Il Jin Kim

Address2340 Sutter Street
San Francisco CA 94115
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    Collapse Biography 
    Collapse education and training
    Seoul National UniversityBS, DVM1999
    Seoul National UniversityPhD2003
    Korean Hereditary Tumor RegistryGroup Leader2006
    University of California, San FranciscoAssistant Research Geneticist2010Cancer Center
    Collapse Awards and Honors
    Mesothelioma Applied Research Foundation2013 - 2014Mesothelioma Research Grant Award
    Uniting Against Lung Cancer 2012 - 2014Uniting Against Lung Cancer Research Grant Award
    The American Society of Colon and Rectal Surgeons 2008Impact Paper of the Year Award
    American Association for Cancer Research 2006AACR ITO-EN Scholar-In-Training Award
    Korean Cancer Association2005GlaxoSmithKline (GSK) Award
    American Association for Cancer Research 2005AACR ITO-EN Scholar-In-Training Award
    National Cancer Center, Korea2005Best Research Award
    Korea Cancer Research Foundation2004Best Research Award
    National Cancer Center, Korea2004National Cancer Center Travel Award to AACR annual meeting
    Korean Federation of Science and Technology Societies2004Outstanding Science and Technology Publication Award,
    American Association for Cancer Research2003AACR ITO-EN Scholar-In-Training Award
    BK21, Korea2003 - 2004BK21 (Brain Korea 21) Postdoctoral Fellowship
    Korea Cancer Research Foundation2003Best Research Award
    Korea Cancer Research Foundation2002Best Research Award
    Seoul National University, Korea1999Graduation with Honors (Magna Cum Laude)
    Seoul National University, Korea1997Presidential Honors Student

    Collapse Overview 
    Collapse overview
    Dr. Il-Jin Kim is a Principal Investigator and Director of Applied Genomics in the UCSF Thoracic Oncology Program. His work focuses on the identification of novel diagnostic markers and therapeutic targets in various types of human cancers. Dr. Kim investigates human cancers using state-of-the-art technologies including next-generation sequencing (NGS) and system genetics, Dr. Kim has developed several innovative microarrays (RET, beta-catenin, K-ras, and BRAF) and pioneered new methods of high-throughput mutation screening for which he holds numerous patents. He is also an inventor of the World-fast targeted NGS technologies (DNA/RNA extraction, new targeted NGS library prep, NGS data analysis program, and data interpretation tool).

    Dr. Il-Jin Kim has identified novel potential diagnostic markers and/or therapeutic targets for human cancers using Integrative Systems Genetics system that he developed with his colleagues, such as PEBP4 (novel type II pneumocyte gene/marker for lung – Nature Commun, 2013), VRK1 (novel cancer-specific mitosis marker and a potential therapeutic target– Nature Commun, 2013), GREM1 (potential lung cancer oncogene and diagnostic marker (lung adenocarcinoma) – Plos One, 2012), SETDB1 (one of the frequently mutated genes and a potential therapeutic target in malignant mesotheliomas –Oncotarget, 2016), and FAIM2 (novel diagnostic marker for SCLC and atypical carcinoids by mRNA expression or IHC and a potential therapeutic target for SCLC- Sci Rep, 2016).

    His research and paper for the 'Prediction of response to preoperative chemoradiotherapy in colorectal cancer patients' was named the best publication of 2007 by the journal "Dis Colon Rectum", the award given at the 2008 ASCRS (American Society of Colon and Rectal Surgeons) Annual Meeting. He has also three times received awards for development of innovative genetic and diagnostic assays by AACR (American Association for Cancer Research).

    Dr. Il-Jin Kim served as a group leader of the Korean Hereditary Tumor Registry from 2001-2006, an organization of which he has been a member since 1999. As group leader, he led a project that screened approximately 1,000 patients from 400 hereditary cancer families, looking at 12 inherited cancer syndromes. Dr. Kim graduated the College of Veterinary Medicine , Seoul National University with a B.S. and D.V.M. (Magna Cum Laude) , and an M.S. and Ph.D. in Tumor Biology from the College of Medicine at Seoul National University. In 2010, Dr. Kim joined the UCSF faculty in the Department of Surgery.

    Journal Editor.
    2012-present: ISRN Biotechnology,
    2013-present: Journal of Surgery

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kang HC, Kim JI, Chang HK, Woodard G, Choi YS, Ku JL, Jablons DM, Kim I, et al. FAIM2, as a novel diagnostic maker and a potential therapeutic target for small-cell lung cancer and atypical carcinoid. Sci Rep. 2016; 6:34022. PMID: 27677402.
      View in: PubMed
    2. Dang J, Mendez P, Lee S, Kim JW, Yoon JH, Kim TW, Sailey CJ, Jablons DM, Kim I, et al. Development of a robust DNA quality and quantity assessment qPCR assay for targeted next-generation sequencing library preparation. Int J Oncol. 2016 Aug 11. PMID: 27511764.
      View in: PubMed
    3. Mendez P, Dang J, Kim JW, Lee S, Yoon JH, Kim T, Sailey CJ, Jablons DM, Kim I. Comprehensive evaluation and validation of targeted next-generation sequencing performance in two clinical laboratories. Int J Oncol. 2016 Jul; 49(1):235-42. PMID: 27121194.
      View in: PubMed
    4. Kang HC, Kim HK, Lee S, Mendez P, Kim JW, Woodard G, Yoon JH, Jen KY, Fang LT, Jones K, Jablons DM, Kim I. Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas. Oncotarget. 2016 Feb 16; 7(7):8321-31. PMID: 26824986.
      View in: PubMed
    5. Agostini M, Janssen KP, Kim I, D'Angelo E, Pizzini S, Zangrando A, Zanon C, Pastrello C, Maretto I, Digito M, Bedin C, Jurisica I, Rizzolio F, Giordano A, Bortoluzzi S, Nitti D, Pucciarelli S. An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer. Oncotarget. 2015 Oct 20; 6(32):32561-74. PMID: 26359356.
      View in: PubMed
    6. Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ. Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14. Front Genet. 2015; 6:67. PMID: 25815003; PMCID: PMC4357294.
    7. Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. CK2a, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells. J Exp Clin Cancer Res. 2014; 33:93. PMID: 25422081; PMCID: PMC4254219.
    8. Fang LT, Lee S, Choi H, Kim HK, Jew G, Kang HC, Chen L, Jablons D, Kim IJ. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. Int J Oncol. 2014 Jan; 44(1):211-21. PMID: 24172857.
      View in: PubMed
    9. Kim HK, Jablons DM, Kim I . Multistep Progression from Atypical Adenomatous Hyperplasia to Lung Adenocarcinoma: Clinico-Pathologic, Epigenetic and Genetic Aspects. J Surgery. 2013; 1(1):10.
    10. Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene. 2014 Apr 17; 33(16):2087-97. PMID: 23686308; PMCID: PMC3947751.
    11. Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. J Invest Dermatol. 2013 Jul; 133(7):1907-10. PMID: 23358096; PMCID: PMC3664264.
    12. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013; 4:1701. PMID: 23591868; PMCID: PMC4450149.
    13. Mulvihill MS, Kwon YW, Lee S, Fang LT, Choi H, Ray R, Kang HC, Mao JH, Jablons D, Kim IJ. Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. PLoS One. 2012; 7(8):e42264. PMID: 22870311; PMCID: PMC3411619.
    14. Kim JW, Lee S, Lui N, Choi H, Mulvihill M, Fang LT, Kang HC, Kwon YW, Jablons D, Kim IJ. A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease. Oncol Rep. 2012 Oct; 28(4):1225-30. PMID: 22842620.
      View in: PubMed
    15. Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L. Inhibition of CK2a down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One. 2012; 7(6):e38996. PMID: 22768056; PMCID: PMC3387212.
    16. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun; 10(6):834-44. PMID: 22513362; PMCID: PMC3388112.
    17. Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ. Development of a rapid and practical mutation screening assay for human lung adenocarcinoma. Int J Oncol. 2012 Jun; 40(6):1900-6. PMID: 22407457.
      View in: PubMed
    18. Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress ?-ray radiation-induced mouse thymic lymphoma. Oncogene. 2012 Mar 1; 31(9):1176-80. PMID: 21785465; PMCID: PMC3307058.
    19. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5. PMID: 21244661; PMCID: PMC3091303.
    20. Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 2010 Aug 10; 28(23):3770-8. PMID: 20625127; PMCID: PMC2917310.
    21. Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One. 2010; 5(7):e11418. PMID: 20625391; PMCID: PMC2896393.
    22. Ku JL, Shin YK, Kim DW, Kim KH, Choi JS, Hong SH, Jeon YK, Kim SH, Kim HS, Park JH, Kim IJ, Park JG. Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis. 2010 Jun; 31(6):1003-9. PMID: 20176655.
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    23. Yoo BC, Hong SH, Ku JL, Kim YH, Shin YK, Jang SG, Kim IJ, Jeong SY, Park JG. Galectin-3 stabilizes heterogeneous nuclear ribonucleoprotein Q to maintain proliferation of human colon cancer cells. Cell Mol Life Sci. 2009 Jan; 66(2):350-64. PMID: 19137262.
      View in: PubMed
    24. Ju W, Yoo BC, Kim IJ, Kim JW, Kim SC, Lee HP. Identification of genes with differential expression in chemoresistant epithelial ovarian cancer using high-density oligonucleotide microarrays. Oncol Res. 2009; 18(2-3):47-56. PMID: 20066894.
      View in: PubMed
    25. Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008 Sep 12; 321(5895):1499-502. PMID: 18787170; PMCID: PMC2849753.
    26. Kim IJ, Kim K, Kang HC, Jang SG, Park JG. DHPLC analysis of adenomatous polyposis coli (APC) mutations using ready-to-use APC plates: simple detection of multiple base pair deletion mutations. Genet Test. 2008 Jun; 12(2):295-8. PMID: 18554166.
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    27. Kang HC, Kim IJ, Jang SG, Hong SH, Hwang JA, Shin HR, Park JG. Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk. Cancer Lett. 2008 Feb 18; 260(1-2):170-9. PMID: 18079053.
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    28. Kim IJ, Lim SB, Kang HC, Chang HJ, Ahn SA, Park HW, Jang SG, Park JH, Kim DY, Jung KH, Choi HS, Jeong SY, Sohn DK, Kim DW, Park JG. Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer. Dis Colon Rectum. 2007 Sep; 50(9):1342-53. PMID: 17665260.
      View in: PubMed
    29. Park HW, Kim IJ, Kang HC, Jang SG, Ahn SA, Lee JS, Shin HR, Park JG. The hOGG1 Ser326Cys polymorphism is not associated with colorectal cancer risk. J Epidemiol. 2007 Sep; 17(5):156-60. PMID: 17827862.
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    30. Kang HC, Kim IJ, Kim K, Yoon HJ, Jang SG, Park JG. km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers. Cancer Genet Cytogenet. 2007 Jun; 175(2):173-4. PMID: 17556076.
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    31. Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW. Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells. Exp Mol Med. 2007 Apr 30; 39(2):195-204. PMID: 17464181.
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    32. Kim DW, Kim IJ, Kang HC, Jang SG, Kim K, Yoon HJ, Ahn SA, Han SY, Hong SH, Hwang JA, Sohn DK, Jeong SY, Choi HS, Hong CW, Lim SB, Park JG. Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas. Int J Colorectal Dis. 2007 Oct; 22(10):1173-8. PMID: 17703316.
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    33. Kim IJ, Kang HC, Jang SG, Ahn SA, Yoon HJ, Park JG. Development and applications of a BRAF oligonucleotide microarray. J Mol Diagn. 2007 Feb; 9(1):55-63. PMID: 17251336; PMCID: PMC1867429.
    34. Jang SG, Kim IJ, Kang HC, Park HW, Ahn SA, Yoon HJ, Kim K, Shin HR, Lee JS, Park JG. GSTT2 promoter polymorphisms and colorectal cancer risk. BMC Cancer. 2007; 7:16. PMID: 17250773; PMCID: PMC1793996.
    35. Park HW, Kang HC, Kim IJ, Jang SG, Kim K, Yoon HJ, Jeong SY, Park JG. Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers. Int J Cancer. 2007 Jan 1; 120(1):7-12. PMID: 17013898.
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    36. Koh CS, Ku JL, Park SY, Kim KH, Choi JS, Kim IJ, Park JH, Oh SK, Chung JK, Lee JH, Kim WH, Kim CW, Cho BY, Park JG. Establishment and characterization of cell lines from three human thyroid carcinomas: responses to all-trans-retinoic acid and mutations in the BRAF gene. Mol Cell Endocrinol. 2007 Jan 29; 264(1-2):118-27. PMID: 17134824.
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    37. Lim SB, Jeong SY, Kim IJ, Kim DY, Jung KH, Chang HJ, Choi HS, Sohn DK, Kang HC, Shin Y, Jang SG, Park JH, Park JG. Analysis of microsatellite instability in stool DNA of patients with colorectal cancer using denaturing high performance liquid chromatography. World J Gastroenterol. 2006 Nov 7; 12(41):6689-92. PMID: 17075985; PMCID: PMC4125677.
    38. Kim KH, Choi JS, Kim IJ, Ku JL, Park JG. Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues. World J Gastroenterol. 2006 Sep 21; 12(35):5651-7. PMID: 17007017; PMCID: PMC4088165.
    39. Ku JL, Park SH, Yoon KA, Shin YK, Kim KH, Choi JS, Kang HC, Kim IJ, Han IO, Park JG. Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation. Cancer Lett. 2007 Mar 18; 247(2):283-92. PMID: 16828225.
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    40. Yoon KA, Hwangbo B, Kim IJ, Park S, Kim HS, Kee HJ, Lee JE, Jang YK, Park JG, Lee JS. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. Carcinogenesis. 2006 Nov; 27(11):2217-22. PMID: 16774942.
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    41. Park JG, Kim DW, Hong CW, Nam BH, Shin YK, Hong SH, Kim IJ, Lim SB, Aronson M, Bisgaard ML, Brown GJ, Burn J, Chow E, Conrad P, Douglas F, Dunlop M, Ford J, Greenblatt MS, Heikki J, Heinimann K, Lynch EL, Macrae F, McKinnon WC, Möeslein G, Rossi BM, Rozen P, Schofield L, Vaccaro C, Vasen H, Velthuizen M, Viel A, Wijnen J. Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study. Clin Cancer Res. 2006 Jun 1; 12(11 Pt 1):3389-93. PMID: 16740762.
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    42. Kang HC, Kim IJ, Park HW, Jang SG, Ahn SA, Yoon SN, Chang HJ, Yoo BC, Park JG. Regulation of MDK expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance. Cancer Lett. 2007 Mar 8; 247(1):40-7. PMID: 16644108.
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    43. Kim IJ, Kang HC, Park JG. Evaluation of microarray analysis for predicting treatment responsiveness in patients with chronic hepatitis C viral infection. Gastroenterology. 2005 Nov; 129(5):1803; author reply 1803-4. PMID: 16285984.
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    44. Kim IJ, Kang HC, Jang SG, Kim K, Ahn SA, Yoon HJ, Yoon SN, Park JG. Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations. Carcinogenesis. 2006 Mar; 27(3):392-404. PMID: 16219636.
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    45. Kang HC, Kim IJ, Park JH, Shin Y, Jang SG, Ahn SA, Park HW, Lim SK, Oh SK, Kim DJ, Lee KW, Choi YS, Park YJ, Lee MR, Kim DW, Park JG. Three novel VHL germline mutations in Korean patients with von Hippel-Lindau disease and pheochromocytomas. Oncol Rep. 2005 Oct; 14(4):879-83. PMID: 16142346.
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    46. Kim DW, Kim IJ, Kang HC, Park HW, Shin Y, Park JH, Jang SG, Yoo BC, Lee MR, Hong CW, Park KJ, Oh NG, Kim NK, Sung MK, Lee BW, Kim YJ, Lee H, Park JG. Mutation spectrum of the APC gene in 83 Korean FAP families. Hum Mutat. 2005 Sep; 26(3):281. PMID: 16088911.
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    47. Kim IJ, Kang HC, Shin Y, Yoo BC, Yang HK, Park JG. Familial gastric cancers with Li-Fraumeni Syndrome: a case repast. World J Gastroenterol. 2005 Jul 14; 11(26):4124-6. PMID: 15996045; PMCID: PMC4502116.
    48. Chang HJ, Jung KH, Kim DY, Jeong SY, Choi HS, Kim YH, Sohn DK, Yoo BC, Lim SB, Kim DH, Ahn JB, Kim IJ, Kim JM, Yoon WH, Park JG. Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. Hum Pathol. 2005 Apr; 36(4):364-71. PMID: 15891997.
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    49. Park JG, Kim IJ. [Hereditary colorectal cancer]. Korean J Gastroenterol. 2005 Feb; 45(2):78-87. PMID: 15725711.
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    50. Moon SD, Park JH, Kim EM, Kim JH, Han JH, Yoo SJ, Yoon KH, Kang MI, Lee KW, Son HY, Kang SK, Oh SJ, Kim KM, Yoon SJ, Park JG, Kim IJ, Kang HC, Hong SW, Kim KR, Cha BY. A Novel IVS2-1G>A mutation causes aberrant splicing of the HRPT2 gene in a family with hyperparathyroidism-jaw tumor syndrome. J Clin Endocrinol Metab. 2005 Feb; 90(2):878-83. PMID: 15613436.
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    51. Shin YK, Heo SC, Shin JH, Hong SH, Ku JL, Yoo BC, Kim IJ, Park JG. Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families. Hum Mutat. 2004 Oct; 24(4):351. PMID: 15365995.
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    52. Kim IJ, Ku JL, Kang HC, Park JH, Yoon KA, Shin Y, Park HW, Jang SG, Lim SK, Han SY, Shin YK, Lee MR, Jeong SY, Shin HR, Lee JS, Kim WH, Park JG. Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. Hum Genet. 2004 Nov; 115(6):498-503. PMID: 15449173.
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    53. Kim IJ, Kang HC, Shin Y, Park HW, Jang SG, Han SY, Lim SK, Lee MR, Chang HJ, Ku JL, Yang HK, Park JG. A TP53-truncating germline mutation (E287X) in a family with characteristics of both hereditary diffuse gastric cancer and Li-Fraumeni syndrome. J Hum Genet. 2004; 49(11):591-5. PMID: 15368100.
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    54. Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG. Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene. 2004 Sep 2; 23(40):6736-42. PMID: 15273736.
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    55. Park JH, Kim IJ, Kang HC, Shin Y, Park HW, Jang SG, Ku JL, Lim SB, Jeong SY, Park JG. Oligonucleotide microarray-based mutation detection of the K-ras gene in colorectal cancers with use of competitive DNA hybridization. Clin Chem. 2004 Sep; 50(9):1688-91. PMID: 15331511.
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    56. Kim IJ, Kang HC, Park JG. Microarray applications in cancer research. Cancer Res Treat. 2004 Aug; 36(4):207-13. PMID: 20368836; PMCID: PMC2843894.
    57. Chun JH, Kim HK, Kim E, Kim IH, Kim JH, Chang HJ, Choi IJ, Lim HS, Kim IJ, Kang HC, Park JH, Bae JM, Park JG. Increased expression of metallothionein is associated with irinotecan resistance in gastric cancer. Cancer Res. 2004 Jul 15; 64(14):4703-6. PMID: 15256434.
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    58. Kang HC, Kim IJ, Park JH, Shin Y, Park HW, Ku JL, Yang HK, Lee KU, Choe KJ, Park JG. Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers. Oncol Rep. 2004 Jul; 12(1):129-33. PMID: 15201973.
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    59. Shin Y, Kim IJ, Kang HC, Park JH, Park HW, Jang SG, Lee MR, Jeong SY, Chang HJ, Ku JL, Park JG. A functional polymorphism (-347 G-->GA) in the E-cadherin gene is associated with colorectal cancer. Carcinogenesis. 2004 Nov; 25(11):2173-6. PMID: 15231691.
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    60. Kim HK, Choi IJ, Kim HS, Kim JH, Kim E, Park IS, Chun JH, Kim IH, Kim IJ, Kang HC, Park JH, Bae JM, Lee JS, Park JG. DNA microarray analysis of the correlation between gene expression patterns and acquired resistance to 5-FU/cisplatin in gastric cancer. Biochem Biophys Res Commun. 2004 Apr 9; 316(3):781-9. PMID: 15033468.
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    61. Shin Y, Kim IJ, Kang HC, Park JH, Park HR, Park HW, Park MA, Lee JS, Yoon KA, Ku JL, Park JG. The E-cadherin -347G->GA promoter polymorphism and its effect on transcriptional regulation. Carcinogenesis. 2004 Jun; 25(6):895-9. PMID: 14729585.
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    62. Kang HC, Kim IJ, Park JH, Shin Y, Ku JL, Jung MS, Yoo BC, Kim HK, Park JG. Identification of genes with differential expression in acquired drug-resistant gastric cancer cells using high-density oligonucleotide microarrays. Clin Cancer Res. 2004 Jan 1; 10(1 Pt 1):272-84. PMID: 14734480.
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    63. Kim IJ, Park JH, Kang HC, Shin Y, Park HW, Park HR, Ku JL, Lim SB, Park JG. Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. Hum Genet. 2003 Dec; 114(1):118-20. PMID: 14513361.
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    64. Kim IJ, Shin Y, Kang HC, Park JH, Ku JL, Park HW, Park HR, Lim SB, Jeong SY, Kim WH, Park JG. Robust microsatellite instability (MSI) analysis by denaturing high-performance liquid chromatography (DHPLC). J Hum Genet. 2003; 48(10):525-30. PMID: 13680299.
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    65. Kim IJ, Kang HC, Park JH, Shin Y, Ku JL, Lim SB, Park SY, Jung SY, Kim HK, Park JG. Development and applications of a beta-catenin oligonucleotide microarray: beta-catenin mutations are dominantly found in the proximal colon cancers with microsatellite instability. Clin Cancer Res. 2003 Aug 1; 9(8):2920-5. PMID: 12912937.
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    66. Kim IJ, Park JH, Kang HC, Shin Y, Lim SB, Ku JL, Yang HK, Lee KU, Park JG. A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer. J Med Genet. 2003 Aug; 40(8):e97. PMID: 12920089; PMCID: PMC1735541.
    67. Park JH, Kim IJ, Kang HC, Lee SH, Shin Y, Kim KH, Lim SB, Kang SB, Lee K, Kim SY, Lee MS, Lee MK, Park JH, Moon SD, Park JG. Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders. Clin Genet. 2003 Jul; 64(1):48-53. PMID: 12791038.
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    68. Kim IJ, Park JH, Kang HC, Kim KH, Kim JH, Ku JL, Kang SB, Park SY, Lee JS, Park JG. Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation. Clin Genet. 2003 Feb; 63(2):126-30. PMID: 12630959.
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    69. Kang HC, Kim IJ, Park JH, Kwon HJ, Won YJ, Heo SC, Lee SY, Kim KH, Shin Y, Noh DY, Yang DH, Choe KJ, Lee BH, King SB, Park JG. Germline mutations of BRCA1 and BRCA2 in Korean breast and/or ovarian cancer families. Hum Mutat. 2002 Sep; 20(3):235. PMID: 12204006.
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    70. Ku JL, Yoon KA, Kim IJ, Kim WH, Jang JY, Suh KS, Kim SW, Park YH, Hwang JH, Yoon YB, Park JG. Establishment and characterisation of six human biliary tract cancer cell lines. Br J Cancer. 2002 Jul 15; 87(2):187-93. PMID: 12107841; PMCID: PMC2376107.
    71. Kim IJ, Kang HC, Park JH, Ku JL, Lee JS, Kwon HJ, Yoon KA, Heo SC, Yang HY, Cho BY, Kim SY, Oh SK, Youn YK, Park DJ, Lee MS, Lee KW, Park JG. RET oligonucleotide microarray for the detection of RET mutations in multiple endocrine neoplasia type 2 syndromes. Clin Cancer Res. 2002 Feb; 8(2):457-63. PMID: 11839664.
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    72. Yu YS, Kim IJ, Ku JL, Park JG. Identification of four novel RB1 germline mutations in Korean retinoblastoma patients. Hum Mutat. 2001 Sep; 18(3):252. PMID: 11524739.
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    73. Kim IJ, Ku JL, Yoon KA, Heo SC, Jeong SY, Choi HS, Hong KH, Yang SK, Park JG. Germline mutations of the dpc4 gene in Korean juvenile polyposis patients. Int J Cancer. 2000 May 15; 86(4):529-32. PMID: 10797267.
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