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    Gary Cecchini, PhD

    TitleRes-FY
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address4150 Clement Street
    Phone415-221-4810x4416
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Maklashina E, Rajagukguk S, Starbird CA, McDonald WH, Koganitsky A, Eisenbach M, Iverson TM, Cecchini G. Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II. J Biol Chem. 2016 Feb 5; 291(6):2904-16. PMID: 26644464.
        View in: PubMed
      2. Cheng VW, Piragasam RS, Rothery RA, Maklashina E, Cecchini G, Weiner JH. Redox state of flavin adenine dinucleotide drives substrate binding and product release in Escherichia coli succinate dehydrogenase. Biochemistry. 2015 Feb 3; 54(4):1043-52. PMID: 25569225.
        View in: PubMed
      3. Melin F, Noor MR, Pardieu E, Boulmedais F, Banhart F, Cecchini G, Soulimane T, Hellwig P. Investigating the thermostability of succinate: quinone oxidoreductase enzymes by direct electrochemistry at SWNTs-modified electrodes and FTIR spectroscopy. Chemphyschem. 2014 Nov 10; 15(16):3572-9. PMID: 25139263; PMCID: PMC4369915.
      4. Anderson RF, Shinde SS, Hille R, Rothery RA, Weiner JH, Rajagukguk S, Maklashina E, Cecchini G. Electron-transfer pathways in the heme and quinone-binding domain of complex II (succinate dehydrogenase). Biochemistry. 2014 Mar 18; 53(10):1637-46. PMID: 24559074; PMCID: PMC3985935.
      5. Singh PK, Sarwar M, Maklashina E, Kotlyar V, Rajagukguk S, Tomasiak TM, Cecchini G, Iverson TM. Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase. J Biol Chem. 2013 Aug 23; 288(34):24293-301. PMID: 23836905; PMCID: PMC3750132.
      6. Cheng VW, Tran QM, Boroumand N, Rothery RA, Maklashina E, Cecchini G, Weiner JH. A conserved lysine residue controls iron-sulfur cluster redox chemistry in Escherichia coli fumarate reductase. Biochim Biophys Acta. 2013 Oct; 1827(10):1141-7. PMID: 23711795; PMCID: PMC4354731.
      7. Cecchini G. Respiratory complex II: role in cellular physiology and disease. Biochim Biophys Acta. 2013 May; 1827(5):541-2. PMID: 23544420.
        View in: PubMed
      8. Maklashina E, Cecchini G, Dikanov SA. Defining a direction: electron transfer and catalysis in Escherichia coli complex II enzymes. Biochim Biophys Acta. 2013 May; 1827(5):668-78. PMID: 23396003; PMCID: PMC3615059.
      9. Iverson TM, Maklashina E, Cecchini G. Structural basis for malfunction in complex II. J Biol Chem. 2012 Oct 12; 287(42):35430-8. PMID: 22904323; PMCID: PMC3471735.
      10. Charruyer A, Strachan LR, Yue L, Toth AS, Cecchini G, Mancianti ML, Ghadially R. CD133 is a marker for long-term repopulating murine epidermal stem cells. J Invest Dermatol. 2012 Nov; 132(11):2522-33. PMID: 22763787; PMCID: PMC3997791.
      11. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS One. 2012; 7(4):e34177. PMID: 22509276; PMCID: PMC3317925.
      12. Tran QM, Fong C, Rothery RA, Maklashina E, Cecchini G, Weiner JH. Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. PLoS One. 2012; 7(2):e32641. PMID: 22393428; PMCID: PMC3290573.
      13. Zarbiv G, Li H, Wolf A, Cecchini G, Caplan SR, Sourjik V, Eisenbach M. Energy complexes are apparently associated with the switch-motor complex of bacterial flagella. J Mol Biol. 2012 Feb 17; 416(2):192-207. PMID: 22210351; PMCID: PMC4361073.
      14. Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM. A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS Pathog. 2011 Jul; 7(7):e1002112. PMID: 21765814; PMCID: PMC3131266.
      15. Ruprecht J, Iwata S, Rothery RA, Weiner JH, Maklashina E, Cecchini G. Perturbation of the quinone-binding site of complex II alters the electronic properties of the proximal [3Fe-4S] iron-sulfur cluster. J Biol Chem. 2011 Apr 8; 286(14):12756-65. PMID: 21310949; PMCID: PMC3069475.
      16. Kareyeva AV, Grivennikova VG, Cecchini G, Vinogradov AD. Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production. FEBS Lett. 2011 Jan 21; 585(2):385-9. PMID: 21168410; PMCID: PMC3022077.
      17. Tomasiak TM, Archuleta TL, Andréll J, Luna-Chávez C, Davis TA, Sarwar M, Ham AJ, McDonald WH, Yankovskaya V, Stern HA, Johnston JN, Maklashina E, Cecchini G, Iverson TM. Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase. J Biol Chem. 2011 Jan 28; 286(4):3047-56. PMID: 21098488; PMCID: PMC3024798.
      18. Pyburn TM, Yankovskaya V, Bensing BA, Cecchini G, Sullam PM, Iverson TM. Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1; 66(Pt 11):1503-7. PMID: 21045307; PMCID: PMC3001660.
      19. Maklashina E, Cecchini G. The quinone-binding and catalytic site of complex II. Biochim Biophys Acta. 2010 Dec; 1797(12):1877-82. PMID: 20175986; PMCID: PMC2891400.
      20. Maklashina E, Rajagukguk S, McIntire WS, Cecchini G. Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):747-54. PMID: 20100456; PMCID: PMC2888824.
      21. Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G. Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. FEBS Lett. 2010 Jan 4; 584(1):159-65. PMID: 19913538; PMCID: PMC2794998.
      22. Ruprecht J, Yankovskaya V, Maklashina E, Iwata S, Cecchini G. Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site. J Biol Chem. 2009 Oct 23; 284(43):29836-46. PMID: 19710024; PMCID: PMC2785614.
      23. Gavrikova EV, Grivennikova VG, Borisov VB, Cecchini G, Vinogradov AD. Assembly of a chimeric respiratory chain from bovine heart submitochondrial particles and cytochrome bd terminal oxidase of Escherichia coli. FEBS Lett. 2009 Apr 17; 583(8):1287-91. PMID: 19303413; PMCID: PMC2703750.
      24. Grivennikova VG, Cecchini G, Vinogradov AD. Ammonium-dependent hydrogen peroxide production by mitochondria. FEBS Lett. 2008 Aug 6; 582(18):2719-24. PMID: 18619961.
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      25. Tomasiak TM, Maklashina E, Cecchini G, Iverson TM. A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II. J Biol Chem. 2008 May 30; 283(22):15460-8. PMID: 18385138; PMCID: PMC2397489.
      26. Cohen-Ben-Lulu GN, Francis NR, Shimoni E, Noy D, Davidov Y, Prasad K, Sagi Y, Cecchini G, Johnstone RM, Eisenbach M. The bacterial flagellar switch complex is getting more complex. EMBO J. 2008 Apr 9; 27(7):1134-44. PMID: 18337747; PMCID: PMC2323253.
      27. Gostimskaya IS, Grivennikova VG, Cecchini G, Vinogradov AD. Reversible dissociation of flavin mononucleotide from the mammalian membrane-bound NADH: ubiquinone oxidoreductase (complex I). FEBS Lett. 2007 Dec 22; 581(30):5803-6. PMID: 18037377; PMCID: PMC2440658.
      28. Tran QM, Rothery RA, Maklashina E, Cecchini G, Weiner JH. Escherichia coli succinate dehydrogenase variant lacking the heme b. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18007-12. PMID: 17989224; PMCID: PMC2084287.
      29. Grivennikova VG, Kotlyar AB, Karliner JS, Cecchini G, Vinogradov AD. Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I. Biochemistry. 2007 Sep 25; 46(38):10971-8. PMID: 17760425; PMCID: PMC2258335.
      30. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):189-95. PMID: 17475219; PMCID: PMC3423089.
      31. Tomasiak TM, Cecchini G, Iverson TM. Succinate as Donor; Fumarate as Acceptor. Ecosal Plus. 2007 Apr; 2(2). PMID: 26443593.
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      32. Tran QM, Rothery RA, Maklashina E, Cecchini G, Weiner JH. The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b. J Biol Chem. 2006 Oct 27; 281(43):32310-7. PMID: 16950775.
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      33. Maklashina E, Hellwig P, Rothery RA, Kotlyar V, Sher Y, Weiner JH, Cecchini G. Differences in protonation of ubiquinone and menaquinone in fumarate reductase from Escherichia coli. J Biol Chem. 2006 Sep 8; 281(36):26655-64. PMID: 16829675.
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      34. Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, Teerlink JR, Karliner JS. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006 Jun; 11(2):119-28. PMID: 16891289.
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      35. Gostimskaya IS, Cecchini G, Vinogradov AD. Topography and chemical reactivity of the active-inactive transition-sensitive SH-group in the mitochondrial NADH:ubiquinone oxidoreductase (Complex I). Biochim Biophys Acta. 2006 Sep-Oct; 1757(9-10):1155-61. PMID: 16777054; PMCID: PMC2292829.
      36. Zhou HZ, Swanson RA, Simonis U, Ma X, Cecchini G, Gray MO. Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H714-23. PMID: 16582021.
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      37. Maklashina E, Iverson TM, Sher Y, Kotlyar V, Andréll J, Mirza O, Hudson JM, Armstrong FA, Rothery RA, Weiner JH, Cecchini G. Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain. J Biol Chem. 2006 Apr 21; 281(16):11357-65. PMID: 16484232.
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      38. Horsefield R, Yankovskaya V, Sexton G, Whittingham W, Shiomi K, Omura S, Byrne B, Cecchini G, Iwata S. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem. 2006 Mar 17; 281(11):7309-16. PMID: 16407191.
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      39. Kotlyar AB, Karliner JS, Cecchini G. A novel strong competitive inhibitor of complex I. FEBS Lett. 2005 Aug 29; 579(21):4861-6. PMID: 16107251.
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      40. Anderson RF, Hille R, Shinde SS, Cecchini G. Electron transfer within complex II. Succinate:ubiquinone oxidoreductase of Escherichia coli. J Biol Chem. 2005 Sep 30; 280(39):33331-7. PMID: 16085649.
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      41. Hudson JM, Heffron K, Kotlyar V, Sher Y, Maklashina E, Cecchini G, Armstrong FA. Electron transfer and catalytic control by the iron-sulfur clusters in a respiratory enzyme, E. coli fumarate reductase. J Am Chem Soc. 2005 May 18; 127(19):6977-89. PMID: 15884941.
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      42. Loskovich MV, Grivennikova VG, Cecchini G, Vinogradov AD. Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active-de-active enzyme transition. Biochem J. 2005 May 1; 387(Pt 3):677-83. PMID: 15571492; PMCID: PMC1134997.
      43. Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2986-94. PMID: 15681709.
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      44. Rothery RA, Seime AM, Spiers AM, Maklashina E, Schröder I, Gunsalus RP, Cecchini G, Weiner JH. Defining the Q-site of Escherichia coli fumarate reductase by site-directed mutagenesis, fluorescence quench titrations and EPR spectroscopy. FEBS J. 2005 Jan; 272(2):313-26. PMID: 15654871.
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      45. Kotlyar AB, Maklashina E, Cecchini G. Absence of NADH channeling in coupled reaction of mitochondrial malate dehydrogenase and complex I in alamethicin-permeabilized rat liver mitochondria. Biochem Biophys Res Commun. 2004 Jun 11; 318(4):987-91. PMID: 15147970.
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      46. Maklashina E, Kotlyar AB, Karliner JS, Cecchini G. Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart. FEBS Lett. 2004 Jan 2; 556(1-3):64-8. PMID: 14706827.
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      47. Maklashina E, Kotlyar AB, Cecchini G. Active/de-active transition of respiratory complex I in bacteria, fungi, and animals. Biochim Biophys Acta. 2003 Sep 30; 1606(1-3):95-103. PMID: 14507430.
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      48. Cecchini G, Maklashina E, Yankovskaya V, Iverson TM, Iwata S. Variation in proton donor/acceptor pathways in succinate:quinone oxidoreductases. FEBS Lett. 2003 Jun 12; 545(1):31-8. PMID: 12788489.
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      49. Horsefield R, Yankovskaya V, Törnroth S, Luna-Chavez C, Stambouli E, Barber J, Byrne B, Cecchini G, Iwata S. Using rational screening and electron microscopy to optimize the crystallization of succinate:ubiquinone oxidoreductase from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2003 Mar; 59(Pt 3):600-2. PMID: 12595738.
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      50. Yankovskaya V, Horsefield R, Törnroth S, Luna-Chavez C, Miyoshi H, Léger C, Byrne B, Cecchini G, Iwata S. Architecture of succinate dehydrogenase and reactive oxygen species generation. Science. 2003 Jan 31; 299(5607):700-4. PMID: 12560550.
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      51. Cecchini G. Function and structure of complex II of the respiratory chain. Annu Rev Biochem. 2003; 72:77-109. PMID: 14527321.
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      52. Maklashina E, Sher Y, Zhou HZ, Gray MO, Karliner JS, Cecchini G. Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heart. Biochim Biophys Acta. 2002 Oct 3; 1556(1):6-12. PMID: 12351213.
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      53. Jeuken LJ, Jones AK, Chapman SK, Cecchini G, Armstrong FA. Electron-transfer mechanisms through biological redox chains in multicenter enzymes. J Am Chem Soc. 2002 May 22; 124(20):5702-13. PMID: 12010043.
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      54. Iverson TM, Luna-Chavez C, Croal LR, Cecchini G, Rees DC. Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site. J Biol Chem. 2002 May 3; 277(18):16124-30. PMID: 11850430.
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      55. Törnroth S, Yankovskaya V, Cecchini G, Iwata S. Purification, crystallisation and preliminary crystallographic studies of succinate:ubiquinone oxidoreductase from Escherichia coli. Biochim Biophys Acta. 2002 Jan 17; 1553(1-2):171-6. PMID: 11803025.
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      56. Cecchini G, Schröder I, Gunsalus RP, Maklashina E. Succinate dehydrogenase and fumarate reductase from Escherichia coli. Biochim Biophys Acta. 2002 Jan 17; 1553(1-2):140-57. PMID: 11803023.
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      57. Maklashina E, Rothery RA, Weiner JH, Cecchini G. Retention of heme in axial ligand mutants of succinate-ubiquinone xxidoreductase (complex II) from Escherichia coli. J Biol Chem. 2001 Jun 1; 276(22):18968-76. PMID: 11259408.
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      58. Luna-Chavez C, Iverson TM, Rees DC, Cecchini G. Overexpression, purification, and crystallization of the membrane-bound fumarate reductase from Escherichia coli. Protein Expr Purif. 2000 Jun; 19(1):188-96. PMID: 10833406.
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      59. Maklashina E, Cecchini G. Comparison of catalytic activity and inhibitors of quinone reactions of succinate dehydrogenase (Succinate-ubiquinone oxidoreductase) and fumarate reductase (Menaquinol-fumarate oxidoreductase) from Escherichia coli. Arch Biochem Biophys. 1999 Sep 15; 369(2):223-32. PMID: 10486141.
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      60. Maklashina E, Berthold DA, Cecchini G. Anaerobic expression of Escherichia coli succinate dehydrogenase: functional replacement of fumarate reductase in the respiratory chain during anaerobic growth. J Bacteriol. 1998 Nov; 180(22):5989-96. PMID: 9811659; PMCID: PMC107675.
      61. Yankovskaya V, Sablin SO, Ramsay RR, Singer TP, Ackrell BA, Cecchini G, Miyoshi H. Inhibitor probes of the quinone binding sites of mammalian complex II and Escherichia coli fumarate reductase. J Biol Chem. 1996 Aug 30; 271(35):21020-4. PMID: 8702865.
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      62. Cecchini G, Sices H, Schröder I, Gunsalus RP. Aerobic inactivation of fumarate reductase from Escherichia coli by mutation of the [3Fe-4S]-quinone binding domain. J Bacteriol. 1995 Aug; 177(16):4587-92. PMID: 7642483; PMCID: PMC177221.
      63. Kim J, Fuller JH, Cecchini G, McIntire WS. Cloning, sequencing, and expression of the structural genes for the cytochrome and flavoprotein subunits of p-cresol methylhydroxylase from two strains of Pseudomonas putida. J Bacteriol. 1994 Oct; 176(20):6349-61. PMID: 7929007; PMCID: PMC196977.
      64. Manodori A, Cecchini G, Schröder I, Gunsalus RP, Werth MT, Johnson MK. [3Fe-4S] to [4Fe-4S] cluster conversion in Escherichia coli fumarate reductase by site-directed mutagenesis. Biochemistry. 1992 Mar 17; 31(10):2703-12. PMID: 1312345.
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      65. Ackrell BA, Cochran B, Cecchini G. Interactions of oxaloacetate with Escherichia coli fumarate reductase. Arch Biochem Biophys. 1989 Jan; 268(1):26-34. PMID: 2643383.
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      66. Cecchini GL, O'Brien RT. Detection of Escherichia coli by gas chromatography. J Bacteriol. 1968 Mar; 95(3):1205-6. PMID: 4868361; PMCID: PMC252163.
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