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    Harlan Ives, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-476-2172

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Lu M, Wang J, Ives HE, Pearce D. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 2; 286(35):30647-54.
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      2. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8.
        View in: PubMed
      3. Liang CJ, Ives HE, Yang CM, Ma YH. 20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta. J Lipid Res. 2008 Jan; 49(1):66-73.
        View in: PubMed
      4. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503.
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      5. Ma YH, Wei HW, Su KH, Ives HE, Morris RC. Chloride-dependent calcium transients induced by angiotensin II in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2004 Jan; 286(1):C112-8.
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      6. Ling S, Deng G, Ives HE, Chatterjee K, Rubanyi GM, Komesaroff PA, Sudhir K. Estrogen inhibits mechanical strain-induced mitogenesis in human vascular smooth muscle cells via down-regulation of Sp-1. Cardiovasc Res. 2001 Apr; 50(1):108-14.
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      7. Perini S, LaBerge JM, Pearl JM, Santiestiban HL, Ives HE, Omachi RS, Graber M, Wilson MW, Marder SR, Don BR, Kerlan RK, Gordon RL. Tesio catheter: radiologically guided placement, mechanical performance, and adequacy of delivered dialysis. Radiology. 2000 Apr; 215(1):129-37.
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      8. Bedford RF, Ives HE. The renal safety of sevoflurane. Anesth Analg. 2000 Mar; 90(3):505-8.
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      9. Ma YH, Ling S, Ives HE. Mechanical strain increases PDGF-B and PDGF beta receptor expression in vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Nov 19; 265(2):606-10.
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      10. Ling S, Dai A, Ma YH, Wilson E, Chatterjee K, Ives HE, Sudhir K. Matrix-dependent gene expression of egr-1 and PDGF A regulate angiotensin II-induced proliferation in human vascular smooth muscle cells. Hypertension. 1999 Nov; 34(5):1141-6.
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      11. Morawietz H, Ma YH, Vives F, Wilson E, Sukhatme VP, Holtz J, Ives HE. Rapid induction and translocation of Egr-1 in response to mechanical strain in vascular smooth muscle cells. Circ Res. 1999 Apr 2; 84(6):678-87.
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      12. Mathias RS, Mikoshiba K, Michikawa T, Miyawaki A, Ives HE. IP3 receptor blockade fails to prevent intracellular Ca2+ release by ET-1 and alpha-thrombin. Am J Physiol. 1998 Jun; 274(6 Pt 1):C1456-65.
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      13. Wilson E, Vives F, Collins T, Ives HE. Strain-responsive regions in the platelet-derived growth factor-A gene promoter. Hypertension. 1998 Jan; 31(1 Pt 2):170-5.
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      14. Mathias RS, Zhang SJ, Wilson E, Gardner P, Ives HE. Non-capacitative calcium entry in Chinese hamster ovary cells expressing the platelet-derived growth factor receptor. J Biol Chem. 1997 Nov 14; 272(46):29076-82.
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      15. Reusch HP, Chan G, Ives HE, Nemenoff RA. Activation of JNK/SAPK and ERK by mechanical strain in vascular smooth muscle cells depends on extracellular matrix composition. Biochem Biophys Res Commun. 1997 Aug 18; 237(2):239-44.
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      16. Reusch P, Wagdy H, Reusch R, Wilson E, Ives HE. Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells. Circ Res. 1996 Nov; 79(5):1046-53.
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      17. Wilson E, Sudhir K, Ives HE. Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. J Clin Invest. 1995 Nov; 96(5):2364-72.
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      18. Reusch HP, Lowe J, Ives HE. Osmotic activation of a Na(+)-dependent Cl-/HCO3- exchanger. Am J Physiol. 1995 Jan; 268(1 Pt 1):C147-53.
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      19. Ma YH, Reusch HP, Wilson E, Escobedo JA, Fantl WJ, Williams LT, Ives HE. Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma. J Biol Chem. 1994 Dec 2; 269(48):30734-9.
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      20. Clyman RI, Peters KG, Chen YQ, Escobedo J, Williams LT, Ives HE, Wilson E. Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis. Cell Adhes Commun. 1994 Jan; 1(4):333-42.
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      21. Sudhir K, Wilson E, Chatterjee K, Ives HE. Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells. J Clin Invest. 1993 Dec; 92(6):3003-7.
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      22. Wilson E, Mai Q, Sudhir K, Weiss RH, Ives HE. Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF. J Cell Biol. 1993 Nov; 123(3):741-7.
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      23. Tu-Yu AH, Morris RC, Ives HE. Differential modulation of fos and jun gene expression by 1,25-dihydroxyvitamin D3. Biochem Biophys Res Commun. 1993 May 28; 193(1):161-6.
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      24. Winkel GK, Sardet C, Pouyssegur J, Ives HE. Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation. J Biol Chem. 1993 Feb 15; 268(5):3396-400.
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      25. Peters KG, Marie J, Wilson E, Ives HE, Escobedo J, Del Rosario M, Mirda D, Williams LT. Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis. Nature. 1992 Aug 20; 358(6388):678-81.
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      26. Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol. 1992 Apr; 6(4):551-6.
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      27. Weiss RH, Ives HE. Dissociation between activation of growth-related genes and mitogenic responses of neonatal vascular smooth muscle cells. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):617-22.
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      28. Weiss RH, Huang CL, Ives HE. Sphingosine reverses growth inhibition caused by activation of protein kinase C in vascular smooth muscle cells. J Cell Physiol. 1991 Nov; 149(2):307-12.
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      29. Mitsuhashi T, Morris RC, Ives HE. 1,25-dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells. J Clin Invest. 1991 Jun; 87(6):1889-95.
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      30. Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF. Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3185-9.
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      31. Huang CL, Takenawa T, Ives HE. Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors. J Biol Chem. 1991 Mar 5; 266(7):4045-8.
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      32. Ives HE. GTP binding proteins and growth factor signal transduction. Cell Signal. 1991; 3(6):491-9.
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      33. Ives HE. Essential hypertension--where are we going? West J Med. 1990 Oct; 153(4):415-20.
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      34. Lowe JH, Huang CL, Ives HE. Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors. J Biol Chem. 1990 May 5; 265(13):7188-94.
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      35. Ives HE. Ion transport defects and hypertension. Where is the link? Hypertension. 1989 Dec; 14(6):590-7.
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      36. Mitsuhashi T, Morris RC, Ives HE. Endothelin-induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine-sensitive Ca2+ channels. J Clin Invest. 1989 Aug; 84(2):635-9.
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      37. Perez HD, Elfman F, Marder S, Lobo E, Ives HE. Formyl peptide-induced chemotaxis of human polymorphonuclear leukocytes does not require either marked changes in cytosolic calcium or specific granule discharge. Role of formyl peptide receptor reexpression (or recycling). J Clin Invest. 1989 Jun; 83(6):1963-70.
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      38. Huang CL, Ives HE. Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters. J Biol Chem. 1989 Mar 15; 264(8):4391-7.
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      39. Van Dyke RW, Ives HE. Na+/H+ exchange: what, where and why? Hepatology. 1988 Jul-Aug; 8(4):960-5.
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      40. Kavanaugh WM, Williams LT, Ives HE, Coughlin SR. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol Endocrinol. 1988 Jul; 2(7):599-605.
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      41. Mitsuhashi T, Ives HE. Intracellular Ca2+ requirement for activation of the Na+/H+ exchanger in vascular smooth muscle cells. J Biol Chem. 1988 Jun 25; 263(18):8790-5.
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      42. Escobedo JA, Keating MT, Ives HE, Williams LT. Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation. J Biol Chem. 1988 Jan 25; 263(3):1482-7.
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      43. Huang CL, Cogan MG, Cragoe EJ, Ives HE. Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive. J Biol Chem. 1987 Oct 15; 262(29):14134-40.
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      44. Preisig PA, Ives HE, Cragoe EJ, Alpern RJ, Rector FC. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. J Clin Invest. 1987 Oct; 80(4):970-8.
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      45. Huang CL, Ives HE. Growth inhibition by protein kinase C late in mitogenesis. Nature. 1987 Oct 29-Nov 4; 329(6142):849-50.
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      46. Perez HD, Marder S, Elfman F, Ives HE. Human neutrophils contain subpopulations of specific granules exhibiting different sensitivities to changes in cytosolic free calcium. Biochem Biophys Res Commun. 1987 Jun 15; 145(2):976-81.
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      47. Daniel TO, Ives HE. Cyclosporin A inhibits kinase C-independent activation of the Na+/H+ exchanger by PDGF and vanadate. Biochem Biophys Res Commun. 1987 May 29; 145(1):111-7.
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      48. Ives HE, Daniel TO. Interrelationship between growth factor-induced pH changes and intracellular Ca2+. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):1950-4.
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      49. Ives HE, Chen PY, Verkman AS. Mechanism of coupling between Cl- and OH- transport in renal brush-border membranes. Biochim Biophys Acta. 1986 Dec 1; 863(1):91-100.
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      50. Huang CL, Ives HE, Cogan MG. In vivo evidence that cGMP is the second messenger for atrial natriuretic factor. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):8015-8.
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      51. Verkman AS, Ives HE. Anomalous driving force for renal brush border H+/OH-transport characterized by using 6-carboxyfluorescein. Biochemistry. 1986 May 20; 25(10):2876-82.
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      52. Verkman AS, Ives HE. Water permeability and fluidity of renal basolateral membranes. Am J Physiol. 1986 Apr; 250(4 Pt 2):F633-43.
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      53. Ives HE, Verkman AS. Effects of membrane fluidizing agents on renal brush border proton permeability. Am J Physiol. 1985 Dec; 249(6 Pt 2):F933-40.
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      54. Ives HE. Na+-H+ exchange, oncogenes and growth regulation in normal and tumor cells. West J Med. 1985 Sep; 143(3):365-70.
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      55. Ives HE. Proton/hydroxyl permeability of proximal tubule brush border vesicles. Am J Physiol. 1985 Jan; 248(1 Pt 2):F78-86.
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      56. Tsai CJ, Ives HE, Alpern RJ, Yee VJ, Warnock DG, Rector FC. Increased Vmax for Na+/H+ antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosis. Am J Physiol. 1984 Aug; 247(2 Pt 2):F339-43.
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      57. Warnock DG, Greger R, Dunham PB, Benjamin MA, Frizzell RA, Field M, Spring KR, Ives HE, Aronson PS, Seifter J. Ion transport processes in apical membranes of epithelia. Fed Proc. 1984 Jul; 43(10):2473-87.
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      58. Mircheff AK, Ives HE, Yee VJ, Warnock DG. Na+/H+ antiporter in membrane populations resolved from a renal brush border vesicle preparation. Am J Physiol. 1984 Jun; 246(6 Pt 2):F853-8.
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      59. Ives HE, Rector FC. Proton transport and cell function. J Clin Invest. 1984 Feb; 73(2):285-90.
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      60. Ives HE, Yee VJ, Warnock DG. Asymmetric distribution of the Na+/H+ antiporter in the renal proximal tubule epithelial cell. J Biol Chem. 1983 Nov 25; 258(22):13513-6.
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      61. Chung CH, Ives HE, Almeda S, Goldberg AL. Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases. J Biol Chem. 1983 Sep 25; 258(18):11032-8.
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      62. Ives HE, Yee VJ, Warnock DG. Mixed type inhibition of the renal Na+/H+ antiporter by Li+ and amiloride. Evidence for a modifier site. J Biol Chem. 1983 Aug 25; 258(16):9710-6.
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      63. Ives HE, Casnellie JE, Greengard P, Jamieson JD. Subcellular localization of cyclic GMP-dependent protein kinase and its substrates in vascular smooth muscle. J Biol Chem. 1980 Apr 25; 255(8):3777-85.
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      64. Casnellie JE, Ives HE, Jamieson JD, Greengard P. Cyclic GMP-dependent protein phosphorylation in intact medial tissue and isolated cells from vascular smooth muscle. J Biol Chem. 1980 Apr 25; 255(8):3770-6.
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      65. Ives HE, Schultz GS, Galardy RE, Jamieson JD. Preparation of functional smooth muscle cells from the rabbit aorta. J Exp Med. 1978 Nov 1; 148(5):1400-13.
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