Gaetano Faleo, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|University of Bologna, Italy||2002||Recipient of European Socrates Fellowship|
|University of Bologna, Italy||2003||Recipient of European Leonardo Fellowship|
|University of Foggia, Italy||2006||Young Investigator Award|
|American Transplant Congress||2007||Recipient of Young Investigator Award|
|The Transplantation Society - Cell Transplantation Society||2015||TTS-CTS Scientific Award|
Gaetano is currently finalizing his work on assessing immune response to stem-cell derived islet grafts and on evaluating effectiveness of immune protection using a novel encapsulation device. The results obtained during this investigation led to a phase 1/2 clinical trial (NCT02239354) initiated in September 2014 to assess safety, tolerability, and efficacy of (VC-01™), a combination product of hESC-derived islets encapsulated in Encaptra™ devices.
Gaetano is also currently interested to understand the molecular mechanisms underlying islet death in the first few days after transplant and to develop biochemical and bioengineering approaches to prevent islet death. Successful completion of this work has the potential to dramatically decrease the number of islets required to achieve insulin independence and improve long-term outcome. When combined with stem cell-derived islet transplantation, prevention of islet attrition during peri-transplant period will enable broader clinical use of islet transplantation for diabetic patients
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