 Fred Cohen, PhD
|
|
| Title | Professor |
|---|
| School | UCSF School of Medicine |
|---|
| Department | Cellular & Molecular Pharmacology |
|---|
| Address | GH 600 16th St
San Francisco CA 94158
|
|---|
| Phone | 415-476-8519 |
|---|
|
|
 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Researchers can login to make corrections and additions, or contact us for help.
-
Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864.
-
Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10; 55(9):4101-13.
-
Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012; 7(1):e30376.
-
Cohen F, Bergeron P, Blackwood E, Bowman KK, Chen H, Dipasquale AG, Epler JA, Koehler MF, Lau K, Lewis C, Liu L, Ly CQ, Malek S, Nonomiya J, Ortwine DF, Pei Z, Robarge KD, Sideris S, Trinh L, Truong T, Wu J, Zhao X, Lyssikatos JP. Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine. J Med Chem. 2011 May 12; 54(9):3426-35.
-
Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett. 2010 Apr 1; 20(7):2229-33.
-
Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB. Protease-sensitive synthetic prions. PLoS Pathog. 2010 Jan; 6(1):e1000736.
-
Choi JH, May BC, Wille H, Cohen FE. Molecular modeling of the misfolded insulin subunit and amyloid fibril. Biophys J. 2009 Dec 16; 97(12):3187-95.
-
Ndubaku C, Cohen F, Varfolomeev E, Vucic D. Targeting inhibitor of apoptosis proteins for therapeutic intervention. Future Med Chem. 2009 Nov; 1(8):1509-25.
-
Wille H, Bian W, McDonald M, Kendall A, Colby DW, Bloch L, Ollesch J, Borovinskiy AL, Cohen FE, Prusiner SB, Stubbs G. Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40):16990-5.
-
Choi JH, May BC, Govaerts C, Cohen FE. Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein. Structure. 2009 Jul 15; 17(7):1014-23.
-
Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem. 2009 Mar 26; 52(6):1723-30.
-
Choi JH, Govaerts C, May BC, Cohen FE. Analysis of the sequence and structural features of the left-handed beta-helical fold. Proteins. 2008 Oct; 73(1):150-60.
-
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-88.
-
Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, Prusiner SB. Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):17971-6.
-
Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, Prusiner SB. Electron crystallography of the scrapie prion protein complexed with heavy metals. Arch Biochem Biophys. 2007 Nov 15; 467(2):239-48.
-
Phuan PW, Zorn JA, Safar J, Giles K, Prusiner SB, Cohen FE, May BC. Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds. J Gen Virol. 2007 Apr; 88(Pt 4):1392-401.
-
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72.
-
Lee LC, Horn F, Cohen FE. Automatic extraction of protein point mutations using a graph bigram association. PLoS Comput Biol. 2007 Feb 2; 3(2):e16.
-
May BC, Zorn JA, Witkop J, Sherrill J, Wallace AC, Legname G, Prusiner SB, Cohen FE. Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. J Med Chem. 2007 Jan 11; 50(1):65-73.
-
Legname G, Nguyen HO, Peretz D, Cohen FE, DeArmond SJ, Prusiner SB. Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19105-10.
-
May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorg Med Chem Lett. 2006 Sep 15; 16(18):4913-6.
-
Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97.
-
Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL. Searching for new antimalarial therapeutics amongst known drugs. Chem Biol Drug Des. 2006 Jun; 67(6):409-16.
-
May BC, Govaerts C, Cohen FE. Developing therapeutics for the diseases of protein misfolding. Neurology. 2006 Jan 24; 66(2 Suppl 1):S118-22.
-
Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18700-5.
-
Legname G, Nguyen HO, Baskakov IV, Cohen FE, Dearmond SJ, Prusiner SB. Strain-specified characteristics of mouse synthetic prions. Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):2168-73.
-
Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, Prusiner SB. Synthetic mammalian prions. Science. 2004 Jul 30; 305(5684):673-6.
-
Govaerts C, Wille H, Prusiner SB, Cohen FE. Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A. 2004 Jun 1; 101(22):8342-7.
-
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA. Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol. 2004 Jun; 22(6):724-31.
-
May BC, Govaerts C, Prusiner SB, Cohen FE. Prions: so many fibers, so little infectivity. Trends Biochem Sci. 2004 Apr; 29(4):162-5.
-
Tremblay P, Ball HL, Kaneko K, Groth D, Hegde RS, Cohen FE, DeArmond SJ, Prusiner SB, Safar JG. Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol. 2004 Feb; 78(4):2088-99.
-
Horn F, Lau AL, Cohen FE. Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors. Bioinformatics. 2004 Mar 1; 20(4):557-68.
-
Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 2003 Dec 18; 426(6968):905-9.
-
Chandonia JM, Cohen FE. New local potential useful for genome annotation and 3D modeling. J Mol Biol. 2003 Sep 26; 332(4):835-50.
-
May BC, Fafarman AT, Hong SB, Rogers M, Deady LW, Prusiner SB, Cohen FE. Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3416-21.
-
Bozdech Z, Zhu J, Joachimiak MP, Cohen FE, Pulliam B, DeRisi JL. Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol. 2003; 4(2):R9.
-
Devoto A, Hartmann HA, Piffanelli P, Elliott C, Simmons C, Taramino G, Goh CS, Cohen FE, Emerson BC, Schulze-Lefert P, Panstruga R. Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family. J Mol Evol. 2003 Jan; 56(1):77-88.
-
Horn F, Bettler E, Oliveira L, Campagne F, Cohen FE, Vriend G. GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res. 2003 Jan 1; 31(1):294-7.
-
Joachimiak MP, Cohen FE. JEvTrace: refinement and variations of the evolutionary trace in JAVA. Genome Biol. 2002; 3(12):RESEARCH0077.
-
Goh CS, Cohen FE. Co-evolutionary analysis reveals insights into protein-protein interactions. J Mol Biol. 2002 Nov 15; 324(1):177-92.
-
Perrier V, Kaneko K, Safar J, Vergara J, Tremblay P, DeArmond SJ, Cohen FE, Prusiner SB, Wallace AC. Dominant-negative inhibition of prion replication in transgenic mice. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):13079-84.
-
Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707.
-
Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 3; 12(11):1537-41.
-
Burkoth TS, Beausoleil E, Kaur S, Tang D, Cohen FE, Zuckermann RN. Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly. Chem Biol. 2002 May; 9(5):647-54.
-
Baskakov IV, Legname G, Baldwin MA, Prusiner SB, Cohen FE. Pathway complexity of prion protein assembly into amyloid. J Biol Chem. 2002 Jun 14; 277(24):21140-8.
-
Wille H, Michelitsch MD, Guenebaut V, Supattapone S, Serban A, Cohen FE, Agard DA, Prusiner SB. Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3563-8.
-
Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31.
-
Nicholson EM, Mo H, Prusiner SB, Cohen FE, Marqusee S. Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation. J Mol Biol. 2002 Feb 22; 316(3):807-15.
-
Avery MA, Alvim-Gaston M, Rodrigues CR, Barreiro EJ, Cohen FE, Sabnis YA, Woolfrey JR. Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies. J Med Chem. 2002 Jan 17; 45(2):292-303.
-
Cohen FE. Protein misfolding and prion diseases. J Mol Biol. 1999 Oct 22; 293(2):313-20.
-
Byington CL, Dunbrack RL, Whitby FG, Cohen FE, Agabian N. Entamoeba histolytica: computer-assisted modeling of phosphofructokinase for the prediction of broad-spectrum antiparasitic agents. Exp Parasitol. 1997 Nov; 87(3):194-202.
-
Pan Y, DeFay T, Gitschier J, Cohen FE. Proposed structure of the A domains of factor VIII by homology modelling. Nat Struct Biol. 1995 Sep; 2(9):740-4.
-
Ma S, McGregor MJ, Cohen FE, Pallai PV. Conformation of CD4-derived cyclic hexapeptides by NMR and molecular dynamics. Biopolymers. 1994 Aug; 34(8):987-1000.
-
Cohen FE. The parallel beta helix of pectate lyase C: something to sneeze at. Science. 1993 Jun 4; 260(5113):1444-5.
-
Ring CS, Cohen FE. Modeling protein structures: construction and their applications. FASEB J. 1993 Jun; 7(9):783-90.
-
Cohen BI, Presnell SR, Cohen FE. Pattern-based approaches to protein structure prediction. Methods Enzymol. 1991; 202:252-68.
-
Chiche L, Gregoret LM, Cohen FE, Kollman PA. Protein model structure evaluation using the solvation free energy of folding. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3240-3.
-
Ciardelli TL, Landgraf B, Gadski R, Strnad J, Cohen FE, Smith KA. A design approach to the structural analysis of interleukin-2. J Mol Recognit. 1988 Feb; 1(1):42-7.
-
Cohen FE, Kosen PA, Kuntz ID, Epstein LB, Ciardelli TL, Smith KA. Structure-activity studies of interleukin-2. Science. 1986 Oct 17; 234(4774):349-52.
-
Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Turn prediction in proteins using a pattern-matching approach. Biochemistry. 1986 Jan 14; 25(1):266-75.
-
Blanar MA, Kneller D, Clark AJ, Karu AE, Cohen FE, Langridge R, Kuntz ID. A model for the core structure of the Escherichia coli RecA protein. Cold Spring Harb Symp Quant Biol. 1984; 49:507-11.
-
Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Secondary structure assignment for alpha/beta proteins by a combinatorial approach. Biochemistry. 1983 Oct 11; 22(21):4894-904.
-
Cohen FE, Sternberg MJ, Phillips DC, Kuntz ID, Kollman PA. A diffusion--collision--adhesion model for the kinetics of myoglobin refolding. Nature. 1980 Aug 7; 286(5773):632-4.
|
Fred's Networks
Click the "See All" links for more information and interactive visualizations!
Related Concepts Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Related Authors People who share similar concepts with this person. _
|
