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    Gabe Ortiz, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 5
    San Francisco CA 94143
    Phone415-206-2355

       Overview 
       Overview
      Gabriel Ortiz, MD, PhD completed medical training at the Weill Cornell Medical College and graduate training at The Rockefeller University as a student in the Tri-Institutional MD-PhD Program. He went on to an Internal Medicine residency at the University of California, San Francisco (UCSF). He served as a Chief Resident in the Department of Medicine at UCSF and subsequently completed fellowship training in Infectious Diseases before recently joining the Division of Hospital Medicine.

      While at UCSF, Dr. Ortiz has performed biomedical research focused on HIV immunology in the laboratory of Dr. Joseph M. McCune. His research activities have aimed at understanding the importance of innate immune responses in HIV infection, with a focus on myeloid cell subsets. This work has culminated in two submitted publications to the Journal of Infectious Diseases and Molecular and Cellular Proteomics. This work has also extended into a new line of investigation focused on how the development of the immune system, particularly of myeloid cell subsets, may impact childhood vaccine responses.

      Dr. Ortiz was most recently hired as an Assistant Clinical Professor in the Division of Hospital Medicine at San Francisco General Hospital, UCSF. He will continue to devote a small fraction of his time to studying the immune system. In addition, he practices hospital medicine and plans to apply his extensive biomedical training towards improving patient outcomes and satisfaction, decreasing in-hospital infection rates, and exploring co-management services.

      Education:
      1992 - 1996 Yale University BS Molecular Biophysics and Biochemistry
      1992 - 1996 Yale University MS Molecular Biophysics and Biochemistry
      1996 - 2004 Tri-Institutional MD-PhD Program of Weill Medical College of Cornell University, The Rockefeller University, and Memorial Sloan-Kettering Institute MD, PhD Medicine, Human Cellular Immunology

      Training:
      2004 - 2005 University of California, San Francisco Internship Internal Medicine
      2005 - 2006 University of California, San Francisco Residency Internal Medicine
      2006 - 2011 University of California, San Francisco Fellowship Infectious Diseases
      2007 - 2008 University of California, San Francisco Chief Resident Internal Medicine
      2007 - 2012 University of California, San Francisco Hospitalist Internal Medicine
      2008 - 2011 University of California, San Francisco Fellowship (Research Years) Infectious Diseases
      2010 - 2012 University of California, San Francisco Sub-specialist consultant Infectious Diseases
      2011 - 2012 University of California, San Francisco Clinical Instructor Infectious Diseases
      2012 - Present University of California, San Francisco Assistant Clinical Professor Division of Hospital Medicine, SFGH

      Certification:
      2006 California Medical License #A95266
      2007 ABIM Board Certification in Internal Medicine
      2008 DEA licensed physician, Schedules II - IV

      Memberships:
      2004 - 2008 American Medical Association, Member
      2006 - present Infectious Diseases Society of America, Member
      2007 - 2008 Infectious Diseases Support Team for www.Antimicrobe.org, Member
      2009 - 2010 USMLERx Multimedia Project, Member

      Service to Professional Organizations:
      2012 - present Associate Faculty Member at F1000, Member providing post-publication peer review.

      Service to Professional Publications:
      2011 - present Reviewer for journal PLOS One


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. AIDS Res Ther. 2014; 11:27.
        View in: PubMed
      2. Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM. Higher CD27(+)CD8(+) T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4(+) T Cell Recovery in Treated HIV Infection. PLoS One. 2013; 8(12):e84091.
        View in: PubMed
      3. Brown JN, Ortiz GM, Angel TE, Jacobs JM, Gritsenko M, Chan EY, Purdy DE, Murnane RD, Larsen K, Palermo RE, Shukla AK, Clauss TR, Katze MG, McCune JM, Smith RD. Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Mol Cell Proteomics. 2012 Sep; 11(9):605-18.
        View in: PubMed
      4. L. Seu, G.M. Ortiz, T.D. Burt, Y. Huang, S.G. Deeks, J.N. Martin, and J.M. McCune. “Heme Oxygenase-1 Up-regulation in Classical Monocytes Is Predictive of CD4+ T Cell Recovery after Highly Active Antiretroviral Therapy in HIV-infected Subjects.” Journal of Infectious Diseases. Submitted. April. 2012.
      5. Rakoff-Nahoum S, Kuebler PJ, Heymann JJ, E Sheehy M, Ortiz GM, S Ogg G, Barbour JD, Lenz J, Steinfeld AD, Nixon DF. Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. AIDS Res Hum Retroviruses. 2006 Jan; 22(1):52-6.
        View in: PubMed
      6. Plana M, Garcia F, Oxenius A, Ortiz GM, Lopez A, Cruceta A, Mestre G, Fumero E, Fagard C, Sambeat MA, Segura F, Miró JM, Arnedo M, Lopalcos L, Pumarola T, Hirschel B, Phillips RE, Nixon DF, Gallart T, Gatell JM. Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3. J Acquir Immune Defic Syndr. 2004 Jul 1; 36(3):791-9.
        View in: PubMed
      7. Alexander TH, Ortiz GM, Wellons MF, Allen A, Grace EJ, Schweighardt B, Brancato J, Sandberg JK, Furlan SN, Miralles GD, Nixon DF, Bartlett JA. Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection. J Acquir Immune Defic Syndr. 2003 Dec 15; 34(5):475-81.
        View in: PubMed
      8. Karlsson AC, Deeks SG, Barbour JD, Heiken BD, Younger SR, Hoh R, Lane M, Sällberg M, Ortiz GM, Demarest JF, Liegler T, Grant RM, Martin JN, Nixon DF. Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene. J Virol. 2003 Jun; 77(12):6743-52.
        View in: PubMed
      9. García F, Plana M, Arnedo M, Ortiz GM, Miró JM, Lopalco L, Lori F, Pumarola T, Gallart T, Gatell JM. A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized study. AIDS. 2003 Jan 3; 17(1):43-51.
        View in: PubMed
      10. Schweighardt B, Ortiz GM, Grant RM, Wellons M, Miralles GD, Kostrikis LG, Bartlett JA, Nixon DF. Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions. AIDS. 2002 Nov 22; 16(17):2342-4.
        View in: PubMed
      11. Ortiz GM, Hu J, Goldwitz JA, Chandwani R, Larsson M, Bhardwaj N, Bonhoeffer S, Ramratnam B, Zhang L, Markowitz MM, Nixon DF. Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection. J Virol. 2002 Jan; 76(1):411-5.
        View in: PubMed
      12. Ortiz GM, Wellons M, Brancato J, Vo HT, Zinn RL, Clarkson DE, Van Loon K, Bonhoeffer S, Miralles GD, Montefiori D, Bartlett JA, Nixon DF. Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects. Proc Natl Acad Sci U S A. 2001 Nov 6; 98(23):13288-93.
        View in: PubMed
      13. García F, Plana M, Ortiz GM, Bonhoeffer S, Soriano A, Vidal C, Cruceta A, Arnedo M, Gil C, Pantaleo G, Pumarola T, Gallart T, Nixon DF, Miró JM, Gatell JM. The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection. AIDS. 2001 Jun 15; 15(9):F29-40.
        View in: PubMed
      14. Bonhoeffer S, Rembiszewski M, Ortiz GM, Nixon DF. Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection. AIDS. 2000 Oct 20; 14(15):2313-22.
        View in: PubMed
      15. Papasavvas E, Ortiz GM, Gross R, Sun J, Moore EC, Heymann JJ, Moonis M, Sandberg JK, Drohan LA, Gallagher B, Shull J, Nixon DF, Kostman JR, Montaner LJ. Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption. J Infect Dis. 2000 Sep; 182(3):766-75.
        View in: PubMed
      16. Binley JM, Schiller DS, Ortiz GM, Hurley A, Nixon DF, Markowitz MM, Moore JP. The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy. J Infect Dis. 2000 Apr; 181(4):1249-63.
        View in: PubMed
      17. Ortiz GM, Nixon DF, Trkola A, Binley J, Jin X, Bonhoeffer S, Kuebler PJ, Donahoe SM, Demoitie MA, Kakimoto WM, Ketas T, Clas B, Heymann JJ, Zhang L, Cao Y, Hurley A, Moore JP, Ho DD, Markowitz M. HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest. 1999 Sep; 104(6):R13-8.
        View in: PubMed
      18. Gabriel M. Ortiz and David Graham. “Acinetobacter in military personnel.” Case vignette as part of www.antimicrobe.org.
      19. G.M. Ortiz, J.N. Brown, T.E. Angel, J.M. Jacobs, M. Gritsenko, E.Y. Chan, D.E. Purdy, R.D. Murnane, K. Larsen, R.E. Palermo, A.K. Shukla, T.R. Clauss, M.G. Katze,R.D. Smith, and J.M. McCune. “Pig-tailed macaques treated with morphine are able to preserve their CD4+ T cell counts after SIV infection.” In preparation.
      20. G.M. Ortiz, J.N. Brown, T.E. Angel, J.M. Jacobs, R.D. Smith, E. McCance-Katz, S. Dominy, and J.M. McCune. “The proteomic and immunologic effect of heroin withdrawal in human subjects.” In preparation.
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