Jeffrey Mugridge, PhD

TitleAssociate Specialist
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address600 16th St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of ChicagoBS (Honors)2006Chemistry
    University of California, BerkeleyPhD2010Chemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Structural basis of mRNA decapping by Dcp2: conformational changes &co-activator
    NIH/NIGMS F32GM105313Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sgarlata C, Mugridge JS, Pluth MD, Zito V, Arena G, Raymond K. Different and often opposing forces drive the encapsulation and multiple exterior binding of charged guests to a M4L6 supramolecular vessel in water. Chemistry. 2017 Sep 12. PMID: 28898458.
      View in: PubMed
    2. Mugridge JS, Ziemniak M, Jemielity J, Gross JD. Structural basis of mRNA-cap recognition by Dcp1-Dcp2. Nat Struct Mol Biol. 2016 Nov; 23(11):987-994. PMID: 27694842.
      View in: PubMed
    3. Ziemniak M, Mugridge JS, Kowalska J, Rhoads RE, Gross JD, Jemielity J. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex. RNA. 2016 Apr; 22(4):518-29. PMID: 26826132; PMCID: PMC4793208 [Available on 04/01/17].
    4. Mugridge JS, Gross JD. Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control. Mol Cell. 2013 Apr 11; 50(1):2-4. PMID: 23582258; PMCID: PMC3665275.
    5. Mugridge JS, Zahl A, van Eldik R, Bergman RG, Raymond KN. Solvent and pressure effects on the motions of encapsulated guests: tuning the flexibility of a supramolecular host. J Am Chem Soc. 2013 Mar 20; 135(11):4299-306. PMID: 23391095.
      View in: PubMed
    6. Mugridge JS, Bergman RG, Raymond KN. Equilibrium isotope effects on noncovalent interactions in a supramolecular host-guest system. J Am Chem Soc. 2012 Feb 01; 134(4):2057-66. PMID: 22145944.
      View in: PubMed
    7. Mugridge JS, Bergman RG, Raymond KN. 1H NMR chemical shift calculations as a probe of supramolecular host-guest geometry. J Am Chem Soc. 2011 Jul 27; 133(29):11205-12. PMID: 21714506.
      View in: PubMed
    8. Mugridge JS, Szigethy G, Bergman RG, Raymond KN. Encapsulated guest-host dynamics: guest rotational barriers and tumbling as a probe of host interior cavity space. J Am Chem Soc. 2010 Nov 17; 132(45):16256-64. PMID: 20977233.
      View in: PubMed
    9. Mugridge JS, Bergman RG, Raymond KN. Does size really matter? The steric isotope effect in a supramolecular host-guest exchange reaction. Angew Chem Int Ed Engl. 2010 May 10; 49(21):3635-7. PMID: 20394089.
      View in: PubMed
    10. Sun J, Shaner SE, Jones MK, O'Hanlon DC, Mugridge JS, Hopkins MD. Synthesis, structures, bonding, and redox chemistry of ditungsten butadiyne complexes with W[triple bond]C-C[triple bond]W backbones. Inorg Chem. 2010 Feb 15; 49(4):1687-98. PMID: 20095626.
      View in: PubMed
    11. Mugridge JS, Bergman RG, Raymond KN. High-precision measurement of isotope effects on noncovalent host-guest interactions. J Am Chem Soc. 2010 Feb 03; 132(4):1182-3. PMID: 20050653.
      View in: PubMed
    12. Sgarlata C, Mugridge JS, Pluth MD, Tiedemann BE, Zito V, Arena G, Raymond KN. External and internal guest binding of a highly charged supramolecular host in water: deconvoluting the very different thermodynamics. J Am Chem Soc. 2010 Jan 27; 132(3):1005-9. PMID: 20043697.
      View in: PubMed
    13. Pluth MD, Fiedler D, Mugridge JS, Bergman RG, Raymond KN. Molecular recognition and self-assembly special feature: Encapsulation and characterization of proton-bound amine homodimers in a water-soluble, self-assembled supramolecular host. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10438-43. PMID: 19181859; PMCID: PMC2705522.
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