Erin Simonds, PhD
|School||UCSF School of Medicine|
|Address||1450 3rd Street|
San Francisco CA 94158
|Damon Runyon Cancer Research Foundation||2014
||2018||Damon Runyon Postdoctoral Fellowship|
|Alex's Lemonade Stand Foundation||2013
||2015||Young Investigator Award|
|Stanford University Dept. of Microbiology & Immunology||2012
||2012||Sidney Raffel Award for Outstanding PhD Dissertation|
Coming from an immunology background, I have a longstanding interest in cellular phenotypic heterogeneity and the relationship between different cell fates and their underlying signaling biology. Now, as a cancer biologist, I am applying single-cell analysis techniques to understand how phenotypic heterogeneity contributes to cancer growth and resistance to therapy.
As a PhD student, I helped develop single-cell assays to study signaling in the healthy immune system (Science 2011), and in childhood leukemias (Cell 2015). As a postdoc, I am applying these same approaches to investigate phenotypic plasticity and immune infiltration in glioblastoma, the most common and lethal brain tumor.
Many of my experiments are enabled by a next-generation flow cytometry platform (CyTOF mass cytometry), which can measure up to 42 protein expression and intracellular signaling markers at the single-cell level in millions of cancer cells. This platform provides detailed biochemical profiles of rare and complex samples, uncovering subpopulations that would have been overlooked by classical bulk protein and genetic assays.
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