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Eric Lam, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Han L, Xu J, Xu Q, Zhang B, Lam EW, Sun Y. Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies. Med Res Rev. 2017 Jun 06. PMID: 28586517.
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    2. Alasiri G, Fan LY, Zona S, Goldsbrough IG, Ke HL, Auner HW, Lam EW. ER stress and cancer: The FOXO forkhead transcription factor link. Mol Cell Endocrinol. 2017 May 29. PMID: 28572047.
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    3. Shahidi N, Ou G, Lam E, Enns R, Telford J. When trainees reach competency in performing endoscopic ultrasound: a systematic review. Endosc Int Open. 2017 Apr; 5(4):E239-E243. PMID: 28367496.
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    4. Saavedra-García P, Fan LY, Lam EW. Multifaceted link between metabolism and cancer. Mol Cell Endocrinol. 2017 Mar 25. PMID: 28351646.
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    5. Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Coombes RC, Lam EW, Hu Y, Yagüe E. Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. Breast Cancer Res Treat. 2017 Jun; 163(3):461-474. PMID: 28341962.
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    6. Fan LY, Saavedra-García P, Lam EW. Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism. Data Brief. 2017 Apr; 11:606-610. PMID: 28349111.
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    7. Kamran M, Long ZJ, Xu D, Lv SS, Liu B, Wang CL, Xu J, Lam EW, Liu Q. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Oncogenesis. 2017 Feb 20; 6(2):e298. PMID: 28218735.
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    8. Sundriyal S, Moniot S, Mahmud Z, Yao S, Di Fruscia P, Reynolds CR, Dexter DT, Sternberg MJ, Lam EW, Steegborn C, Fuchter MJ. Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J Med Chem. 2017 Mar 09; 60(5):1928-1945. PMID: 28135086.
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    9. Yang N, Wang C, Wang Z, Zona S, Lin SX, Wang X, Yan M, Zheng FM, Li SS, Xu B, Bella L, Yong JS, Lam EW, Liu Q. FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells. Oncogene. 2017 Jun 15; 36(24):3428-3440. PMID: 28114286.
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    10. Peng F, Li TT, Wang KL, Xiao GQ, Wang JH, Zhao HD, Kang ZJ, Fan WJ, Zhu LL, Li M, Cui B, Zheng FM, Wang HJ, Lam EW, Wang B, Xu J, Liu Q. H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance. Cell Death Dis. 2017 Jan 19; 8(1):e2569. PMID: 28102845.
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    11. Saavedra-García P, Nichols K, Mahmud Z, Fan LY, Lam EW. Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis. Mol Cell Endocrinol. 2017 Jan 11. PMID: 28087388.
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    12. Marzi L, Combes E, Vié N, Ayrolles-Torro A, Tosi D, Desigaud D, Perez-Gracia E, Larbouret C, Montagut C, Iglesias M, Jarlier M, Denis V, Linares LK, Lam EW, Martineau P, Del Rio M, Gongora C. FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer. Br J Cancer. 2016 Nov 08; 115(10):1223-1233. PMID: 27685445.
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    13. Mitchell RA, Stanger D, Shuster C, Telford J, Lam E, Enns R. Repeat Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Patients with Suspected Pancreatic Cancer: Diagnostic Yield and Associated Change in Access to Appropriate Care. Can J Gastroenterol Hepatol. 2016; 2016:7678403. PMID: 27648440.
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    14. Gómez-Puerto MC, Verhagen LP, Braat AK, Lam EW, Coffer PJ, Lorenowicz MJ. Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation. Autophagy. 2016 Oct 02; 12(10):1804-1816. PMID: 27532863.
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    15. Kongsema M, Zona S, Karunarathna U, Cabrera E, Man EP, Yao S, Shibakawa A, Khoo US, Medema RH, Freire R, Lam EW. RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment. Oncogenesis. 2016 Aug 15; 5(8):e252. PMID: 27526106; PMCID: PMC5007831.
    16. Lemos LG, Nestal de Moraes G, Delbue D, Vasconcelos Fda C, Bernardo PS, Lam EW, Buarque CD, Costa PR, Maia RC. 11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes. J Cancer Res Clin Oncol. 2016 Oct; 142(10):2119-30. PMID: 27520309.
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    17. Yan M, Wang C, He B, Yang M, Tong M, Long Z, Liu B, Peng F, Xu L, Zhang Y, Liang D, Lei H, Subrata S, Kelley KW, Lam EW, Jin B, Liu Q. Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy. Med Res Rev. 2016 Nov; 36(6):1036-1079. PMID: 27406026.
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    18. Xu LZ, Li SS, Zhou W, Kang ZJ, Zhang QX, Kamran M, Xu J, Liang DP, Wang CL, Hou ZJ, Wan XB, Wang HJ, Lam EW, Zhao ZW, Liu Q. p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA. Oncogene. 2017 Jan 19; 36(3):304-317. PMID: 27345399.
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    19. Anghelina D, Lam E, Falck-Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016 Jul 01; 90(13):5915-27. PMID: 27076643; PMCID: PMC4907218 [Available on 12/10/16].
    20. Yong JS, Intriago-Baldeón DP, Lam EW. FOXD3 controls pluripotency through modulating enhancer activity. Stem Cell Investig. 2016; 3:17. PMID: 27488581; PMCID: PMC4958055.
    21. Guaita-Esteruelas S, Bosquet A, Saavedra P, Gumà J, Girona J, Lam E, Amillano K, Borràs J, Masana L. Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins. Mol Carcinog. 2017 Jan; 56(1):208-217. PMID: 27061264.
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    22. Gong C, Yao S, Gomes AR, Man EP, Lee HJ, Gong G, Chang S, Kim SB, Fujino K, Kim SW, Park SK, Lee JW, Lee MH, Khoo US, Lam EW. BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer. Oncogenesis. 2016 Apr 04; 5:e214. PMID: 27043660; PMCID: PMC4848836.
    23. Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW, Hung MC, Liu Q. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016 Jan 19; 7:10180. PMID: 26782714; PMCID: PMC4735655.
    24. Khongkow P, Middleton AW, Middleton AK, Wong JP, Kandola NK, Kongsema M, de Moraes GN, Gomes AR, Lam EW. In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs. Methods Mol Biol. 2016; 1395:39-53. PMID: 26910067.
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    25. Gomes AR, Yong JS, Kiew KC, Aydin E, Khongkow M, Laohasinnarong S, Lam EW. Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins. Methods Mol Biol. 2016; 1436:169-88. PMID: 27246215.
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    26. Nestal de Moraes G, Bella L, Zona S, Burton MJ, Lam EW. Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance. Curr Drug Targets. 2016; 17(2):164-77. PMID: 25418858.
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    27. Khongkow P, Middleton AW, Wong JP, Kandola NK, Kongsema M, de Moraes GN, Gomes AR, Lam EW. Erratum to: In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs. Methods Mol Biol. 2016; 1395:E1. PMID: 27488409.
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    28. Lucas ES, Dyer NP, Murakami K, Lee YH, Chan YW, Grimaldi G, Muter J, Brighton PJ, Moore JD, Patel G, Chan JK, Takeda S, Lam EW, Quenby S, Ott S, Brosens JJ. Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells. 2016 Feb; 34(2):346-56. PMID: 26418742.
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    29. Silva LS, Goncalves LG, Silva F, Domingues G, Maximo V, Ferreira J, Lam EW, Dias S, Felix A, Serpa J. STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. Tumour Biol. 2016 Apr; 37(4):5385-95. PMID: 26563366.
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    30. Nestal de Moraes G, Delbue D, Silva KL, Robaina MC, Khongkow P, Gomes AR, Zona S, Crocamo S, Mencalha AL, Magalhães LM, Lam EW, Maia RC. FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance. Cell Signal. 2015 Dec; 27(12):2496-505. PMID: 26404623.
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    31. Consolaro F, Ghaem-Maghami S, Bortolozzi R, Zona S, Khongkow M, Basso G, Viola G, Lam EW. FOXO3a and Posttranslational Modifications Mediate Glucocorticoid Sensitivity in B-ALL. Mol Cancer Res. 2015 Dec; 13(12):1578-90. PMID: 26376801.
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    32. Magnani L, Patten DK, Nguyen VT, Hong SP, Steel JH, Patel N, Lombardo Y, Faronato M, Gomes AR, Woodley L, Page K, Guttery D, Primrose L, Fernandez Garcia D, Shaw J, Viola P, Green A, Nolan C, Ellis IO, Rakha EA, Shousha S, Lam EW, Gyorffy B, Lupien M, Coombes RC. The pioneer factor PBX1 is a novel driver of metastatic progression in ERa-positive breast cancer. Oncotarget. 2015 Sep 08; 6(26):21878-91. PMID: 26215677; PMCID: PMC4673133.
    33. Nestal de Moraes G, Khongkow P, Gong C, Yao S, Gomes AR, Ji Z, Kandola N, Delbue D, Man EP, Khoo US, Sharrocks AD, Lam EW. Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer. Oncogenesis. 2015 Sep 07; 4:e167. PMID: 26344694; PMCID: PMC4767938.
    34. Consolaro F, Basso G, Ghaem-Magami S, Lam EW, Viola G. FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs. Int J Oncol. 2015 Oct; 47(4):1230-40. PMID: 26316295; PMCID: PMC4583527.
    35. Lam E, Choi SH, Pareek TK, Kim BG, Letterio JJ. Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727. Mol Immunol. 2015 Oct; 67(2 Pt B):317-24. PMID: 26198700; PMCID: PMC4734131 [Available on 10/01/16].
    36. Karunarathna U, Kongsema M, Zona S, Gong C, Cabrera E, Gomes AR, Man EP, Khongkow P, Tsang JW, Khoo US, Medema RH, Freire R, Lam EW. OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance. Oncogene. 2016 Mar 17; 35(11):1433-44. PMID: 26148240; PMCID: PMC4606987.
    37. Khongkow P, Gomes AR, Gong C, Man EP, Tsang JW, Zhao F, Monteiro LJ, Coombes RC, Medema RH, Khoo US, Lam EW. Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance. Oncogene. 2016 Feb 25; 35(8):990-1002. PMID: 25961928; PMCID: PMC4538879.
    38. Muter J, Lucas ES, Chan YW, Brighton PJ, Moore JD, Lacey L, Quenby S, Lam EW, Brosens JJ. The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. FASEB J. 2015 Apr; 29(4):1603-14. PMID: 25573754; PMCID: PMC4396614.
    39. Lam E, Pareek TK, Letterio JJ. Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex. Cell Cycle. 2015; 14(8):1327-36. PMID: 25785643; PMCID: PMC4614394.
    40. Gong C, Fujino K, Monteiro LJ, Gomes AR, Drost R, Davidson-Smith H, Takeda S, Khoo US, Jonkers J, Sproul D, Lam EW. FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer. Oncogene. 2015 Sep 24; 34(39):5012-24. PMID: 25531315; PMCID: PMC4430311.
    41. Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY, Le XF, Wong OG, Wong ES, Gomes AR, Bella L, Khongkow P, Lam EW, Cheung AN. Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. PLoS One. 2014; 9(11):e113478. PMID: 25411964; PMCID: PMC4239070.
    42. Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam EW, Fuchter MJ. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. ChemMedChem. 2015 Jan; 10(1):69-82. PMID: 25395356.
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    43. Lam EW, Gomes AR. Forkhead box transcription factors in cancer initiation, progression and chemotherapeutic drug response. Front Oncol. 2014; 4:305. PMID: 25401090; PMCID: PMC4212617.
    44. Lam E, Falck-Pedersen E. Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells. J Virol. 2014 Dec; 88(24):14426-39. PMID: 25297994; PMCID: PMC4249147.
    45. Zona S, Bella L, Burton MJ, Nestal de Moraes G, Lam EW. FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Biophys Acta. 2014 Nov; 1839(11):1316-22. PMID: 25287128; PMCID: PMC4316173.
    46. Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam EW, Costa PR, Maia RC. The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. Int J Oncol. 2014 Nov; 45(5):1949-58. PMID: 25174716.
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    47. Bella L, Zona S, Nestal de Moraes G, Lam EW. FOXM1: A key oncofoetal transcription factor in health and disease. Semin Cancer Biol. 2014 Dec; 29:32-9. PMID: 25068996.
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    48. Mowla SN, Lam EW, Jat PS. Cellular senescence and aging: the role of B-MYB. Aging Cell. 2014 Oct; 13(5):773-9. PMID: 24981831; PMCID: PMC4331756.
    49. Zheng FM, Long ZJ, Hou ZJ, Luo Y, Xu LZ, Xia JL, Lai XJ, Liu JW, Wang X, Kamran M, Yan M, Shao SJ, Lam EW, Wang SW, Lu G, Liu Q. A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther. 2014 Aug; 13(8):1991-2003. PMID: 24899685.
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    50. Wang J, Taylor A, Showeil R, Trivedi P, Horimoto Y, Bagwan I, Ewington L, Lam EW, El-Bahrawy MA. Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma. Cytokine. 2014 Aug; 68(2):94-100. PMID: 24845798.
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    51. Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang Y, Li LH, Zeng YX, Lam EW, Hung MC, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun. 2014 Apr 17; 5:3661. PMID: 24739462.
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    52. Ou G, Kim E, Lakzadeh P, Tong J, Enns R, Ramji A, Whittaker S, Ko HH, Bressler B, Halparin L, Lam E, Amar J, Telford J. A randomized controlled trial assessing the effect of prescribed patient position changes during colonoscope withdrawal on adenoma detection. Gastrointest Endosc. 2014 Aug; 80(2):277-83. PMID: 24629419.
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    53. Luo C, Lam E. Quantitatively profiling genome-wide patterns of histone modifications in Arabidopsis thaliana using ChIP-seq. Methods Mol Biol. 2014; 1112:177-93. PMID: 24478015.
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    54. Myatt SS, Kongsema M, Man CW, Kelly DJ, Gomes AR, Khongkow P, Karunarathna U, Zona S, Langer JK, Dunsby CW, Coombes RC, French PM, Brosens JJ, Lam EW. SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene. 2014 Aug 21; 33(34):4316-29. PMID: 24362530; PMCID: PMC4096495.
    55. Lam E, Stein S, Falck-Pedersen E. Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol. 2014 Jan; 88(2):974-81. PMID: 24198409; PMCID: PMC3911663.
    56. Brahmania M, Ou G, Bressler B, Ko HK, Lam E, Telford J, Enns R. 2 L versus 4 L of PEG3350 + electrolytes for outpatient colonic preparation: a randomized, controlled trial. Gastrointest Endosc. 2014 Mar; 79(3):408-416.e4. PMID: 24206747.
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    57. Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, Freire R, Lam EW. FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene. 2014 Aug 07; 33(32):4144-55. PMID: 24141789; PMCID: PMC3969838.
    58. Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, Gan B. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene. 2014 Jun 12; 33(24):3183-94. PMID: 23851496; PMCID: PMC4365448.
    59. van Boxtel R, Gomez-Puerto C, Mokry M, Eijkelenboom A, van der Vos KE, Nieuwenhuis EE, Burgering BM, Lam EW, Coffer PJ. FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis. Cell Death Differ. 2013 Sep; 20(9):1219-29. PMID: 23832113; PMCID: PMC3741507.
    60. Lam EW, Brosens JJ, Gomes AR, Koo CY. Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer. 2013 Jul; 13(7):482-95. PMID: 23792361.
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    61. Gomes AR, Zhao F, Lam EW. Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance. Chin J Cancer. 2013 Jul; 32(7):365-70. PMID: 23706767; PMCID: PMC3845605.
    62. Brosens JJ, Lam EW. Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer. Cell Cycle. 2013 Jun 01; 12(11):1660-1. PMID: 23708447; PMCID: PMC3713121.
    63. Coombes RC, Tat T, Miller ML, Reise JA, Mansi JL, Hadjiminas DJ, Shousha S, Elsheikh SE, Lam EW, Horimoto Y, El-Bahrawy M, Aboagye EO, Contractor KB, Shaw JA, Walker RA, Marconell MH, Palmieri C, Stebbing J. An open-label study of lapatinib in women with HER-2-negative early breast cancer: the lapatinib pre-surgical study (LPS study). Ann Oncol. 2013 Apr; 24(4):924-30. PMID: 23233650.
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    64. Zhao F, Lam EW. Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance. Front Med. 2012 Dec; 6(4):376-80. PMID: 23124885.
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    65. Monteiro LJ, Khongkow P, Kongsema M, Morris JR, Man C, Weekes D, Koo CY, Gomes AR, Pinto PH, Varghese V, Kenny LM, Charles Coombes R, Freire R, Medema RH, Lam EW. The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene. 2013 Sep 26; 32(39):4634-45. PMID: 23108394; PMCID: PMC3874579.
    66. Stein SC, Lam E, Falck-Pedersen E. Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. J Virol. 2012 Dec; 86(24):13303-12. PMID: 23015711; PMCID: PMC3503059.
    67. Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, Lam EW, Chan KK, Ngan HY, Le XF, Cheung AN. Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene. 2013 Jul 25; 32(30):3500-9. PMID: 22945654.
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    68. McGonnell IM, Grigoriadis AE, Lam EW, Price JS, Sunters A. A specific role for phosphoinositide 3-kinase and AKT in osteoblasts? Front Endocrinol (Lausanne). 2012; 3:88. PMID: 22833734; PMCID: PMC3400941.
    69. de Olano N, Koo CY, Monteiro LJ, Pinto PH, Gomes AR, Aligue R, Lam EW. The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Mol Cancer Res. 2012 Sep; 10(9):1189-202. PMID: 22802261; PMCID: PMC3447739.
    70. Barros P, Lam EW, Jordan P, Matos P. Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters. Nucleic Acids Res. 2012 Sep; 40(16):7776-87. PMID: 22723377; PMCID: PMC3439931.
    71. Lam E, Zhang Y. Regulating the reapers: activating metacaspases for programmed cell death. Trends Plant Sci. 2012 Aug; 17(8):487-94. PMID: 22658651.
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    72. Ewington L, Taylor A, Sriraksa R, Horimoto Y, Lam EW, El-Bahrawy MA. The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. Cytokine. 2012 Aug; 59(2):417-22. PMID: 22626766.
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    73. Down CF, Millour J, Lam EW, Watson RJ. Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb. Biochim Biophys Acta. 2012 Aug; 1819(8):855-62. PMID: 22513242.
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    74. Choi O, Heathcote DA, Ho KK, Müller PJ, Ghani H, Lam EW, Ashton-Rickardt PG, Rutschmann S. A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival. J Immunol. 2012 Apr 15; 188(8):3920-7. PMID: 22407915; PMCID: PMC3378644.
    75. Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012 Mar 07; 32(10):3333-8. PMID: 22399755; PMCID: PMC3569730.
    76. Di Fruscia P, Ho KK, Laohasinnarong S, Khongkow M, Kroll SH, Islam SA, Sternberg MJ, Schmidtkunz K, Jung M, Lam EW, Fuchter MJ. The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors. Medchemcomm. 2012 Mar 01; (3). PMID: 24340169.
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    77. Zhao H, Appenroth K, Landesman L, Salmeán AA, Lam E. Duckweed rising at Chengdu: summary of the 1st International Conference on Duckweed Application and Research. Plant Mol Biol. 2012 Apr; 78(6):627-32. PMID: 22318677.
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    78. McKie AB, Vaughan S, Zanini E, Okon IS, Louis L, de Sousa C, Greene MI, Wang Q, Agarwal R, Shaposhnikov D, Wong JL, Gungor H, Janczar S, El-Bahrawy M, Lam EW, Chayen NE, Gabra H. The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer. Cancer Discov. 2012 Feb; 2(2):156-71. PMID: 22585860; PMCID: PMC3378039.
    79. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. PMID: 22458515; PMCID: PMC3439975.
    80. Ho KK, McGuire VA, Koo CY, Muir KW, de Olano N, Maifoshie E, Kelly DJ, McGovern UB, Monteiro LJ, Gomes AR, Nebreda AR, Campbell DG, Arthur JS, Lam EW. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem. 2012 Jan 06; 287(2):1545-55. PMID: 22128155; PMCID: PMC3256863.
    81. Al-Sabbagh M, Lam EW, Brosens JJ. Mechanisms of endometrial progesterone resistance. Mol Cell Endocrinol. 2012 Jul 25; 358(2):208-15. PMID: 22085558.
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    82. Koo CY, Muir KW, Lam EW. FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 2012 Jan; 1819(1):28-37. PMID: 21978825.
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    83. Jiang L, Siu MK, Wong OG, Tam KF, Lu X, Lam EW, Ngan HY, Le XF, Wong ES, Monteiro LJ, Chan HY, Cheung AN. iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe. Clin Cancer Res. 2011 Nov 01; 17(21):6924-33. PMID: 21926165.
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    84. Karadedou CT, Gomes AR, Chen J, Petkovic M, Ho KK, Zwolinska AK, Feltes A, Wong SY, Chan KY, Cheung YN, Tsang JW, Brosens JJ, Khoo US, Lam EW. FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene. 2012 Apr 05; 31(14):1845-58. PMID: 21860419; PMCID: PMC3232453.
    85. Wilson MS, Brosens JJ, Schwenen HD, Lam EW. FOXO and FOXM1 in cancer: the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy. Curr Drug Targets. 2011 Aug; 12(9):1256-66. PMID: 21443467.
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    86. Christian M, Lam EW, Wilson MS, Brosens JJ. FOXO transcription factors and their role in disorders of the female reproductive tract. Curr Drug Targets. 2011 Aug; 12(9):1291-302. PMID: 21443468.
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    87. Horimoto Y, Hartman J, Millour J, Pollock S, Olmos Y, Ho KK, Coombes RC, Poutanen M, Mäkelä SI, El-Bahrawy M, Speirs V, Lam EW. ERß1 represses FOXM1 expression through targeting ERa to control cell proliferation in breast cancer. Am J Pathol. 2011 Sep; 179(3):1148-56. PMID: 21763263; PMCID: PMC3157253.
    88. Kenny LM, Lam EW. Review: lapatinib in metastatic colorectal cancer-another strategy for disease control? Clin Adv Hematol Oncol. 2011 Jun; 9(6):500-1. PMID: 21841752.
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    89. Ishikawa T, Watanabe N, Nagano M, Kawai-Yamada M, Lam E. Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor. Cell Death Differ. 2011 Aug; 18(8):1271-8. PMID: 21597463; PMCID: PMC3172100.
    90. Watanabe N, Lam E. Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses. Plant J. 2011 Jun; 66(6):969-82. PMID: 21395887.
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    91. Millour J, de Olano N, Horimoto Y, Monteiro LJ, Langer JK, Aligue R, Hajji N, Lam EW. ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Mol Cancer Ther. 2011 Jun; 10(6):1046-58. PMID: 21518729; PMCID: PMC4845881.
    92. van Loosdregt J, Brunen D, Fleskens V, Pals CE, Lam EW, Coffer PJ. Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One. 2011 Apr 20; 6(4):e19047. PMID: 21533107; PMCID: PMC3080399.
    93. Lam EW, Shah K, Brosens JJ. The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. J Endocrinol. 2012 Jan; 212(1):13-25. PMID: 21382987.
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    94. Kumar S, Alibhai D, Margineanu A, Laine R, Kennedy G, McGinty J, Warren S, Kelly D, Alexandrov Y, Munro I, Talbot C, Stuckey DW, Kimberly C, Viellerobe B, Lacombe F, Lam EW, Taylor H, Dallman MJ, Stamp G, Murray EJ, Stuhmeier F, Sardini A, Katan M, Elson DS, Neil MA, Dunsby C, French PM. FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ. Chemphyschem. 2011 Feb 25; 12(3):609-26. PMID: 21337485; PMCID: PMC3084521.
    95. Watanabe N, Lam E. Calcium-dependent activation and autolysis of Arabidopsis metacaspase 2d. J Biol Chem. 2011 Mar 25; 286(12):10027-40. PMID: 21209078; PMCID: PMC3060454.
    96. Amini A, Luo C, Lam E. Chromatin beacons: global sampling of chromatin physical properties using chromatin charting lines. Methods Mol Biol. 2011; 701:301-14. PMID: 21181538.
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    97. Olmos Y, Brosens JJ, Lam EW. Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. Drug Resist Updat. 2011 Feb; 14(1):35-44. PMID: 21195657.
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    98. Jiang L, Siu MK, Wong OG, Tam KF, Lam EW, Ngan HY, Le XF, Wong ES, Chan HY, Cheung AN. Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers. Mol Cancer. 2010 Dec 21; 9:318. PMID: 21176152; PMCID: PMC3022670.
    99. Al-Sabbagh M, Fusi L, Higham J, Lee Y, Lei K, Hanyaloglu AC, Lam EW, Christian M, Brosens JJ. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology. 2011 Feb; 152(2):730-40. PMID: 21159852; PMCID: PMC3037160.
    100. Lee MM, Jacques A, Lam E, Kwok R, Lakzadeh P, Sandhar A, Segal B, Svarta S, Law J, Enns R. Factors associated with incomplete small bowel capsule endoscopy studies. World J Gastroenterol. 2010 Nov 14; 16(42):5329-33. PMID: 21072896; PMCID: PMC2980682.
    101. Myatt SS, Brosens JJ, Lam EW. Sense and sensitivity: FOXO and ROS in cancer development and treatment. Antioxid Redox Signal. 2011 Feb 15; 14(4):675-87. PMID: 20649462.
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    102. Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med. 2010 Oct 25; 207(11):2507-19. PMID: 20937706; PMCID: PMC2964575.
    103. Serpa J, Caiado F, Carvalho T, Torre C, Gonçalves LG, Casalou C, Lamosa P, Rodrigues M, Zhu Z, Lam EW, Dias S. Butyrate-rich colonic microenvironment is a relevant selection factor for metabolically adapted tumor cells. J Biol Chem. 2010 Dec 10; 285(50):39211-23. PMID: 20926374; PMCID: PMC2998102.
    104. Mena AL, Lam EW, Chatterjee S. Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1. PLoS One. 2010 Sep 28; 5(9). PMID: 20927403; PMCID: PMC2946930.
    105. Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, Sunters A, Chan KY, Lam EW, Khoo US. Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS One. 2010 Aug 20; 5(8):e12293. PMID: 20808831; PMCID: PMC2924889.
    106. Ferrari-Amorotti G, Mariani SA, Novi C, Cattelani S, Pecorari L, Corradini F, Soliera AR, Manzotti G, Fragliasso V, Zhang Y, Martinez RV, Lam EW, Guerzoni C, Calabretta B. The biological effects of C/EBPalpha in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain. J Biol Chem. 2010 Oct 01; 285(40):30837-50. PMID: 20659895; PMCID: PMC2945577.
    107. Karim Z, Walker B, Lam E. Lymphoepithelial cysts of the pancreas: the use of endoscopic ultrasound-guided fine-needle aspiration in diagnosis. Can J Gastroenterol. 2010 Jun; 24(6):348-50. PMID: 20559575; PMCID: PMC2898487.
    108. Packard CE, Murarka A, Lam EW, Schmidt MA, Bulovic V. Contact-printed microelectromechanical systems. Adv Mater. 2010 Apr 22; 22(16):1840-4. PMID: 20512958.
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    109. Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr; 9(4):844-55. PMID: 20371709.
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    110. Brahmania M, Lam E, Telford J, Enns R. Endoscopic mucosal resection: early experience in British Columbia. Can J Gastroenterol. 2010 Apr; 24(4):239-44. PMID: 20431812; PMCID: PMC2864619.
    111. Millour J, Constantinidou D, Stavropoulou AV, Wilson MS, Myatt SS, Kwok JM, Sivanandan K, Coombes RC, Medema RH, Hartman J, Lykkesfeldt AE, Lam EW. FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance. Oncogene. 2010 May 20; 29(20):2983-95. PMID: 20208560; PMCID: PMC2874720.
    112. Vianello F, Villanova F, Tisato V, Lymperi S, Ho KK, Gomes AR, Marin D, Bonnet D, Apperley J, Lam EW, Dazzi F. Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis. Haematologica. 2010 Jul; 95(7):1081-9. PMID: 20179085; PMCID: PMC2895031.
    113. Pedroza-Saavedra A, Lam EW, Esquivel-Guadarrama F, Gutierrez-Xicotencatl L. The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27(Kip1). Virology. 2010 Apr 25; 400(1):44-52. PMID: 20144468.
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    114. Kwok JM, Peck B, Monteiro LJ, Schwenen HD, Millour J, Coombes RC, Myatt SS, Lam EW. FOXM1 confers acquired cisplatin resistance in breast cancer cells. Mol Cancer Res. 2010 Jan; 8(1):24-34. PMID: 20068070; PMCID: PMC2809047.
    115. Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, Dina RE, Brosens JJ, Ghaem-Maghami S, Lam EW. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Res. 2010 Jan 01; 70(1):367-77. PMID: 20028871; PMCID: PMC2880714.
    116. Leitao B, Jones MC, Fusi L, Higham J, Lee Y, Takano M, Goto T, Christian M, Lam EW, Brosens JJ. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J. 2010 May; 24(5):1541-51. PMID: 20026682; PMCID: PMC2857868.
    117. Hussain F, Wang J, Ahmed R, Guest SK, Lam EW, Stamp G, El-Bahrawy M. The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours. Cytokine. 2010 Feb; 49(2):134-40. PMID: 20005738.
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    118. Hartman J, Lam EW, Gustafsson JA, Ström A. Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast Cancer Res. 2009; 11(6):R79. PMID: 19891787; PMCID: PMC2815541.
    119. Watanabe N, Lam E. Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants. Int J Mol Sci. 2009 Jul 10; 10(7):3149-67. PMID: 19742129; PMCID: PMC2738916.
    120. Segal B, Lam E, Amar J, Bressler B, Halparin L, Ramji A, Telford J, Whittaker S, Enns R. Add-on cases in the endoscopy unit: Factors that affect volume. Can J Gastroenterol. 2009 Jul; 23(7):485-8. PMID: 19623331; PMCID: PMC2722468.
    121. Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW. FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. Int J Oncol. 2009 Jul; 35(1):57-68. PMID: 19513552; PMCID: PMC3065068.
    122. Albergaria A, Paredes J, Sousa B, Milanezi F, Carneiro V, Bastos J, Costa S, Vieira D, Lopes N, Lam EW, Lunet N, Schmitt F. Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast Cancer Res. 2009; 11(3):R40. PMID: 19549328; PMCID: PMC2716509.
    123. Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW. The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells. FEBS J. 2009 Aug; 276(15):4037-50. PMID: 19549188.
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    124. Luo C, Durgin BG, Watanabe N, Lam E. Defining the functional network of epigenetic regulators in Arabidopsis thaliana. Mol Plant. 2009 Jul; 2(4):661-74. PMID: 19825647.
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    125. McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM, Polychronis A, Coombes RC, Lam EW. Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Mol Cancer Ther. 2009 Mar; 8(3):582-91. PMID: 19276163.
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    126. Batlle A, Papadopoulou V, Gomes AR, Willimott S, Melo JV, Naresh K, Lam EW, Wagner SD. CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression. Mol Immunol. 2009 May; 46(8-9):1727-35. PMID: 19268365.
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    127. Essafi A, Gomes AR, Pomeranz KM, Zwolinska AK, Varshochi R, McGovern UB, Lam EW. Studying the subcellular localization and DNA-binding activity of FoxO transcription factors, downstream effectors of PI3K/Akt. Methods Mol Biol. 2009; 462:201-11. PMID: 19160671.
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    128. Luo C, Lam E. Chromatin charting: global mapping of epigenetic effects. Methods Mol Biol. 2009; 553:127-39. PMID: 19588104.
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    129. Brosens JJ, Wilson MS, Lam EW. FOXO transcription factors: from cell fate decisions to regulation of human female reproduction. Adv Exp Med Biol. 2009; 665:227-41. PMID: 20429428.
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    130. Nordigården A, Kraft M, Eliasson P, Labi V, Lam EW, Villunger A, Jönsson JI. BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood. 2009 Mar 05; 113(10):2302-11. PMID: 19064725; PMCID: PMC3272395.
    131. Bertoli C, Copetti T, Lam EW, Demarchi F, Schneider C. Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. Oncogene. 2009 Feb 05; 28(5):721-33. PMID: 19029949.
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    132. Gomes AR, Brosens JJ, Lam EW. Resist or die: FOXO transcription factors determine the cellular response to chemotherapy. Cell Cycle. 2008 Oct; 7(20):3133-6. PMID: 18927504.
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    133. Fernández de Mattos S, Villalonga P, Clardy J, Lam EW. FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther. 2008 Oct; 7(10):3237-46. PMID: 18852127; PMCID: PMC2748241.
    134. Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, Wymann MP, Brosens JJ, Schulze A, Lam EW. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol. 2008 Oct; 28(19):5886-98. PMID: 18644865; PMCID: PMC2547013.
    135. Kwok JM, Myatt SS, Marson CM, Coombes RC, Constantinidou D, Lam EW. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol Cancer Ther. 2008 Jul; 7(7):2022-32. PMID: 18645012.
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    136. Cloke B, Huhtinen K, Fusi L, Kajihara T, Yliheikkilä M, Ho KK, Teklenburg G, Lavery S, Jones MC, Trew G, Kim JJ, Lam EW, Cartwright JE, Poutanen M, Brosens JJ. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology. 2008 Sep; 149(9):4462-74. PMID: 18511503.
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    137. Li SK, Smith DK, Leung WY, Cheung AM, Lam EW, Dimri GP, Yao KM. FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression. J Biol Chem. 2008 Jun 13; 283(24):16545-53. PMID: 18408007; PMCID: PMC2423239.
    138. Ho KK, Myatt SS, Lam EW. Many forks in the path: cycling with FoxO. Oncogene. 2008 Apr 07; 27(16):2300-11. PMID: 18391972.
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    139. Myatt SS, Lam EW. Targeting FOXM1. Nat Rev Cancer. 2008 Mar; 8(3):242. PMID: 18297052.
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    140. Hui RC, Francis RE, Guest SK, Costa JR, Gomes AR, Myatt SS, Brosens JJ, Lam EW. Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol Cancer Ther. 2008 Mar; 7(3):670-8. PMID: 18347152.
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    141. Mahmoudi N, Enns R, Amar J, AlAli J, Lam E, Telford J. Biliary brush cytology: factors associated with positive yields on biliary brush cytology. World J Gastroenterol. 2008 Jan 28; 14(4):569-73. PMID: 18203289; PMCID: PMC2681148.
    142. Jovtchev G, Watanabe K, Pecinka A, Rosin FM, Mette MF, Lam E, Schubert I. Size and number of tandem repeat arrays can determine somatic homologous pairing of transgene loci mediated by epigenetic modifications in Arabidopsis thaliana nuclei. Chromosoma. 2008 Jun; 117(3):267-76. PMID: 18200447.
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    143. Ho KK, Anderson AA, Rosivatz E, Lam EW, Woscholski R, Mann DJ. Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network. J Biol Chem. 2008 Feb 29; 283(9):5477-85. PMID: 18077453.
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    144. Krol J, Francis RE, Albergaria A, Sunters A, Polychronis A, Coombes RC, Lam EW. The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells. Mol Cancer Ther. 2007 Dec; 6(12 Pt 1):3169-79. PMID: 18089711.
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    145. Watanabe N, Lam E. BAX inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis. J Biol Chem. 2008 Feb 08; 283(6):3200-10. PMID: 18039663.
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    146. Myatt SS, Lam EW. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 2007 Nov; 7(11):847-59. PMID: 17943136.
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    147. Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31; 26(21):4445-56. PMID: 17932483; PMCID: PMC2063472.
    148. Glassford J, Rabin N, Lam EW, Yong KL. Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells. Br J Haematol. 2007 Oct; 139(2):243-54. PMID: 17897300.
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    149. Feroze-Zaidi F, Fusi L, Takano M, Higham J, Salker MS, Goto T, Edassery S, Klingel K, Boini KM, Palmada M, Kamps R, Groothuis PG, Lam EW, Smith SK, Lang F, Sharkey AM, Brosens JJ. Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium. Endocrinology. 2007 Oct; 148(10):5020-9. PMID: 17640988.
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    150. Takano M, Lu Z, Goto T, Fusi L, Higham J, Francis J, Withey A, Hardt J, Cloke B, Stavropoulou AV, Ishihara O, Lam EW, Unterman TG, Brosens JJ, Kim JJ. Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells. Mol Endocrinol. 2007 Oct; 21(10):2334-49. PMID: 17609436.
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    151. Goto T, Takano M, Albergaria A, Briese J, Pomeranz KM, Cloke B, Fusi L, Feroze-Zaidi F, Maywald N, Sajin M, Dina RE, Ishihara O, Takeda S, Lam EW, Bamberger AM, Ghaem-Maghami S, Brosens JJ. Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene. 2008 Jan 03; 27(1):9-19. PMID: 17599040.
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    152. Delpuech O, Griffiths B, East P, Essafi A, Lam EW, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol. 2007 Jul; 27(13):4917-30. PMID: 17452451; PMCID: PMC1951505.
    153. Zhao C, Matthews J, Tujague M, Wan J, Ström A, Toresson G, Lam EW, Cheng G, Gustafsson JA, Dahlman-Wright K. Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res. 2007 Apr 15; 67(8):3955-62. PMID: 17440111.
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    154. Myatt SS, Lam EW. Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis. Cell Div. 2007 Feb 12; 2:6. PMID: 17295909; PMCID: PMC1802072.
    155. Ramasamy R, Fazekasova H, Lam EW, Soeiro I, Lombardi G, Dazzi F. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation. 2007 Jan 15; 83(1):71-6. PMID: 17220794.
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    156. Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski R. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15; 1(12):780-90. PMID: 17240976.
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    157. Ramasamy R, Lam EW, Soeiro I, Tisato V, Bonnet D, Dazzi F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia. 2007 Feb; 21(2):304-10. PMID: 17170725.
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    158. Birkenkamp KU, Essafi A, van der Vos KE, da Costa M, Hui RC, Holstege F, Koenderman L, Lam EW, Coffer PJ. FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem. 2007 Jan 26; 282(4):2211-20. PMID: 17132628.
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    159. Muñoz-Fontela C, Marcos-Villar L, Gallego P, Arroyo J, Da Costa M, Pomeranz KM, Lam EW, Rivas C. Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol. 2007 Feb; 81(3):1511-6. PMID: 17108038; PMCID: PMC1797526.
    160. van Gorp AG, Pomeranz KM, Birkenkamp KU, Hui RC, Lam EW, Coffer PJ. Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res. 2006 Nov 15; 66(22):10760-9. PMID: 17108112.
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    161. Lam EW, Francis RE, Petkovic M. FOXO transcription factors: key regulators of cell fate. Biochem Soc Trans. 2006 Nov; 34(Pt 5):722-6. PMID: 17052182.
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    162. Jones MC, Fusi L, Higham JH, Abdel-Hafiz H, Horwitz KB, Lam EW, Brosens JJ. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16272-7. PMID: 17053081; PMCID: PMC1637572.
    163. Alao JP, Stavropoulou AV, Lam EW, Coombes RC. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006 Oct 03; 5:40. PMID: 17018141; PMCID: PMC1592505.
    164. Krietsch T, Fernandes MS, Kero J, Lösel R, Heyens M, Lam EW, Huhtaniemi I, Brosens JJ, Gellersen B. Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol. 2006 Dec; 20(12):3146-64. PMID: 16959873.
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    165. Shore AM, White PC, Hui RC, Essafi A, Lam EW, Rowe M, Brennan P. Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A. J Virol. 2006 Nov; 80(22):11191-9. PMID: 16943287; PMCID: PMC1642148.
    166. Lee MY, Zhou Y, Lung RW, Chye ML, Yip WK, Zee SY, Lam E. Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1. Biotechnol Bioeng. 2006 Aug 20; 94(6):1129-37. PMID: 16586511.
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    167. Soeiro I, Mohamedali A, Romanska HM, Lea NC, Child ES, Glassford J, Orr SJ, Roberts C, Naresh KN, Lalani el-N, Mann DJ, Watson RJ, Thomas NS, Lam EW. p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. Mol Cell Biol. 2006 Aug; 26(16):6170-84. PMID: 16880527; PMCID: PMC1592787.
    168. Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EW, Workman P, Vigushin DM, Aboagye EO. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography. Cancer Res. 2006 Aug 01; 66(15):7621-9. PMID: 16885362.
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    169. Madureira PA, Varshochi R, Constantinidou D, Francis RE, Coombes RC, Yao KM, Lam EW. The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem. 2006 Sep 01; 281(35):25167-76. PMID: 16809346.
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    170. Kajihara T, Jones M, Fusi L, Takano M, Feroze-Zaidi F, Pirianov G, Mehmet H, Ishihara O, Higham JM, Lam EW, Brosens JJ. Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct; 20(10):2444-55. PMID: 16709600.
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    171. White PC, Shore AM, Clement M, McLaren J, Soeiro I, Lam EW, Brennan P. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene. 2006 Apr 06; 25(15):2170-80. PMID: 16301994.
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    172. Belkacemi L, Lam E, Caldwell JD, Siemens DR, Graham CH. Stimulation of human breast carcinoma cell invasiveness and urokinase plasminogen activator activity by glucose deprivation. Exp Cell Res. 2006 Jun 10; 312(10):1685-92. PMID: 16564525.
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    173. Hills FA, Abrahams VM, González-Timón B, Francis J, Cloke B, Hinkson L, Rai R, Mor G, Regan L, Sullivan M, Lam EW, Brosens JJ. Heparin prevents programmed cell death in human trophoblast. Mol Hum Reprod. 2006 Apr; 12(4):237-43. PMID: 16556679.
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    174. Watanabe N, Lam E. Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. Plant J. 2006 Mar; 45(6):884-94. PMID: 16507080.
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    175. Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM. Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer. 2006 Feb 20; 5:8. PMID: 16504004; PMCID: PMC1397858.
    176. Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, Vigushin DM. The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer. 2006 Feb 17; 5:7. PMID: 16503970; PMCID: PMC1388232.
    177. Brosens JJ, Lam EW, Parker MG. Inflammation and sex steroid receptors: a motif for change. Cell. 2006 Feb 10; 124(3):466-8. PMID: 16469693.
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    178. Zhou YX, Lee MY, Ng JM, Chye ML, Yip WK, Zee SY, Lam E. A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice. World J Gastroenterol. 2006 Jan 14; 12(2):306-12. PMID: 16482635; PMCID: PMC4066044.
    179. Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC, Lam EW. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res. 2006 Jan 01; 66(1):212-20. PMID: 16397234.
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    180. Watanabe K, Pecinka A, Meister A, Schubert I, Lam E. DNA hypomethylation reduces homologous pairing of inserted tandem repeat arrays in somatic nuclei of Arabidopsis thaliana. Plant J. 2005 Nov; 44(4):531-40. PMID: 16262704.
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    181. Fernandes MS, Pierron V, Michalovich D, Astle S, Thornton S, Peltoketo H, Lam EW, Gellersen B, Huhtaniemi I, Allen J, Brosens JJ. Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues. J Endocrinol. 2005 Oct; 187(1):89-101. PMID: 16214944.
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    182. Madureira PA, Matos P, Soeiro I, Dixon LK, Simas JP, Lam EW. Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells. J Biol Chem. 2005 Nov 11; 280(45):37310-8. PMID: 16150693.
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    183. Glassford J, Vigorito E, Soeiro I, Madureira PA, Zoumpoulidou G, Brosens JJ, Turner M, Lam EW. Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes. Eur J Immunol. 2005 Sep; 35(9):2748-61. PMID: 16114097.
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    184. Labied S, Kajihara T, Madureira PA, Fusi L, Jones MC, Higham JM, Varshochi R, Francis JM, Zoumpoulidou G, Essafi A, Fernandez de Mattos S, Lam EW, Brosens JJ. Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium. Mol Endocrinol. 2006 Jan; 20(1):35-44. PMID: 16123151.
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    185. Essafi A, Fernández de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam EW. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene. 2005 Mar 31; 24(14):2317-29. PMID: 15688014.
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    186. Dunne PJ, Belaramani L, Fletcher JM, Fernandez de Mattos S, Lawrenz M, Soares MV, Rustin MH, Lam EW, Salmon M, Akbar AN. Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection. Blood. 2005 Jul 15; 106(2):558-65. PMID: 15797994.
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    187. Lo C, Wang N, Lam E. Inducible double-stranded RNA expression activates reversible transcript turnover and stable translational suppression of a target gene in transgenic tobacco. FEBS Lett. 2005 Feb 28; 579(6):1498-502. PMID: 15733863.
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    188. Watanabe N, Lam E. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. J Biol Chem. 2005 Apr 15; 280(15):14691-9. PMID: 15691845.
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    189. Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005 Apr 01; 105(7):2821-7. PMID: 15591115.
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    190. Alao JP, Lam EW, Ali S, Buluwela L, Bordogna W, Lockey P, Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res. 2004 Dec 01; 10(23):8094-104. PMID: 15585645.
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    191. Barley RD, Pollock S, Shallow MC, Peters E, Lam EW. Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch. J Dent Res. 2004 Dec; 83(12):903-8. PMID: 15557395.
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    192. Zhou Y, Chan JH, Chan AY, Chak RK, Wong EY, Chye ML, Peiris JS, Poon LL, Lam E. Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian cells. FEBS Lett. 2004 Nov 19; 577(3):345-50. PMID: 15556607.
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    193. Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC, Lam EW. ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. J Biol Chem. 2005 Feb 04; 280(5):3185-96. PMID: 15557281.
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    194. Fernández de Mattos S, Essafi A, Soeiro I, Pietersen AM, Birkenkamp KU, Edwards CS, Martino A, Nelson BH, Francis JM, Jones MC, Brosens JJ, Coffer PJ, Lam EW. FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol. 2004 Nov; 24(22):10058-71. PMID: 15509806; PMCID: PMC525464.
    195. Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M. Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol. 2004 Sep 01; 173(5):3209-14. PMID: 15322182.
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    196. Palmieri C, Saji S, Sakaguchi H, Cheng G, Sunters A, O'Hare MJ, Warner M, Gustafsson JA, Coombes RC, Lam EW. The expression of oestrogen receptor (ER)-beta and its variants, but not ERalpha, in adult human mammary fibroblasts. J Mol Endocrinol. 2004 Aug; 33(1):35-50. PMID: 15291741.
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    197. Rainer TH, Griffith JF, Lam E, Lam PK, Metreweli C. Comparison of thoracic ultrasound, clinical acumen, and radiography in patients with minor chest injury. J Trauma. 2004 Jun; 56(6):1211-3. PMID: 15211127.
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    198. Zoumpoulidou G, Jones MC, Fernandez de Mattos S, Francis JM, Fusi L, Lee YS, Christian M, Varshochi R, Lam EW, Brosens JJ. Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). Mol Endocrinol. 2004 Aug; 18(8):1988-99. PMID: 15155784.
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    199. Palmieri C, Lam EW, Vigushin D, Coombes RC. Value of SERMs in postmenopausal women. Lancet. 2004 May 01; 363(9419):1477-8. PMID: 15121421.
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    200. Gamble SC, Odontiadis M, Waxman J, Westbrook JA, Dunn MJ, Wait R, Lam EW, Bevan CL. Androgens target prohibitin to regulate proliferation of prostate cancer cells. Oncogene. 2004 Apr 15; 23(17):2996-3004. PMID: 14968116.
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    201. Lam E. Controlled cell death, plant survival and development. Nat Rev Mol Cell Biol. 2004 Apr; 5(4):305-15. PMID: 15071555.
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    202. Palmieri C, Lam EW, Mansi J, MacDonald C, Shousha S, Madden P, Omoto Y, Sunters A, Warner M, Gustafsson JA, Coombes RC. The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival. Clin Cancer Res. 2004 Apr 01; 10(7):2421-8. PMID: 15073120.
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    203. Brosens JJ, Tullet J, Varshochi R, Lam EW. Steroid receptor action. Best Pract Res Clin Obstet Gynaecol. 2004 Apr; 18(2):265-83. PMID: 15157642.
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    204. Watanabe N, Lam E. Recent advance in the study of caspase-like proteases and Bax inhibitor-1 in plants: their possible roles as regulator of programmed cell death. Mol Plant Pathol. 2004 Jan 01; 5(1):65-70. PMID: 20565583.
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    205. Ng DS, Xie C, Maguire GF, Zhu X, Ugwu F, Lam E, Connelly PW. Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance. J Biol Chem. 2004 Feb 27; 279(9):7636-42. PMID: 14668345.
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    206. Mohamedali A, Soeiro I, Lea NC, Glassford J, Banerji L, Mufti GJ, Lam EW, Thomas NS. Cyclin D2 controls B cell progenitor numbers. J Leukoc Biol. 2003 Dec; 74(6):1139-43. PMID: 14612431.
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    207. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene. 2003 Oct 23; 22(48):7600-6. PMID: 14576822.
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    208. Sunters A, Fernández de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003 Dec 12; 278(50):49795-805. PMID: 14527951.
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    209. del Pozo O, Lam E. Expression of the baculovirus p35 protein in tobacco affects cell death progression and compromises N gene-mediated disease resistance response to Tobacco mosaic virus. Mol Plant Microbe Interact. 2003 Jun; 16(6):485-94. PMID: 12795375.
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    210. Lagrange T, Hakimi MA, Pontier D, Courtois F, Alcaraz JP, Grunwald D, Lam E, Lerbs-Mache S. Transcription factor IIB (TFIIB)-related protein (pBrp), a plant-specific member of the TFIIB-related protein family. Mol Cell Biol. 2003 May; 23(9):3274-86. PMID: 12697827; PMCID: PMC153204.
    211. Glassford J, Soeiro I, Skarell SM, Banerji L, Holman M, Klaus GG, Kadowaki T, Koyasu S, Lam EW. BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene. 2003 Apr 17; 22(15):2248-59. PMID: 12700661.
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    212. Palmieri C, Roberts-Clark D, Assadi-Sabet A, Coope RC, O'Hare M, Sunters A, Hanby A, Slade MJ, Gomm JJ, Lam EW, Coombes RC. Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells. J Endocrinol. 2003 Apr; 177(1):65-81. PMID: 12697038.
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    213. Lea NC, Orr SJ, Stoeber K, Williams GH, Lam EW, Ibrahim MA, Mufti GJ, Thomas NS. Commitment point during G0-->G1 that controls entry into the cell cycle. Mol Cell Biol. 2003 Apr; 23(7):2351-61. PMID: 12640120; PMCID: PMC150729.
    214. Pontier D, Privat I, Trifa Y, Zhou JM, Klessig DF, Lam E. Differential regulation of TGA transcription factors by post-transcriptional control. Plant J. 2002 Dec; 32(5):641-53. PMID: 12472682.
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    215. Fernández de Mattos S, Lam EW, Tauler A. An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase. Biochem J. 2002 Nov 15; 368(Pt 1):283-91. PMID: 12139485; PMCID: PMC1222960.
    216. Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol. 2002 Nov; 22(22):7842-52. PMID: 12391153; PMCID: PMC134724.
    217. Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ. Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. J Biol Chem. 2002 Sep 06; 277(36):32413-6. PMID: 12119282.
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    218. Pontier D, Mittler R, Lam E. Mechanism of cell death and disease resistance induction by transgenic expression of bacterio-opsin. Plant J. 2002 Jun; 30(5):499-509. PMID: 12047625.
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    219. Barnouin K, Dubuisson ML, Child ES, Fernandez de Mattos S, Glassford J, Medema RH, Mann DJ, Lam EW. H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression. J Biol Chem. 2002 Apr 19; 277(16):13761-70. PMID: 11827966.
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    220. Banerji L, Glassford J, Lea NC, Thomas NS, Klaus GG, Lam EW. BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells. Oncogene. 2001 Nov 01; 20(50):7352-67. PMID: 11704865.
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    221. Deininger MW, Vieira SA, Parada Y, Banerji L, Lam EW, Peters G, Mahon FX, Köhler T, Goldman JM, Melo JV. Direct relation between BCR-ABL tyrosine kinase activity and cyclin D2 expression in lymphoblasts. Cancer Res. 2001 Nov 01; 61(21):8005-13. PMID: 11691826.
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    222. Kato N, Lam E. Detection of chromosomes tagged with green fluorescent protein in live Arabidopsis thaliana plants. Genome Biol. 2001; 2(11):RESEARCH0045. PMID: 11737944; PMCID: PMC60307.
    223. Glassford J, Holman M, Banerji L, Clayton E, Klaus GG, Turner M, Lam EW. Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor. J Biol Chem. 2001 Nov 02; 276(44):41040-8. PMID: 11546804.
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    224. Pontier D, Miao ZH, Lam E. Trans-dominant suppression of plant TGA factors reveals their negative and positive roles in plant defense responses. Plant J. 2001 Sep; 27(6):529-38. PMID: 11576436.
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    225. Rivas C, Miller AR, Collado M, Lam EW, Apperley JF, Melo JV. BCR-ABL-expressing cells transduced with the HSV-tk gene die by apoptosis upon treatment with ganciclovir. Mol Ther. 2001 May; 3(5 Pt 1):642-52. PMID: 11356068.
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    226. Lewis JL, Chinswangwatanakul W, Zheng B, Marley SB, Nguyen DX, Cross NC, Banerji L, Glassford J, Thomas NS, Goldman JM, Lam EW, Gordon MY. The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells. Blood. 2001 May 01; 97(9):2604-10. PMID: 11313248.
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    227. Parada Y, Banerji L, Glassford J, Lea NC, Collado M, Rivas C, Lewis JL, Gordon MY, Thomas NS, Lam EW. BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression. J Biol Chem. 2001 Jun 29; 276(26):23572-80. PMID: 11323429.
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    228. Wong WR, Lam E, Huang RC, Wong RS, Morris C, Hackett J. Applications, and efficient large-scale production, of recombinant human epidermal growth factor. Biotechnol Genet Eng Rev. 2001; 18:51-71. PMID: 11530698.
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    229. Kirkham PA, Takamatsu HH, Lam EW, Parkhouse RM. Ligation of the WC1 receptor induces gamma delta T cell growth arrest through fumonisin B1-sensitive increases in cellular ceramide. J Immunol. 2000 Oct 01; 165(7):3564-70. PMID: 11034356.
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    230. Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, Rivas C, Burgering BM, Serrano M, Lam EW. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem. 2000 Jul 21; 275(29):21960-8. PMID: 10791951.
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    231. Lam EW, Hammad HM, Zwacka R, Darby CJ, Baumgardner KR, Davidson BL, Oberley TD, Engelhardt JF, Oberley LW. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent Res. 2000 Jun; 79(6):1410-7. PMID: 10890721.
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    232. Solvason N, Wu WW, Parry D, Mahony D, Lam EW, Glassford J, Klaus GG, Sicinski P, Weinberg R, Liu YJ, Howard M, Lees E. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Int Immunol. 2000 May; 12(5):631-8. PMID: 10784609.
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    233. Lam EW, Glassford J, Banerji L, Thomas NS, Sicinski P, Klaus GG. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J Biol Chem. 2000 Feb 04; 275(5):3479-84. PMID: 10652342.
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    234. Zhou JM, Trifa Y, Silva H, Pontier D, Lam E, Shah J, Klessig DF. NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Mol Plant Microbe Interact. 2000 Feb; 13(2):191-202. PMID: 10659709.
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    235. Lenigk R, Lam E, Lai A, Wang H, Han Y, Carlier P, Renneberg R. Enzyme biosensor for studying therapeutics of Alzheimer's disease. Biosens Bioelectron. 2000; 15(9-10):541-7. PMID: 11419651.
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    236. Powell AJ, Darmon AJ, Gonos ES, Lam EW, Peden KW, Jat PS. Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen. Oncogene. 1999 Dec 02; 18(51):7343-50. PMID: 10602490.
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    237. Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG. Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors. Eur J Immunol. 1999 Oct; 29(10):3380-9. PMID: 10540350.
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    238. van der Sman J, Thomas NS, Lam EW. Modulation of E2F complexes during G0 to S phase transition in human primary B-lymphocytes. J Biol Chem. 1999 Apr 23; 274(17):12009-16. PMID: 10207023.
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    239. Lagaud GJ, Lam E, Lui A, van Breemen C, Laher I. Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries. Biochem Biophys Res Commun. 1999 Apr 13; 257(2):523-7. PMID: 10198244.
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    240. Pontier D, Gan S, Amasino RM, Roby D, Lam E. Markers for hypersensitive response and senescence show distinct patterns of expression. Plant Mol Biol. 1999 Apr; 39(6):1243-55. PMID: 10380810.
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    241. Mittler R, Lam E, Shulaev V, Cohen M. Signals controlling the expression of cytosolic ascorbate peroxidase during pathogen-induced programmed cell death in tobacco. Plant Mol Biol. 1999 Mar; 39(5):1025-35. PMID: 10344207.
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    242. Voorhoeve PM, Watson RJ, Farlie PG, Bernards R, Lam EW. Rapid dephosphorylation of p107 following UV irradiation. Oncogene. 1999 Jan 21; 18(3):679-88. PMID: 9989818.
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    243. Lam E, Skarsgard P, Laher I. Inhibition of myogenic tone by mibefradil in rat cerebral arteries. Eur J Pharmacol. 1998 Oct 02; 358(2):165-8. PMID: 9808266.
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    244. Kirkham PA, Lam EW, Takamatsu HH, Parkhouse RM. Transcription factor E2F controls the reversible gamma delta T cell growth arrest mediated through WC1. J Immunol. 1998 Aug 15; 161(4):1630-6. PMID: 9712024.
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    245. Gopalkrishnan RV, Lam EW, Kedinger C. The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter. J Biol Chem. 1998 May 01; 273(18):10972-8. PMID: 9556576.
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    246. Lam EW, Choi MS, van der Sman J, Burbidge SA, Klaus GG. Modulation of E2F activity via signaling through surface IgM and CD40 receptors in WEHI-231 B lymphoma cells. J Biol Chem. 1998 Apr 17; 273(16):10051-7. PMID: 9545352.
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    247. Lam EW, Zwacka R, Engelhardt JF, Davidson BL, Domann FE, Yan T, Oberley LW. Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells. Cancer Res. 1997 Dec 15; 57(24):5550-6. PMID: 9407966.
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    248. Xiang C, Miao Z, Lam E. DNA-binding properties, genomic organization and expression pattern of TGA6, a new member of the TGA family of bZIP transcription factors in Arabidopsis thaliana. Plant Mol Biol. 1997 Jun; 34(3):403-15. PMID: 9225852.
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    249. Klaus GG, Choi MS, Lam EW, Johnson-Léger C, Cliff J. CD40: a pivotal receptor in the determination of life/death decisions in B lymphocytes. Int Rev Immunol. 1997; 15(1-2):5-31. PMID: 9178070.
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    250. Xiang C, Miao ZH, Lam E. Coordinated activation of as-1-type elements and a tobacco glutathione S-transferase gene by auxins, salicylic acid, methyl-jasmonate and hydrogen peroxide. Plant Mol Biol. 1996 Nov; 32(3):415-26. PMID: 8980490.
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    251. Meisel L, Lam E. The conserved ELK-homeodomain of KNOTTED-1 contains two regions that signal nuclear localization. Plant Mol Biol. 1996 Jan; 30(1):1-14. PMID: 8616227.
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    252. O'Connor DJ, Lam EW, Griffin S, Zhong S, Leighton LC, Burbidge SA, Lu X. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J. 1995 Dec 15; 14(24):6184-92. PMID: 8557038; PMCID: PMC394743.
    253. Lam E, Martin MM, Timerman AP, Sabers C, Fleischer S, Lukas T, Abraham RT, O'Keefe SJ, O'Neill EA, Wiederrecht GJ. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 03; 270(44):26511-22. PMID: 7592869.
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    254. Lam E, Lam YK. Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity. Nucleic Acids Res. 1995 Sep 25; 23(18):3778-85. PMID: 7479010; PMCID: PMC307279.
    255. Hao XF, Alphey L, Bandara LR, Lam EW, Glover D, La Thangue NB. Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. J Cell Sci. 1995 Sep; 108 ( Pt 9):2945-54. PMID: 8537434.
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    256. Lam E, Martin M, Wiederrecht G. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. Gene. 1995 Jul 28; 160(2):297-302. PMID: 7543869.
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    257. Lam EW, Bennett JD, Watson RJ. Cell-cycle regulation of human B-myb transcription. Gene. 1995 Jul 28; 160(2):277-81. PMID: 7642110.
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    258. Miao ZH, Lam E. Construction of a trans-dominant inhibitor for members of the TGA family of transcription factors conserved in higher plants. Plant J. 1995 Jun; 7(6):887-96. PMID: 7599649.
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    259. Jooss K, Lam EW, Bybee A, Girling R, Müller R, La Thangue NB. Proto-oncogenic properties of the DP family of proteins. Oncogene. 1995 Apr 20; 10(8):1529-36. PMID: 7731707.
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    260. Miao ZH, Lam E. Targeted disruption of the TGA3 locus in Arabidopsis thaliana. Plant J. 1995 Feb; 7(2):359-65. PMID: 7704051.
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    261. Lam E. Domain analysis of the plant DNA-binding protein GT1a: requirement of four putative alpha-helices for DNA binding and identification of a novel oligomerization region. Mol Cell Biol. 1995 Feb; 15(2):1014-20. PMID: 7823917; PMCID: PMC231998.
    262. Ji Y, Qu D, Jia G, Ren Q, Fang CT, Lam E, Ha BT, Dodd RY, Sullivan MT, Williams AE. Study of HIV antibody screening for blood donors by a pooling-serum method. Vox Sang. 1995; 69(3):255-6. PMID: 8578741.
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    263. Xie S, Lam E. Abundance of nuclear DNA topoisomerase II is correlated with proliferation in Arabidopsis thaliana. Nucleic Acids Res. 1994 Dec 25; 22(25):5729-36. PMID: 7838729; PMCID: PMC310140.
    264. Lam EW, La Thangue NB. DP and E2F proteins: coordinating transcription with cell cycle progression. Curr Opin Cell Biol. 1994 Dec; 6(6):859-66. PMID: 7880534.
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    265. Girling R, Bandara LR, Ormondroyd E, Lam EW, Kotecha S, Mohun T, La Thangue NB. Molecular characterization of Xenopus laevis DP proteins. Mol Biol Cell. 1994 Oct; 5(10):1081-92. PMID: 7865876; PMCID: PMC301132.
    266. Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J. 1994 Jul 01; 13(13):3104-14. PMID: 8039504; PMCID: PMC395201.
    267. Miao ZH, Liu X, Lam E. TGA3 is a distinct member of the TGA family of bZIP transcription factors in Arabidopsis thaliana. Plant Mol Biol. 1994 Apr; 25(1):1-11. PMID: 8003690.
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    268. Lam EW, Morris JD, Davies R, Crook T, Watson RJ, Vousden KH. HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J. 1994 Feb 15; 13(4):871-8. PMID: 8112300; PMCID: PMC394886.
    269. Liu X, Lam E. Two binding sites for the plant transcription factor ASF-1 can respond to auxin treatments in transgenic tobacco. J Biol Chem. 1994 Jan 07; 269(1):668-75. PMID: 8276868.
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    270. Lam EW, Watson RJ. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 1993 Jul; 12(7):2705-13. PMID: 8334989; PMCID: PMC413519.
    271. Watson RJ, Robinson C, Lam EW. Transcription regulation by murine B-myb is distinct from that by c-myb. Nucleic Acids Res. 1993 Jan 25; 21(2):267-72. PMID: 8382794; PMCID: PMC309102.
    272. Lam EW, Robinson C, Watson RJ. Characterization and cell cycle-regulated expression of mouse B-myb. Oncogene. 1992 Sep; 7(9):1885-90. PMID: 1501895.
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    273. Perisic O, Lam E. A tobacco DNA binding protein that interacts with a light-responsive box II element. Plant Cell. 1992 Jul; 4(7):831-8. PMID: 1392597; PMCID: PMC160178.
    274. Lam EW, Hannam AG. Regional 31P magnetic resonance spectroscopy of exercising human masseter muscle. Arch Oral Biol. 1992 Jan; 37(1):49-56. PMID: 1596208.
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    275. Lam E, Chua NH. Tetramer of a 21-base pair synthetic element confers seed expression and transcriptional enhancement in response to water stress and abscisic acid. J Biol Chem. 1991 Sep 15; 266(26):17131-5. PMID: 1832669.
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    276. Lam EW, Hannam AG, Christiansen EL. Estimation of tendon-plane orientation within human masseter muscle from reconstructed magnetic resonance images. Arch Oral Biol. 1991; 36(11):845-53. PMID: 1763981.
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    277. Lam E, Kano-Murakami Y, Gilmartin P, Niner B, Chua NH. A metal-dependent DNA-binding protein interacts with a constitutive element of a light-responsive promoter. Plant Cell. 1990 Sep; 2(9):857-66. PMID: 2152132; PMCID: PMC159936.
    278. Lam E, Katagiri F, Chua NH. Plant nuclear factor ASF-1 binds to an essential region of the nopaline synthase promoter. J Biol Chem. 1990 Jun 15; 265(17):9909-13. PMID: 2351681.
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    279. Lam E, Chua NH. GT-1 binding site confers light responsive expression in transgenic tobacco. Science. 1990 Apr 27; 248(4954):471-4. PMID: 2330508.
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    280. Lam E. From footprint to function: an approach to study gene expression and regulatory factors in transgenic plants. Genet Eng (N Y). 1990; 12:73-86. PMID: 1366708.
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    281. Lam E, Chua NH. ASF-2: a factor that binds to the cauliflower mosaic virus 35S promoter and a conserved GATA motif in Cab promoters. Plant Cell. 1989 Dec; 1(12):1147-56. PMID: 2535536; PMCID: PMC159850.
    282. Lam E, Benedyk M, Chua NH. Characterization of phytochrome-regulated gene expression in a photoautotrophic cell suspension: possible role for calmodulin. Mol Cell Biol. 1989 Nov; 9(11):4819-23. PMID: 2689868; PMCID: PMC363631.
    283. Lam E, Green PJ, Wong M, Chua NH. Phytochrome activation of two nuclear genes requires cytoplasmic protein synthesis. EMBO J. 1989 Oct; 8(10):2777-83. PMID: 2583082; PMCID: PMC401321.
    284. Katagiri F, Lam E, Chua NH. Two tobacco DNA-binding proteins with homology to the nuclear factor CREB. Nature. 1989 Aug 31; 340(6236):727-30. PMID: 2528073.
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    285. Lam EW, Hannam AG, Wood WW, Fache JS, Watanabe M. Imaging orofacial tissues by magnetic resonance. Oral Surg Oral Med Oral Pathol. 1989 Jul; 68(1):2-8. PMID: 2755685.
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    286. Steger RW, Amador A, Lam E, Rathert J, Weis J, Smith MS. Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology. 1989 Apr; 124(4):1737-43. PMID: 2522388.
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    287. Lees AW, Jenkins HJ, May CL, Cherian G, Lam EW, Hanson J. Risk factors and 10-year breast cancer survival in northern Alberta. Breast Cancer Res Treat. 1989 Mar; 13(2):143-51. PMID: 2730961.
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    288. Lam E. Nearest-neighbor relationships of the constituent polypeptides in plastoquinol-plastocyanin oxidoreductase. Biochim Biophys Acta. 1986 Mar 12; 848(3):324-32. PMID: 3081025.
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    289. Lam E, Malkin R. Characterization of a photosynthetic mutant of Lemna lacking the cytochrome b6-f complex. Biochim Biophys Acta. 1985 Oct 29; 810(1):106-9. PMID: 3899174.
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    290. Timmermans PB, de Jonge A, van Meel JC, Slothorst-Grisdijk FP, Lam E, van Zwieten PA. Characterization of alpha-adrenoceptor populations. Quantitative relationships between cardiovascular effects initiated at central and peripheral alpha-adrenoceptors. J Med Chem. 1981 May; 24(5):502-7. PMID: 6264080.
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