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    Frances Brodsky, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-6406

       Biography 
       Awards and Honors
      1975Phi Beta Kappa, Junior year Camille and Henry Dreyfus Fellowship for Summer Research
      1976Marshall Scholarship
      1980Damon Runyon-Walter Winchell Fund Postdoctoral Fellowship
      1987Pharmaceutical Manufacturers Association Fund, Research Starter Grant
      1988Pew Scholars Program
      McGill University2005Boehringer-Ingleheim Lecturer
      University of Queensland2005Honorary Professor
      University of California, San Francisco2005Commencement Speaker for Graduate Programs
      National Institutes of Health2006Margaret Pittman Lecturer
      King's College, Cambridge2006Visiting Fellowship
      American Society of Cell Biology2007Senior Career Award, Women in Cell Biology
      University of Massachusetts2008Kai Lin Memorial Lecturer
      Lysosomes Gordon Research Conference2008Elected Vice-Chair
      Lysosomes Gordon Research Conference2010Elected Chair
      Harris-Manchester College, Oxford University2010Lord Harris Visiting Professor
      Karolinska Institute Stockholm, Sweden2011Diabetes Symposium Invited Speaker

       Overview 
       Overview
      Clathrin is a self-assembling protein that controls the formation of intracellular transport vesicles required for several key membrane traffic pathways. These include receptor-mediated endocytosis and biogenesis of lysosomes and secretory granules. Thus clathrin plays a critical role in cell growth control, antigen presentation, neuronal function and hormone secretion. Malfunction of clathrin pathways is associated with development of cancer, heart disease and neuronal defects. Clathrin-mediated pathways are also subverted by certain viruses and intracellular bacteria to facilitate their infection. A novel isoform of clathrin (CHC22) that is primarily expressed in skeletal muscle, cardiac muscle and fat has been recently characterized by the Brodsky laboratory. Its tissue-specific function is to package the GLUT4 glucose transporter into intracellular vesicles that are released in response to insulin stimulation, leading to clearance of glucose from the bloodstream. This CHC22 clathrin isoform is therefore associated with pathways that are defective in type 2 diabetes. The focus of the Brodsky laboratory since 1982 has been to define the biochemistry, regulation, evolution and physiological function of the clathrin subunits and their isoforms, focusing on their role in disease states, as well as in normal cellular physiology. The laboratory has made significant contributions in these areas over the years and maintains an international reputation for expertise on clathrin structure and function.
      There are four current projects in the laboratory. These projects aim to define the comparative functions of the two clathrin heavy chain (CHC) isoforms (CHC17 and CHC22) and the two clathrin light chain isoforms (LCa and LCb). The regulation of CHC17 clathrin function by signaling pathways and the cooperation of CHC17 clathrin with the actin cytoskeleton through clathrin light chain interaction with the actin-binding Hip proteins is being investigated in the context of cell adhesion and migration. Establishing the mechanistic role of CHC22 clathrin in GLUT4 transport and pathways that malfunction in type 2 diabetes is also a major goal for the laboratory.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun. 2014; 5:3891.
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      2. Vassilopoulos S, Gentil C, Lainé J, Buclez PO, Franck A, Ferry A, Précigout G, Roth R, Heuser JE, Brodsky FM, Garcia L, Bonne G, Voit T, Piétri-Rouxel F, Bitoun M. Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. J Cell Biol. 2014 May 12; 205(3):377-93.
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      3. Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Mol Biol Cell. 2014 Jun 15; 25(12):1925-36.
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      4. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. Self-Assembly of VPS41 Promotes Sorting Required for Biogenesis of the Regulated Secretory Pathway. Dev Cell. 2013 Nov 25; 27(4):425-37.
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      5. Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM. The CHC22 Clathrin-GLUT4 Transport Pathway Contributes to Skeletal Muscle Regeneration. PLoS One. 2013; 8(10):e77787.
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      6. Brodsky F. Frances Brodsky: so you think you know all about clathrin? Interview by Caitlin Sedwick. J Cell Biol. 2013 Sep 16; 202(6):830-1.
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      7. Stachowiak JC, Brodsky FM, Miller EA. A cost-benefit analysis of the physical mechanisms of membrane curvature. Nat Cell Biol. 2013 Sep; 15(9):1019-27.
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      8. Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47.
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      9. Young A, Stoilova-McPhie S, Rothnie A, Vallis Y, Harvey-Smith P, Ranson N, Kent H, Brodsky FM, Pearse BM, Roseman A, Smith CJ. Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly. Traffic. 2013 Sep; 14(9):987-96.
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      10. Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P. A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. Traffic. 2012 Dec; 13(12):1653-66.
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      11. Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR, Doxsey SJ, Brodsky FM. Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol. 2012 Aug 20; 198(4):591-605.
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      12. Brodsky FM. Diversity of clathrin function: new tricks for an old protein. Annu Rev Cell Dev Biol. 2012; 28:309-36.
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      13. Brodsky FM, Thattai M, Mayor S. Evolutionary cell biology: Lessons from diversity. Nat Cell Biol. 2012 Jul; 14(7):651.
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      14. Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P. Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. J Cell Biol. 2011 Oct 31; 195(3):525-36.
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      15. Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM. The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice. Oncogene. 2012 Jan 26; 31(4):494-506.
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      16. Shieh JC, Schaar BT, Srinivasan K, Brodsky FM, McConnell SK. Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS One. 2011; 6(3):e17802.
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      17. Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM. Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol. 2011 Jan 1; 186(1):62-72.
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      18. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
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      19. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
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      20. Esk C, Chen CY, Johannes L, Brodsky FM. The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step. J Cell Biol. 2010 Jan 11; 188(1):131-44.
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      21. Vassilopoulos S, Esk C, Hoshino S, Brodsky FM. [The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes]. Med Sci (Paris). 2010 Jan; 26(1):33-6.
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      22. Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P. Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. J Immunol. 2009 Oct 1; 183(7):4569-82.
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      23. Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 2009 May 29; 324(5931):1192-6.
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      24. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9.
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      25. Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG. Evolutionary analysis and molecular dissection of caveola biogenesis. J Cell Sci. 2008 Jun 15; 121(Pt 12):2075-86.
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      26. Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM. Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol. 2008 Feb; 10(2):211-9.
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      27. Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM. Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic. 2006 Dec; 7(12):1688-700.
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      28. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65.
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      29. Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7209-14.
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      30. Wilbur JD, Hwang PK, Brodsky FM. New faces of the familiar clathrin lattice. Traffic. 2005 Apr; 6(4):346-50.
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      31. Stoddart A, Jackson AP, Brodsky FM. Plasticity of B cell receptor internalization upon conditional depletion of clathrin. Mol Biol Cell. 2005 May; 16(5):2339-48.
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      32. Brodsky FM. Cell biology: clathrin's Achilles' ankle. Nature. 2004 Dec 2; 432(7017):568-9.
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      33. Chen CY, Brodsky FM. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J Biol Chem. 2005 Feb 18; 280(7):6109-17.
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      34. Niiro H, Allam A, Stoddart A, Brodsky FM, Marshall AJ, Clark EA. The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. J Immunol. 2004 Nov 1; 173(9):5601-9.
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      35. Towler MC, Gleeson PA, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, Ordahl C, Parton RG, Brodsky FM. Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol Biol Cell. 2004 Jul; 15(7):3181-95.
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      36. Crotzer VL, Mabardy AS, Weiss A, Brodsky FM. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J Exp Med. 2004 Apr 5; 199(7):981-91.
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      37. Towler MC, Kaufman SJ, Brodsky FM. Membrane traffic in skeletal muscle. Traffic. 2004 Mar; 5(3):129-39.
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      38. Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM. Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation. EMBO J. 2003 Oct 1; 22(19):4980-90.
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      39. Knuehl C, Brodsky FM. The long and short of adaptor appendages. Nat Struct Biol. 2003 Aug; 10(8):580-2.
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      40. Chen CY, Reese ML, Hwang PK, Ota N, Agard D, Brodsky FM. Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans. EMBO J. 2002 Nov 15; 21(22):6072-82.
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      41. Stoddart A, Dykstra ML, Brown BK, Song W, Pierce SK, Brodsky FM. Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity. 2002 Oct; 17(4):451-62.
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      42. Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9942-7.
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      43. Bennett EM, Chen CY, Engqvist-Goldstein AE, Drubin DG, Brodsky FM. Clathrin hub expression dissociates the actin-binding protein Hip1R from coated pits and disrupts their alignment with the actin cytoskeleton. Traffic. 2001 Nov; 2(11):851-8.
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      44. Bennett EM, Lin SX, Towler MC, Maxfield FR, Brodsky FM. Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling. Mol Biol Cell. 2001 Sep; 12(9):2790-9.
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      45. Molinete M, Dupuis S, Brodsky FM, Halban PA. Role of clathrin in the regulated secretory pathway of pancreatic beta-cells. J Cell Sci. 2001 Aug; 114(Pt 16):3059-66.
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      46. Liu SH, Towler MC, Chen E, Chen CY, Song W, Apodaca G, Brodsky FM. A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network. EMBO J. 2001 Jan 15; 20(1-2):272-84.
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      47. Brodsky FM, Chen CY, Knuehl C, Towler MC, Wakeham DE. Biological basket weaving: formation and function of clathrin-coated vesicles. Annu Rev Cell Dev Biol. 2001; 17:517-68.
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      48. Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci. 2000 Oct 1; 20(19):7325-33.
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      49. Ybe JA, Wakeham DE, Brodsky FM, Hwang PK. Molecular structures of proteins involved in vesicle fusion. Traffic. 2000 Jun; 1(6):474-9.
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      50. Wakeham DE, Ybe JA, Brodsky FM, Hwang PK. Molecular structures of proteins involved in vesicle coat formation. Traffic. 2000 May; 1(5):393-8.
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      51. Jahn R, Brodsky FM. Transport of proteins and membrane in eukaryotic cells (Göttingen, September 29-October 1, 1999). Traffic. 2000 Feb; 1(2):187-8.
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      52. Greene B, Liu SH, Wilde A, Brodsky FM. Complete reconstitution of clathrin basket formation with recombinant protein fragments: adaptor control of clathrin self-assembly. Traffic. 2000 Jan; 1(1):69-75.
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      53. Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol. 1999 Oct 4; 147(1):7-12.
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      54. Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK. Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature. 1999 May 27; 399(6734):371-5.
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      55. Bennett EM, Bennink JR, Yewdell JW, Brodsky FM. Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression. J Immunol. 1999 May 1; 162(9):5049-52.
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      56. Brodsky FM. Stealth, sabotage and exploitation. Immunol Rev. 1999 Apr; 168:5-11.
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      57. Brodsky FM, Lem L, Solache A, Bennett EM. Human pathogen subversion of antigen presentation. Immunol Rev. 1999 Apr; 168:199-215.
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      58. Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 1999 Mar 5; 96(5):677-87.
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      59. Lem L, Riethof DA, Scidmore-Carlson M, Griffiths GM, Hackstadt T, Brodsky FM. Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases. J Immunol. 1999 Jan 1; 162(1):523-32.
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      60. Ybe JA, Greene B, Liu SH, Pley U, Parham P, Brodsky FM. Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges. EMBO J. 1998 Aug 10; 17(5):1297-303.
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      61. Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity. 1998 May; 8(5):647-56.
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      62. Bursztajn S, Vincent S, Brodsky FM, Benes F, Morris SA. A novel AP180-related protein in vesicles that concentrate at acetylcholine receptor clusters. J Cell Biochem. 1998 Mar 15; 68(4):457-71.
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      63. Liu SH, Marks MS, Brodsky FM. A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway. J Cell Biol. 1998 Mar 9; 140(5):1023-37.
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      64. Brodsky FM. New fashions in vesicle coats. Trends Cell Biol. 1997 May; 7(5):175-9.
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      65. Bresnahan PA, Barber LD, Brodsky FM. Localization of class I histocompatibility molecule assembly by subfractionation of the early secretory pathway. Hum Immunol. 1997 Apr 1; 53(2):129-39.
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      66. Wilde A, Brodsky FM, Boll W. Clathrin assembly: phosphorylation and peptides provide new tools. Trends Cell Biol. 1997 Feb; 7(2):47.
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      67. Mallet WG, Brodsky FM. A membrane-associated protein complex with selective binding to the clathrin coat adaptor AP1. J Cell Sci. 1996 Dec; 109 ( Pt 13):3059-68.
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      68. Wilde A, Brodsky FM. In vivo phosphorylation of adaptors regulates their interaction with clathrin. J Cell Biol. 1996 Nov; 135(3):635-45.
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      69. Brodsky FM, Lem L, Bresnahan PA. Antigen processing and presentation. Tissue Antigens. 1996 Jun; 47(6):464-71.
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      70. Liu SH, Wong ML, Craik CS, Brodsky FM. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell. 1995 Oct 20; 83(2):257-67.
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      71. Pley UM, Hill BL, Alibert C, Brodsky FM, Parham P. The interaction of calmodulin with clathrin-coated vesicles, triskelions, and light chains. Localization of a binding site. J Biol Chem. 1995 Feb 3; 270(5):2395-402.
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      72. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995 Jan; 1(1):2-4.
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      73. Acton SL, Wong DH, Parham P, Brodsky FM, Jackson AP. Alteration of clathrin light chain expression by transfection and gene disruption. Mol Biol Cell. 1993 Jun; 4(6):647-60.
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      74. Chang MP, Mallet WG, Mostov KE, Brodsky FM. Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits. EMBO J. 1993 May; 12(5):2169-80.
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      75. Beck KA, Chang M, Brodsky FM, Keen JH. Clathrin assembly protein AP-2 induces aggregation of membrane vesicles: a possible role for AP-2 in endosome formation. J Cell Biol. 1992 Nov; 119(4):787-96.
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      76. Hille A, Klumperman J, Geuze HJ, Peters C, Brodsky FM, von Figura K. Lysosomal acid phosphatase is internalized via clathrin-coated pits. Eur J Cell Biol. 1992 Oct; 59(1):106-15.
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      77. Wong DH, Brodsky FM. 100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties. J Cell Biol. 1992 Jun; 117(6):1171-9.
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      78. Koppelman B, Zimmerman DL, Walter P, Brodsky FM. Evidence for peptide transport across microsomal membranes. Proc Natl Acad Sci U S A. 1992 May 1; 89(9):3908-12.
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      79. Brodsky FM. Antigen processing and presentation: close encounters in the endocytic pathway. Trends Cell Biol. 1992 Apr; 2(4):109-15.
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      80. Näthke IS, Heuser J, Lupas A, Stock J, Turck CW, Brodsky FM. Folding and trimerization of clathrin subunits at the triskelion hub. Cell. 1992 Mar 6; 68(5):899-910.
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      81. Brodsky FM. What's the score? Nature. 1991 Jul 25; 352(6333):288-9.
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      82. Brodsky FM. Intracellular routes for antigen processing and presentation. Res Immunol. 1991 Jun-Aug; 142(5-6):453-8.
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      83. Brodsky FM, Hill BL, Acton SL, Näthke I, Wong DH, Ponnambalam S, Parham P. Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics. Trends Biochem Sci. 1991 Jun; 16(6):208-13.
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      84. VanBuskirk AM, DeNagel DC, Guagliardi LE, Brodsky FM, Pierce SK. Cellular and subcellular distribution of PBP72/74, a peptide-binding protein that plays a role in antigen processing. J Immunol. 1991 Jan 15; 146(2):500-6.
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      85. Brodsky FM, Guagliardi LE. The cell biology of antigen processing and presentation. Annu Rev Immunol. 1991; 9:707-44.
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      86. Brodsky FM. Immunology. The invariant dating service. Nature. 1990 Dec 13; 348(6302):581-2.
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      87. Näthke I, Hill BL, Parham P, Brodsky FM. The calcium-binding site of clathrin light chains. J Biol Chem. 1990 Oct 25; 265(30):18621-7.
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      88. Acton SL, Brodsky FM. Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway. J Cell Biol. 1990 Oct; 111(4):1419-26.
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      89. Mahaffey DT, Peeler JS, Brodsky FM, Anderson RG. Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity. J Biol Chem. 1990 Sep 25; 265(27):16514-20.
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      90. Wong DH, Ignatius MJ, Parosky G, Parham P, Trojanowski JQ, Brodsky FM. Neuron-specific expression of high-molecular-weight clathrin light chain. J Neurosci. 1990 Sep; 10(9):3025-31.
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      91. Draper RK, Goda Y, Brodsky FM, Pfeffer SR. Antibodies to clathrin inhibit endocytosis but not recycling to the trans Golgi network in vitro. Science. 1990 Jun 22; 248(4962):1539-41.
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      92. Guagliardi LE, Koppelman B, Blum JS, Marks MS, Cresswell P, Brodsky FM. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature. 1990 Jan 11; 343(6254):133-9.
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      93. Chin DJ, Straubinger RM, Acton S, Näthke I, Brodsky FM. 100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9289-93.
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      94. Szöllösi J, Damjanovich S, Balàzs M, Nagy P, Trón L, Fulwyler MJ, Brodsky FM. Physical association between MHC class I and class II molecules detected on the cell surface by flow cytometric energy transfer. J Immunol. 1989 Jul 1; 143(1):208-13.
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      95. Mahaffey DT, Moore MS, Brodsky FM, Anderson RG. Coat proteins isolated from clathrin coated vesicles can assemble into coated pits. J Cell Biol. 1989 May; 108(5):1615-24.
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      96. Parham P, Brodsky FM, Drickamer K. The occurrence of disulphide bonds in purified clathrin light chains. Biochem J. 1989 Feb 1; 257(3):775-81.
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      97. Brodsky FM, Koppelman B, Blum JS, Marks MS, Cresswell P, Guagliardi L. Intracellular colocalization of molecules involved in antigen processing and presentation by B cells. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:319-31.
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      98. Brodsky FM. Living with clathrin: its role in intracellular membrane traffic. Science. 1988 Dec 9; 242(4884):1396-402.
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      99. Robbins PA, Maino VC, Warner NL, Brodsky FM. Activated T cells and monocytes have characteristic patterns of class II antigen expression. J Immunol. 1988 Aug 15; 141(4):1281-7.
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      100. Hill BL, Drickamer K, Brodsky FM, Parham P. Identification of the phosphorylation sites of clathrin light chain LCb. J Biol Chem. 1988 Apr 25; 263(12):5499-501.
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      101. Brodsky FM. Analysis of coated vesicle structure and function using anti-clathrin monoclonal antibodies. Prog Clin Biol Res. 1988; 270:141-52.
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      102. Metzker A, Brodsky F. Traumatic plantar urticaria--an unrecognized entity? J Am Acad Dermatol. 1988 Jan; 18(1 Pt 1):144-6.
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      103. Brodsky FM. Monoclonal antibodies as magic bullets. Pharm Res. 1988 Jan; 5(1):1-9.
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      104. Blank GS, Brodsky FM. Clathrin assembly involves a light chain-binding region. J Cell Biol. 1987 Nov; 105(5):2011-9.
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      105. Sadée W, Yu VC, Richards ML, Preis PN, Schwab MR, Brodsky FM, Biedler JL. Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line. Cancer Res. 1987 Oct 1; 47(19):5207-12.
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      106. Doxsey SJ, Brodsky FM, Blank GS, Helenius A. Inhibition of endocytosis by anti-clathrin antibodies. Cell. 1987 Jul 31; 50(3):453-63.
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      107. Moore MS, Mahaffey DT, Brodsky FM, Anderson RG. Assembly of clathrin-coated pits onto purified plasma membranes. Science. 1987 May 1; 236(4801):558-63.
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      108. Robbins PA, Evans EL, Ding AH, Warner NL, Brodsky FM. Monoclonal antibodies that distinguish between class II antigens (HLA-DP, DQ, and DR) in 14 haplotypes. Hum Immunol. 1987 Apr; 18(4):301-13.
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      109. Clayberger C, Krensky AM, McIntyre BW, Koller TD, Parham P, Brodsky F, Linn DJ, Evans EL. Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25. J Immunol. 1987 Mar 1; 138(5):1510-4.
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      110. Brodsky FM, Galloway CJ, Blank GS, Jackson AP, Seow HF, Drickamer K, Parham P. Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity. Nature. 1987 Mar 12-18; 326(6109):203-5.
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      111. Blank GS, Brodsky FM. Site-specific disruption of clathrin assembly produces novel structures. EMBO J. 1986 Sep; 5(9):2087-95.
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      112. Radka SF, Charron DJ, Brodsky FM. Class II molecules of the major histocompatibility complex considered as differentiation markers. Hum Immunol. 1986 Aug; 16(4):390-400.
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      113. Brodsky FM. Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites. J Cell Biol. 1985 Dec; 101(6):2047-54.
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      114. Brodsky FM. Clathrin structure characterized with monoclonal antibodies. II. Identification of in vivo forms of clathrin. J Cell Biol. 1985 Dec; 101(6):2055-62.
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      115. Brodsky FM. The intracellular traffic of immunologically active molecules. Immunol Today. 1984 Dec; 5(12):350-7.
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      116. Chen YX, Evans RL, Pollack MS, Lanier LL, Phillips JH, Rousso C, Warner NL, Brodsky FM. Characterization and expression of the HLA-DC antigens defined by anti-Leu 10. Hum Immunol. 1984 Aug; 10(4):221-35.
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      117. Holmes N, Biermann JS, Brodsky FM, Bharucha D, Parham P. Comparison of the primary structures of clathrin light chains from bovine brain and adrenal gland by peptide mapping. EMBO J. 1984 Jul; 3(7):1621-7.
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      118. Brodsky FM. A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics. 1984; 19(3):179-94.
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      119. Brodsky FM, Parham P. Polymorphism in clathrin light chains from different tissues. J Mol Biol. 1983 Jun 15; 167(1):197-204.
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      120. Kirchhausen T, Harrison SC, Parham P, Brodsky FM. Location and distribution of the light chains in clathrin trimers. Proc Natl Acad Sci U S A. 1983 May; 80(9):2481-5.
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      121. Payne R, Brodsky FM, Peterlin BM, Young LM. "Bare lymphocytes" without immunodeficiency. Hum Immunol. 1983 Apr; 6(4):219-27.
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      122. Brodsky FM, Holmes NJ, Parham P. Tropomyosin-like properties of clathrin light chains allow a rapid, high-yield purification. J Cell Biol. 1983 Mar; 96(3):911-4.
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      123. Parham P, Androlewicz MJ, Brodsky FM, Holmes NJ, Ways JP. Monoclonal antibodies: purification, fragmentation and application to structural and functional studies of class I MHC antigens. J Immunol Methods. 1982 Sep 17; 53(2):133-73.
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      124. Mason R, Austyn J, Brodsky F, Gordon S. Monoclonal antimacrophage antibodies: human pulmonary macrophages express HLA-DR (Ia-like) antigens in culture. Am Rev Respir Dis. 1982 May; 125(5):586-93.
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      125. Brodsky FM, Parham P. Monomorphic anti-HLA-A,B,C monoclonal antibodies detecting molecular subunits and combinatorial determinants. J Immunol. 1982 Jan; 128(1):129-35.
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      126. Brodsky FM, Parham P. Evolution of HLA antigenic determinants: species cross-reactions of monoclonal antibodies. Immunogenetics. 1982; 15(2):151-66.
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      127. Parham P, Brodsky FM. Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Hum Immunol. 1981 Dec; 3(4):277-99.
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      128. Brodsky FM, Stone WH, Parham P. Of cows and men: a comparative study of histocompatibility antigens. Hum Immunol. 1981 Oct; 3(2):143-52.
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      129. McMichael AJ, Parham P, Rust N, Brodsky F. A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17. Hum Immunol. 1980 Sep; 1(2):121-9.
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      130. McMichael AJ, Parham P, Brodsky FM, Pilch JR. Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies. J Exp Med. 1980 Aug 1; 152(2 Pt 2):195s-203s.
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      131. Brodsky FM, Parham P, Bodmer WF. Monoclonal antibodies to HLA--DRw determinants. Tissue Antigens. 1980 Jul; 16(1):30-48.
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      132. Brodsky FM, Bodmer WF, Parham P. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol. 1979 Jul; 9(7):536-45.
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      133. Parham P, Sehgal PK, Brodsky FM. Anti-HLA-A,B,C monoclonal antibodies with no alloantigenic specificity in humans define polymorphisms in other primate species. Nature. 1979 Jun 14; 279(5714):639-41.
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      134. Feuerman EJ, Brodsky F. Nonthrombocytopenic purpura induced by carbromal. Cutis. 1979 Apr; 23(4):489-90.
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      135. Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF. Monoclonal antibodies for analysis of the HLA system. Immunol Rev. 1979; 47:3-61.
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      136. Brodsky F, Alteras I, Feuerman EJ. [Opportunistic fungi in the sputum of patients with malignancy]. Harefuah. 1978 May 15; 94(10):317-9.
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      137. Brodsky FM, Wray SH, Tabira T, de F Webster H. Preparation of whole mounts of rabbit retina for examination with the differential-interference microscope: a technique for morphological studies of CNS demyelination. Brain Res. 1977 Mar 18; 124(1):140-6.
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