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    Geeta Narlikar, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentBiochemistry & Biophysics
    AddressGenentech Hall
    Phone415-514-0394xbioch

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Shiau C, Trnka MJ, Bozicevic A, Torres IO, Al-Sady B, Burlingame AL, Narlikar GJ, Fujimori DG. Reconstitution of nucleosome demethylation and catalytic properties of a jumonji histone demethylase. Chem Biol. 2013 Apr 18; 20(4):494-9.
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      2. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
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      3. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. Ers1 links HP1 to RNAi. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11258-63.
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      4. Shahian T, Narlikar GJ. Analysis of changes in nucleosome conformation using fluorescence resonance energy transfer. Methods Mol Biol. 2012; 833:337-49.
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      5. Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011 Nov 18; 334(6058):977-82.
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      6. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10620-5.
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      7. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 7; 41(1):67-81.
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      8. Rowe CE, Narlikar GJ. The ATP-dependent remodeler RSC transfers histone dimers and octamers through the rapid formation of an unstable encounter intermediate. Biochemistry. 2010 Nov 16; 49(45):9882-90.
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      9. Narlikar GJ. A proposal for kinetic proof reading by ISWI family chromatin remodeling motors. Curr Opin Chem Biol. 2010 Oct; 14(5):660-5.
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      10. Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ. The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24; 462(7276):1016-21.
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      11. Blosser TR, Yang JG, Stone MD, Narlikar GJ, Zhuang X. Dynamics of nucleosome remodelling by individual ACF complexes. Nature. 2009 Dec 24; 462(7276):1022-7.
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      12. Partensky PD, Narlikar GJ. Chromatin remodelers act globally, sequence positions nucleosomes locally. J Mol Biol. 2009 Aug 7; 391(1):12-25.
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      13. Chang EY, Ferreira H, Somers J, Nusinow DA, Owen-Hughes T, Narlikar GJ. MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF. Biochemistry. 2008 Dec 23; 47(51):13726-32.
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      14. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 3; 322(5898):43-4.
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      15. Racki LR, Narlikar GJ. ATP-dependent chromatin remodeling enzymes: two heads are not better, just different. Curr Opin Genet Dev. 2008 Apr; 18(2):137-44.
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      16. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 2007 Mar 9; 128(5):1003-12.
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      17. Yang JG, Narlikar GJ. FRET-based methods to study ATP-dependent changes in chromatin structure. Methods. 2007 Mar; 41(3):291-5.
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      18. Yang JG, Madrid TS, Sevastopoulos E, Narlikar GJ. The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing. Nat Struct Mol Biol. 2006 Dec; 13(12):1078-83.
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      19. He X, Fan HY, Narlikar GJ, Kingston RE. Human ACF1 alters the remodeling strategy of SNF2h. J Biol Chem. 2006 Sep 29; 281(39):28636-47.
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      20. Mahajan MC, Narlikar GJ, Boyapaty G, Kingston RE, Weissman SM. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15012-7.
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      21. Fan HY, Narlikar GJ, Kingston RE. Noncovalent modification of chromatin: different remodeled products with different ATPase domains. Cold Spring Harb Symp Quant Biol. 2004; 69:183-92.
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      22. Fan HY, He X, Kingston RE, Narlikar GJ. Distinct strategies to make nucleosomal DNA accessible. Mol Cell. 2003 May; 11(5):1311-22.
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      23. Aoyagi S, Narlikar G, Zheng C, Sif S, Kingston RE, Hayes JJ. Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions. Mol Cell Biol. 2002 Jun; 22(11):3653-62.
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      24. Narlikar GJ, Fan HY, Kingston RE. Cooperation between complexes that regulate chromatin structure and transcription. Cell. 2002 Feb 22; 108(4):475-87.
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      25. Narlikar GJ, Phelan ML, Kingston RE. Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity. Mol Cell. 2001 Dec; 8(6):1219-30.
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      26. Aalfs JD, Narlikar GJ, Kingston RE. Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H. J Biol Chem. 2001 Sep 7; 276(36):34270-8.
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      27. Lee KM, Narlikar G. Assembly of nucleosomal templates by salt dialysis. Curr Protoc Mol Biol. 2001 May; Chapter 21:Unit 21.6.
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      28. Jónsson ZO, Dhar SK, Narlikar GJ, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem. 2001 May 11; 276(19):16279-88.
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      29. Guyon JR, Narlikar GJ, Sullivan EK, Kingston RE. Stability of a human SWI-SNF remodeled nucleosomal array. Mol Cell Biol. 2001 Feb; 21(4):1132-44.
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      30. Narlikar GJ, Bartley LE, Herschlag D. Use of duplex rigidity for stability and specificity in RNA tertiary structure. Biochemistry. 2000 May 23; 39(20):6183-9.
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      31. Narlikar GJ, Bartley LE, Khosla M, Herschlag D. Characterization of a local folding event of the Tetrahymena group I ribozyme: effects of oligonucleotide substrate length, pH, and temperature on the two substrate binding steps. Biochemistry. 1999 Oct 26; 38(43):14192-204.
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      32. Kingston RE, Narlikar GJ. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev. 1999 Sep 15; 13(18):2339-52.
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      33. Shan SO, Narlikar GJ, Herschlag D. Protonated 2'-aminoguanosine as a probe of the electrostatic environment of the active site of the Tetrahymena group I ribozyme. Biochemistry. 1999 Aug 24; 38(34):10976-88.
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      34. Guyon JR, Narlikar GJ, Sif S, Kingston RE. Stable remodeling of tailless nucleosomes by the human SWI-SNF complex. Mol Cell Biol. 1999 Mar; 19(3):2088-97.
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      35. Phelan ML, Sif S, Narlikar GJ, Kingston RE. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol Cell. 1999 Feb; 3(2):247-53.
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      36. Narlikar GJ, Herschlag D. Direct demonstration of the catalytic role of binding interactions in an enzymatic reaction. Biochemistry. 1998 Jul 14; 37(28):9902-11.
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      37. Narlikar GJ, Khosla M, Usman N, Herschlag D. Quantitating tertiary binding energies of 2' OH groups on the P1 duplex of the Tetrahymena ribozyme: intrinsic binding energy in an RNA enzyme. Biochemistry. 1997 Mar 4; 36(9):2465-77.
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      38. Narlikar GJ, Herschlag D. Mechanistic aspects of enzymatic catalysis: lessons from comparison of RNA and protein enzymes. Annu Rev Biochem. 1997; 66:19-59.
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      39. Narlikar GJ, Herschlag D. Isolation of a local tertiary folding transition in the context of a globally folded RNA. Nat Struct Biol. 1996 Aug; 3(8):701-10.
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      40. Narlikar GJ, Gopalakrishnan V, McConnell TS, Usman N, Herschlag D. Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3668-72.
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      41. Knitt DS, Narlikar GJ, Herschlag D. Dissection of the role of the conserved G.U pair in group I RNA self-splicing. Biochemistry. 1994 Nov 22; 33(46):13864-79.
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