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    John Chorba, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 100
    San Francisco CA 94110
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      Collapse Biography 
      Collapse Education and Training
      Harvard Medical SchoolM.D.2007
      Massachusetts General HospitalInternal Medicine Residency2010
      University of California, San FranciscoCardiology Fellowship2014
      Collapse Awards and Honors
      American Heart Association2011Laennec Young Clinician Award
      NIH/NHLBI2012 - 2014Ruth L. Kirschstein F32 National Research Service Award
      NIH/NHLBI2013 - 2017Loan Repayment Program
      Gilead Sciences2013 - 2016Research Scholar in Cardiovascular Disease Award
      NIH/NHLBI2015 - 2020K08 Mentored Clinical Scientist Development Award
      UCSF CTSI2015 - 2016Catalyst Award
      UCSF Academic Senate2015 - 2017Pilot Investigator Award
      Hellman Fellows Fund2015 - 2017Hellman Fellowship
      Pfizer2015 - 2018ASPIRE Cardiovascular Award

      Collapse Overview 
      Collapse Overview
      My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. PMID: 25210046; PMCID: PMC4200258.
      2. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5. PMID: 22116811; PMCID: PMC3265658.
      3. Dewland TA, Chorba JS, Goldschlager N, Marcus GM. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13; 171(11):973, 974-5. PMID: 21670368.
        View in: PubMed
      4. Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15. PMID: 17301155; PMCID: PMC1866143.
      5. Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6. PMID: 12565968.
        View in: PubMed
      6. Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51. PMID: 12565969.
        View in: PubMed
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