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    Jason Cyster, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMicrobiology and Immunology
    AddressCore Campus, HSE
    San Francisco CA
    Phone415-502-6427
    vCardDownload vCard
      Other Positions
      TitleHoward Hughes Investigator


      Collapse Biography 
      Collapse Education and Training
      University of Western AustraliaB.Sc. (Hons)Biochemistry & Microbiology1988
      University of Oxford, EnglandD. Phil.Sir William Dunn School of Pathology1992
      Stanford Univ. Med Center, Stanford, CAPD Fellow1995
      Collapse Awards and Honors
      1996 - 2000Pew Scholar in the Biomedical Sciences
      1998 - 2003David and Lucile Packard Foundation Fellow
      2002NIH MERIT Award
      2005AAI BD Biosciences Investigator Award
      2010Cancer Research Institute Fredrick W. Alt Award
      2011American Association for the Advancement of Science Fellow
      2014Member of the National Academy of Sciences

      Collapse Overview 
      Collapse Overview
      Cell Migration and Interaction Dynamics Underlying Innate and Adaptive Immunity

      Background: The rapid production of antibodies is critical for host defense against pathogens. Reciprocally, antibody responses against self-components are a cause of autoimmune disease. To mount antibody responses, antigen-specific B and T cells that may be as rare as 1 in 100,000 cells must first encounter the antigen and then interact with each other. These encounters occur within lymphoid organs - lymph nodes, spleen, and mucosal lymphoid tissues - but the mechanisms that control immune cell migration and that promote interactions between rare antigen-specific cells are far from understood. Similar challenges exist in understanding the cell migration and interaction dynamics needed for immune defenses at barrier surfaces.

      Major goals: (i) decipher the guidance cue code controlling leukocyte migration and interactions during immune responses; (ii) characterize selection events required for induction of high affinity antibodies; (iii) define the dynamics of antigen encounter and immune responses at epithelial surfaces.

      On-going Research:

      Chemokines and lipid mediators as lymphoid tissue organizers: Chemokines are small secreted chemoattractive proteins that signal via heterotrimeric G-protein coupled receptors (GPCRs). We have demonstrated that several chemokines are expressed in lymphoid organs and function in guiding lymphocyte migration. We have also identified roles for lipid mediators, including an oxysterol, in guiding cell movements necessary for mounting dendritic cell- and T cell-dependent B cell responses. Transgenic and gene knockout experiments in mice are further defining the organizing functions of these guidance factors. Efforts are ongoing using RNAseq, CRISPR/Cas9 knockdown and retroviral over-expression approaches to test the role of novel guidance factors in promoting cell interactions during innate and adaptive immune responses. Based on our work so far, groups in industry are developing small molecule inhibitors of lymphoid chemoattractant receptors to be tested as modulators of the immune response.

      Lymphocyte Egress and the role of S1P: A lot is known about how cells get into tissues from blood, but much less is understood about how they get out. Yet they must get out to mediate their effector function at sites of infection or autoimmune inflammation. In work over the last 10 years we established that the circulatory lipid, sphingosine-1-phosphate (S1P), is critical for this process. Like chemokines, S1P signals via GPCRs, and we found that if lymphocytes lack one of the five S1P receptors, S1PR1, they are unable to leave the thymus or peripheral lymphoid organs. The compound FTY720 disrupts the function of this receptor and inhibits lymphocyte egress. FTY720 (Fingolimod) was FDA approved in 2010 as a treatment for multiple sclerosis. On-going studies, involving molecular, genetic and imaging approaches, are aimed at defining how this GPCR instructs lymphocytes to exit lymphoid organs. Findings from this work are likely to point to new therapeutic targets for inhibition of unwanted immune responses.

      Affinity Maturation and the Germinal Center response: Although first identified in the 1800's, the inner workings of the germinal center - the site of antibody affinity maturation - are still poorly defined. We have found a role for chemokines in organizing the structure into light and dark zones. Using 2-photon microscopy and real-time imaging of intact lymph nodes we have begun to characterize B and T cell migration and interaction dynamics during the selection events associated with this tightly regulated response. In ongoing work we combine perturbations in organizing molecules with methods to measure affinity maturation and 2-photon microscopy-based imaging approaches to further define how selection of high affinity clones - and elimination of low affinity and autoreactive clones - occurs. This work has direct implications for methods to improve vaccine design.

      Barrier Immunity: IgA is a major antibody isotype made at mucosal surfaces and it functions to shape the commensal populations and to protect from gut pathogens. We are studying how B cells encounter and mount responses against mucosal antigens. We are also interested in understanding how chronic mucosal antigen exposure drives sustained germinal center responses and sometimes leads to lymphomagenesis. As well as IgA, the intestine and skin contain large numbers of innate-like lymphocytes that help maintain tissue homeostasis and barrier immunity. In ongoing work, we are studying the migration and response dynamics of innate-like lymphocytes at epithelial surfaces.


      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Awarded Grants
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM, et al. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 Aug 18. PMID: 27540116.
        View in: PubMed
      2. Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016; 5. PMID: 27487469.
        View in: PubMed
      3. Han BY, Foo CS, Wu S, Cyster JG. The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays. Genes Dev. 2016 Jul 1; 30(13):1509-14. PMID: 27401554.
        View in: PubMed
      4. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. PMID: 27174992.
        View in: PubMed
      5. Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med. 2016 May 30; 213(6):993-1009. PMID: 27162138.
        View in: PubMed
      6. Li J, Lu E, Yi T, Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 5; 533(7601):110-4. PMID: 27147029.
        View in: PubMed
      7. Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45. PMID: 27088918.
        View in: PubMed
      8. Cyster JG. Germinal Centers: Gaining Strength from the Dark Side. Immunity. 2015 Dec 15; 43(6):1026-8. PMID: 26682975.
        View in: PubMed
      9. Muppidi JR, Lu E, Cyster JG. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015 Dec 14; 212(13):2213-22. PMID: 26573295.
        View in: PubMed
      10. Rodda LB, Bannard O, Ludewig B, Nagasawa T, Cyster JG. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol. 2015 Nov 15; 195(10):4781-91. PMID: 26453751; PMCID: PMC4637241 [Available on 05/15/16].
      11. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. PMID: 26453377; PMCID: PMC4618158 [Available on 10/20/16].
      12. Cyster JG. Getting close to the action elicits better memories. J Exp Med. 2015 Sep 21; 212(10):1484. PMID: 26392428; PMCID: PMC4577844 [Available on 03/21/16].
      13. Barnes MJ, Li CM, Xu Y, An J, Huang Y, Cyster JG. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015 Jun 29; 212(7):1011-20. PMID: 26077720; PMCID: PMC4493414 [Available on 12/29/15].
      14. Ramírez-Valle F, Gray EE, Cyster JG. Inflammation induces dermal V?4+ ?dT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):8046-51. PMID: 26080440; PMCID: PMC4491769 [Available on 12/30/15].
      15. Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014 Dec 15; 211(13):2567-81. PMID: 25403444; PMCID: PMC4267240.
      16. Wang X, Sumida H, Cyster JG. GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014 Nov 17; 211(12):2351-9. PMID: 25348153; PMCID: PMC4235638.
      17. Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife. 2014; 3. PMID: 25343476; PMCID: PMC4371841.
      18. Cyster JG, Dang EV, Reboldi A, Yi T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43. PMID: 25324126.
        View in: PubMed
      19. Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG. Loss of signalling via Ga13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Dec 11; 516(7530):254-8. PMID: 25274307; PMCID: PMC4267955.
      20. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 8; 345(6197):679-84. PMID: 25104388; PMCID: PMC4289637.
      21. Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30; 211(7):1297-305. PMID: 24913235; PMCID: PMC4076581.
      22. Wang X, Rodda LB, Bannard O, Cyster JG. Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol. 2014 May 15; 192(10):4601-9. PMID: 24740506; PMCID: PMC4056595.
      23. Cyster JG. Blown away: the unexpected role of lymphotoxin in lymphoid organ development. J Immunol. 2014 Mar 1; 192(5):2007-9. PMID: 24563503.
        View in: PubMed
      24. Arnon TI, Cyster JG. Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. Curr Top Microbiol Immunol. 2014; 378:107-28. PMID: 24728595.
        View in: PubMed
      25. Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios? T cells and autoantibodies. Elife. 2013; 2:e01020. PMID: 24336796; PMCID: PMC3858598.
      26. Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013 Nov 14; 39(5):912-24. PMID: 24184055; PMCID: PMC3828484.
      27. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. PMID: 23925290; PMCID: PMC3754256.
      28. Yi T, Cyster JG. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013; 2:e00757. PMID: 23682316; PMCID: PMC3654440.
      29. Schmidt TH, Bannard O, Gray EE, Cyster JG. CXCR4 promotes B cell egress from Peyer's patches. J Exp Med. 2013 Jun 3; 210(6):1099-107. PMID: 23669394; PMCID: PMC3674699.
      30. Gray EE, Ramírez-Valle F, Xu Y, Wu S, Wu Z, Karjalainen KE, Cyster JG. Deficiency in IL-17-committed V?4(+) ?d T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol. 2013 Jun; 14(6):584-92. PMID: 23624556; PMCID: PMC3660499.
      31. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 6; 121(23):4740-8. PMID: 23570798; PMCID: PMC3674672.
      32. Arnon TI, Horton RM, Grigorova IL, Cyster JG. Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. 2013 Jan 31; 493(7434):684-8. PMID: 23263181; PMCID: PMC3561487.
      33. Matloubian M, Cyster JG. Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6. PMID: 23244716; PMCID: PMC3540980.
      34. Yi T, Wang X, Kelly LM, An J, Xu Y, Sailer AW, Gustafsson JA, Russell DW, Cyster JG. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012 Sep 21; 37(3):535-48. PMID: 22999953; PMCID: PMC3465460.
      35. Bannard OM, Cyster JG. Immunology. When less signaling is more. Science. 2012 Jun 1; 336(6085):1120-1. PMID: 22654048.
        View in: PubMed
      36. Gray EE, Friend S, Suzuki K, Phan TG, Cyster JG. Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One. 2012; 7(6):e38258. PMID: 22675532; PMCID: PMC3365896.
      37. Green JA, Cyster JG. S1PR2 links germinal center confinement and growth regulation. Immunol Rev. 2012 May; 247(1):36-51. PMID: 22500830; PMCID: PMC3335345.
      38. Gray EE, Cyster JG. Lymph node macrophages. J Innate Immun. 2012; 4(5-6):424-36. PMID: 22488251; PMCID: PMC3574571.
      39. Cyster JG, Schwab SR. Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu Rev Immunol. 2012; 30:69-94. PMID: 22149932.
        View in: PubMed
      40. Vinuesa CG, Cyster JG. How T cells earn the follicular rite of passage. Immunity. 2011 Nov 23; 35(5):671-80. PMID: 22118524.
        View in: PubMed
      41. Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, Pham TH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ. DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol. 2011 Dec; 41(12):3423-35. PMID: 21969276; PMCID: PMC3517112.
      42. Wang X, Cho B, Suzuki K, Xu Y, Green JA, An J, Cyster JG. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J Exp Med. 2011 Nov 21; 208(12):2497-510. PMID: 22042977; PMCID: PMC3256970.
      43. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. PMID: 21960637; PMCID: PMC3267326.
      44. Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med. 2011 Sep 26; 208(10):1941-8. PMID: 21875957; PMCID: PMC3182059.
      45. Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol. 2011 Sep 15; 187(6):3026-32. PMID: 21844396; PMCID: PMC3169736.
      46. Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 28; 475(7357):524-7. PMID: 21796212; PMCID: PMC4297623.
      47. Zhi L, Kim P, Thompson BD, Pitsillides C, Bankovich AJ, Yun SH, Lin CP, Cyster JG, Wu MX. FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol. 2011 Sep 1; 187(5):2244-51. PMID: 21788441; PMCID: PMC3167479.
      48. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jul; 12(7):672-80. PMID: 21642988; PMCID: PMC3158008.
      49. Beltman JB, Allen CD, Cyster JG, de Boer RJ. B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8755-60. PMID: 21555569; PMCID: PMC3102384.
      50. Gray EE, Suzuki K, Cyster JG. Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis. J Immunol. 2011 Jun 1; 186(11):6091-5. PMID: 21536803; PMCID: PMC3098921.
      51. Link A, Hardie DL, Favre S, Britschgi MR, Adams DH, Sixt M, Cyster JG, Buckley CD, Luther SA. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am J Pathol. 2011 Apr; 178(4):1662-75. PMID: 21435450; PMCID: PMC3070229.
      52. Cyster JG. Shining a light on germinal center B cells. Cell. 2010 Nov 12; 143(4):503-5. PMID: 21074042.
        View in: PubMed
      53. Grigorova IL, Panteleev M, Cyster JG. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20447-52. PMID: 21059923; PMCID: PMC2996652.
      54. Cyster JG. B cell follicles and antigen encounters of the third kind. Nat Immunol. 2010 Nov; 11(11):989-96. PMID: 20959804.
        View in: PubMed
      55. Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 2010 Sep 23; 467(7314):460-4. PMID: 20827270; PMCID: PMC3657719.
      56. Cyster JG. Visualizing influenza virus capture in the lymph node following vaccination. Immunol Cell Biol. 2010 Aug; 88(6):617-9. PMID: 20531362.
        View in: PubMed
      57. Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol. 2010 Jun; 22(6):413-9. PMID: 20508253; PMCID: PMC2877811.
      58. Bankovich AJ, Shiow LR, Cyster JG. CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J Biol Chem. 2010 Jul 16; 285(29):22328-37. PMID: 20463015; PMCID: PMC2903414.
      59. Zachariah MA, Cyster JG. Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science. 2010 May 28; 328(5982):1129-35. PMID: 20413455; PMCID: PMC3107339.
      60. Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest. 2010 Mar; 120(3):883-93. PMID: 20179354; PMCID: PMC2827959.
      61. Pereira JP, Xu Y, Cyster JG. A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One. 2010; 5(2):e9277. PMID: 20174580; PMCID: PMC2823786.
      62. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. PMID: 20026661; PMCID: PMC2812554.
      63. Randall KL, Lambe T, Johnson AL, Johnson A, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol. 2009 Dec; 10(12):1283-91. PMID: 19898472; PMCID: PMC3437189.
      64. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009 Oct 26; 206(11):2469-81. PMID: 19808259; PMCID: PMC2768857.
      65. Zachariah MA, Cyster JG. Thymic egress: S1P of 1000. F1000 Biol Rep. 2009; 1:60. PMID: 20948623; PMCID: PMC2948249.
      66. Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature. 2009 Aug 27; 460(7259):1122-6. PMID: 19597478; PMCID: PMC2809436.
      67. Suzuki K, Grigorova I, Phan TG, Kelly LM, Cyster JG. Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med. 2009 Jul 6; 206(7):1485-93. PMID: 19506051; PMCID: PMC2715076.
      68. Phan TG, Green JA, Gray EE, Xu Y, Cyster JG. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol. 2009 Jul; 10(7):786-93. PMID: 19503106; PMCID: PMC2776777.
      69. Phan TG, Gray EE, Cyster JG. The microanatomy of B cell activation. Curr Opin Immunol. 2009 Jun; 21(3):258-65. PMID: 19481917; PMCID: PMC3736860.
      70. Cyster JG. Settling the thymus: immigration requirements. J Exp Med. 2009 Apr 13; 206(4):731-4. PMID: 19349460; PMCID: PMC2715109.
      71. Pereira JP, An J, Xu Y, Huang Y, Cyster JG. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol. 2009 Apr; 10(4):403-11. PMID: 19252491; PMCID: PMC2768754.
      72. Shiow LR, Paris K, Akana MC, Cyster JG, Sorensen RU, Puck JM. Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. Clin Immunol. 2009 Apr; 131(1):24-30. PMID: 19097825; PMCID: PMC2692687.
      73. Grigorova IL, Schwab SR, Phan TG, Pham TH, Okada T, Cyster JG. Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol. 2009 Jan; 10(1):58-65. PMID: 19060900; PMCID: PMC2710451.
      74. Khiem D, Cyster JG, Schwarz JJ, Black BL. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):17067-72. PMID: 18955699; PMCID: PMC2579379.
      75. Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol. 2008 Nov; 9(11):1307-15. PMID: 18836449; PMCID: PMC2672406.
      76. Allen CD, Cyster JG. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol. 2008 Feb; 20(1):14-25. PMID: 18261920; PMCID: PMC2366796.
      77. Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity. 2008 Jan; 28(1):122-33. PMID: 18164221; PMCID: PMC2691390.
      78. Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol. 2007 Dec; 8(12):1295-301. PMID: 18026082.
        View in: PubMed
      79. Cinamon G, Zachariah MA, Lam OM, Foss FW, Cyster JG. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol. 2008 Jan; 9(1):54-62. PMID: 18037889; PMCID: PMC2488964.
      80. Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108. PMID: 17911595.
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      81. Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG, Luther SA. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007 Nov; 8(11):1255-65. PMID: 17893676.
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      82. Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol. 2007 Oct; 8(10):1076-85. PMID: 17721537.
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      83. Allen CD, Okada T, Cyster JG. Germinal-center organization and cellular dynamics. Immunity. 2007 Aug; 27(2):190-202. PMID: 17723214; PMCID: PMC2242846.
      84. Phan TG, Grigorova I, Okada T, Cyster JG. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol. 2007 Sep; 8(9):992-1000. PMID: 17660822.
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      85. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13; 316(5822):295-8. PMID: 17363629.
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      86. Okada T, Cyster JG. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol. 2007 Mar 1; 178(5):2973-8. PMID: 17312142.
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      87. Cyster JG. Specifying the patterns of immune cell migration. Novartis Found Symp. 2007; 281:54-61; discussion 61-4, 208-9. PMID: 17534065.
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      88. Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science. 2007 Jan 26; 315(5811):528-31. PMID: 17185562.
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      89. Kabashima K, Haynes NM, Xu Y, Nutt SL, Allende ML, Proia RL, Cyster JG. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med. 2006 Nov 27; 203(12):2683-90. PMID: 17101733; PMCID: PMC2118149.
      90. Silver K, Bouriez-Jones T, Crockford T, Ferry H, Tang HL, Cyster JG, Cornall RJ. Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice. Eur J Immunol. 2006 Nov; 36(11):2920-7. PMID: 17039569.
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      91. Lesley R, Kelly LM, Xu Y, Cyster JG. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10717-22. PMID: 16815973; PMCID: PMC1484418.
      92. Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006 Mar 23; 440(7083):540-4. PMID: 16525420.
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      93. Okada T, Cyster JG. B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol. 2006 Jun; 18(3):278-85. PMID: 16516453.
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      94. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65. PMID: 16203866; PMCID: PMC2213179.
      95. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9; 309(5741):1735-9. PMID: 16151014.
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      96. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150. PMID: 15857154; PMCID: PMC1088276.
      97. Kabashima K, Banks TA, Ansel KM, Lu TT, Ware CF, Cyster JG. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity. 2005 Apr; 22(4):439-50. PMID: 15845449.
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      98. Lo CG, Xu Y, Proia RL, Cyster JG. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med. 2005 Jan 17; 201(2):291-301. PMID: 15657295; PMCID: PMC2212802.
      99. Cyster JG. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol. 2005; 23:127-59. PMID: 15771568.
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      100. Cupedo T, Lund FE, Ngo VN, Randall TD, Jansen W, Greuter MJ, de Waal-Malefyt R, Kraal G, Cyster JG, Mebius RE. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol. 2004 Oct 15; 173(8):4889-96. PMID: 15470030.
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      101. Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG. Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 2004 Aug 15; 173(4):2236-40. PMID: 15294934.
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      102. Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004 Sep; 5(9):943-52. PMID: 15300245.
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      103. Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant. 2004 Jul; 4(7):1019-25. PMID: 15196057.
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      104. Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol. 2004 Jun 15; 172(12):7647-53. PMID: 15187146.
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      105. Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 2004 Jul; 5(7):713-20. PMID: 15184895.
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      106. Bistrup A, Tsay D, Shenoy P, Singer MS, Bangia N, Luther SA, Cyster JG, Ruddle NH, Rosen SD. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol. 2004 May; 164(5):1635-44. PMID: 15111310; PMCID: PMC1615668.
      107. Ekland EH, Forster R, Lipp M, Cyster JG. Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol. 2004 Apr 15; 172(8):4700-8. PMID: 15067045.
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      108. Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, Cyster JG. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 2004 Apr; 20(4):441-53. PMID: 15084273.
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      109. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22; 427(6972):355-60. PMID: 14737169.
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      110. Cyster JG. Lymphoid organ development and cell migration. Immunol Rev. 2003 Oct; 195:5-14. PMID: 12969306.
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      111. Cyster JG. Homing of antibody secreting cells. Immunol Rev. 2003 Aug; 194:48-60. PMID: 12846807.
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      112. Pape KA, Kouskoff V, Nemazee D, Tang HL, Cyster JG, Tze LE, Hippen KL, Behrens TW, Jenkins MK. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med. 2003 Jun 16; 197(12):1677-87. PMID: 12796466; PMCID: PMC2193962.
      113. Luther SA, Ansel KM, Cyster JG. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003 May 5; 197(9):1191-8. PMID: 12732660; PMCID: PMC2193976.
      114. Lo CG, Lu TT, Cyster JG. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 2003 Feb 3; 197(3):353-61. PMID: 12566419; PMCID: PMC2193837.
      115. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
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      116. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol. 2002 Dec; 3(12):1135-41. PMID: 12415265.
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      117. Reif K, Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol. 2002 Aug; 12(8):368-73. PMID: 12191913.
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      118. Lu TT, Cyster JG. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science. 2002 Jul 19; 297(5580):409-12. PMID: 12130787.
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      119. Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 1; 169(1):424-33. PMID: 12077273.
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      120. Okada T, Ngo VN, Ekland EH, Förster R, Lipp M, Littman DR, Cyster JG. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med. 2002 Jul 1; 196(1):65-75. PMID: 12093871; PMCID: PMC2194009.
      121. Yu P, Wang Y, Chin RK, Martinez-Pomares L, Gordon S, Kosco-Vibois MH, Cyster J, Fu YX. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol. 2002 May 15; 168(10):5117-23. PMID: 11994465.
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      122. Cyster JG. Chemorepulsion and thymocyte emigration. J Clin Invest. 2002 Apr; 109(8):1011-2. PMID: 11956237; PMCID: PMC150955.
      123. Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 2002 Mar 7; 416(6876):94-9. PMID: 11882900.
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      124. Ansel KM, Harris RB, Cyster JG. CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity. 2002 Jan; 16(1):67-76. PMID: 11825566.
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      125. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. PMID: 12405185.
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      126. Ngo VN, Cornall RJ, Cyster JG. Splenic T zone development is B cell dependent. J Exp Med. 2001 Dec 3; 194(11):1649-60. PMID: 11733579; PMCID: PMC2193532.
      127. Ruuls SR, Hoek RM, Ngo VN, McNeil T, Lucian LA, Janatpour MJ, Körner H, Scheerens H, Hessel EM, Cyster JG, McEvoy LM, Sedgwick JD. Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. Immunity. 2001 Oct; 15(4):533-43. PMID: 11672536.
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      128. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med. 2001 Jul 2; 194(1):45-56. PMID: 11435471; PMCID: PMC2193440.
      129. Ansel KM, Cyster JG. Chemokines in lymphopoiesis and lymphoid organ development. Curr Opin Immunol. 2001 Apr; 13(2):172-9. PMID: 11228410.
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      130. Luther SA, Cyster JG. Chemokines as regulators of T cell differentiation. Nat Immunol. 2001 Feb; 2(2):102-7. PMID: 11175801.
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      131. Luther SA, Tang HL, Hyman PL, Farr AG, Cyster JG. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc Natl Acad Sci U S A. 2000 Nov 7; 97(23):12694-9. PMID: 11070085; PMCID: PMC18826.
      132. Matloubian M, David A, Engel S, Ryan JE, Cyster JG. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct; 1(4):298-304. PMID: 11017100.
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      133. Cyster JG, Ansel KM, Reif K, Ekland EH, Hyman PL, Tang HL, Luther SA, Ngo VN. Follicular stromal cells and lymphocyte homing to follicles. Immunol Rev. 2000 Aug; 176:181-93. PMID: 11043777.
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      134. Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000 Jul 20; 406(6793):309-14. PMID: 10917533.
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      135. Cyster JG. B cells on the front line. Nat Immunol. 2000 Jul; 1(1):9-10. PMID: 10881164.
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      136. Reif K, Cyster JG. RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines. J Immunol. 2000 May 1; 164(9):4720-9. PMID: 10779778.
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      137. Luther SA, Lopez T, Bai W, Hanahan D, Cyster JG. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity. 2000 May; 12(5):471-81. PMID: 10843380.
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      138. Sedgwick JD, Riminton DS, Cyster JG, Körner H. Tumor necrosis factor: a master-regulator of leukocyte movement. Immunol Today. 2000 Mar; 21(3):110-3. PMID: 10689296.
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      139. Cyster JG. Leukocyte migration: scent of the T zone. Curr Biol. 2000 Jan 13; 10(1):R30-3. PMID: 10660291.
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      140. Cyster JG. Chemokines and cell migration in secondary lymphoid organs. Science. 1999 Dec 10; 286(5447):2098-102. PMID: 10617422.
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      141. Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med. 1999 Oct 18; 190(8):1123-34. PMID: 10523610; PMCID: PMC2195660.
      142. Tang HL, Cyster JG. Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells. Science. 1999 Apr 30; 284(5415):819-22. PMID: 10221917.
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      143. Cyster JG. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J Exp Med. 1999 Feb 1; 189(3):447-50. PMID: 9927506; PMCID: PMC2192905.
      144. Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med. 1999 Jan 18; 189(2):403-12. PMID: 9892622; PMCID: PMC2192983.
      145. Cornall RJ, Goodnow CC, Cyster JG. Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway. Curr Top Microbiol Immunol. 1999; 244:57-68. PMID: 10453649.
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      146. Cyster JG, Ngo VN, Ekland EH, Gunn MD, Sedgwick JD, Ansel KM. Chemokines and B-cell homing to follicles. Curr Top Microbiol Immunol. 1999; 246:87-92; discussion 93. PMID: 10396043.
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      147. Schmidt KN, Cyster JG. Follicular exclusion and rapid elimination of hen egg lysozyme autoantigen-binding B cells are dependent on competitor B cells, but not on T cells. J Immunol. 1999 Jan 1; 162(1):284-91. PMID: 9886397.
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      148. Cook MC, Körner H, Riminton DS, Lemckert FA, Hasbold J, Amesbury M, Hodgkin PD, Cyster JG, Sedgwick JD, Basten A. Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice. J Exp Med. 1998 Oct 19; 188(8):1503-10. PMID: 9782127; PMCID: PMC2213402.
      149. Ngo VN, Tang HL, Cyster JG. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med. 1998 Jul 6; 188(1):181-91. PMID: 9653094; PMCID: PMC2525549.
      150. Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA, Goodnow CC. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity. 1998 Apr; 8(4):497-508. PMID: 9586639.
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      151. Schmidt KN, Hsu CW, Griffin CT, Goodnow CC, Cyster JG. Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. J Exp Med. 1998 Mar 16; 187(6):929-37. PMID: 9500795; PMCID: PMC2212192.
      152. Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998 Feb 19; 391(6669):799-803. PMID: 9486651.
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      153. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):258-63. PMID: 9419363; PMCID: PMC18193.
      154. Cyster JG, Goodnow CC. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity. 1997 May; 6(5):509-17. PMID: 9175829.
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      155. Goodnow CC, Cyster JG. Lymphocyte homing: the scent of a follicle. Curr Biol. 1997 Apr 1; 7(4):R219-22. PMID: 9162495.
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      156. Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 1997 Apr; 6(4):419-28. PMID: 9133421.
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      157. Cyster JG. Signaling thresholds and interclonal competition in preimmune B-cell selection. Immunol Rev. 1997 Apr; 156:87-101. PMID: 9176702.
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      158. Cyster JG, Healy JI, Kishihara K, Mak TW, Thomas ML, Goodnow CC. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature. 1996 May 23; 381(6580):325-8. PMID: 8692271.
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      159. Cornall RJ, Goodnow CC, Cyster JG. The regulation of self-reactive B cells. Curr Opin Immunol. 1995 Dec; 7(6):804-11. PMID: 8679124.
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      160. Cyster JG, Goodnow CC. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. 1995 Dec; 3(6):691-701. PMID: 8777715.
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      161. Cyster JG, Goodnow CC. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. J Exp Med. 1995 Aug 1; 182(2):581-6. PMID: 7629515; PMCID: PMC2192114.
      162. Cyster JG, Goodnow CC. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity. 1995 Jan; 2(1):13-24. PMID: 7600299.
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      163. Goodnow CC, Cyster JG, Hartley SB, Bell SE, Cooke MP, Healy JI, Akkaraju S, Rathmell JC, Pogue SL, Shokat KP. Self-tolerance checkpoints in B lymphocyte development. Adv Immunol. 1995; 59:279-368. PMID: 7484462.
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      164. Cyster JG, Fowell D, Barclay AN. Antigenic determinants encoded by alternatively spliced exons of CD45 are determined by the polypeptide but influenced by glycosylation. Int Immunol. 1994 Dec; 6(12):1875-81. PMID: 7535096.
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      165. Cyster JG, Hartley SB, Goodnow CC. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 1994 Sep 29; 371(6496):389-95. PMID: 7522305.
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      166. Gray F, Cyster JG, Willis AC, Barclay AN, Williams AF. Structural analysis of the CD2 T lymphocyte antigen by site-directed mutagenesis to introduce a disulphide bond into domain 1. Protein Eng. 1993 Nov; 6(8):965-70. PMID: 7508627.
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      167. Driscoll PC, Cyster JG, Somoza C, Crawford DA, Howe P, Harvey TS, Kieffer B, Campbell ID, Williams AF. Structure-function studies of CD2 by n.m.r. and mutagenesis. Biochem Soc Trans. 1993 Nov; 21(4):947-52. PMID: 7907561.
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      168. Somoza C, Driscoll PC, Cyster JG, Williams AF. Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2. J Exp Med. 1993 Aug 1; 178(2):549-58. PMID: 7688025; PMCID: PMC2191138.
      169. van der Merwe PA, McPherson DC, Brown MH, Barclay AN, Cyster JG, Williams AF, Davis SJ. The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2. Eur J Immunol. 1993 Jun; 23(6):1373-7. PMID: 8099016.
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      170. Cyster JG, Williams AF. The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies. Eur J Immunol. 1992 Oct; 22(10):2565-72. PMID: 1382990.
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      171. Greene WK, Cyster JG, Chua KY, O'Brien RM, Thomas WR. IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I. J Immunol. 1991 Dec 1; 147(11):3768-73. PMID: 1940366.
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      172. Driscoll PC, Cyster JG, Campbell ID, Williams AF. Structure of domain 1 of rat T lymphocyte CD2 antigen. Nature. 1991 Oct 24; 353(6346):762-5. PMID: 1682812.
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      173. Cyster JG, Shotton DM, Williams AF. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 1991 Apr; 10(4):893-902. PMID: 1706994; PMCID: PMC452732.
      174. Cyster J, Somoza C, Killeen N, Williams AF. Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr; 20(4):875-81. PMID: 2347365.
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