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    Jeoung-Sook Shin, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMicrobiology and Immunology
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-5451
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      Dendritic cells play important roles in inducing immunity against microbial antigens while developing tolerance against self or innocuous foreign antigens. Our laboratory is interested in identifying the specific mechanism by which dendritic cells mediate regulatory T cell (Treg) development and defining the biological impact that dendritic cells make on immune suppressive function of Treg. Our recent study implicates the role of Membrane-Associated RING finger CH 1 (MARCH1) ubiquitin ligase in dendritic cell selection of natural Treg. Current research focuses on defining the molecular mechanism by which MARCH1 mediates Treg development and determining functional specialization of Treg generated in this MARCH1-dependent manner.

      Our laboratory is also interested in understanding how dendritic cells participate in IgE-mediated asthma pathogenesis. Asthma represents a serious inflammatory airway disease affecting hundred millions of adults and children in the world. IgE is one of the most important pathologic players in this disease, however the underlying mechanism is not completely understood. Our recent study indicates that dendritic cells constitutively internalize circulating IgE via the high affinity IgE receptor (FceRI) and promote serum IgE clearance, which implicates dendritic cells in IgE turnover. In asthma however, dendritic cells accumulate IgE at their surface and infiltrate airway epithelium, suggesting functional alteration and contribution of dendritic cells to this disease. Current research aims to identify the molecular mechanism by which FceRI mediates internalization of IgE in dendritic cells and determine the specific contribution that these cells make to asthma.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med. 2016 May 30; 213(6):993-1009. PMID: 27162138.
        View in: PubMed
      2. Oh J, Shin JS. Molecular mechanism and cellular function of MHCII ubiquitination. Immunol Rev. 2015 Jul; 266(1):134-44. PMID: 26085212.
        View in: PubMed
      3. Oh J, Shin JS. The Role of Dendritic Cells in Central Tolerance. Immune Netw. 2015 Jun; 15(3):111-20. PMID: 26140042; PMCID: PMC4486773.
      4. Shin JS, Greer AM. The role of FceRI expressed in dendritic cells and monocytes. Cell Mol Life Sci. 2015 Jun; 72(12):2349-60. PMID: 25715742; PMCID: PMC4479177.
      5. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
      6. Eggel A, Baravalle G, Hobi G, Kim B, Buschor P, Forrer P, Shin JS, Vogel M, Stadler BM, Dahinden CA, Jardetzky TS. Accelerated dissociation of IgE-FceRI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J Allergy Clin Immunol. 2014 Jun; 133(6):1709-19.e8. PMID: 24642143; PMCID: PMC4083100.
      7. Baravalle G, Greer AM, LaFlam TN, Shin JS. Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model. J Immunol. 2014 Apr 1; 192(7):3280-8. PMID: 24610015; PMCID: PMC4472313.
      8. Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin JS. Serum IgE clearance is facilitated by human FceRI internalization. J Clin Invest. 2014 Mar; 124(3):1187-98. PMID: 24569373; PMCID: PMC3938266.
      9. Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med. 2013 Jun 3; 210(6):1069-77. PMID: 23712430; PMCID: PMC3674695.
      10. Ma JK, Platt MY, Eastham-Anderson J, Shin JS, Mellman I. MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length. Proc Natl Acad Sci U S A. 2012 Jun 5; 109(23):8820-7. PMID: 22566640; PMCID: PMC3384207.
      11. Baravalle G, Park H, McSweeney M, Ohmura-Hoshino M, Matsuki Y, Ishido S, Shin JS. Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells. J Immunol. 2011 Sep 15; 187(6):2966-73. PMID: 21849678; PMCID: PMC4496154.
      12. Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008 Apr 21; 181(2):203-11. PMID: 18411312; PMCID: PMC2315669.
      13. Shin JS, Shelburne CP, Jin C, LeFurgey EA, Abraham SN. Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. J Immunol. 2006 Nov 1; 177(9):5791-800. PMID: 17056503.
        View in: PubMed
      14. Shin JS, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature. 2006 Nov 2; 444(7115):115-8. PMID: 17051151.
        View in: PubMed
      15. Duncan MJ, Li G, Shin JS, Carson JL, Abraham SN. Bacterial penetration of bladder epithelium through lipid rafts. J Biol Chem. 2004 Apr 30; 279(18):18944-51. PMID: 14976212.
        View in: PubMed
      16. Duncan MJ, Shin JS, Abraham SN. Microbial entry through caveolae: variations on a theme. Cell Microbiol. 2002 Dec; 4(12):783-91. PMID: 12464009.
        View in: PubMed
      17. Shin JS, Abraham SN. Cell biology. Caveolae--not just craters in the cellular landscape. Science. 2001 Aug 24; 293(5534):1447-8. PMID: 11520975.
        View in: PubMed
      18. Shin JS, Abraham SN. Caveolae as portals of entry for microbes. Microbes Infect. 2001 Jul; 3(9):755-61. PMID: 11489424.
        View in: PubMed
      19. Shin JS, Abraham SN. Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. FEMS Microbiol Lett. 2001 Apr 13; 197(2):131-8. PMID: 11313125.
        View in: PubMed
      20. Abraham S, Shin J, Malaviya R. Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis. J Infect Dis. 2001 Mar 1; 183 Suppl 1:S51-5. PMID: 11171015.
        View in: PubMed
      21. Shin JS, Abraham SN. Co-option of endocytic functions of cellular caveolae by pathogens. Immunology. 2001 Jan; 102(1):2-7. PMID: 11168630; PMCID: PMC1783146.
      22. Shin JS, Gao Z, Abraham SN. Involvement of cellular caveolae in bacterial entry into mast cells. Science. 2000 Aug 4; 289(5480):785-8. PMID: 10926542.
        View in: PubMed
      23. Shin JS, Gao Z, Abraham SN. Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. Biosci Rep. 1999 Oct; 19(5):421-32. PMID: 10763810.
        View in: PubMed
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