PMID: 12430618.
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      166. Vichinsky E. New therapies in sickle cell disease. Lancet. 2002 Aug 24; 360(9333):629-31. PMID: 12241949.
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      167. VanderJagt DJ, Harmatz P, Scott-Emuakpor AB, Vichinsky E, Glew RH. Bioelectrical impedance analysis of the body composition of children and adolescents with sickle cell disease. J Pediatr. 2002 Jun; 140(6):681-7. PMID: 12072870.
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      168. Files B, Brambilla D, Kutlar A, Miller S, Vichinsky E, Wang W, Granger S, Adams RJ. Longitudinal changes in ferritin during chronic transfusion: a report from the Stroke Prevention Trial in Sickle Cell Anemia (STOP). J Pediatr Hematol Oncol. 2002 May; 24(4):284-90. PMID: 11972097.
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      169. Pegelow CH, Macklin EA, Moser FG, Wang WC, Bello JA, Miller ST, Vichinsky EP, DeBaun MR, Guarini L, Zimmerman RA, Younkin DP, Gallagher DM, Kinney TR. Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood. 2002 Apr 15; 99(8):3014-8. PMID: 11929794.
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      170. Wang WC, Helms RW, Lynn HS, Redding-Lallinger R, Gee BE, Ohene-Frempong K, Smith-Whitley K, Waclawiw MA, Vichinsky EP, Styles LA, Ware RE, Kinney TR. Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study. J Pediatr. 2002 Feb; 140(2):225-9. PMID: 11865275.
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      171. Jeng MR, Feusner J, Skibola C, Vichinsky E. Central venous catheter complications in sickle cell disease. Am J Hematol. 2002 Feb; 69(2):103-8. PMID: 11835345.
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      172. Treadwell MJ, Franck LS, Vichinsky E. Using quality improvement strategies to enhance pediatric pain assessment. Int J Qual Health Care. 2002 Feb; 14(1):39-47. PMID: 11871628.
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      173. Franck LS, Treadwell M, Jacob E, Vichinsky E. Assessment of sickle cell pain in children and young adults using the adolescent pediatric pain tool. J Pain Symptom Manage. 2002 Feb; 23(2):114-20. PMID: 11844631.
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      174. Walters MC, Nienhuis AW, Vichinsky E. Novel therapeutic approaches in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2002; 10-34. PMID: 12446417.
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      175. Pegelow CH, Wang W, Granger S, Hsu LL, Vichinsky E, Moser FG, Bello J, Zimmerman RA, Adams RJ, Brambilla D. Silent infarcts in children with sickle cell anemia and abnormal cerebral artery velocity. Arch Neurol. 2001 Dec; 58(12):2017-21. PMID: 11735775.
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      176. Miller ST, Macklin EA, Pegelow CH, Kinney TR, Sleeper LA, Bello JA, DeWitt LD, Gallagher DM, Guarini L, Moser FG, Ohene-Frempong K, Sanchez N, Vichinsky EP, Wang WC, Wethers DL, Younkin DP, Zimmerman RA, DeBaun MR. Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr. 2001 Sep; 139(3):385-90. PMID: 11562618.
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      177. Wang W, Enos L, Gallagher D, Thompson R, Guarini L, Vichinsky E, Wright E, Zimmerman R, Armstrong FD. Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr. 2001 Sep; 139(3):391-7. PMID: 11562619.
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      178. Vichinsky EP, Luban NL, Wright E, Olivieri N, Driscoll C, Pegelow CH, Adams RJ. Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial. Transfusion. 2001 Sep; 41(9):1086-92. PMID: 11552063.
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      179. Hoppe C, Cheng S, Grow M, Silbergleit A, Klitz W, Trachtenberg E, Erlich H, Vichinsky E, Styles L. A novel multilocus genotyping assay to identify genetic predictors of stroke in sickle cell anaemia. Br J Haematol. 2001 Sep; 114(3):718-20. PMID: 11553004.
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      180. Cheung AT, Harmatz P, Wun T, Chen PC, Larkin EC, Adams RJ, Vichinsky EP. Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood. 2001 Jun 1; 97(11):3401-4. PMID: 11369629.
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      181. Reed W, Vichinsky EP. Transfusion therapy: a coming-of-age treatment for patients with sickle cell disease. J Pediatr Hematol Oncol. 2001 May; 23(4):197-202. PMID: 11846294.
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      182. Culberson DE, Manci EA, Shah AK, Haynes J, Ballas SK, Pegelow C, Vichinsky E. Nesidioblastosis in sickle cell disease. Pediatr Pathol Mol Med. 2001 Mar-Apr; 20(2):155-65. PMID: 12673839.
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      183. Vichinsky E. Consensus document for transfusion-related iron overload. Semin Hematol. 2001 Jan; 38(1 Suppl 1):2-4. PMID: 11206957.
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      184. Walters MC, Patience M, Leisenring W, Rogers ZR, Aquino VM, Buchanan GR, Roberts IA, Yeager AM, Hsu L, Adamkiewicz T, Kurtzberg J, Vichinsky E, Storer B, Storb R, Sullivan KM. Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. Biol Blood Marrow Transplant. 2001; 7(12):665-73. PMID: 11787529.
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      185. Vichinsky EP. Current issues with blood transfusions in sickle cell disease. Semin Hematol. 2001 Jan; 38(1 Suppl 1):14-22. PMID: 11206956.
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      186. Fixler J, Vichinsky E, Walters MC. Stem cell transplantation for sickle cell disease: can we reduce the toxicity? Pediatr Pathol Mol Med. 2001 Jan-Feb; 20(1):73-86. PMID: 12673845.
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      187. Lorey F, Cunningham G, Vichinsky EP, Lubin BH, Witkowska HE, Matsunaga A, Azimi M, Sherwin J, Eastman J, Farina F, Waye JS, Chui DH. Universal newborn screening for Hb H disease in California. Genet Test. 2001; 5(2):93-100. PMID: 11551109.
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      188. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P, Vichinsky EP. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent. Blood. 2000 Nov 15; 96(10):3369-73. PMID: 11071629.
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      189. Choy J, Foote D, Bojanowski J, Yamashita R, Vichinsky E. Outreach strategies for Southeast Asian communities: experience, practice, and suggestions for approaching Southeast Asian immigrant and refugee communities to provide thalassemia education and trait testing. J Pediatr Hematol Oncol. 2000 Nov-Dec; 22(6):588-92. PMID: 11132235.
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      190. Morris CR, Kuypers FA, Larkin S, Vichinsky EP, Styles LA. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Pediatr Hematol Oncol. 2000 Nov-Dec; 22(6):515-20. PMID: 11132219.
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      191. Styles LA, Aarsman AJ, Vichinsky EP, Kuypers FA. Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease. Blood. 2000 Nov 1; 96(9):3276-8. PMID: 11050014.
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      192. Singer ST, Styles L, Bojanowski J, Quirolo K, Foote D, Vichinsky EP. Changing outcome of homozygous alpha-thalassemia: cautious optimism. J Pediatr Hematol Oncol. 2000 Nov-Dec; 22(6):539-42. PMID: 11132224.
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      193. Morris CR, Kuypers FA, Larkin S, Sweeters N, Simon J, Vichinsky EP, Styles LA. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. 2000 Nov; 111(2):498-500. PMID: 11122090.
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      194. Hoppe C, Vichinsky E, Quirolo K, van Warmerdam J, Allen K, Styles L. Use of hydroxyurea in children ages 2 to 5 years with sickle cell disease. J Pediatr Hematol Oncol. 2000 Jul-Aug; 22(4):330-4. PMID: 10959903.
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      195. Harmatz P, Butensky E, Quirolo K, Williams R, Ferrell L, Moyer T, Golden D, Neumayr L, Vichinsky E. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood. 2000 Jul 1; 96(1):76-9. PMID: 10891433.
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      196. Wang WC, Gallagher DM, Pegelow CH, Wright EC, Vichinsky EP, Abboud MR, Moser FG, Adams RJ. Multicenter comparison of magnetic resonance imaging and transcranial Doppler ultrasonography in the evaluation of the central nervous system in children with sickle cell disease. J Pediatr Hematol Oncol. 2000 Jul-Aug; 22(4):335-9. PMID: 10959904.
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      197. Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, Daeschner C, Manci EA. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000 Jun 22; 342(25):1855-65. PMID: 10861320.
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      198. Styles LA, Hoppe C, Klitz W, Vichinsky E, Lubin B, Trachtenberg E. Evidence for HLA-related susceptibility for stroke in children with sickle cell disease. Blood. 2000 Jun 1; 95(11):3562-7. PMID: 10828044.
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      199. Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GE, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong WY, Scott JP, Margolis D, Vichinsky E, Wall DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, Sullivan KM. Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. Blood. 2000 Mar 15; 95(6):1918-24. PMID: 10706855.
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      200. Reed W, Lane PA, Lorey F, Bojanowski J, Glass M, Louie RR, Lubin BH, Vichinsky EP. Sickle-cell disease not identified by newborn screening because of prior transfusion. J Pediatr. 2000 Feb; 136(2):248-50. PMID: 10657834.
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      201. Hagar RW, Vichinsky EP. Major changes in sickle cell disease. Adv Pediatr. 2000; 47:249-72. PMID: 10959446.
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      202. Hoppe C, Vichinsky E, Lewis B, Foote D, Styles L. Hydroxyurea and sodium phenylbutyrate therapy in thalassemia intermedia. Am J Hematol. 1999 Dec; 62(4):221-7. PMID: 10589077.
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      203. Vichinsky EP, Neumayr LD, Haberkern C, Earles AN, Eckman J, Koshy M, Black DM. The perioperative complication rate of orthopedic surgery in sickle cell disease: report of the National Sickle Cell Surgery Study Group. Am J Hematol. 1999 Nov; 62(3):129-38. PMID: 10539878.
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      204. Reed WF, Vichinsky EP. Transfusion practice for patients with sickle cell disease. Curr Opin Hematol. 1999 Nov; 6(6):432-6. PMID: 10546799.
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      205. Singer ST, Vichinsky EP. Bone disease in beta-thalassaemia. Lancet. 1999 Sep 11; 354(9182):881-2. PMID: 10489942.
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      206. Kinney TR, Helms RW, O'Branski EE, Ohene-Frempong K, Wang W, Daeschner C, Vichinsky E, Redding-Lallinger R, Gee B, Platt OS, Ware RE. Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood. 1999 Sep 1; 94(5):1550-4. PMID: 10477679.
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      207. Harmatz P, Heyman MB, Cunningham J, Lee PD, Styles L, Quirolo K, Kopp-Hoolihan L, Ghiron J, Hintz RL, Vichinsky E. Effects of red blood cell transfusion on resting energy expenditure in adolescents with sickle cell anemia. J Pediatr Gastroenterol Nutr. 1999 Aug; 29(2):127-31. PMID: 10435647.
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      208. Morris C, Vichinsky E, Styles L. Clinician assessment for acute chest syndrome in febrile patients with sickle cell disease: is it accurate enough? Ann Emerg Med. 1999 Jul; 34(1):64-9. PMID: 10381996.
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      209. Reed W, Jagust W, Al-Mateen M, Vichinsky E. Role of positron emission tomography in determining the extent of CNS ischemia in patients with sickle cell disease. Am J Hematol. 1999 Apr; 60(4):268-72. PMID: 10203099.
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      210. Waldron P, Pegelow C, Neumayr L, Haberkern C, Earles A, Wesman R, Vichinsky E. Tonsillectomy, adenoidectomy, and myringotomy in sickle cell disease: perioperative morbidity. Preoperative Transfusion in Sickle Cell Disease Study Group. J Pediatr Hematol Oncol. 1999 Mar-Apr; 21(2):129-35. PMID: 10206459.
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      211. Kinney TR, Sleeper LA, Wang WC, Zimmerman RA, Pegelow CH, Ohene-Frempong K, Wethers DL, Bello JA, Vichinsky EP, Moser FG, Gallagher DM, DeBaun MR, Platt OS, Miller ST. Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease. Pediatrics. 1999 Mar; 103(3):640-5. PMID: 10049969.
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      212. Singer ST, Quirolo K, Nishi K, Hackney-Stephens E, Evans C, Vichinsky EP. Erythrocytapheresis for chronically transfused children with sickle cell disease: an effective method for maintaining a low hemoglobin S level and reducing iron overload. J Clin Apher. 1999; 14(3):122-5. PMID: 10540366.
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      213. Singer ST, Vichinsky EP. Deferoxamine treatment during pregnancy: is it harmful? Am J Hematol. 1999 Jan; 60(1):24-6. PMID: 9883802.
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      214. Reed W, Lee TH, Vichinsky EP, Lubin BH, Busch MP. Sample suitability for the detection of minor white cell populations (microchimerism) by polymerase chain reaction. Transfusion. 1998 Nov-Dec; 38(11-12):1041-5. PMID: 9838935.
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      215. Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, Abboud M, Gallagher D, Kutlar A, Nichols FT, Bonds DR, Brambilla D. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998 Jul 2; 339(1):5-11. PMID: 9647873.
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      216. Choy J, Yamashita RC, Foote D, Heer N, Vichinsky EP. Outreach strategies for Asian Pacific Island (API) communities. Ann N Y Acad Sci. 1998 Jun 30; 850:514-5. PMID: 9705740.
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      217. Rees DC, Styles L, Vichinsky EP, Clegg JB, Weatherall DJ. The hemoglobin E syndromes. Ann N Y Acad Sci. 1998 Jun 30; 850:334-43. PMID: 9668555.
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      218. Styles L, Lewis B, Foote D, Cuda L, Vichinsky EP. Preliminary report: hydroxyurea produces significant clinical response in thalassemia intermedia. Ann N Y Acad Sci. 1998 Jun 30; 850:461-2. PMID: 9668584.
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      219. Vichinsky EP. The morbidity of bone disease in thalassemia. Ann N Y Acad Sci. 1998 Jun 30; 850:344-8. PMID: 9668556.
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      220. Weissman L, Treadwell M, Foote D, Heer N, Vichinsky EP. Approaches to working with adult thalassemia patients in pediatric settings. Ann N Y Acad Sci. 1998 Jun 30; 850:516-7. PMID: 9668599.
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      221. Heer N, Choy J, Vichinsky EP. The social impact of migration on disease. Cooley's anemia, thalassemia, and new Asian immigrants. Ann N Y Acad Sci. 1998 Jun 30; 850:509-11. PMID: 9668597.
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      222. Lee YS, Kristovich KM, Ducore JM, Vichinsky E, Crouse VL, Glader BE, Amylon MD. Bone marrow transplant in thalassemia. A role for radiation? Ann N Y Acad Sci. 1998 Jun 30; 850:503-5. PMID: 9668596.
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      223. Fridge JL, Vichinsky EP. Correction of the anemia of epidermolysis bullosa with intravenous iron and erythropoietin. J Pediatr. 1998 May; 132(5):871-3. PMID: 9602203.
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      224. Golden C, Styles L, Vichinsky E. Acute chest syndrome and sickle cell disease. Curr Opin Hematol. 1998 Mar; 5(2):89-92. PMID: 9570700.
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      225. Neumayr L, Koshy M, Haberkern C, Earles AN, Bellevue R, Hassell K, Miller S, Black D, Vichinsky E. Surgery in patients with hemoglobin SC disease. Preoperative Transfusion in Sickle Cell Disease Study Group. Am J Hematol. 1998 Feb; 57(2):101-8. PMID: 9462540.
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      226. Hoppe C, Styles L, Vichinsky E. The natural history of sickle cell disease. Curr Opin Pediatr. 1998 Feb; 10(1):49-52. PMID: 9529638.
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      227. Adams RJ, McKie VC, Brambilla D, Carl E, Gallagher D, Nichols FT, Roach S, Abboud M, Berman B, Driscoll C, Files B, Hsu L, Hurlet A, Miller S, Olivieri N, Pegelow C, Scher C, Vichinsky E, Wang W, Woods G, Kutlar A, Wright E, Hagner S, Tighe F, Waclawiw MA. Stroke prevention trial in sickle cell anemia. Control Clin Trials. 1998 Feb; 19(1):110-29. PMID: 9492971.
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      228. Olivieri NF, Vichinsky EP. Hydroxyurea in children with sickle cell disease: impact on splenic function and compliance with therapy. J Pediatr Hematol Oncol. 1998 Jan-Feb; 20(1):26-31. PMID: 9482409.
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      229. Reed W, Vichinsky EP. New considerations in the treatment of sickle cell disease. Annu Rev Med. 1998; 49:461-74. PMID: 9509275.
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      230. Woods GM, Jorgensen JH, Waclawiw MA, Reid C, Wang W, Pegelow CH, Rogers ZR, Iyer RV, Holbrook CT, Kinney TR, Vichinsky E, DeBaun MR, Grossman NJ, Thomas MD, Falletta JM. Influence of penicillin prophylaxis on antimicrobial resistance in nasopharyngeal S. pneumoniae among children with sickle cell anemia. The Ancillary Nasopharyngeal Culture Study of Prophylactic Penicillin Study II. J Pediatr Hematol Oncol. 1997 Jul-Aug; 19(4):327-33. PMID: 9256832.
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      231. Vichinsky EP. Hydroxyurea in children: present and future. Semin Hematol. 1997 Jul; 34(3 Suppl 3):22-9. PMID: 9317198.
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      232. Kelly P, Kurtzberg J, Vichinsky E, Lubin B. Umbilical cord blood stem cells: application for the treatment of patients with hemoglobinopathies. J Pediatr. 1997 May; 130(5):695-703. PMID: 9152276.
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      233. Styles LA, Lubin B, Vichinsky E, Lawrence S, Hua M, Test S, Kuypers F. Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea. Blood. 1997 Apr 1; 89(7):2554-9. PMID: 9116302.
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      234. Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B. Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease. Blood. 1997 Mar 1; 89(5):1787-92. PMID: 9057664.
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      235. Haberkern CM, Neumayr LD, Orringer EP, Earles AN, Robertson SM, Black D, Abboud MR, Koshy M, Idowu O, Vichinsky EP. Cholecystectomy in sickle cell anemia patients: perioperative outcome of 364 cases from the National Preoperative Transfusion Study. Preoperative Transfusion in Sickle Cell Disease Study Group. Blood. 1997 Mar 1; 89(5):1533-42. PMID: 9057634.
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      236. Styles LA, Vichinsky EP. New therapies and approaches to transfusion in sickle cell disease in children. Curr Opin Pediatr. 1997 Feb; 9(1):41-5. PMID: 9088754.
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      237. Pegelow CH, Colangelo L, Steinberg M, Wright EC, Smith J, Phillips G, Vichinsky E. Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia. Am J Med. 1997 Feb; 102(2):171-7. PMID: 9217567.
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      238. Vichinsky E, Styles L. Pulmonary complications. Hematol Oncol Clin North Am. 1996 Dec; 10(6):1275-87. PMID: 8956016.
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      239. Bjornson AB, Falletta JM, Verter JI, Buchanan GR, Miller ST, Pegelow CH, Iyer RV, Johnstone HS, DeBaun MR, Wethers DL, Wang WC, Woods GM, Holbrook CT, Becton DL, Kinney TR, Reaman GH, Kalinyak K, Grossman NJ, Vichinsky E, Reid CD. Serotype-specific immunoglobulin G antibody responses to pneumococcal polysaccharide vaccine in children with sickle cell anemia: effects of continued penicillin prophylaxis. J Pediatr. 1996 Dec; 129(6):828-35. PMID: 8969724.
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      240. Claster S, Vichinsky E. First report of reversal of organ dysfunction in sickle cell anemia by the use of hydroxyurea: splenic regeneration. Blood. 1996 Sep 15; 88(6):1951-3. PMID: 8822912.
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      241. Styles LA, Vichinsky EP. Core decompression in avascular necrosis of the hip in sickle-cell disease. Am J Hematol. 1996 Jun; 52(2):103-7. PMID: 8638629.
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      242. Walters MC, Patience M, Leisenring W, Eckman JR, Buchanan GR, Rogers ZR, Olivieri NE, Vichinsky E, Davies SC, Mentzer WC, Powars D, Scott JP, Bernaudin F, Ohene-Frempong K, Darbyshire PJ, Wayne A, Roberts IA, Dinndorf P, Brandalise S, Sanders JE, Matthews DC, Appelbaum FR, Storb R, Sullivan KM. Barriers to bone marrow transplantation for sickle cell anemia. Biol Blood Marrow Transplant. 1996 May; 2(2):100-4. PMID: 9118298.
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      243. Moser FG, Miller ST, Bello JA, Pegelow CH, Zimmerman RA, Wang WC, Ohene-Frempong K, Schwartz A, Vichinsky EP, Gallagher D, Kinney TR. The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. AJNR Am J Neuroradiol. 1996 May; 17(5):965-72. PMID: 8733975.
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      244. Styles LA, Schalkwijk CG, Aarsman AJ, Vichinsky EP, Lubin BH, Kuypers FA. Phospholipase A2 levels in acute chest syndrome of sickle cell disease. Blood. 1996 Mar 15; 87(6):2573-8. PMID: 8630425.
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      245. Shafer FE, Lorey F, Cunningham GC, Klumpp C, Vichinsky E, Lubin B. Newborn screening for sickle cell disease: 4 years of experience from California's newborn screening program. J Pediatr Hematol Oncol. 1996 Feb; 18(1):36-41. PMID: 8556368.
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      246. Styles LA, Vichinsky EP. Ototoxicity in hemoglobinopathy patients chelated with desferrioxamine. J Pediatr Hematol Oncol. 1996 Feb; 18(1):42-5. PMID: 8556369.
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      247. Koshy M, Weiner SJ, Miller ST, Sleeper LA, Vichinsky E, Brown AK, Khakoo Y, Kinney TR. Surgery and anesthesia in sickle cell disease. Cooperative Study of Sickle Cell Diseases. Blood. 1995 Nov 15; 86(10):3676-84. PMID: 7579333.
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      248. Falletta JM, Woods GM, Verter JI, Buchanan GR, Pegelow CH, Iyer RV, Miller ST, Holbrook CT, Kinney TR, Vichinsky E. Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II. J Pediatr. 1995 Nov; 127(5):685-90. PMID: 7472817.
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      249. Vichinsky EP, Haberkern CM, Neumayr L, Earles AN, Black D, Koshy M, Pegelow C, Abboud M, Ohene-Frempong K, Iyer RV. A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease. The Preoperative Transfusion in Sickle Cell Disease Study Group. N Engl J Med. 1995 Jul 27; 333(4):206-13. PMID: 7791837.
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      250. Gill FM, Sleeper LA, Weiner SJ, Brown AK, Bellevue R, Grover R, Pegelow CH, Vichinsky E. Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease. Blood. 1995 Jul 15; 86(2):776-83. PMID: 7606007.
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      251. Pegelow CH, Adams RJ, McKie V, Abboud M, Berman B, Miller ST, Olivieri N, Vichinsky E, Wang W, Brambilla D. Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions. J Pediatr. 1995 Jun; 126(6):896-9. PMID: 7776091.
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      252. Lang T, Berquist WE, So SK, Cox KL, Rich EJ, Vichinsky E, Concepcion W, Esquivel CO. Liver transplantation in a child with sickle cell anemia. Transplantation. 1995 May 27; 59(10):1490-2. PMID: 7770941.
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      253. Aquino SL, Gamsu G, Fahy JV, Claster S, Embury SH, Mentzer WC, Vichinsky EP. Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT. Radiology. 1994 Dec; 193(3):807-11. PMID: 7972829.
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      254. Styles LA, Vichinsky E. Effects of a long-term transfusion regimen on sickle cell-related illnesses. J Pediatr. 1994 Dec; 125(6 Pt 1):909-11. PMID: 7996363.
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      255. Vichinsky E, Williams R, Das M, Earles AN, Lewis N, Adler A, McQuitty J. Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia. Blood. 1994 Jun 1; 83(11):3107-12. PMID: 8193347.
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      256. Shafer FE, Vichinsky E. New advances in the pathophysiology and management of sickle cell disease. Curr Opin Hematol. 1994 Mar; 1(2):125-35. PMID: 9371271.
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      257. Vichinsky EP, Lubin BH. A cautionary note regarding hydroxyurea in sickle cell disease. Blood. 1994 Feb 15; 83(4):1124-8. PMID: 7509209.
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      258. Perrine SP, Olivieri NF, Faller DV, Vichinsky EP, Dover GJ, Ginder GD. Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders. Am J Pediatr Hematol Oncol. 1994 Feb; 16(1):67-71. PMID: 7508690.
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      259. Mentzer WC, Heller S, Pearle PR, Hackney E, Vichinsky E. Availability of related donors for bone marrow transplantation in sickle cell anemia. Am J Pediatr Hematol Oncol. 1994 Feb; 16(1):27-9. PMID: 8311169.
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      260. Lorey F, Cunningham G, Shafer F, Lubin B, Vichinsky E. Universal screening for hemoglobinopathies using high-performance liquid chromatography: clinical results of 2.2 million screens. Eur J Hum Genet. 1994; 2(4):262-71. PMID: 7704556.
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      261. Lorey FW, Cunningham GC, Vichinsky E, Lubin B, Shafer F, Eastman J. Detection of Hb E/beta-thalassemia versus homozygous EE using high-performance liquid chromatography results from newborns. Biochem Med Metab Biol. 1993 Feb; 49(1):67-73. PMID: 7679916.
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      262. Perrine SP, Ginder GD, Faller DV, Dover GH, Ikuta T, Witkowska HE, Cai SP, Vichinsky EP, Olivieri NF. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N Engl J Med. 1993 Jan 14; 328(2):81-6. PMID: 7677966.
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      263. Nagel RL, Vichinsky E, Shah M, Johnson R, Spadacino E, Fabry ME, Mangahas L, Abel R, Stamatoyannopoulos G. F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study. Blood. 1993 Jan 1; 81(1):9-14. PMID: 8417806.
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      264. Johnson JP, Vichinsky E, Hurst D, Camber A, Lubin B, Louie E. Differentiation of homozygous hemoglobin E from compound heterozygous hemoglobin E-beta O-thalassemia by hemoglobin E mutation analysis. J Pediatr. 1992 May; 120(5):775-9. PMID: 1374466.
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      265. Witkowska HE, Lubin BH, Beuzard Y, Baruchel S, Esseltine DW, Vichinsky EP, Kleman KM, Bardakdjian-Michau J, Pinkoski L, Cahn S. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. N Engl J Med. 1991 Oct 17; 325(16):1150-4. PMID: 1891024.
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      266. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR. Pain in sickle cell disease. Rates and risk factors. N Engl J Med. 1991 Jul 4; 325(1):11-6. PMID: 1710777.
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      267. Vichinsky EP. Comprehensive care in sickle cell disease: its impact on morbidity and mortality. Semin Hematol. 1991 Jul; 28(3):220-6. PMID: 1887248.
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      268. Vichinsky EP, Earles A, Johnson RA, Hoag MS, Williams A, Lubin B. Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood. N Engl J Med. 1990 Jun 7; 322(23):1617-21. PMID: 2342522.
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      269. Chiu D, Vichinsky E, Ho SL, Liu T, Lubin BH. Vitamin C deficiency in patients with sickle cell anemia. Am J Pediatr Hematol Oncol. 1990; 12(3):262-7. PMID: 2240472.
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      270. Perrine SP, Miller BA, Faller DV, Cohen RA, Vichinsky EP, Hurst D, Lubin BH, Papayannopoulou T. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. Blood. 1989 Jul; 74(1):454-9. PMID: 2473801.
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      271. Kleman KM, Vichinsky E, Lubin BH. Experience with newborn screening using isoelectric focusing. Pediatrics. 1989 May; 83(5 Pt 2):852-4. PMID: 2717314.
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      272. Heyman MB, Lande W, Vichinsky E, Mentzer W. Elevated fasting breath hydrogen and abnormal hydrogen breath tests in children with sickle cell disease: a preliminary report. Am J Clin Nutr. 1989 Apr; 49(4):654-7. PMID: 2929487.
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      273. Perrine SP, Miller BA, Papayannopoulou T, Faller DV, Rudolph AM, Vichinsky E, Hurst D, Kan YW. Butyrate analogues modulate globin gene expression in human and ovine erythroid cells. Prog Clin Biol Res. 1989; 316B:341-50. PMID: 2616579.
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      274. Perrine SP, Vichinsky E, Faller DV. Hematopoietic hormones: from cloning to clinic. Am J Pediatr Hematol Oncol. 1989; 11(3):268-75. PMID: 2675659.
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      275. Vichinsky E, Hurst D, Earles A, Kleman K, Lubin B. Newborn screening for sickle cell disease: effect on mortality. Pediatrics. 1988 Jun; 81(6):749-55. PMID: 3368274.
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      276. Vichinsky E, McDonald C. Contraceptive use in the chronically ill adolescent female. J Adolesc Health Care. 1988 Jan; 9(1):87. PMID: 3335479.
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      277. Vichinsky E, Lubin BH. Suggested guidelines for the treatment of children with sickle cell anemia. Hematol Oncol Clin North Am. 1987 Sep; 1(3):483-501. PMID: 3329183.
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      278. Gaston MH, Verter JI, Woods G, Pegelow C, Kelleher J, Presbury G, Zarkowsky H, Vichinsky E, Iyer R, Lobel JS. Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. N Engl J Med. 1986 Jun 19; 314(25):1593-9. PMID: 3086721.
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      279. Heyman MB, Vichinsky E, Katz R, Gaffield B, Hurst D, Castillo R, Chiu D, Kleman K, Ammann AJ, Thaler MM. Growth retardation in sickle-cell disease treated by nutritional support. Lancet. 1985 Apr 20; 1(8434):903-6. PMID: 2858749.
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      280. Weintrub PS, Schiffman G, Addiego JE, Matthay KK, Vichinsky E, Johnson R, Lubin B, Mentzer WC, Ammann AJ. Long-term follow-up and booster immunization with polyvalent pneumococcal polysaccharide in patients with sickle cell anemia. J Pediatr. 1984 Aug; 105(2):261-3. PMID: 6747758.
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      281. Vichinsky EP, Pennathur-Das R, Nickerson B, Minor M, Kleman K, Higashino S, Lubin B. Inadequate erythroid response to hypoxia in cystic fibrosis. J Pediatr. 1984 Jul; 105(1):15-21. PMID: 6737132.
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      282. Pennathur-Das R, Alpen E, Vichinsky E, Garcia J, Lubin B. Evidence for the presence of CFU-E with increased in vitro sensitivity to erythropoietin in sickle cell anemia. Blood. 1984 May; 63(5):1168-71. PMID: 6713094.
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      283. Pennathur-Das R, Alpen E, Vichinsky E, Lubin B. Evidence for a heterogeneous response to erythropoietin in the CFUE pool of human bone marrow. Exp Hematol. 1984 Jan; 12(1):31-7. PMID: 6583068.
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      284. Reeves JD, Vichinsky E, Addiego J, Lubin BH. Iron deficiency in health and disease. Adv Pediatr. 1983; 30:281-320. PMID: 6369941.
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      285. Embury SH, Dozy AM, Miller J, Davis JR, Kleman KM, Preisler H, Vichinsky E, Lande WN, Lubin BH, Kan YW, Mentzer WC. Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia. N Engl J Med. 1982 Feb 4; 306(5):270-4. PMID: 6172710.
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      286. Chiu D, Vichinsky E, Yee M, Kleman K, Lubin B. Peroxidation, vitamin E, and sickle-cell anemia. Ann N Y Acad Sci. 1982; 393:323-35. PMID: 6959561.
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      287. Vichinsky EP, Johnson R, Lubin BH. Multidisciplinary approach to pain management in sickle cell disease. Am J Pediatr Hematol Oncol. 1982; 4(3):328-33. PMID: 6128939.
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      288. Vichinsky E, Kleman K, Embury S, Lubin B. The diagnosis of iron deficiency anemia in sickle cell disease. Blood. 1981 Nov; 58(5):963-8. PMID: 7296005.
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      289. Davis JR, Vichinsky EP, Lubin BH. Current treatment of sickle cell disease. Curr Probl Pediatr. 1980 Oct; 10(12):1-64. PMID: 7428420.
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      290. Vichinsky EP, Lubin BH. Sickle cell anemia and related hemoglobinopathies. Pediatr Clin North Am. 1980 May; 27(2):429-47. PMID: 6155657.
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      291. Vichinsky EP, Lubin BH. Unstable hemoglobins, hemoglobins with altered oxygen affinity, and m-hemoglobins. Pediatr Clin North Am. 1980 May; 27(2):421-8. PMID: 7383714.
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      292. Papayannopoulou T, Vichinsky E, Stamatoyannopoulos G. Fetal Hb production during acute erythroid expansion. I. Observations in patients with transient erythroblastopenia and post-phlebotomy. Br J Haematol. 1980 Apr; 44(4):535-46. PMID: 6155136.
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      293. Lubin B, Vichinsky E. Anemia in the newborn period. Pediatr Ann. 1979 Jul; 8(7):416-34. PMID: 471553.
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      294. Vichinsky EP. Anemia associated with rheumatoid arthritis. J Pediatr. 1979 Apr; 94(4):678. PMID: 430321.
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      295. Sullivan JL, Ochs HD, Schiffman G, Hammerschlag MR, Miser J, Vichinsky E, Wedgwood RJ. Immune response after splenectomy. Lancet. 1978 Jan 28; 1(8057):178-81. PMID: 74605.
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      296. Gaylor JL, Delwiche CV, Brady DR, Green AJ. Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. J Lipid Res. 1966 Jul; 7(4):501-10. PMID: 4290536.
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      297. Taher A, Vichinsky E, Musallam K, Cappellini MD, Viprakasit V. . Guidelines for the Management of Non Tranfusion Dependent Thalassemia (NTDT). Thalassemia International Federation, 2013.
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