Gira Bhabha, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
Address600 16th Street
San Francisco CA 94158
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    Structure and mechanism of cytoplasmic and axonemal dyneins
    NIH K99GM112982Mar 1, 2015 - Feb 28, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D. Exploring the repeat protein universe through computational protein design. Nature. 2015 Dec 24; 528(7583):580-4. PMID: 26675729.
      View in: PubMed
    2. Bhabha G, Johnson GT, Schroeder CM, Vale RD. How Dynein Moves Along Microtubules. Trends Biochem Sci. 2016 Jan; 41(1):94-105. PMID: 26678005.
      View in: PubMed
    3. Bhabha G, Biel JT, Fraser JS. Keep on moving: discovering and perturbing the conformational dynamics of enzymes. Acc Chem Res. 2015 Feb 17; 48(2):423-30. PMID: 25539415; PMCID: PMC4334266 [Available on 12/24/15].
    4. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 6; 159(4):857-68. PMID: 25417161; PMCID: PMC4269335.
    5. Liu Y, Zhang X, Tan YL, Bhabha G, Ekiert DC, Kipnis Y, Bjelic S, Baker D, Kelly JW. De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J Am Chem Soc. 2014 Sep 24; 136(38):13102-5. PMID: 25209927; PMCID: PMC4183642.
    6. McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014 Jul 18; 345(6194):337-41. PMID: 25035494; PMCID: PMC4224444.
    7. Liu Y, Tan YL, Zhang X, Bhabha G, Ekiert DC, Genereux JC, Cho Y, Kipnis Y, Bjelic S, Baker D, Kelly JW. Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4449-54. PMID: 24591605; PMCID: PMC3970509.
    8. Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA. A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):445-50. PMID: 24335589; PMCID: PMC3890827.
    9. Bhabha G, Ekiert DC, Jennewein M, Zmasek CM, Tuttle LM, Kroon G, Dyson HJ, Godzik A, Wilson IA, Wright PE. Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat Struct Mol Biol. 2013 Nov; 20(11):1243-9. PMID: 24077226; PMCID: PMC3823643.
    10. van den Bedem H, Bhabha G, Yang K, Wright PE, Fraser JS. Automated identification of functional dynamic contact networks from X-ray crystallography. Nat Methods. 2013 Sep; 10(9):896-902. PMID: 23913260; PMCID: PMC3760795.
    11. Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 2012 Sep 27; 489(7417):526-32. PMID: 22982990; PMCID: PMC3538848.
    12. Bhabha G, Tuttle L, Martinez-Yamout MA, Wright PE. Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR. FEBS Lett. 2011 Nov 16; 585(22):3528-32. PMID: 22024482; PMCID: PMC3215841.
    13. Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, Poon LL, Peiris M, Koudstaal W, Wilson IA, Goudsmit J. A highly conserved neutralizing epitope on group 2 influenza A viruses. Science. 2011 Aug 12; 333(6044):843-50. PMID: 21737702; PMCID: PMC3210727.
    14. Bhabha G, Lee J, Ekiert DC, Gam J, Wilson IA, Dyson HJ, Benkovic SJ, Wright PE. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science. 2011 Apr 8; 332(6026):234-8. PMID: 21474759; PMCID: PMC3151171.
    15. Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as beta-sheet folding nucleators. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11067-72. PMID: 19541614; PMCID: PMC2708776.
    16. Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science. 2009 Apr 10; 324(5924):246-51. PMID: 19251591; PMCID: PMC2758658.
    17. Yao Y, Bhabha G, Kroon G, Landes M, Dyson HJ. Structure discrimination for the C-terminal domain of Escherichia coli trigger factor in solution. J Biomol NMR. 2008 Jan; 40(1):23-30. PMID: 18043871.
      View in: PubMed
    18. Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet. 2007 Dec 1; 16(23):2933-43. PMID: 17855453.
      View in: PubMed
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