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    Gilad Doitsh, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address530 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Awards and Honors
      UCSF2014 - 2015CFAR Early Career Investigator Award for Excellence in Basic Research.
      The Gladstone Institutes, UCSF2010 - 2011The Gladstone Institute of Virology and Immunology Award for Scientific Excellence

      Collapse Overview 
      Collapse Interests
      HIV, AIDS, HIV Pathogenesis, Abortive HIV Infection, Innate Immunity, Caspase-1, Pyroptosis, Inflammation, HIV accessory proteins (e.g. Vpr, Vpx), Cell-to-cell transmission of viruses, Virological synapse, LFA-1, ICAM-1, Lymphoid Tissues, CD4 T cells, Sensing of intracellular viral DNA and other pathogen-associated molecular patterns (PAMPS) by pattern recognition receptors (PRRs)

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Doitsh G, Greene WC. Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 2016 Mar 9; 19(3):280-91. PMID: 26962940.
        View in: PubMed
      2. Muñoz-Arias I, Doitsh G, Yang Z, Sowinski S, Ruelas D, Greene WC. Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection. Cell Host Microbe. 2015 Oct 14; 18(4):463-70. PMID: 26468749; PMCID: PMC4627664 [Available on 10/14/16].
      3. Galloway NL, Doitsh G, Monroe KM, Yang Z, Muñoz-Arias I, Levy DN, Greene WC. Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells. Cell Rep. 2015 Sep 8; 12(10):1555-63. PMID: 26321639; PMCID: PMC4565731.
      4. Geng X, Doitsh G, Yang Z, Galloway NL, Greene WC. Efficient delivery of lentiviral vectors into resting human CD4 T cells. Gene Ther. 2014 Apr; 21(4):444-9. PMID: 24572792; PMCID: PMC4006095.
      5. Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014 Jan 23; 505(7484):509-14. PMID: 24356306; PMCID: PMC4047036.
      6. Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32. PMID: 24356113; PMCID: PMC3976200.
      7. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. PMID: 21111238; PMCID: PMC3026834.
      8. Doitsh G, Shaul Y. Enhancer I predominance in hepatitis B virus gene expression. Mol Cell Biol. 2004 Feb; 24(4):1799-808. PMID: 14749394; PMCID: PMC344184.
      9. Doitsh G, Shaul Y. A long HBV transcript encoding pX is inefficiently exported from the nucleus. Virology. 2003 May 10; 309(2):339-49. PMID: 12758180.
        View in: PubMed
      10. Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem. 2002 Mar 22; 277(12):9982-8. PMID: 11788598.
        View in: PubMed
      11. Doitsh G, Shaul Y. HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX. Oncogene. 1999 Dec 9; 18(52):7506-13. PMID: 10602509.
        View in: PubMed
      12. Haviv I, Shamay M, Doitsh G, Shaul Y. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol. 1998 Mar; 18(3):1562-9. PMID: 9488473; PMCID: PMC108871.
      13. Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. EMBO J. 1998 Jan 15; 17(2):544-53. PMID: 9430645; PMCID: PMC1170404.
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