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    Joel Chasis, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Ave, Moffitt
    San Francisco CA 94143
    Phone510-486-6408
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 2014 Jan 2; 14(1):81-93. PMID: 24268694; PMCID: PMC3969018.
      2. Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18892-7. PMID: 24191023; PMCID: PMC3839750.
      3. Spring FA, Griffiths RE, Mankelow TJ, Agnew C, Parsons SF, Chasis JA, Anstee DJ. Tetraspanins CD81 and CD82 facilitate a4ß1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1. PLoS One. 2013; 8(5):e62654. PMID: 23704882; PMCID: PMC3660455.
      4. Hu J, Liu J, Xue F, Halverson G, Reid M, Guo A, Chen L, Raza A, Galili N, Jaffray J, Lane J, Chasis JA, Taylor N, Mohandas N, An X. Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo. Blood. 2013 Apr 18; 121(16):3246-53. PMID: 23422750; PMCID: PMC3630836.
      5. Liu J, Zhang J, Ginzburg Y, Li H, Xue F, De Franceschi L, Chasis JA, Mohandas N, An X. Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis. Blood. 2013 Feb 21; 121(8):e43-9. PMID: 23287863; PMCID: PMC3578961.
      6. Chasis JA. Marching single file or 2 abreast. Blood. 2011 Jul 7; 118(1):6-7. PMID: 21737608.
        View in: PubMed
      7. Chasis JA. Red or green? Enucleation traffic light. Blood. 2010 Oct 28; 116(17):3122. PMID: 21030567.
        View in: PubMed
      8. Mohandas N, Chasis JA. The erythroid niche: molecular processes occurring within erythroblastic islands. Transfus Clin Biol. 2010 Sep; 17(3):110-1. PMID: 20655267; PMCID: PMC3684560.
      9. Salomao M, Chen K, Villalobos J, Mohandas N, An X, Chasis JA. Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation. Blood. 2010 Jul 15; 116(2):267-9. PMID: 20339087; PMCID: PMC2910610.
      10. Liu J, Guo X, Mohandas N, Chasis JA, An X. Membrane remodeling during reticulocyte maturation. Blood. 2010 Mar 11; 115(10):2021-7. PMID: 20038785; PMCID: PMC2837329.
      11. Chen K, Liu J, Heck S, Chasis JA, An X, Mohandas N. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17413-8. PMID: 19805084; PMCID: PMC2762680.
      12. Blanc L, Liu J, Vidal M, Chasis JA, An X, Mohandas N. The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood. 2009 Oct 29; 114(18):3928-34. PMID: 19724054; PMCID: PMC2773486.
      13. Popova EY, Krauss SW, Short SA, Lee G, Villalobos J, Etzell J, Koury MJ, Ney PA, Chasis JA, Grigoryev SA. Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. Chromosome Res. 2009; 17(1):47-64. PMID: 19172406; PMCID: PMC2667965.
      14. An X, Gauthier E, Zhang X, Guo X, Anstee DJ, Mohandas N, Chasis JA. Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin. Blood. 2008 Dec 15; 112(13):5212-8. PMID: 18815288; PMCID: PMC2597615.
      15. Chasis JA, Mohandas N. Erythroblastic islands: niches for erythropoiesis. Blood. 2008 Aug 1; 112(3):470-8. PMID: 18650462; PMCID: PMC2481536.
      16. Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X. Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8026-31. PMID: 18524950; PMCID: PMC2430353.
      17. Mankelow TJ, Burton N, Stefansdottir FO, Spring FA, Parsons SF, Pedersen JS, Oliveira CL, Lammie D, Wess T, Mohandas N, Chasis JA, Brady RL, Anstee DJ. The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. Blood. 2007 Nov 1; 110(9):3398-406. PMID: 17638854; PMCID: PMC2200917.
      18. Kaul DK, Liu XD, Zhang X, Mankelow T, Parsons S, Spring F, An X, Mohandas N, Anstee D, Chasis JA. Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C922-30. PMID: 16738001.
        View in: PubMed
      19. Lee G, Lo A, Short SA, Mankelow TJ, Spring F, Parsons SF, Yazdanbakhsh K, Mohandas N, Anstee DJ, Chasis JA. Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood. 2006 Sep 15; 108(6):2064-71. PMID: 16690966; PMCID: PMC1895542.
      20. Chasis JA. Erythroblastic islands: specialized microenvironmental niches for erythropoiesis. Curr Opin Hematol. 2006 May; 13(3):137-41. PMID: 16567955.
        View in: PubMed
      21. Ponthier JL, Schluepen C, Chen W, Lersch RA, Gee SL, Hou VC, Lo AJ, Short SA, Chasis JA, Winkelmann JC, Conboy JG. Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16. J Biol Chem. 2006 May 5; 281(18):12468-74. PMID: 16537540.
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      22. Krauss SW, Lo AJ, Short SA, Koury MJ, Mohandas N, Chasis JA. Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins. Blood. 2005 Sep 15; 106(6):2200-5. PMID: 15933051; PMCID: PMC1895142.
      23. Krauss SW, Lee G, Chasis JA, Mohandas N, Heald R. Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. J Biol Chem. 2004 Jun 25; 279(26):27591-8. PMID: 15102852.
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      24. Lee JC, Gimm JA, Lo AJ, Koury MJ, Krauss SW, Mohandas N, Chasis JA. Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivity. Blood. 2004 Mar 1; 103(5):1912-9. PMID: 14563645.
        View in: PubMed
      25. Mankelow TJ, Spring FA, Parsons SF, Brady RL, Mohandas N, Chasis JA, Anstee DJ. Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to alpha V integrins. Blood. 2004 Feb 15; 103(4):1503-8. PMID: 14551135.
        View in: PubMed
      26. Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P. Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. Kidney Int. 2003 Apr; 63(4):1321-37. PMID: 12631349.
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      27. Da Costa L, Tchernia G, Gascard P, Lo A, Meerpohl J, Niemeyer C, Chasis JA, Fixler J, Mohandas N. Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology. Blood. 2003 Jun 15; 101(12):5039-45. PMID: 12586610.
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      28. Bruce LJ, Beckmann R, Ribeiro ML, Peters LL, Chasis JA, Delaunay J, Mohandas N, Anstee DJ, Tanner MJ. A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane. Blood. 2003 May 15; 101(10):4180-8. PMID: 12531814.
        View in: PubMed
      29. Lee G, Spring FA, Parsons SF, Mankelow TJ, Peters LL, Koury MJ, Mohandas N, Anstee DJ, Chasis JA. Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions. Blood. 2003 Mar 1; 101(5):1790-7. PMID: 12406883.
        View in: PubMed
      30. Krauss SW, Heald R, Lee G, Nunomura W, Gimm JA, Mohandas N, Chasis JA. Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro. J Biol Chem. 2002 Nov 15; 277(46):44339-46. PMID: 12171917.
        View in: PubMed
      31. An X, Lecomte MC, Chasis JA, Mohandas N, Gratzer W. Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane. J Biol Chem. 2002 Aug 30; 277(35):31796-800. PMID: 12105217.
        View in: PubMed
      32. Van Dort HM, Knowles DW, Chasis JA, Lee G, Mohandas N, Low PS. Analysis of integral membrane protein contributions to the deformability and stability of the human erythrocyte membrane. J Biol Chem. 2001 Dec 14; 276(50):46968-74. PMID: 11595743.
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      33. Auffray I, Marfatia S, de Jong K, Lee G, Huang CH, Paszty C, Tanner MJ, Mohandas N, Chasis JA. Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice. Blood. 2001 May 1; 97(9):2872-8. PMID: 11313283.
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      34. Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA. Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. Blood. 2001 Jan 1; 97(1):312-20. PMID: 11133776.
        View in: PubMed
      35. Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain. J Biol Chem. 2000 Feb 4; 275(5):3247-55. PMID: 10652311.
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      36. Parsons SF, Spring FA, Chasis JA, Anstee DJ. Erythroid cell adhesion molecules Lutheran and LW in health and disease. Baillieres Best Pract Res Clin Haematol. 1999 Dec; 12(4):729-45. PMID: 10895261.
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      37. Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG. Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. Mol Biol Cell. 1999 Jun; 10(6):1783-98. PMID: 10359596; PMCID: PMC25371.
      38. Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Peters LL, Mohandas N, Rubin E, Conboy JG. Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities. J Clin Invest. 1999 Feb; 103(3):331-40. PMID: 9927493; PMCID: PMC407893.
      39. Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, Conboy JG, Mohandas N, Chasis JA. Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation. Blood. 1998 Dec 1; 92(11):4404-14. PMID: 9834247.
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      40. Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB. The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci. 1998 Aug; 23(8):281-2. PMID: 9757824.
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      41. Knowles DW, Tilley L, Mohandas N, Chasis JA. Erythrocyte membrane vesiculation: model for the molecular mechanism of protein sorting. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12969-74. PMID: 9371784; PMCID: PMC24247.
      42. Krauss SW, Chasis JA, Rogers C, Mohandas N, Krockmalnic G, Penman S. Structural protein 4.1 is located in mammalian centrosomes. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7297-302. PMID: 9207085; PMCID: PMC23815.
      43. Krauss SW, Larabell CA, Lockett S, Gascard P, Penman S, Mohandas N, Chasis JA. Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division. J Cell Biol. 1997 Apr 21; 137(2):275-89. PMID: 9128242; PMCID: PMC2139783.
      44. Schischmanoff PO, Yaswen P, Parra MK, Lee G, Chasis JA, Mohandas N, Conboy JG. Cell shape-dependent regulation of protein 4.1 alternative pre-mRNA splicing in mammary epithelial cells. J Biol Chem. 1997 Apr 11; 272(15):10254-9. PMID: 9092575.
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      45. Chasis JA, Coulombel L, McGee S, Lee G, Tchernia G, Conboy J, Mohandas N. Differential use of protein 4.1 translation initiation sites during erythropoiesis: implications for a mutation-induced stage-specific deficiency of protein 4.1 during erythroid development. Blood. 1996 Jun 15; 87(12):5324-31. PMID: 8652848.
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      46. Knowles DW, Chasis JA, Evans EA, Mohandas N. Cooperative action between band 3 and glycophorin A in human erythrocytes: immobilization of band 3 induced by antibodies to glycophorin A. Biophys J. 1994 May; 66(5):1726-32. PMID: 8061221; PMCID: PMC1275892.
      47. Mohandas N, Chasis JA. Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids. Semin Hematol. 1993 Jul; 30(3):171-92. PMID: 8211222.
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      48. Tchernia G, Gauthier F, Mielot F, Dommergues JP, Yvart J, Chasis JA, Mohandas N. Initial assessment of the beneficial effect of partial splenectomy in hereditary spherocytosis. Blood. 1993 Apr 15; 81(8):2014-20. PMID: 8471763.
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      49. Conboy JG, Chasis JA, Winardi R, Tchernia G, Kan YW, Mohandas N. An isoform-specific mutation in the protein 4.1 gene results in hereditary elliptocytosis and complete deficiency of protein 4.1 in erythrocytes but not in nonerythroid cells. J Clin Invest. 1993 Jan; 91(1):77-82. PMID: 8423235; PMCID: PMC329997.
      50. Chasis JA, Coulombel L, Conboy J, McGee S, Andrews K, Kan YW, Mohandas N. Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis. J Clin Invest. 1993 Jan; 91(1):329-38. PMID: 8423229; PMCID: PMC330030.
      51. Chasis JA, Mohandas N. Red blood cell glycophorins. Blood. 1992 Oct 15; 80(8):1869-79. PMID: 1391951.
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      52. Mohandas N, Winardi R, Knowles D, Leung A, Parra M, George E, Conboy J, Chasis J. Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3. J Clin Invest. 1992 Feb; 89(2):686-92. PMID: 1737855; PMCID: PMC442903.
      53. Conboy JG, Chan JY, Chasis JA, Kan YW, Mohandas N. Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1. J Biol Chem. 1991 May 5; 266(13):8273-80. PMID: 2022644.
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      54. Telen MJ, Chasis JA. Relationship of the human erythrocyte Wrb antigen to an interaction between glycophorin A and band 3. Blood. 1990 Aug 15; 76(4):842-8. PMID: 2383660.
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      55. Chasis JA, Schrier SL. Membrane deformability and the capacity for shape change in the erythrocyte. Blood. 1989 Nov 15; 74(7):2562-8. PMID: 2804378.
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      56. Pasvol G, Chasis JA, Mohandas N, Anstee DJ, Tanner MJ, Merry AH. Inhibition of malarial parasite invasion by monoclonal antibodies against glycophorin A correlates with reduction in red cell membrane deformability. Blood. 1989 Oct; 74(5):1836-43. PMID: 2676019.
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      57. Chasis JA, Prenant M, Leung A, Mohandas N. Membrane assembly and remodeling during reticulocyte maturation. Blood. 1989 Aug 15; 74(3):1112-20. PMID: 2752157.
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      58. Reid ME, Takakuwa Y, Tchernia G, Jensen RH, Chasis JA, Mohandas N. Functional role for glycophorin C and its interaction with the human red cell membrane skeletal component, protein 4.1. Prog Clin Biol Res. 1989; 319:553-71; discussion 572-3. PMID: 2622928.
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      59. Chasis JA, Reid ME, Jensen RH, Mohandas N. Signal transduction by glycophorin A: role of extracellular and cytoplasmic domains in a modulatable process. J Cell Biol. 1988 Oct; 107(4):1351-7. PMID: 2844827; PMCID: PMC2115236.
      60. Chasis JA, Agre P, Mohandas N. Decreased membrane mechanical stability and in vivo loss of surface area reflect spectrin deficiencies in hereditary spherocytosis. J Clin Invest. 1988 Aug; 82(2):617-23. PMID: 3403720; PMCID: PMC303556.
      61. Reid ME, Chasis JA, Mohandas N. Identification of a functional role for human erythrocyte sialoglycoproteins beta and gamma. Blood. 1987 Apr; 69(4):1068-72. PMID: 3828531.
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      62. Chasis JA, Shohet SB. Red cell biochemical anatomy and membrane properties. Annu Rev Physiol. 1987; 49:237-48. PMID: 3551800.
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      63. Chasis JA, Mohandas N. Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations. J Cell Biol. 1986 Aug; 103(2):343-50. PMID: 3733870; PMCID: PMC2113818.
      64. Chasis JA, Mohandas N, Shohet SB. Erythrocyte membrane rigidity induced by glycophorin A-ligand interaction. Evidence for a ligand-induced association between glycophorin A and skeletal proteins. J Clin Invest. 1985 Jun; 75(6):1919-26. PMID: 4008645; PMCID: PMC425549.
      65. Knowles WJ, Bologna ML, Chasis JA, Marchesi SL, Marchesi VT. Common structural polymorphisms in human erythrocyte spectrin. J Clin Invest. 1984 Apr; 73(4):973-9. PMID: 6707213; PMCID: PMC425109.
      66. Mohandas N, Chasis JA, Shohet SB. The influence of membrane skeleton on red cell deformability, membrane material properties, and shape. Semin Hematol. 1983 Jul; 20(3):225-42. PMID: 6353591.
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      67. Mazur EM, Hoffman R, Chasis J, Marchesi S, Bruno E. Immunofluorescent identification of human megakaryocyte colonies using an antiplatelet glycoprotein antiserum. Blood. 1981 Feb; 57(2):277-86. PMID: 7004535.
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      68. Marchesi SL, Chasis JA. Isolation of human platelet glycoproteins. Biochim Biophys Acta. 1979 Aug 23; 555(3):442-59. PMID: 486461.
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