John Mackenzie, MD

TitleAssociate Professor
SchoolUCSF School of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Children's Hospital of PhiladelphiaFellowship2007Radiology - Pediatric Imaging
    Hospital of the University of PennsylvaniaFellowship2006Radiology - Musculoskeletal Radiology
    Harvard: Brigham & Women's HospitalResidency2005Radiology - Diagnostic Imaging
    Hospital of the University of PennsylvaniaInternship2001Medicine
    Albert Einstein College of MedicineM.D.2000School of Medicine
    Stanford UniversityM.S.1995Biology
    Stanford UniversityB.S.1995Double major: Computer Science & Biology with Honors
    Collapse Awards and Honors
    Radiology Society of North America 2007Fellow Research Trainee Prize
    Radiology Society of North America2005RSNA Roentgen Resident/Fellow Research Award
    American Board of Radiology2003 - 2005Leonard Holman Pathway Research Resident
    UCSF Department of Pediatrics Grand Rounds2013Invited Lecturer; "Hyperpolarized Carbon-13 MRI for Pediatrics Disease"
    University of California, San Francisco 2012Coro Faculty Leadership Collaborative
    Pacific Coast Pediatric Radiology Association2011Award for Best Paper Presentation - Carbon-13 Imaging of Pediatric Disease
    National Academies Keck Futures Initiative2010Futures Initiative – Imaging Science Conference
    Radiology Society of North America2004Resident Research Trainee Prize
    Brigham and Women’s Hospital Radiology Department2005Resident Award for Research
    ISMRM/Amersham Health2004MRI Fellowship Program
    Siemens Medical Systems2004Research Resident Scholarship
    Brigham and Women’s Hospital Radiology Department2004Resident Award for Research
    Brigham and Women’s Hospital Radiology Department2002Resident Award for Teaching
    Radiology Society of North America2002Introduction to Research Program
    Brigham and Women’s Hospital Radiology Department2002Resident Award for Teaching
    Albert Einstein College of Medicine2000Alpha Omega Alpha
    Albert Einstein College of Medicine2000Research Scholarship
    Harvard Medical School1997Summer Research Grant Scholar
    Stanford University 1995Firestone Medal for Excellence in Biological Research
    Stanford University 1993Award for Excellence in Teaching Biological Sciences
    1988Boettcher Scholarship
    UCSF Department of Radiology2013Award for Best Scientific Poster (mentor to Julia Nguyen)
    UCSF Department of Radiology2012Award for Best Scientific Poster (mentor to Linda Nguyen)
    Radiology Society of North America2012Poster Presentation Award - Isolated Fallopian Tubal torsion: Causes, Imaging Findings, and How to

    Collapse Overview 
    Collapse Overview
    John MacKenzie, MD, is an Associate Professor in Residence, Chief of Radiology at Mission Bay Medical Center, and Section Chief of Pediatric Radiology at the University of California, San Francisco. He provides expert interpretation and consultation on pediatric imaging studies for a broad spectrum of congenital and acquired fetal and neonatal conditions and disorders affecting children and adolescents. Dr. MacKenzie earned his BS in Computer Science and Biology and MS in Biological Science from Stanford University in 1995. He received his MD in Medicine from the Albert Einstein College of Medicine, New York in 2000. Dr. MacKenzie completed his residency in Radiology at the Brigham and Women’s Hospital, Harvard University. He went on to study for two years at the University of Pennsylvania where he completed a fellowship in Musculoskeletal Imaging at the Hospital of the University of Pennsylvania in 2006 and a second fellowship in Pediatric Imaging in 2007 at the Children’s Hospital of Philadelphia. Prior to accepting his UCSF position, Dr. MacKenzie was a member of the faculty at Stanford University as the Chief of Pediatric Musculoskeletal Imaging at Lucile Packard Children’s Hospital from 2007-2010.

    Dr. MacKenzie is a nationally recognized expert in the imaging of the pediatric musculoskeletal system and is asked to lecture on this topic across the country. Dr. MacKenzie’s research focuses on developing imaging techniques for the detection and treatment monitoring of autoimmune diseases of the bones and joints. He studies how novel carbon-based imaging probes may depict molecular alterations in inflammatory arthritis, including rheumatoid arthritis, a disease that is common in adults, and juvenile idiopathic arthritis, the most common form of inflammatory arthritis in children. His long-term goal is to develop sensitive non-invasive imaging modalities to help guide the diagnosis and management of patients with common autoimmune diseases.

    Dr. MacKenzie has been awarded grants from the National Institutes of Health, National Academies Keck Futures Initiative Imaging Science, Radiological Society of North America and the Society of Pediatric Radiology. He has served as the Principal Investigator and Co-Principal Investigator on these projects. His work is published in 5 book chapters, 14 review articles, and 29 peer-reviewed research articles.

    Pediatric Radiology
    Pediatric Musculoskeletal Imaging

    Specialized imaging for infants, children with a focus on pediatric bones and joints

    Professional Interests:
    Pediatric imaging, musculoskeletal imaging, arthritis and immunology, molecular imaging, hyperpolarized carbon-13 imaging, magnetic resonance imaging

    Education and Training:
    • Medical School: Albert Einstein College of Medicine, New York - Medicine
    • Internship: Hospital of the University of Pennsylvania - Medicine
    • Residency: Brigham and Women’s Hospital, Boston - Radiology
    • Fellowship: Hospital of the University of Pennsylvania - Musculoskeletal Imaging
    • Fellowship: Children’s Hospital of Philadelphia - Pediatric Imaging
    • Master of Science: Stanford University, California - Biological Science
    • Bachelor’s of Science: Stanford University, California - Computer Science and Biology
    • Medical License, California
    • DEA, United States of America
    • X-Ray Supervisor, California
    • Diagnostic Radiology, American Board of Radiology
    • Pediatric Imaging, Certificate of Added Qualification, American Board of Radiology

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Imaging for Detection and Treatment Monitoring of Arthritis
    NIH/NIAMS K08AR061412Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Li Y, Lee MM, Worters PW, MacKenzie JD, Laszik Z, Courtier JL. Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts. AJR Am J Roentgenol. 2017 Apr 05; 1-7. PMID: 28379715.
      View in: PubMed
    2. Villanueva-Meyer JE, Naeger DM, Courtier JL, Hope MD, Lambert JW, MacKenzie JD, Phelps AS. Pediatric chest CT at chest radiograph doses: when is the ultralow-dose chest CT clinically appropriate? Emerg Radiol. 2017 Mar 14. PMID: 28289906.
      View in: PubMed
    3. Leelakanok N, Zapala MA, Edwards EA, Phelps AS, Mackenzie J, Courtier J. Incidental Findings on Pediatric Abdominal Magnetic Resonance Angiography. Acad Radiol. 2017 Mar 09. PMID: 28285838.
      View in: PubMed
    4. Phelps A, Ramachandran R, Courtier J, Perito E, Rosenthal P, MacKenzie JD. Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation? Clin Imaging. 2016 Oct 17; 41:95-100. PMID: 27840268.
      View in: PubMed
    5. Ehman EC, Phelps AS, Ohliger MA, Rhee SJ, MacKenzie JD, Courtier JL. Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation. Clin Imaging. 2016 Nov - Dec; 40(6):1135-1139. PMID: 27497037.
      View in: PubMed
    6. Zhang Y, Yang L, MacKenzie JD, Ramachandran R, Chen DZ. A seeding-searching-ensemble method for gland segmentation in H&E-stained images. BMC Med Inform Decis Mak. 2016; 16 Suppl 2:80. PMID: 27460014.
      View in: PubMed
    7. Steineck A, MacKenzie JD, Twist CJ. Premature physeal closure following 13-cis-retinoic acid and prolonged fenretinide administration in neuroblastoma. Pediatr Blood Cancer. 2016 Nov; 63(11):2050-3. PMID: 27399265.
      View in: PubMed
    8. Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. Mycobacterium bovis Enterocolitis in an Immunocompromised Host. J Pediatr Gastroenterol Nutr. 2016 Jul; 63(1):e17-9. PMID: 26020480.
      View in: PubMed
    9. Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805. PMID: 27229498.
      View in: PubMed
    10. Patel MV, Leibowich S, Courtier JL, Rhee S, MacKenzie JD. Disodium gadoxetate uptake in progressive familial intrahepatic cholestasis type I: Enhancing our understanding of the cholestatic disease. Radiol Case Rep. 2013; 8(1):661. PMID: 27330609.
      View in: PubMed
    11. Kim MJ, Rinsky LA, MacKenzie JD. Scapular stress fracture initially masquerading as tumor or infection. Radiol Case Rep. 2011; 6(4):510. PMID: 27307926.
      View in: PubMed
    12. Lambert JW, Phelps AS, Courtier JL, Gould RG, MacKenzie JD. Image quality and dose optimisation for infant CT using a paediatric phantom. Eur Radiol. 2016 May; 26(5):1387-95. PMID: 26304803.
      View in: PubMed
    13. Courtier J, Cardenas A, Tan C, Towne M, Rhee SJ, Heyman MB, MacKenzie JD. Nonanesthesia magnetic resonance enterography in young children: feasibility, technique, and performance. J Pediatr Gastroenterol Nutr. 2015 Jun; 60(6):754-61. PMID: 25996792.
      View in: PubMed
    14. Basta AM, Courtier J, Phelps A, Copp HL, MacKenzie JD. Scrotal swelling in the neonate. J Ultrasound Med. 2015 Mar; 34(3):495-505. PMID: 25715370.
      View in: PubMed
    15. Courtier J, Cardenas A, Tan C, Towne M, Rhee SJ, Heyman M, MacKenzie JD. Non-Anesthesia MR Enterography in Very Young Children-Feasibility, Technique and Performance. J Pediatr Gastroenterol Nutr. 2015 Jan 05. PMID: 25564800.
      View in: PubMed
    16. Phelps AS, Naeger DM, Courtier JL, Lambert JW, Marcovici PA, Villanueva-Meyer JE, MacKenzie JD. Pairwise comparison versus Likert scale for biomedical image assessment. AJR Am J Roentgenol. 2015 Jan; 204(1):8-14. PMID: 25539230.
      View in: PubMed
    17. Lin C, MacKenzie JD, Courtier JL, Gu JT, Milojevic D. Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging. Pediatr Rheumatol Online J. 2014; 12:25. PMID: 25067925; PMCID: PMC4110533.
    18. Lambert J, MacKenzie JD, Cody DD, Gould R. Techniques and tactics for optimizing CT dose in adults and children: state of the art and future advances. J Am Coll Radiol. 2014 Mar; 11(3):262-6. PMID: 24589401.
      View in: PubMed
    19. Koc G, Courtier JL, Phelps A, Marcovici PA, MacKenzie JD. Computed tomography depiction of small pediatric vessels with model-based iterative reconstruction. Pediatr Radiol. 2014 Jul; 44(7):787-94. PMID: 24531191.
      View in: PubMed
    20. Wang J, MacKenzie JD, Ramachandran R, Chen DZ. Identifying neutrophils in H&E staining histology tissue images. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):73-80. PMID: 25333103.
      View in: PubMed
    21. Courtier J, Ohliger M, Rhee SJ, Terreblanche O, Heyman MB, MacKenzie JD. Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):426-31. PMID: 24080754.
      View in: PubMed
    22. Koc G, Courtier JL, Kim JS, Miniati DN, MacKenzie JD. Intra-abdominal inverted umblical cord in gastroschisis: a unique ultrasound finding. Pediatr Radiol. 2014 Jan; 44(1):109-11. PMID: 23907187.
      View in: PubMed
    23. Patel AS, Soares B, Courtier J, Mackenzie JD. Radiation dose reduction in pediatric CT-guided musculoskeletal procedures. Pediatr Radiol. 2013 Oct; 43(10):1303-8. PMID: 23624510; PMCID: PMC3769501.
    24. Courtier J, Robbins E, Soares B, Horvai A, Mackenzie JD. Primary mixed malignant tumor of bone in an 18-year-old male: Report of a case with radiologic-pathologic correlation. J Bone Oncol. 2012 Dec; 1(3):101-5. PMID: 26909264.
      View in: PubMed
    25. Shive ML, Baskin LS, Harris CR, Bonham M, MacKenzie JD. Ureteral fibroepithelial polyp causing urinary obstruction. J Radiol Case Rep. 2012 Jul; 6(7):23-8. PMID: 23365709; PMCID: PMC3558047.
    26. Courtier JL, Perito ER, Rhee S, Tsai P, Heyman MB, MacKenzie JD. Targeted MRI contrast agents for pediatric hepatobiliary disease. J Pediatr Gastroenterol Nutr. 2012 Apr; 54(4):454-62. PMID: 22193178; PMCID: PMC3744898.
    27. Mackenzie JD, Hernandez A, Pena A, Ruppert K, Khrichenko D, Gonzalez L, Jawad AF, Wells L, Smith-Whitley K, Jaramillo D. Magnetic resonance imaging in children with sickle cell disease--detecting alterations in the apparent diffusion coefficient in hips with avascular necrosis. Pediatr Radiol. 2012 Jun; 42(6):706-13. PMID: 22200862.
      View in: PubMed
    28. Phelps A, Naeger DM, MacKenzie J, Qayyum A. Educating radiology residents in the new era: implementation and evaluation of online end-of-rotation examinations. Acad Radiol. 2011 Nov; 18(11):1442-6. PMID: 21971261.
      View in: PubMed
    29. Gu JT, Nguyen L, Chaudhari AJ, MacKenzie JD. Molecular characterization of rheumatoid arthritis with magnetic resonance imaging. Top Magn Reson Imaging. 2011 Apr; 22(2):61-9. PMID: 22648081; PMCID: PMC3387734.
    30. MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM. Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology. 2011 May; 259(2):414-20. PMID: 21406626; PMCID: PMC3079121.
    31. MacKenzie JD, Vasanawala SS. State-of-the-art in pediatric body and musculoskeletal magnetic resonance imaging. Semin Ultrasound CT MR. 2010 Apr; 31(2):86-99. PMID: 20304318.
      View in: PubMed
    32. Melvin JS, Mackenzie JD, Nacke E, Sennett BJ, Wells L. MRI of HAGL lesions: four arthroscopically confirmed cases of false-positive diagnosis. AJR Am J Roentgenol. 2008 Sep; 191(3):730-4. PMID: 18716101.
      View in: PubMed
    33. MacKenzie JD, Vasanawala SS. Advances in pediatric MR imaging. Magn Reson Imaging Clin N Am. 2008 Aug; 16(3):385-402, v. PMID: 18585595.
      View in: PubMed
    34. MacKenzie JD. MR arthrography made simple: indications and techniques. Pediatr Radiol. 2008 May; 38 Suppl 2:S240-2. PMID: 18401618.
      View in: PubMed
    35. MacKenzie JD, Nazario-Larrieu J, Cai T, Ledbetter MS, Duran-Mendicuti MA, Judy PF, Rybicki FJ. Reduced-dose CT: effect on reader evaluation in detection of pulmonary embolism. AJR Am J Roentgenol. 2007 Dec; 189(6):1371-9. PMID: 18029873.
      View in: PubMed
    36. MacKenzie JD, Gonzalez L, Hernandez A, Ruppert K, Jaramillo D. Diffusion-weighted and diffusion tensor imaging for pediatric musculoskeletal disorders. Pediatr Radiol. 2007 Aug; 37(8):781-8. PMID: 17598099.
      View in: PubMed
    37. Choi MH, MacKenzie JD, Dalinka MK. Imaging features of crystal-induced arthropathy. Rheum Dis Clin North Am. 2006 May; 32(2):427-46, viii. PMID: 16716888.
      View in: PubMed
    38. Shu KM, MacKenzie JD, Smith JB, Blinder EM, Bourgeois LM, Ledbetter S, Castronovo FP, Judy PF, Rybicki F. Lowering the thyroid dose in screening examinations of the cervical spine. Emerg Radiol. 2006 Mar; 12(3):133-6. PMID: 16362270.
      View in: PubMed
    39. Villalba ML, Huynh B, So M, Mackenzie JD, Ledbetter S, Rybicki F. An ovary with a twist: a case of interesting sonographic findings of ovarian torsion. J Emerg Med. 2005 Nov; 29(4):443-6. PMID: 16243204.
      View in: PubMed
    40. Vargas TM, Rybicki FJ, Ledbetter SM, MacKenzie JD. Atlantoaxial instability associated with an orthotopic os odontoideum: a multimodality imaging assessment. Emerg Radiol. 2005 Jun; 11(4):223-5. PMID: 16133608.
      View in: PubMed
    41. Viscomi S, Shu KM, Blinder EM, MacKenzie JD, Ledbetter S, Rybicki FJ. Quantification of clinical consultations in academic emergency radiology. Acad Radiol. 2004 Nov; 11(11):1294-7. PMID: 15561578.
      View in: PubMed
    42. Blinder E, MacKenzie JD, Cranmer HH, Ledbetter S, Rybicki F. Uterine rupture with peritonitis in a nongravid uterus eight weeks after cesarean section. Emerg Radiol. 2003 Apr; 10(1):57-9. PMID: 15290535.
      View in: PubMed
    43. MacKenzie JD, Siddiqi F, Babb JS, Bagley LJ, Mannon LJ, Sinson GP, Grossman RI. Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. AJNR Am J Neuroradiol. 2002 Oct; 23(9):1509-15. PMID: 12372740.
      View in: PubMed
    44. Seidl KJ, Wilshire JA, MacKenzie JD, Kantor AB, Herzenberg LA, Herzenberg LA. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2262-7. PMID: 10051629; PMCID: PMC26771.
    45. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol. 1997 May; 9(5):689-702. PMID: 9184914.
      View in: PubMed
    46. Seidl KJ, MacKenzie JD, Wang D, Kantor AB, Kabat EA, Herzenberg LA, Herzenberg LA. Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Ann N Y Acad Sci. 1997 Apr 5; 815:484-8. PMID: 9186705.
      View in: PubMed
    47. Kantor AB, Merrill CE, MacKenzie JD, Herzenberg LA, Hillson JL. Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Ann N Y Acad Sci. 1995 Sep 29; 764:224-7. PMID: 7486528.
      View in: PubMed
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