Emmanuelle Passegue, PhD

SchoolUCSF School of Medicine
Address35 Medical Center Way
San Francisco CA 94143
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    Role of autophagy in normal and transformed hematopoietic stem cells
    NIH/NCI R01CA184014Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Mechanisms of Hematopoietic Stem Cell Maintenance
    NIH/NHLBI R01HL111266Aug 1, 2012 - May 31, 2016
    Role: Principal Investigator
    Mechanisms of Hematopoietic Stem Cell Transformation
    NIH/NHLBI R01HL092471Apr 3, 2008 - May 31, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2016 Dec 19. PMID: 27992400.
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    2. Kohli L, Passegué E. Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol. 2014 Aug; 24(8):479-87. PMID: 24768033; PMCID: PMC4112160.
    3. Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med. 2014 Feb 10; 211(2):245-62. PMID: 24493802; PMCID: PMC3920566.
    4. Bakker ST, Passegué E. Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells. Exp Hematol. 2013 Nov; 41(11):915-23. PMID: 24067363; PMCID: PMC3833969.
    5. Pietras EM, Passegué E. Linking HSCs to their youth. Nat Cell Biol. 2013 Aug; 15(8):885-7. PMID: 23907190.
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    6. Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell. 2013 Sep 5; 13(3):285-99. PMID: 23850243; PMCID: PMC3769504.
    7. Warr MR, Kohli L, Passegué E. Born to survive: autophagy in hematopoietic stem cell maintenance. Cell Cycle. 2013 Jul 1; 12(13):1979-80. PMID: 23759583; PMCID: PMC3737290.
    8. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7. PMID: 23389440; PMCID: PMC3579002.
    9. Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC. Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations. Leukemia. 2013 Jul; 27(7):1570-3. PMID: 23443342; PMCID: PMC3715751.
    10. Warr MR, Passegué E. Metabolic makeover for HSCs. Cell Stem Cell. 2013 Jan 3; 12(1):1-3. PMID: 23290130.
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    11. Schepers K, Hsiao EC, Garg T, Scott MJ, Passegué E. Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood. 2012 Oct 25; 120(17):3425-35. PMID: 22859604; PMCID: PMC3482855.
    12. Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem cells assessed. Nat Rev Mol Cell Biol. 2012 Jul; 13(7):471-6. PMID: 22678486.
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    13. Smith-Berdan S, Schepers K, Ly A, Passegué E, Forsberg EC. Dynamic expression of the Robo ligand Slit2 in bone marrow cell populations. Cell Cycle. 2012 Feb 15; 11(4):675-82. PMID: 22313734.
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    14. Pietras EM, Warr MR, Passegué E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011 Nov 28; 195(5):709-20. PMID: 22123859; PMCID: PMC3257565.
    15. Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M, Sala-Torra O, Radich JP, Passegué E. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell. 2011 Nov 15; 20(5):661-73. PMID: 22094259; PMCID: PMC3220886.
    16. Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev. 2011 Aug 15; 25(16):1746-57. PMID: 21852537; PMCID: PMC3165938.
    17. Warr MR, Pietras EM, Passegué E. Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):681-701. PMID: 21412991.
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    18. Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E. DNA-damage response in tissue-specific and cancer stem cells. Cell Stem Cell. 2011 Jan 7; 8(1):16-29. PMID: 21211780.
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    19. Elefanty AG, Blelloch R, Passegué E, Wernig M, Mummery CL. On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell. 2010 Oct 8; 7(4):443-50. PMID: 20887950.
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    20. Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R. PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010 Nov 1; 70(21):8792-801. PMID: 20861188; PMCID: PMC3021794.
    21. Ragu C, Elain G, Mylonas E, Ottolenghi C, Cagnard N, Daegelen D, Passegué E, Vainchenker W, Bernard OA, Penard-Lacronique V. The transcription factor Srf regulates hematopoietic stem cell adhesion. Blood. 2010 Nov 25; 116(22):4464-73. PMID: 20709909.
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    22. Mohrin M, Bourke E, Alexander D, Warr MR, Barry-Holson K, Le Beau MM, Morrison CG, Passegué E. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010 Aug 6; 7(2):174-85. PMID: 20619762; PMCID: PMC2924905.
    23. Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS One. 2010; 5(1):e8785. PMID: 20098702; PMCID: PMC2808351.
    24. Passegué E, Ernst P. IFN-alpha wakes up sleeping hematopoietic stem cells. Nat Med. 2009 Jun; 15(6):612-3. PMID: 19498372; PMCID: PMC2892628.
    25. Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009 Apr 7; 15(4):341-52. PMID: 19345332; PMCID: PMC2669108.
    26. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59. PMID: 19296721; PMCID: PMC2656550.
    27. Passegué E, Rafii S, Herlyn M. Cancer stem cells are everywhere. Nat Med. 2009 Jan; 15(1):23. PMID: 19129778.
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    28. Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008 Oct 9; 3(4):416-28. PMID: 18940733; PMCID: PMC2646421.
    29. Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C. MicroRNA-126 regulates HOXA9 by binding to the homeobox. Mol Cell Biol. 2008 Jul; 28(14):4609-19. PMID: 18474618; PMCID: PMC2447122.
    30. Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell. 2008 Apr 10; 2(4):380-91. PMID: 18397757.
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    31. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
    32. Rajasekhar VK, Dalerba P, Passegué E, Lagasse E, Najbauer J. The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. Stem Cells. 2008 Jan; 26(1):292-8. PMID: 17962698.
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    33. Hu YL, Passegué E, Fong S, Largman C, Lawrence HJ. Evidence that the Pim1 kinase gene is a direct target of HOXA9. Blood. 2007 Jun 1; 109(11):4732-8. PMID: 17327400; PMCID: PMC1885524.
    34. Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007 Jan 26; 128(2):325-39. PMID: 17254970.
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    35. Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 1; 109(9):3945-52. PMID: 17192389; PMCID: PMC1874575.
    36. Giuriato S, Ryeom S, Fan AC, Bachireddy P, Lynch RC, Rioth MJ, van Riggelen J, Kopelman AM, Passegué E, Tang F, Folkman J, Felsher DW. Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16266-71. PMID: 17056717; PMCID: PMC1637571.
    37. Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG. Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells. Nat Genet. 2006 Nov; 38(11):1269-77. PMID: 17041602.
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    38. Passegué E. Cancer biology: a game of subversion. Nature. 2006 Aug 17; 442(7104):754-5. PMID: 16915276.
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    39. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell. 2006 Jul 28; 126(2):415-26. PMID: 16873070.
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    40. Nyholm SV, Passegue E, Ludington WB, Voskoboynik A, Mitchel K, Weissman IL, De Tomaso AW. fester, A candidate allorecognition receptor from a primitive chordate. Immunity. 2006 Jul; 25(1):163-73. PMID: 16860765.
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    41. Passegué E, Wagers AJ. Regulating quiescence: new insights into hematopoietic stem cell biology. Dev Cell. 2006 Apr; 10(4):415-7. PMID: 16580989.
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    42. Passegué E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 2005 Dec 5; 202(11):1599-611. PMID: 16330818; PMCID: PMC2213324.
    43. Passegué E. Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia. Cell Cycle. 2005 Feb; 4(2):266-8. PMID: 15655369.
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    44. Passegué E, Weisman IL. Leukemic stem cells: where do they come from? Stem Cell Rev. 2005; 1(3):181-8. PMID: 17142854.
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    45. Jamieson CH, Weissman IL, Passegué E. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell. 2004 Dec; 6(6):531-3. PMID: 15607956.
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    46. Passegué E, Wagner EF, Weissman IL. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 2004 Oct 29; 119(3):431-43. PMID: 15507213.
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    47. Cozzio A, Passegué E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003 Dec 15; 17(24):3029-35. PMID: 14701873; PMCID: PMC305255.
    48. Passegué E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11842-9. PMID: 14504387; PMCID: PMC304096.
    49. Szremska AP, Kenner L, Weisz E, Ott RG, Passegué E, Artwohl M, Freissmuth M, Stoxreiter R, Theussl HC, Parzer SB, Moriggl R, Wagner EF, Sexl V. JunB inhibits proliferation and transformation in B-lymphoid cells. Blood. 2003 Dec 1; 102(12):4159-65. PMID: 12907453.
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    50. So CW, Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003 Feb; 3(2):161-71. PMID: 12620410.
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    51. Passegué E, Jochum W, Behrens A, Ricci R, Wagner EF. JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet. 2002 Feb; 30(2):158-66. PMID: 11818961.
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    52. Jochum W, Passegué E, Wagner EF. AP-1 in mouse development and tumorigenesis. Oncogene. 2001 Apr 30; 20(19):2401-12. PMID: 11402336.
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    53. Passegué E, Jochum W, Schorpp-Kistner M, Möhle-Steinlein U, Wagner EF. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell. 2001 Jan 12; 104(1):21-32. PMID: 11163237.
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    54. Passegué E, Wagner EF. JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J. 2000 Jun 15; 19(12):2969-79. PMID: 10856241; PMCID: PMC203376.
    55. Jochum W, Passegue E, Wagner EF. [Loss of junB expression causes a myeloproliferative syndrome resembling chronic myeloid leukemia]. Verh Dtsch Ges Pathol. 1999; 83:216-7. PMID: 10714213.
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    56. Passegue E, Richard JL, Boulla G, Gourdji D. Multiple intracellular signallings are involved in thyrotropin-releasing hormone (TRH)-induced c-fos and jun B mRNA levels in clonal prolactin cells. Mol Cell Endocrinol. 1995 Jan; 107(1):29-40. PMID: 7796933.
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    57. Passegué E, Laverrière JN, Boulla G, Gourdji D. [Stimulation of C-fos and jun B proto-oncogenes: potential role of TRH effects in clone cell line with prolactin (GH3B6)]. C R Seances Soc Biol Fil. 1995; 189(1):97-110. PMID: 7648371.
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    58. Passegue E, Laverriere JN, Gourdji D. Thyrotropin-releasing hormone stimulates in parallel jun B and c-fos messenger ribonucleic acids in GH3B6 pituitary cells: comparison with PRL secretion. Mol Cell Neurosci. 1994 Apr; 5(2):109-18. PMID: 8032680.
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    59. Gourdji D, Laverriere JN, Passegué E, Richard JL. Hypophyseal cells model systems: the "GH" rat tumor-derived cell lines as a tool for the study of gene expression. Cell Biol Toxicol. 1992 Jul-Sep; 8(3):29-38. PMID: 1446255.
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