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    John Mackenzie, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address1975 4th Street C-1758L
    San Francisco CA 94158
    Phone415-476-1364
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      Collapse Biography 
      Collapse Education and Training
      Children's Hospital of PhiladelphiaFellowshipRadiology - Pediatric Imaging2007
      Hospital of the University of PennsylvaniaFellowshipRadiology - Musculoskeletal Radiology2006
      Harvard: Brigham & Women's HospitalResidencyRadiology - Diagnostic Imaging2005
      Hospital of the University of PennsylvaniaInternshipMedicine2001
      Albert Einstein College of MedicineM.D.School of Medicine2000
      Stanford UniversityM.S.Biology1995
      Stanford UniversityB.S.Double major: Computer Science & Biology with Honors1995
      Collapse Awards and Honors
      Radiology Society of North America 2007Fellow Research Trainee Prize
      Radiology Society of North America2005RSNA Roentgen Resident/Fellow Research Award
      American Board of Radiology2003 - 2005Leonard Holman Pathway Research Resident
      UCSF Department of Pediatrics Grand Rounds2013Invited Lecturer; "Hyperpolarized Carbon-13 MRI for Pediatrics Disease"
      University of California, San Francisco 2012Coro Faculty Leadership Collaborative
      Pacific Coast Pediatric Radiology Association2011Award for Best Paper Presentation - Carbon-13 Imaging of Pediatric Disease
      National Academies Keck Futures Initiative2010Futures Initiative – Imaging Science Conference
      Radiology Society of North America2004Resident Research Trainee Prize
      Brigham and Women’s Hospital Radiology Department2005Resident Award for Research
      ISMRM/Amersham Health2004MRI Fellowship Program
      Siemens Medical Systems2004Research Resident Scholarship
      Brigham and Women’s Hospital Radiology Department2004Resident Award for Research
      Brigham and Women’s Hospital Radiology Department2002Resident Award for Teaching
      Radiology Society of North America2002Introduction to Research Program
      Brigham and Women’s Hospital Radiology Department2002Resident Award for Teaching
      Albert Einstein College of Medicine2000Alpha Omega Alpha
      Albert Einstein College of Medicine2000Research Scholarship
      Harvard Medical School1997Summer Research Grant Scholar
      Stanford University 1995Firestone Medal for Excellence in Biological Research
      Stanford University 1993Award for Excellence in Teaching Biological Sciences
      1988Boettcher Scholarship
      UCSF Department of Radiology2013Award for Best Scientific Poster (mentor to Julia Nguyen)
      UCSF Department of Radiology2012Award for Best Scientific Poster (mentor to Linda Nguyen)
      Radiology Society of North America2012Poster Presentation Award - Isolated Fallopian Tubal torsion: Causes, Imaging Findings, and How to

      Collapse Overview 
      Collapse Overview
      John MacKenzie, MD, is an Associate Professor in Residence, Chief of Radiology at Mission Bay Medical Center, and Section Chief of Pediatric Radiology at the University of California, San Francisco. He provides expert interpretation and consultation on pediatric imaging studies for a broad spectrum of congenital and acquired fetal and neonatal conditions and disorders affecting children and adolescents. Dr. MacKenzie earned his BS in Computer Science and Biology and MS in Biological Science from Stanford University in 1995. He received his MD in Medicine from the Albert Einstein College of Medicine, New York in 2000. Dr. MacKenzie completed his residency in Radiology at the Brigham and Women’s Hospital, Harvard University. He went on to study for two years at the University of Pennsylvania where he completed a fellowship in Musculoskeletal Imaging at the Hospital of the University of Pennsylvania in 2006 and a second fellowship in Pediatric Imaging in 2007 at the Children’s Hospital of Philadelphia. Prior to accepting his UCSF position, Dr. MacKenzie was a member of the faculty at Stanford University as the Chief of Pediatric Musculoskeletal Imaging at Lucile Packard Children’s Hospital from 2007-2010.

      Dr. MacKenzie is a nationally recognized expert in the imaging of the pediatric musculoskeletal system and is asked to lecture on this topic across the country. Dr. MacKenzie’s research focuses on developing imaging techniques for the detection and treatment monitoring of autoimmune diseases of the bones and joints. He studies how novel carbon-based imaging probes may depict molecular alterations in inflammatory arthritis, including rheumatoid arthritis, a disease that is common in adults, and juvenile idiopathic arthritis, the most common form of inflammatory arthritis in children. His long-term goal is to develop sensitive non-invasive imaging modalities to help guide the diagnosis and management of patients with common autoimmune diseases.

      Dr. MacKenzie has been awarded grants from the National Institutes of Health, National Academies Keck Futures Initiative Imaging Science, Radiological Society of North America and the Society of Pediatric Radiology. He has served as the Principal Investigator and Co-Principal Investigator on these projects. His work is published in 5 book chapters, 14 review articles, and 29 peer-reviewed research articles.

      Expertise:
      Pediatric Radiology
      Pediatric Musculoskeletal Imaging

      Specialty:
      Specialized imaging for infants, children with a focus on pediatric bones and joints

      Professional Interests:
      Pediatric imaging, musculoskeletal imaging, arthritis and immunology, molecular imaging, hyperpolarized carbon-13 imaging, magnetic resonance imaging

      Education and Training:
      • Medical School: Albert Einstein College of Medicine, New York - Medicine
      • Internship: Hospital of the University of Pennsylvania - Medicine
      • Residency: Brigham and Women’s Hospital, Boston - Radiology
      • Fellowship: Hospital of the University of Pennsylvania - Musculoskeletal Imaging
      • Fellowship: Children’s Hospital of Philadelphia - Pediatric Imaging
      • Master of Science: Stanford University, California - Biological Science
      • Bachelor’s of Science: Stanford University, California - Computer Science and Biology
      • Medical License, California
      • DEA, United States of America
      • X-Ray Supervisor, California
      • Diagnostic Radiology, American Board of Radiology
      • Pediatric Imaging, Certificate of Added Qualification, American Board of Radiology

      Collapse Interests
      Pediatric imaging, musculoskeletal imaging, arthritis and immunology, molecular imaging, hyperpolarized carbon-13 imaging, magnetic resonance imaging.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Phelps A, Ramachandran R, Courtier J, Perito E, Rosenthal P, MacKenzie JD. Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation? Clin Imaging. 2016 Oct 17; 41:95-100. PMID: 27840268.
        View in: PubMed
      2. Zhang Y, Yang L, MacKenzie JD, Ramachandran R, Chen DZ. A seeding-searching-ensemble method for gland segmentation in H&E-stained images. BMC Med Inform Decis Mak. 2016; 16 Suppl 2:80. PMID: 27460014.
        View in: PubMed
      3. Steineck A, MacKenzie JD, Twist CJ. Premature physeal closure following 13-cis-retinoic acid and prolonged fenretinide administration in neuroblastoma. Pediatr Blood Cancer. 2016 Nov; 63(11):2050-3. PMID: 27399265.
        View in: PubMed
      4. Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805. PMID: 27229498.
        View in: PubMed
      5. Patel MV, Leibowich S, Courtier JL, Rhee S, MacKenzie JD. Disodium gadoxetate uptake in progressive familial intrahepatic cholestasis type I: Enhancing our understanding of the cholestatic disease. Radiol Case Rep. 2013; 8(1):661. PMID: 27330609.
        View in: PubMed
      6. Kim MJ, Rinsky LA, MacKenzie JD. Scapular stress fracture initially masquerading as tumor or infection. Radiol Case Rep. 2011; 6(4):510. PMID: 27307926.
        View in: PubMed
      7. Lambert JW, Phelps AS, Courtier JL, Gould RG, MacKenzie JD. Image quality and dose optimisation for infant CT using a paediatric phantom. Eur Radiol. 2016 May; 26(5):1387-95. PMID: 26304803.
        View in: PubMed
      8. Courtier J, Cardenas A, Tan C, Towne M, Rhee SJ, Heyman MB, MacKenzie JD. Nonanesthesia magnetic resonance enterography in young children: feasibility, technique, and performance. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):754-61. PMID: 25996792.
        View in: PubMed
      9. Basta AM, Courtier J, Phelps A, Copp HL, MacKenzie JD. Scrotal swelling in the neonate. J Ultrasound Med. 2015 Mar; 34(3):495-505. PMID: 25715370.
        View in: PubMed
      10. Phelps AS, Naeger DM, Courtier JL, Lambert JW, Marcovici PA, Villanueva-Meyer JE, MacKenzie JD. Pairwise comparison versus Likert scale for biomedical image assessment. AJR Am J Roentgenol. 2015 Jan; 204(1):8-14. PMID: 25539230.
        View in: PubMed
      11. Lin C, MacKenzie JD, Courtier JL, Gu JT, Milojevic D. Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging. Pediatr Rheumatol Online J. 2014; 12:25. PMID: 25067925; PMCID: PMC4110533.
      12. Lambert J, MacKenzie JD, Cody DD, Gould R. Techniques and tactics for optimizing CT dose in adults and children: state of the art and future advances. J Am Coll Radiol. 2014 Mar; 11(3):262-6. PMID: 24589401.
        View in: PubMed
      13. Koc G, Courtier JL, Phelps A, Marcovici PA, MacKenzie JD. Computed tomography depiction of small pediatric vessels with model-based iterative reconstruction. Pediatr Radiol. 2014 Jul; 44(7):787-94. PMID: 24531191.
        View in: PubMed
      14. Wang J, MacKenzie JD, Ramachandran R, Chen DZ. Identifying neutrophils in H&E staining histology tissue images. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):73-80. PMID: 25333103.
        View in: PubMed
      15. Courtier J, Ohliger M, Rhee SJ, Terreblanche O, Heyman MB, MacKenzie JD. Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):426-31. PMID: 24080754.
        View in: PubMed
      16. Koc G, Courtier JL, Kim JS, Miniati DN, MacKenzie JD. Intra-abdominal inverted umblical cord in gastroschisis: a unique ultrasound finding. Pediatr Radiol. 2014 Jan; 44(1):109-11. PMID: 23907187.
        View in: PubMed
      17. Patel AS, Soares B, Courtier J, Mackenzie JD. Radiation dose reduction in pediatric CT-guided musculoskeletal procedures. Pediatr Radiol. 2013 Oct; 43(10):1303-8. PMID: 23624510; PMCID: PMC3769501.
      18. Courtier J, Robbins E, Soares B, Horvai A, Mackenzie JD. Primary mixed malignant tumor of bone in an 18-year-old male: Report of a case with radiologic-pathologic correlation. J Bone Oncol. 2012 Dec; 1(3):101-5. PMID: 26909264.
        View in: PubMed
      19. Shive ML, Baskin LS, Harris CR, Bonham M, MacKenzie JD. Ureteral fibroepithelial polyp causing urinary obstruction. J Radiol Case Rep. 2012 Jul; 6(7):23-8. PMID: 23365709; PMCID: PMC3558047.
      20. Courtier JL, Perito ER, Rhee S, Tsai P, Heyman MB, MacKenzie JD. Targeted MRI contrast agents for pediatric hepatobiliary disease. J Pediatr Gastroenterol Nutr. 2012 Apr; 54(4):454-62. PMID: 22193178; PMCID: PMC3744898.
      21. Mackenzie JD, Hernandez A, Pena A, Ruppert K, Khrichenko D, Gonzalez L, Jawad AF, Wells L, Smith-Whitley K, Jaramillo D. Magnetic resonance imaging in children with sickle cell disease--detecting alterations in the apparent diffusion coefficient in hips with avascular necrosis. Pediatr Radiol. 2012 Jun; 42(6):706-13. PMID: 22200862.
        View in: PubMed
      22. Phelps A, Naeger DM, MacKenzie J, Qayyum A. Educating radiology residents in the new era: implementation and evaluation of online end-of-rotation examinations. Acad Radiol. 2011 Nov; 18(11):1442-6. PMID: 21971261.
        View in: PubMed
      23. Gu JT, Nguyen L, Chaudhari AJ, MacKenzie JD. Molecular characterization of rheumatoid arthritis with magnetic resonance imaging. Top Magn Reson Imaging. 2011 Apr; 22(2):61-9. PMID: 22648081; PMCID: PMC3387734.
      24. MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM. Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology. 2011 May; 259(2):414-20. PMID: 21406626; PMCID: PMC3079121.
      25. MacKenzie JD, Vasanawala SS. State-of-the-art in pediatric body and musculoskeletal magnetic resonance imaging. Semin Ultrasound CT MR. 2010 Apr; 31(2):86-99. PMID: 20304318.
        View in: PubMed
      26. Melvin JS, Mackenzie JD, Nacke E, Sennett BJ, Wells L. MRI of HAGL lesions: four arthroscopically confirmed cases of false-positive diagnosis. AJR Am J Roentgenol. 2008 Sep; 191(3):730-4. PMID: 18716101.
        View in: PubMed
      27. MacKenzie JD, Vasanawala SS. Advances in pediatric MR imaging. Magn Reson Imaging Clin N Am. 2008 Aug; 16(3):385-402, v. PMID: 18585595.
        View in: PubMed
      28. MacKenzie JD. MR arthrography made simple: indications and techniques. Pediatr Radiol. 2008 May; 38 Suppl 2:S240-2. PMID: 18401618.
        View in: PubMed
      29. MacKenzie JD, Nazario-Larrieu J, Cai T, Ledbetter MS, Duran-Mendicuti MA, Judy PF, Rybicki FJ. Reduced-dose CT: effect on reader evaluation in detection of pulmonary embolism. AJR Am J Roentgenol. 2007 Dec; 189(6):1371-9. PMID: 18029873.
        View in: PubMed
      30. MacKenzie JD, Gonzalez L, Hernandez A, Ruppert K, Jaramillo D. Diffusion-weighted and diffusion tensor imaging for pediatric musculoskeletal disorders. Pediatr Radiol. 2007 Aug; 37(8):781-8. PMID: 17598099.
        View in: PubMed
      31. Choi MH, MacKenzie JD, Dalinka MK. Imaging features of crystal-induced arthropathy. Rheum Dis Clin North Am. 2006 May; 32(2):427-46, viii. PMID: 16716888.
        View in: PubMed
      32. Shu KM, MacKenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy PF, Rybicki F. Lowering the thyroid dose in screening examinations of the cervical spine. Emerg Radiol. 2006 Mar; 12(3):133-6. PMID: 16362270.
        View in: PubMed
      33. Villalba ML, Huynh B, So M, Mackenzie JD, Ledbetter S, Rybicki F. An ovary with a twist: a case of interesting sonographic findings of ovarian torsion. J Emerg Med. 2005 Nov; 29(4):443-6. PMID: 16243204.
        View in: PubMed
      34. Vargas TM, Rybicki FJ, Ledbetter SM, MacKenzie JD. Atlantoaxial instability associated with an orthotopic os odontoideum: a multimodality imaging assessment. Emerg Radiol. 2005 Jun; 11(4):223-5. PMID: 16133608.
        View in: PubMed
      35. Viscomi S, Shu KM, Blinder EM, MacKenzie JD, Ledbetter S, Rybicki FJ. Quantification of clinical consultations in academic emergency radiology. Acad Radiol. 2004 Nov; 11(11):1294-7. PMID: 15561578.
        View in: PubMed
      36. Blinder E, MacKenzie JD, Cranmer HH, Ledbetter S, Rybicki F. Uterine rupture with peritonitis in a nongravid uterus eight weeks after cesarean section. Emerg Radiol. 2003 Apr; 10(1):57-9. PMID: 15290535.
        View in: PubMed
      37. MacKenzie JD, Siddiqi F, Babb JS, Bagley LJ, Mannon LJ, Sinson GP, Grossman RI. Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. AJNR Am J Neuroradiol. 2002 Oct; 23(9):1509-15. PMID: 12372740.
        View in: PubMed
      38. Seidl KJ, Wilshire JA, MacKenzie JD, Kantor AB, Herzenberg LA, Herzenberg LA. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2262-7. PMID: 10051629; PMCID: PMC26771.
      39. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol. 1997 May; 9(5):689-702. PMID: 9184914.
        View in: PubMed
      40. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Ann N Y Acad Sci. 1997 Apr 5; 815:484-8. PMID: 9186705.
        View in: PubMed
      41. Kantor AB, Merrill CE, MacKenzie JD, Herzenberg LA, Hillson JL. Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Ann N Y Acad Sci. 1995 Sep 29; 764:224-7. PMID: 7486528.
        View in: PubMed
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