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    James Lee, MD

    SchoolUCSF School of Medicine
    Address505 Parnassus Avenue
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Awards and Honors
      2006 - 2007American Medical Association Seed Grant
      2006 - 2007American Society of Hematology Trainee Award
      2007 - 2008Farr Scholar Award for Leadership and Excellence in Biomedical Research, Yale University
      2008 - 2009American Cancer Society of Connecticut Research Award

      Collapse Overview 
      Collapse Overview
      I am a hematology/oncology fellow with significant research experience in adoptive T cell therapy using chimeric antigen receptors (CARs). My current focus is on the design of next generation CARs for more effective therapy in the setting of a tolerant/suppressive tumor microenvironment in solid malignancies.

      Translating recent advancements in cellular cancer immunotherapy to metastatic solid tumors has been especially challenging, and this is highlighted by the lack clinical response outside of the CD19 ideal antigen as target. Current forms of therapy is likely insufficient to overcome the naturally tolerogenic microenvironment evolved to protect against autoimmunity. Using the liver as a model organ of immune tolerance, I intend to study the mechanism of tumor escape in the setting of checkpoint inhibition and adoptive T cell therapy.

      My hope is to see cellular immunotherapy become a mainstream form of cancer treatment.

      Professional Experience:

      Clinical Instructor, Memorial Sloan-Kettering Cancer Center, New York, NY. July 2012-July 2013

      Clinical Instructor, University of California, San Francisco, CA. July 2013-July 2014


      Medical School: Yale School of Medicine, New Haven, CT. September 2003-May 2009

      Research Fellowship: Memorial Sloan-Kettering Cancer Center, New York, NY. 2006-2009.

      Residency: Mount Sinai Medical Center, New York, NY. July 2009-June 2012

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Holohan DR, Lee JC, Bluestone JA. Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-2. PMID: 26461084.
        View in: PubMed
      2. Lee JC*, Pegram HJ*, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ . . Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012; 18(119):4133-41.
      3. Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, Brentjens R. In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res. 2011 Apr 15; 71(8):2871-81. PMID: 21487038; PMCID: PMC3094720.
      4. Santos EB, Yeh R, Lee J, Nikhamin Y, Punzalan B, Punzalan B, La Perle K, Larson SM, Sadelain M, Brentjens RJ. Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. Nat Med. 2009 Mar; 15(3):338-44. PMID: 19219023; PMCID: PMC2837150.
      5. Lee J, Sadelain M, Brentjens R. Retroviral transduction of murine primary T lymphocytes. Methods Mol Biol. 2009; 506:83-96. PMID: 19110621.
        View in: PubMed
      6. Inventing New CARs: Analysis of Chimeric Antigen Receptor Gene-Targeted T cells Modified to Overcome Regulatory T cell Suppression in the Tumor Microenvironment. Yale University MD Thesis. 2009.
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