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    Hao Shao, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentInstitute for Neurodegenerative Diseases
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-7073
    EmailHao.Shao@ucsf.edu
    vCardDownload vCard

      Collapse Overview 
      Collapse Interests
      HSP70 inhibitors, kinase inhibitors, protein-protein interaction, allosteric inhibitors, structure-based drug design, cancer biology, medicinal chemistry, translational research.

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932. PMID: 27503927.
        View in: PubMed
      2. Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey CA, Gestwicki JE, Kennedy RT. Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis. Anal Chem. 2016 Aug 16; 88(16):8272-8. PMID: 27434096.
        View in: PubMed
      3. Li X, Shao H, Taylor IR, Gestwicki JE. Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70). Curr Top Med Chem. 2016 Apr 13. PMID: 27072701.
        View in: PubMed
      4. Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr; 47(4):289-96. PMID: 27013001.
        View in: PubMed
      5. Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity. Medchemcomm. 2015 May 1; 6(5):912-918. PMID: 27087913.
        View in: PubMed
      6. Lam F, Abbas AY, Shao H, Teo T, Adams J, Li P, Bradshaw TD, Fischer PM, Walsby E, Pepper C, Chen Y, Ding J, Wang S. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73. Oncotarget. 2014 Sep 15; 5(17):7691-704. PMID: 25277198; PMCID: PMC4202154.
      7. Walsby E, Pratt G, Shao H, Abbas AY, Fischer PM, Bradshaw TD, Brennan P, Fegan C, Wang S, Pepper C. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget. 2014 Jan 30; 5(2):375-85. PMID: 24495868; PMCID: PMC3964214.
      8. Shao H, Shi S, Foley DW, Lam F, Abbas AY, Liu X, Huang S, Jiang X, Baharin N, Fischer PM, Wang S. Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents. Eur J Med Chem. 2013; 70:447-55. PMID: 24185375.
        View in: PubMed
      9. Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. J Med Chem. 2013 Feb 14; 56(3):660-70. PMID: 23252711; PMCID: PMC3579457.
      10. Shao H, Shi S, Huang S, Hole AJ, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S. Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities. J Med Chem. 2013 Feb 14; 56(3):640-59. PMID: 23301767; PMCID: PMC3579313.
      11. Lukasik PM, Elabar S, Lam F, Shao H, Liu X, Abbas AY, Wang S. Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents. Eur J Med Chem. 2012 Nov; 57:311-22. PMID: 23085105.
        View in: PubMed
      12. Cao F, Shao H, Li Q, Li J, Li W, Li C. Anti-inflammatory activity of Gentiana striata Maxim. Nat Prod Res. 2012; 26(11):1038-44. PMID: 21985356.
        View in: PubMed
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