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    Jeffrey Martin, MD, MPH

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentEpidemiology & Biostatistics
    Address550 16th Street, 2nd Floor
    San Francisco CA 94158
    Phone415-514-8010
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency Internal Medicine

      Collapse Overview 
      Collapse Overview
      Dr. Martin is professor in the Department of Epidemiology and Biostatistics at the University of California, San Francisco (UCSF), and an attending physician at San Francisco General Hospital (SFGH). His clinical training is in internal medicine and infectious diseases, and he attends at the SFGH HIV/AIDS program clinic. He is formally trained in clinical and epidemiologic research methods at UC Berkeley, where he earned a master of public health degree in epidemiology. He is currently director of UCSF's NIH-funded Training in Clinical Research (TICR) program, in which he serves as director of the UCSF Advanced Training in Clinical Research (ATCR) certificate program and the UCSF Master's Degree Program in clinical research.

      Dr. Martin's research methodology is best characterized as clinical or epidemiologic, using epidemiologic methods to derive biologic and clinical inferences. His substantive area of interest is infectious diseases, with a special focus on HIV infection and its complications, notably Kaposi's sarcoma (KS) and Kaposi's sarcoma–associated herpesvirus (KSHV) infection. All of his work is collaborative and multidisciplinary; indeed, all of his projects are built specifically as robust platforms to support a variety of collaborative projects. Because of the compelling nature of the HIV epidemic in Africa, much of his work in the past several years has centered there.

      Dr. Martin's principal current domestic research project involves direction, along with Dr. Steven Deeks, of the NIH-sponsored Study of the Consequences of the Protease Inhibitor Era (SCOPE), a prospective cohort of HIV-infected adults. SCOPE was established to conduct translational research related to HIV, with the overarching objectives to provide research access to a group of well-characterized, contemporary HIV-infected patients of diverse demographic and clinical status; and methodologic guidance to other researchers in the design and analysis of projects using the cohort's data and biological specimens. As a broad platform, SCOPE has given rise to a large variety of research studies across clinical, virologic, immunologic, and behavioral domains. Since SCOPE's inception, it has provided data or specimens to several hundred investigators nationwide. SCOPE also serves as a fertile training ground, with many faculty members owning NIH K awards that depend on the cohort.

      Dr. Martin heads several ongoing projects in Africa. The first is an NIH-funded randomized clinical trial in Kampala, Uganda, of two therapeutic strategies to treat KS. In sub-Saharan Africa, the intersection of the HIV epidemic and endemic KSHV infection has made KS the most common adult malignancy in the region. In patients with KS in resource-rich areas, use of highly active antiretroviral therapy (HAART) often causes regression of KS even in the absence of conventional chemotherapy. However, it is unknown which specific antiretroviral drugs are critical to convey HAART's effect on KS. Data from in vitro systems and animal models suggest that protease inhibitors — originally developed to block the active site of HIV protease — also have direct anti-KS effects. To test this hypothesis, Dr. Martin's multidisciplinary team from UCSF, Makerere University in Uganda, and the CDC is comparing two different HAART regimens among 224 patients with AIDS-related KS. KSHV-specific virologic and immunologic responses after HAART are also being evaluated.

      The second project in Africa investigates fundamental epidemiologic aspects of KSHV. Dr. Martin and colleagues are investigating patterns of KSHV seroprevalence, peak age of incident infection, the clinical virology of KSHV (i.e., anatomic sites of viral shedding), and routes of KSHV transmission in population-based samples of children and adults in South Africa, Zimbabwe, and Uganda.

      Dr. Martin and colleagues have recently initiated two large cohort studies in Mbarara, Uganda, related to the unprecedented scale-up of antiretroviral therapy. The Uganda AIDS Rural Treatment Outcomes (UARTO) cohort consists of 500 HIV-infected adults who are initiating HAART. Patterned after the SCOPE cohort, UARTO features rigorous research-level questionnaires and biological specimen collection; the focus is translational research. The second study includes all HIV-infected adults — 11,200 currently — at the municipal HIV clinic in Mbarara. In this clinic-based cohort, measurements made during clinical care are captured in an electronic medical record. In both cohorts, the objective is to understand the virologic, immunologic, and clinical outcomes and determinants of patients beginning HAART. The clinic-based cohort is part of a larger network of African HIV clinics whose data are aggregated by the NIH International Epidemiologic Databases to Evaluate AIDS (IeDEA) project. As with the domestic cohorts, the African cohorts are an efficient platform for trainees.

      Collapse Interests
      Implementation Science, Socioeconomically marginalized groups, International (public health), Education, Audit and feedback, HIV infection, Kaposi's sarcoma, Mentoring junior faculty or trainees, Interdisciplinary research collaboration, Implementation & dissemination science listservs

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      Collapse In The News
      Collapse NIH Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hunt PW, Sinclair E, Rodriguez B, Shive C, Clagett B, Funderburg N, Robinson J, Huang Y, Epling L, Martin JN, Deeks SG, Meinert CL, Van Natta ML, Jabs DA, Lederman MM. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis. 2014 Oct 15; 210(8):1228-38.
        View in: PubMed
      2. Byakwaga H, Boum Y, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW. The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. J Infect Dis. 2014 Aug 1; 210(3):383-91.
        View in: PubMed
      3. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis. 2014 Aug 1; 210(3):374-82.
        View in: PubMed
      4. Burbelo PD, Bayat A, Rhodes CS, Hoh R, Martin JN, Fromentin R, Chomont N, Hütter G, Kovacs JA, Deeks SG. HIV antibody characterization as a method to quantify reservoir size during curative interventions. J Infect Dis. 2014 May 15; 209(10):1613-7.
        View in: PubMed
      5. Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J Infect Dis. 2013 Nov 1; 208(9):1436-42.
        View in: PubMed
      6. Unemori P, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, Effros RB, Dock J, Dollard SG, Deeks SG, Martin JN, Maurer TA. Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection. AIDS. 2013 Jul 17; 27(11):1735-42.
        View in: PubMed
      7. Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. J Infect Dis. 2013 Jul; 208(1):50-6.
        View in: PubMed
      8. Semeere AS, Busakhala N, Martin JN. Impact of antiretroviral therapy on the incidence of Kaposi's sarcoma in resource-rich and resource-limited settings. Curr Opin Oncol. 2012 Sep; 24(5):522-30.
        View in: PubMed
      9. Sterling TR, Lau B, Zhang J, Freeman A, Bosch RJ, Brooks JT, Deeks SG, French A, Gange S, Gebo KA, John Gill M, Horberg MA, Jacobson LP, Kirk GD, Kitahata MM, Klein MB, Martin JN, Rodriguez B, Silverberg MJ, Willig JH, Eron JJ, Goedert JJ, Hogg RS, Justice AC, McKaig RG, Napravnik S, Thorne J, Moore RD. Risk factors for tuberculosis after highly active antiretroviral therapy initiation in the United States and Canada: implications for tuberculosis screening. J Infect Dis. 2011 Sep 15; 204(6):893-901.
        View in: PubMed
      10. Hunt PW, Martin JN, Sinclair E, Epling L, Teague J, Jacobson MA, Tracy RP, Corey L, Deeks SG. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis. 2011 May 15; 203(10):1474-83.
        View in: PubMed
      11. Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011 Apr 1; 203(7):960-8.
        View in: PubMed
      12. Dollard SC, Butler LM, Jones AM, Mermin JH, Chidzonga M, Chipato T, Shiboski CH, Brander C, Mosam A, Kiepiela P, Hladik W, Martin JN. Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt". Int J Cancer. 2010 Nov 15; 127(10):2395-401.
        View in: PubMed
      13. Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD. Intracellular Casp8p41 content is inversely associated with CD4 T cell count. J Infect Dis. 2010 Aug 15; 202(3):386-91.
        View in: PubMed
      14. Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN. Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. J Infect Dis. 2009 Aug 1; 200(3):430-8.
        View in: PubMed
      15. Butler LM, Osmond DH, Jones AG, Martin JN. Use of saliva as a lubricant in anal sexual practices among homosexual men. J Acquir Immune Defic Syndr. 2009 Feb 1; 50(2):162-7.
        View in: PubMed
      16. Phillips AM, Jones AG, Osmond DH, Pollack LM, Catania JA, Martin JN. Awareness of Kaposi's sarcoma-associated herpesvirus among men who have sex with men. Sex Transm Dis. 2008 Dec; 35(12):1011-4.
        View in: PubMed
      17. Hsue PY, Deeks SG, Farah HH, Palav S, Ahmed SY, Schnell A, Ellman AB, Huang L, Dollard SC, Martin JN. Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension. AIDS. 2008 Apr 23; 22(7):825-33.
        View in: PubMed
      18. Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, Page-Shafer K, Hsue P, Emu B, Krone M, Lampiris H, Douek D, Martin JN, Deeks SG. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis. 2008 Jan 1; 197(1):126-33.
        View in: PubMed
      19. Martin JN. Moving toward clarity on 2 fronts in the epidemiology of Kaposi sarcoma-associated herpesvirus infection. J Infect Dis. 2007 Jul 15; 196(2):173-5.
        View in: PubMed
      20. Ray N, Harrison JE, Blackburn LA, Martin JN, Deeks SG, Doms RW. Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors. J Virol. 2007 Apr; 81(7):3240-50.
        View in: PubMed
      21. Deeks SG, Lu J, Hoh R, Neilands TB, Beatty G, Huang W, Liegler T, Hunt P, Martin JN, Kuritzkes DR. Interruption of enfuvirtide in HIV-1 infected adults with incomplete viral suppression on an enfuvirtide-based regimen. J Infect Dis. 2007 Feb 1; 195(3):387-91.
        View in: PubMed
      22. Hunt PW, Harrigan PR, Huang W, Bates M, Williamson DW, McCune JM, Price RW, Spudich SS, Lampiris H, Hoh R, Leigler T, Martin JN, Deeks SG. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. J Infect Dis. 2006 Oct 1; 194(7):926-30.
        View in: PubMed
      23. Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos CJ, Hecht FM. Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses. J Virol. 2006 Jun; 80(12):6155-64.
        View in: PubMed
      24. Deeks SG, Hoh R, Neilands TB, Liegler T, Aweeka F, Petropoulos CJ, Grant RM, Martin JN. Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J Infect Dis. 2005 Nov 1; 192(9):1537-44.
        View in: PubMed
      25. Roland ME, Elbeik TA, Kahn JO, Bamberger JD, Coates TJ, Krone MR, Katz MH, Busch MP, Martin JN. HIV RNA testing in the context of nonoccupational postexposure prophylaxis. J Infect Dis. 2004 Aug 1; 190(3):598-604.
        View in: PubMed
      26. Deeks SG, Martin JN, Sinclair E, Harris J, Neilands TB, Maecker HT, Hagos E, Wrin T, Petropoulos CJ, Bredt B, McCune JM. Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1. J Infect Dis. 2004 Jan 15; 189(2):312-21.
        View in: PubMed
      27. Porco TC, Martin JN, Page-Shafer KA, Cheng A, Charlebois E, Grant RM, Osmond DH. Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS. 2004 Jan 2; 18(1):81-8.
        View in: PubMed
      28. Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E, Lampiris H, Deeks SG. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003 May 15; 187(10):1534-43.
        View in: PubMed
      29. Martin JN. Diagnosis and epidemiology of human herpesvirus 8 infection. Semin Hematol. 2003 Apr; 40(2):133-42.
        View in: PubMed
      30. Osmond DH, Buchbinder S, Cheng A, Graves A, Vittinghoff E, Cossen CK, Forghani B, Martin JN. Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA. 2002 Jan 9; 287(2):221-5.
        View in: PubMed
      31. Martin JN, Amad Z, Cossen C, Lam PK, Kedes DH, Page-Shafer KA, Osmond DH, Forghani B. Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies. J Clin Microbiol. 2000 Feb; 38(2):696-701.
        View in: PubMed
      32. Martin JN, Rose DA, Hadley WK, Perdreau-Remington F, Lam PK, Gerberding JL. Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era. J Infect Dis. 1999 Dec; 180(6):1809-18.
        View in: PubMed
      33. Martin JN, Osmond DH. Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk. Curr Opin Oncol. 1999 Nov; 11(6):508-15.
        View in: PubMed
      34. Martin JN, Perdreau-Remington F, Kartalija M, Pasi OG, Webb M, Gerberding JL, Chambers HF, Täuber MG, Lee BL. A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease. J Infect Dis. 1999 Sep; 180(3):896-9.
        View in: PubMed
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