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Jae Kyu Ryu, PhD

TitleStaff Research Scientist I
SchoolUCSF School of Medicine
DepartmentGladstone Institutes
Address
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    Collapse Biography 
    Collapse Education and Training
    Gladstone Institute of Neurological Disease, San Francisco Postdoctoral2013Neuroimmunology
    University of British Columbia, Vancouver, Canada Ph.D. 2008Pharmacology
    Collapse Awards and Honors
    American Heart Association 2016  - 2019Scientist Development Grant
    A Race to Erase MS2016  - 2018Young Investigator Award
    National Multiple Sclerosis Society 2011  - 2014Postdoctoral Fellowship
    American Heart Association 2009  - 2011Postdoctoral Fellowship

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu T, Stewart KM, Wang X, Liu K, Xie M, Kyu Ryu J, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature. 2017 Aug 02. PMID: 28783731.
      View in: PubMed
    2. Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu J, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. Microglial complement receptor 3 regulates brain Aß levels through secreted proteolytic activity. J Exp Med. 2017 Mar 15. PMID: 28298456.
      View in: PubMed
    3. Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu J, Akassoglou K, Mullins ES. Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. J Neurosci. 2017 Apr 05; 37(14):3776-3788. PMID: 28275164.
      View in: PubMed
    4. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu J, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707.
      View in: PubMed
    5. Ryu J, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015; 6:8164. PMID: 26353940; PMCID: PMC4579523.
    6. Ryu JK, Cho T, Choi HB, Jantaratnotai N, McLarnon JG. Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease. J Neuroinflammation. 2015 Aug 09; 12:144. PMID: 26255110; PMCID: PMC4529987.
    7. Schachtrup C, Ryu J, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-ß signaling and astrocyte functions. Nat Neurosci. 2015 Aug; 18(8):1077-80. PMID: 26120963.
      View in: PubMed
    8. Lim HW, Kang SG, Ryu J, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J Exp Med. 2015 May 4; 212(5):607-17. PMID: 25918343; PMCID: PMC4419343.
    9. Terrando N, Yang T, Ryu J, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. Stimulation of the a7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2014; 20:667-75. PMID: 25365546; PMCID: PMC4398668.
    10. Le Moan N, Baeten KM, Rafalski VA, Ryu J, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K. Hypoxia Inducible Factor-1a in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease(,.) Eneuro. 2015 Mar-Apr; 2(2). PMID: 26213713.
      View in: PubMed
    11. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu J, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8. PMID: 24740641; PMCID: PMC4049631.
    12. Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG, Wang YT. Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells. PLoS One. 2013; 8(10):e76860. PMID: 24146937; PMCID: PMC3798289.
    13. Ryu JK, Little JP, Klegeris A, Jantaratnotai N, McLarnon JG. Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease. Curr Alzheimer Res. 2013 Mar; 10(3):252-60. PMID: 23534534.
      View in: PubMed
    14. Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron. 2012 Sep 20; 75(6):1094-104. PMID: 22998876; PMCID: PMC3630998.
    15. Davalos D, Ryu J, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun. 2012; 3:1227. PMID: 23187627; PMCID: PMC3514498.
    16. Terrando N, Eriksson LI, Ryu J, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec; 70(6):986-95. PMID: 22190370; PMCID: PMC4556354.
    17. Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. Int J Alzheimers Dis. 2011; 2011:918280. PMID: 21969915; PMCID: PMC3182764.
    18. Franciosi S, Ryu JK, Shim Y, Hill A, Connolly C, Hayden MR, McLarnon JG, Leavitt BR. Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease. Neurobiol Dis. 2012 Jan; 45(1):438-49. PMID: 21946335.
      View in: PubMed
    19. Hashioka S, McLarnon JG, Ryu JK, Youssef AM, Abd-El-Aziz AS, Neeland EG, Klegeris A. Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo. J Alzheimers Dis. 2011; 27(3):531-41. PMID: 21841251.
      View in: PubMed
    20. Ryu JK, Jantaratnotai N, Serrano-Perez MC, McGeer PL, McLarnon JG. Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model. J Neuropathol Exp Neurol. 2011 Jan; 70(1):13-22. PMID: 21157381.
      View in: PubMed
    21. Schachtrup C, Ryu J, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci. 2010 Apr 28; 30(17):5843-54. PMID: 20427645; PMCID: PMC2871011.
    22. Kim YB, Ryu JK, Lee HJ, Lim IJ, Park D, Lee MC, Kim SU. Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus. BMC Neurosci. 2010 Mar 26; 11:42. PMID: 20346117; PMCID: PMC2861065.
    23. Ryu JK, Cho T, Wang YT, McLarnon JG. Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain. J Neuroinflammation. 2009 Dec 23; 6:39. PMID: 20030829; PMCID: PMC2804572.
    24. Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J. Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia. 2009 Jun; 57(8):898-907. PMID: 19115379.
      View in: PubMed
    25. Ryu JK, Cho T, Choi HB, Wang YT, McLarnon JG. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J Neurosci. 2009 Jan 07; 29(1):3-13. PMID: 19129379.
      View in: PubMed
    26. Ryu JK, McLarnon JG. Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport. 2008 Nov 19; 19(17):1715-9. PMID: 18852683.
      View in: PubMed
    27. Ryu JK, McLarnon JG. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med. 2009 Sep; 13(9A):2911-25. PMID: 18657226; PMCID: PMC4498946.
    28. Ryu JK, McLarnon JG. VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult. J Neuroinflammation. 2008 May 20; 5:18. PMID: 18492281; PMCID: PMC2430697.
    29. Wei W, Ryu JK, Choi HB, McLarnon JG. Expression and function of the P2X(7) receptor in rat C6 glioma cells. Cancer Lett. 2008 Feb 18; 260(1-2):79-87. PMID: 18039556.
      View in: PubMed
    30. Ryu JK, McLarnon JG. Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-alpha in an animal model of inflamed Alzheimer's disease brain. Neurobiol Dis. 2008 Feb; 29(2):254-66. PMID: 17964176.
      View in: PubMed
    31. Choi HB, Ryu JK, Kim SU, McLarnon JG. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci. 2007 May 02; 27(18):4957-68. PMID: 17475804.
      View in: PubMed
    32. Ryu JK, Tran KC, McLarnon JG. Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. Glia. 2007 Mar; 55(4):439-51. PMID: 17203474.
      View in: PubMed
    33. Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG. Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. J Neurosci. 2006 Nov 08; 26(45):11652-64. PMID: 17093087.
      View in: PubMed
    34. McLarnon JG, Ryu JK, Walker DG, Choi HB. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. J Neuropathol Exp Neurol. 2006 Nov; 65(11):1090-7. PMID: 17086106.
      View in: PubMed
    35. Ryu JK, McLarnon JG. Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus. Exp Neurol. 2006 Apr; 198(2):552-7. PMID: 16480717.
      View in: PubMed
    36. Nagai A, Ryu JK, Terashima M, Tanigawa Y, Wakabayashi K, McLarnon JG, Kobayashi S, Masuda J, Kim SU. Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B. Brain Res. 2005 Dec 20; 1066(1-2):120-8. PMID: 16325785.
      View in: PubMed
    37. Ryu JK, Choi HB, McLarnon JG. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol Dis. 2005 Nov; 20(2):550-61. PMID: 15916899.
      View in: PubMed
    38. Tran KC, Ryu JK, McLarnon JG. Induction of angiogenesis by platelet-activating factor in the rat striatum. Neuroreport. 2005 Sep 28; 16(14):1579-83. PMID: 16148749.
      View in: PubMed
    39. Zand L, Ryu JK, McLarnon JG. Induction of angiogenesis in the beta-amyloid peptide-injected rat hippocampus. Neuroreport. 2005 Feb 08; 16(2):129-32. PMID: 15671861.
      View in: PubMed
    40. Ryu JK, Franciosi S, Sattayaprasert P, Kim SU, McLarnon JG. Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus. Glia. 2004 Oct; 48(1):85-90. PMID: 15326618.
      View in: PubMed
    41. Ryu JK, Kim J, Cho SJ, Hatori K, Nagai A, Choi HB, Lee MC, McLarnon JG, Kim SU. Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease. Neurobiol Dis. 2004 Jun; 16(1):68-77. PMID: 15207263.
      View in: PubMed
    42. Ryu JK, Kim SU, McLarnon JG. Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease. Exp Neurol. 2004 May; 187(1):150-9. PMID: 15081596.
      View in: PubMed
    43. Choi SH, Lee DY, Ryu JK, Kim J, Joe EH, Jin BK. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiol Dis. 2003 Nov; 14(2):181-93. PMID: 14572441.
      View in: PubMed
    44. Ryu JK, Kim SU, McLarnon JG. Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease. Exp Neurol. 2003 Oct; 183(2):700-4. PMID: 14552912.
      View in: PubMed
    45. Jantaratnotai N, Ryu JK, Kim SU, McLarnon JG. Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo. Neuroreport. 2003 Aug 06; 14(11):1429-33. PMID: 12960758.
      View in: PubMed
    46. Choi HB, Hong SH, Ryu JK, Kim SU, McLarnon JG. Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia. Glia. 2003 Aug; 43(2):95-103. PMID: 12838502.
      View in: PubMed
    47. Ryu JK, Choi HB, Hatori K, Heisel RL, Pelech SL, McLarnon JG, Kim SU. Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase. J Neurosci Res. 2003 May 01; 72(3):352-62. PMID: 12692902.
      View in: PubMed
    48. Ryu JK, Nagai A, Kim J, Lee MC, McLarnon JG, Kim SU. Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies. Neurobiol Dis. 2003 Mar; 12(2):121-32. PMID: 12667467.
      View in: PubMed
    49. Nagai A, Ryu JK, Kobayash S, Kim SU. Cystatin C induces neuronal cell death in vivo. Ann N Y Acad Sci. 2002 Nov; 977:315-21. PMID: 12480767.
      View in: PubMed
    50. Choi HB, Khoo C, Ryu JK, van Breemen E, Kim SU, McLarnon JG. Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J Neurochem. 2002 Nov; 83(3):546-55. PMID: 12390516.
      View in: PubMed
    51. Ryu JK, Kim J, Choi SH, Oh YJ, Lee YB, Kim SU, Jin BK. ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors. Neuroreport. 2002 Sep 16; 13(13):1611-5. PMID: 12352612.
      View in: PubMed
    52. Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU. Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res. 2002 Aug 01; 69(3):418-26. PMID: 12125082.
      View in: PubMed
    53. Ryu JK, Shin WH, Kim J, Joe EH, Lee YB, Cho KG, Oh YJ, Kim SU, Jin BK. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. 2002 Apr 01; 38(1):15-23. PMID: 11921200.
      View in: PubMed
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