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    Giorgio Lagna, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      The Rockefeller UniversityPostdoctoral Training2000
      University of Rome "La Sapienza"PhD1997

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A, et al. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016; 9(431):ra58. PMID: 27273096.
        View in: PubMed
      2. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205. PMID: 24219989; PMCID: PMC3981142.
      3. Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J Biol Chem. 2012 Nov 9; 287(46):38656-64. PMID: 22988237; PMCID: PMC3493910.
      4. Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77. PMID: 22718766; PMCID: PMC3431673.
      5. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 3; 287(6):3976-86. PMID: 22158624; PMCID: PMC3281737.
      6. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. PMID: 21969601; PMCID: PMC3232924.
      7. Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. PMID: 21673106; PMCID: PMC3151055.
      8. Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30. PMID: 21135135; PMCID: PMC3028626.
      9. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84. PMID: 20705240; PMCID: PMC2921543.
      10. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 3; 29(3):559-73. PMID: 20019669; PMCID: PMC2830697.
      11. Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 8; 284(19):13202-12. PMID: 19265191; PMCID: PMC2676052.
      12. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 6; 284(6):3728-38. PMID: 19088079; PMCID: PMC2635044.
      13. Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 3; 454(7200):56-61. PMID: 18548003; PMCID: PMC2653422.
      14. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55. PMID: 17947237; PMCID: PMC3405982.
      15. Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89. PMID: 17576816; PMCID: PMC1952124.
      16. Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67. PMID: 17030903.
        View in: PubMed
      17. Ku M, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87. PMID: 16373339.
        View in: PubMed
      18. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 2000 Jan 21; 100(2):229-40. PMID: 10660046.
        View in: PubMed
      19. Lagna G, Hemmati-Brivanlou A. A molecular basis for Smad specificity. Dev Dyn. 1999 Mar; 214(3):269-77. PMID: 10090153.
        View in: PubMed
      20. Lagna G, Carnevali F, Marchioni M, Hemmati-Brivanlou A. Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein beta TrCP. Mech Dev. 1999 Jan; 80(1):101-6. PMID: 10096067.
        View in: PubMed
      21. Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998 Jan 15; 12(2):186-97. PMID: 9436979; PMCID: PMC316444.
      22. Lagna G, Hemmati-Brivanlou A. Use of dominant negative constructs to modulate gene expression. Curr Top Dev Biol. 1998; 36:75-98. PMID: 9342522.
        View in: PubMed
      23. Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development. 1997 Aug; 124(16):3177-84. PMID: 9272958.
        View in: PubMed
      24. Hata A, Lo RS, Wotton D, Lagna G, Massagué J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 1997 Jul 3; 388(6637):82-7. PMID: 9214507.
        View in: PubMed
      25. Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature. 1996 Oct 31; 383(6603):832-6. PMID: 8893010.
        View in: PubMed
      26. Martinez E, Lagna G, Roeder RG. Overlapping transcription by RNA polymerases II and III of the Xenopus TFIIIA gene in somatic cells. J Biol Chem. 1994 Oct 14; 269(41):25692-8. PMID: 7929274.
        View in: PubMed
      27. Lagna G, Kovelman R, Sukegawa J, Roeder RG. Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC. Mol Cell Biol. 1994 May; 14(5):3053-64. PMID: 8164661; PMCID: PMC358673.
      28. Lagna G, Loreni F, Beccari E, Carnevali F. HrpF, a human sequence-specific DNA-binding protein homologous to XrpFI, a Xenopus laevis oocyte transcription factor. Nucleic Acids Res. 1990 Oct 11; 18(19):5811-6. PMID: 2216772; PMCID: PMC332319.
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