Igor Rouzine, PhD

SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address600 16th Street
San Francisco CA 94158
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    Working Models of HIV Persistence &Evolution
    NIH/NIAID R01AI063926Aug 1, 2006 - Jul 31, 2010
    Role: Principal Investigator
    NIH/NIAID K25AI001811Sep 30, 2000 - Apr 30, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rast LI, Rouzine I, Rozhnova G, Bishop L, Weinberger AD, Weinberger LS. Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals. PLoS Comput Biol. 2016 May; 12(5):e1004799. PMID: 27152856.
      View in: PubMed
    2. Xiao Y, Rouzine IM, Bianco S, Acevedo A, Goldstein EF, Farkov M, Brodsky L, Andino R. RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence. Cell Host Microbe. 2016 Apr 13; 19(4):493-503. PMID: 27078068.
      View in: PubMed
    3. Rouzine IM, Weinberger AD, Weinberger LS. An evolutionary role for HIV latency in enhancing viral transmission. Cell. 2015 Feb 26; 160(5):1002-12. PMID: 25723173; PMCID: PMC4488136 [Available on 02/26/16].
    4. Razooky BS, Pai A, Aull K, Rouzine IM, Weinberger LS. A hardwired HIV latency program. Cell. 2015 Feb 26; 160(5):990-1001. PMID: 25723172; PMCID: PMC4395878 [Available on 02/26/16].
    5. Batorsky R, Sergeev RA, Rouzine IM. The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations. PLoS Comput Biol. 2014 Oct; 10(10):e1003878. PMID: 25356981; PMCID: PMC4214571.
    6. Rouzine IM, Razooky BS, Weinberger LS. Stochastic variability in HIV affects viral eradication. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13251-2. PMID: 25201951; PMCID: PMC4169906.
    7. Rouzine IM, Coffin JM, Weinberger LS. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo. PLoS Genet. 2014 Feb; 10(2):e1004179. PMID: 24586204; PMCID: PMC3930503.
    8. Rouzine IM, Weinberger LS. Reply to "Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict". J Virol. 2013 Sep; 87(17):9960-2. PMID: 23943740; PMCID: PMC3754088.
    9. Rouzine IM, Weinberger LS. Design requirements for interfering particles to maintain coadaptive stability with HIV-1. J Virol. 2013 Feb; 87(4):2081-93. PMID: 23221552; PMCID: PMC3571494.
    10. Good BH, Rouzine IM, Balick DJ, Hallatschek O, Desai MM. Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4950-5. PMID: 22371564; PMCID: PMC3323973.
    11. Batorsky R, Kearney MF, Palmer SE, Maldarelli F, Rouzine IM, Coffin JM. Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection. Proc Natl Acad Sci U S A. 2011 Apr 5; 108(14):5661-6. PMID: 21436045; PMCID: PMC3078368.
    12. Rouzine IM, Coffin JM. Multi-site adaptation in the presence of infrequent recombination. Theor Popul Biol. 2010 May; 77(3):189-204. PMID: 20149814; PMCID: PMC2849900.
    13. Sergeev RA, Batorsky RE, Coffin JM, Rouzine IM. Interpreting the effect of vaccination on steady state infection in animals challenged with Simian immunodeficiency virus. J Theor Biol. 2010 Apr 7; 263(3):385-92. PMID: 20034499; PMCID: PMC2827631.
    14. Sergeev RA, Batorsky RE, Rouzine IM. Model with two types of CTL regulation and experiments on CTL dynamics. J Theor Biol. 2010 Apr 7; 263(3):369-84. PMID: 19913558; PMCID: PMC2827655.
    15. Brunet E, Rouzine IM, Wilke CO. The stochastic edge in adaptive evolution. Genetics. 2008 May; 179(1):603-20. PMID: 18493075; PMCID: PMC2390637.
    16. Dutta RN, Rouzine IM, Smith SD, Wilke CO, Novella IS. Rapid adaptive amplification of preexisting variation in an RNA virus. J Virol. 2008 May; 82(9):4354-62. PMID: 18287227; PMCID: PMC2293023.
    17. Rouzine IM, Brunet E, Wilke CO. The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. Theor Popul Biol. 2008 Feb; 73(1):24-46. PMID: 18023832; PMCID: PMC2246079.
    18. Gheorghiu-Svirschevski S, Rouzine IM, Coffin JM. Increasing sequence correlation limits the efficiency of recombination in a multisite evolution model. Mol Biol Evol. 2007 Feb; 24(2):574-86. PMID: 17138627.
      View in: PubMed
    19. Rouzine IM, Coffin JM. Highly fit ancestors of a partly sexual haploid population. Theor Popul Biol. 2007 Mar; 71(2):239-50. PMID: 17097121; PMCID: PMC1994660.
    20. Rouzine IM, Sergeev RA, Glushtsov AI. Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):666-71. PMID: 16407101; PMCID: PMC1334670.
    21. Rouzine IM, Coffin JM. Evolution of human immunodeficiency virus under selection and weak recombination. Genetics. 2005 May; 170(1):7-18. PMID: 15744057; PMCID: PMC1449738.
    22. Rouzine IM, McKenzie FE. Link between immune response and parasite synchronization in malaria. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3473-8. PMID: 12621156; PMCID: PMC152317.
    23. Rouzine IM, Wakeley J, Coffin JM. The solitary wave of asexual evolution. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):587-92. PMID: 12525686; PMCID: PMC141040.
    24. Rouzine IM, Rodrigo A, Coffin JM. Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology. Microbiol Mol Biol Rev. 2001 Mar; 65(1):151-85. PMID: 11238990; PMCID: PMC99023.
    25. Rouzine IM, Coffin JM. Search for the mechanism of genetic variation in the pro gene of human immunodeficiency virus. J Virol. 1999 Oct; 73(10):8167-78. PMID: 10482567; PMCID: PMC112834.
    26. Rouzine IM, Coffin JM. Linkage disequilibrium test implies a large effective population number for HIV in vivo. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10758-63. PMID: 10485899; PMCID: PMC17956.
    27. See full list of publications in https://scholar.google.com/citations?user=ygxrMX0AAAAJ&hl=en.
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