Jeroen Roose, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|University of California, San Francisco||Postdoctoral Studies||Graduate Division|
|University of Utrecht||PhD||Immunology|
Our laboratory is interested in genetic lesions that lead to abnormal Ras signal transduction events and development of diseases such as autoimmunity and cancer. Active Ras communicates to many downstream targets and affects many cell biological responses. Our goal is to understand the mechanism of activation of the small GTPase Ras by Ras exchange factors and its role in normal physiology as well as understand how alterations in Ras-kinase signals underlie pathology.
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