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    Gregory Lee, PhD

    TitleAssociate Specialist
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address1700 4th St
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdoctoral StudiesPharmaceutical Chemistry
      University of British ColumbiaPostdoctoral FellowshipBiochemisty & Molecular Biology
      University of WashingtonPh.D.Chemistry1999
      University of California, DavisBachelor of ScienceChemistry1991

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem. 2016 Apr 19; 11(8):862-9. PMID: 26822284.
        View in: PubMed
      2. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. PMID: 24977643; PMCID: PMC4108181.
      3. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. PMID: 23181936; PMCID: PMC3566641.
      4. Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. Enzyme inhibition by allosteric capture of an inactive conformation. J Mol Biol. 2011 Sep 2; 411(5):999-1016. PMID: 21723875; PMCID: PMC3157250.
      5. Webb H, Tynan-Connolly BM, Lee GM, Farrell D, O'Meara F, Søndergaard CR, Teilum K, Hewage C, McIntosh LP, Nielsen JE. Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculations. Proteins. 2011 Mar; 79(3):685-702. PMID: 21287606.
        View in: PubMed
      6. Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10026-31. PMID: 20534573; PMCID: PMC2890480.
      7. Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol. 2009 Sep; 5(9):640-6. PMID: 19633659; PMCID: PMC2752665.
      8. Cort JR, Liu Z, Lee GM, Huggins KN, Janes S, Prickett K, Andersen NH. Solution state structures of human pancreatic amylin and pramlintide. Protein Eng Des Sel. 2009 Aug; 22(8):497-513. PMID: 19596697; PMCID: PMC2719500.
      9. Lee GM, Craik CS. Trapping moving targets with small molecules. Science. 2009 Apr 10; 324(5924):213-5. PMID: 19359579; PMCID: PMC2981433.
      10. Lee GM, Pufall MA, Meeker CA, Kang HS, Graves BJ, McIntosh LP. The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region. J Mol Biol. 2008 Oct 17; 382(4):1014-30. PMID: 18692067.
        View in: PubMed
      11. Lakowski TM, Lee GM, Lelj-Garolla B, Okon M, Reid RE, McIntosh LP. Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. Biochemistry. 2007 Jul 24; 46(29):8525-36. PMID: 17595060.
        View in: PubMed
      12. Lakowski TM, Lee GM, Okon M, Reid RE, McIntosh LP. Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. Protein Sci. 2007 Jun; 16(6):1119-32. PMID: 17473011; PMCID: PMC2206659.
      13. Graves BJ, Pufall MA, Lee GM, and McIntosh LP. . Compositions and methods for providing a Graded Response in a Protein. Patent WO/2007/005867. 2007.
      14. Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science. 2005 Jul 1; 309(5731):142-5. PMID: 15994560.
        View in: PubMed
      15. Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP. The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem. 2005 Feb 25; 280(8):7088-99. PMID: 15591056.
        View in: PubMed
      16. Schärpf M, Connelly GP, Lee GM, Boraston AB, Warren RA, McIntosh LP. Site-specific characterization of the association of xylooligosaccharides with the CBM13 lectin-like xylan binding domain from Streptomyces lividans xylanase 10A by NMR spectroscopy. Biochemistry. 2002 Apr 2; 41(13):4255-63. PMID: 11914071.
        View in: PubMed
      17. Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH. An NMR approach to structural proteomics. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1825-30. PMID: 11854485; PMCID: PMC122278.
      18. Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum. J Biomol NMR. 2001 Sep; 21(1):63-6. PMID: 11693569.
        View in: PubMed
      19. Lee GM. . Solution-State Conformational Analysis of Endothelin Analogs. University of Washington, Ph.D. Dissertation. 1999.
      20. Andersen NH, Neidigh JW, Harris SM, Lee GM, Liu Z, and Tong H. . Extracting Information from the Temperature Gradients of Polypeptide NH Chemical Shifts. 1. The Importance of Conformational Averaging. J. Am. Chem. Soc. 1997; 36(119):8547–8561.
      21. Andersen NH, Chen C, and Lee GM. . The Endothelin C-terminal Signal Fragment: Determinants of Conformational Equilibrium IN SITU and Detached. Prot. Pept. Lett. 1995; 4(1):215-222.
      22. Lee GM, Chen C, Marschner TM, Andersen NH. Does the solid-state structure of endothelin-1 provide insights concerning the solution-state conformational equilibrium? FEBS Lett. 1994 Nov 28; 355(2):140-6. PMID: 7982487.
        View in: PubMed
      23. Cort J, Liu Z, Lee G, Harris SM, Prickett KS, Gaeta LSL, and Andersen NH. . ß-Structure in Human Amylin and 2 Designer ß-Peptides: CD and NMR Spectroscopic Comparisons Suggest Soluble ß-Oligomers and the Absence of Significant Populations of ß-Strand Dimers. Biochem. Biophys. Res. Commun. 1994; 3(204):1088–1095.
      24. Searle PA, Jamal NM, Lee GM, and Moliski TF. . Configurational analysis of new furanosesquiterpenes from Dysidea herbacea. Assignment of absolute stereochemistry. Tetrahedron. 1994; 13(50):3879–3888.
      25. Lee GM, and Molinski TF. . Herbaceamide, a chlorinated N-acyl amino ester from the marine sponge, Dysidea herbacea. Tetrahedron Lett. 1992; 50(33):7671–7674.
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