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    John Murnane, PhD

    TitleProfessor in Residence
    SchoolUCSF School of Medicine
    DepartmentRadiation Oncology
    Address2340 Sutter St.
    San Francisco CA 94143
    Phone415-476-9083

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Muraki K, Han L, Miller D, Murnane JP. The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line. PLoS Genet. 2013 Mar; 9(3):e1003386.
        View in: PubMed
      2. Muraki K, Nyhan K, Han L, Murnane JP. Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol. 2012; 2:135.
        View in: PubMed
      3. Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair (Amst). 2011 Nov 10; 10(11):1164-73.
        View in: PubMed
      4. Murnane JP. Telomere dysfunction and chromosome instability. Mutat Res. 2012 Feb 1; 730(1-2):28-36.
        View in: PubMed
      5. Miller D, Reynolds GE, Mejia R, Stark JM, Murnane JP. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst). 2011 May 5; 10(5):536-44.
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      6. Murnane JP. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010 Jun 1; 70(11):4255-9.
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      7. Kulkarni A, Zschenker O, Reynolds G, Miller D, Murnane JP. Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line. Mol Cell Biol. 2010 Feb; 30(3):578-89.
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      8. Zschenker O, Kulkarni A, Miller D, Reynolds GE, Granger-Locatelli M, Pottier G, Sabatier L, Murnane JP. Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line. DNA Repair (Amst). 2009 Aug 6; 8(8):886-900.
        View in: PubMed
      9. Gao Q, Reynolds GE, Wilcox A, Miller D, Cheung P, Artandi SE, Murnane JP. Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst). 2008 Aug 2; 7(8):1233-49.
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      10. Ho CY, Murnane JP, Yeung AK, Ng HK, Lo AW. Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells. Curr Biol. 2008 Feb 12; 18(3):183-7.
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      11. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92.
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      12. Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):728-34.
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      13. Murnane JP. Telomeres and chromosome instability. DNA Repair (Amst). 2006 Sep 8; 5(9-10):1082-92.
        View in: PubMed
      14. Bailey SM, Murnane JP. Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006; 34(8):2408-17.
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      15. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol. 2006 Mar; 26(5):1865-78.
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      16. Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006 Mar; 16(3):394-404.
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      17. Sabatier L, Ricoul M, Pottier G, Murnane JP. The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol Cancer Res. 2005 Mar; 3(3):139-50.
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      18. Murnane JP, Sabatier L. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays. 2004 Nov; 26(11):1164-74.
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      19. Weier HU, Chu LW, Murnane JP, Weier JF. Applications and technical challenges of fluorescence in situ hybridization in stem cell research. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):68-76.
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      20. Pirzio LM, Freulet-Marrière MA, Bai Y, Fouladi B, Murnane JP, Sabatier L, Desmaze C. Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation. Cytogenet Genome Res. 2004; 104(1-4):87-94.
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      21. Desmaze C, Pirzio LM, Blaise R, Mondello C, Giulotto E, Murnane JP, Sabatier L. Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells. Cytogenet Genome Res. 2004; 104(1-4):123-30.
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      22. Bai Y, Murnane JP. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol Cancer Res. 2003 Dec; 1(14):1058-69.
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      23. Bai Y, Murnane JP. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum Genet. 2003 Sep; 113(4):337-47.
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      24. Morales JF, Snow ET, Murnane JP. Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors. Mutagenesis. 2003 Mar; 18(2):151-8.
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      25. Lo AW, Sabatier L, Fouladi B, Pottier G, Ricoul M, Murnane JP. DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line. Neoplasia. 2002 Nov-Dec; 4(6):531-8.
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      26. Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane JP. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol. 2002 Jul; 22(13):4836-50.
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      27. Morales JF, Snow ET, Murnane JP. Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis. 2002 May; 17(3):193-200.
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      28. Schwartz JL, Jordan R, Liber H, Murnane JP, Evans HH. TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines. Genes Chromosomes Cancer. 2001 Mar; 30(3):236-44.
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      29. Fouladi B, Sabatier L, Miller D, Pottier G, Murnane JP. The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line. Neoplasia. 2000 Nov-Dec; 2(6):540-54.
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      30. Sprung CN, Afshar G, Chavez EA, Lansdorp P, Sabatier L, Murnane JP. Telomere instability in a human cancer cell line. Mutat Res. 1999 Oct 19; 429(2):209-23.
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      31. Afshar G, Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. Gene. 1999 Jun 24; 234(1):161-8.
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      32. Sprung CN, Reynolds GE, Jasin M, Murnane JP. Chromosome healing in mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6781-6.
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      33. Sprung CN, Sabatier L, Murnane JP. Telomere dynamics in a human cancer cell line. Exp Cell Res. 1999 Feb 25; 247(1):29-37.
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      34. Schwartz JL, Murnane J, Weichselbaum RR. The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. Br J Cancer. 1999 Feb; 79(5-6):744-7.
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      35. Desmaze C, Alberti C, Martins L, Pottier G, Sprung CN, Murnane JP, Sabatier L. The influence of interstitial telomeric sequences on chromosome instability in human cells. Cytogenet Cell Genet. 1999; 86(3-4):288-95.
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      36. Murnane JP. Comments on "Telomere-mediated chromosome healing" by P. Slijepcevic and P. E. Bryant (Radiat. Res. 148, 293, 1997) Radiat Res. 1998 Mar; 149(3):309-12.
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      37. Reddel RR, Bryan TM, Murnane JP. Immortalized cells with no detectable telomerase activity. A review. Biochemistry (Mosc). 1997 Nov; 62(11):1254-62.
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      38. Sprung CN, Bryan TM, Reddel RR, Murnane JP. Normal telomere maintenance in immortal ataxia telangiectasia cell lines. Mutat Res. 1997 Oct 6; 379(2):177-84.
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      39. Sprung CN, Sabatier L, Murnane JP. Effect of telomere length on telomeric gene expression. Nucleic Acids Res. 1996 Nov 1; 24(21):4336-40.
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      40. Murnane JP. Role of induced genetic instability in the mutagenic effects of chemicals and radiation. Mutat Res. 1996 Jan; 367(1):11-23.
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      41. Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7824-8.
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      42. Murnane JP, Morales JF. Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes. Nucleic Acids Res. 1995 Aug 11; 23(15):2837-9.
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      43. Hansell EJ, Frisch SM, Tremble P, Murnane JP, Werb Z. Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts. Biochem Cell Biol. 1995 Jul-Aug; 73(7-8):373-89.
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      44. Morgan WF, Murnane JP. A role for genomic instability in cellular radioresistance? Cancer Metastasis Rev. 1995 Mar; 14(1):49-58.
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      45. Murnane JP. Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective. Cancer Metastasis Rev. 1995 Mar; 14(1):17-29.
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      46. Murnane JP, Zhu Y, Young BR, Christman MF. Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation. Int J Radiat Biol. 1994 Dec; 66(6 Suppl):S77-84.
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      47. Murnane JP, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell line. EMBO J. 1994 Oct 17; 13(20):4953-62.
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      48. van Loon N, Miller D, Murnane JP. Formation of extrachromosomal circular DNA in HeLa cells by nonhomologous recombination. Nucleic Acids Res. 1994 Jul 11; 22(13):2447-52.
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      49. Leonhardt EA, Kapp LN, Young BR, Murnane JP. Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC). Genomics. 1994 Jan 1; 19(1):130-6.
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      50. Murnane JP, Schwartz JL. Cell checkpoint and radiosensitivity. Nature. 1993 Sep 2; 365(6441):22.
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      51. Richard CW, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR. A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus. Genomics. 1993 Jul; 17(1):1-5.
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      52. Murnane JP, Kapp LN. A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation. Semin Cancer Biol. 1993 Apr; 4(2):93-104.
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      53. Murnane JP, Yu LC. Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol Cell Biol. 1993 Feb; 13(2):977-83.
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      54. Kapp LN, Painter RB, Yu LC, van Loon N, Richard CW, James MR, Cox DR, Murnane JP. Cloning of a candidate gene for ataxia-telangiectasia group D. Am J Hum Genet. 1992 Jul; 51(1):45-54.
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      55. Nimon RA, Murnane JP, Howard WC. Transporting ESRD patients can be done at reasonable cost. Nephrol News Issues. 1991 Dec; 5(12):24, 30-1.
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      56. Murnane JP. The role of recombinational hotspots in genome instability in mammalian cells. Bioessays. 1990 Dec; 12(12):577-81.
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      57. Aggeler J, Murnane JP. Enhanced expression of procollagenase in ataxia-telangiectasia and xeroderma pigmentosum fibroblasts. In Vitro Cell Dev Biol. 1990 Sep; 26(9):915-22.
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      58. Murnane JP, Yezzi MJ, Young BR. Recombination events during integration of transfected DNA into normal human cells. Nucleic Acids Res. 1990 May 11; 18(9):2733-8.
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      59. Murnane JP. Influence of cellular sequences on instability of plasmid integration sites in human cells. Somat Cell Mol Genet. 1990 May; 16(3):195-209.
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      60. Murnane JP, Young BR. Nucleotide sequence analysis of novel junctions near an unstable integrated plasmid in human cells. Gene. 1989 Dec 7; 84(1):201-5.
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      61. Murnane JP, Yezzi MJ. Association of high rate of recombination with amplification of dominant selectable gene in human cells. Somat Cell Mol Genet. 1988 May; 14(3):273-86.
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      62. Murnane JP. Inducible gene expression by DNA rearrangements in human cells. Mol Cell Biol. 1986 Feb; 6(2):549-58.
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      63. Murnane JP, Fuller LF, Painter RB. Establishment and characterization of a permanent pSV ori--transformed ataxia-telangiectasia cell line. Exp Cell Res. 1985 May; 158(1):119-26.
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      64. Murnane JP, Li GC. Effect of heat shock on the intracellular distribution of proteins. Radiat Res. 1985 Mar; 101(3):480-90.
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      65. Morgan WF, Schwartz JL, Murnane JP, Wolff S. Effect of 3-aminobenzamide on sister chromatid exchange frequency in X-irradiated cells. Radiat Res. 1983 Mar; 93(3):567-71.
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      66. Murnane JP, Painter RB. Altered protein synthesis in ataxia--telangiectasia fibroblasts. Biochemistry. 1983 Mar 1; 22(5):1217-22.
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      67. Murnane JP, Painter RB. Complementation of the defects of DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1960-3.
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      68. Murnane JP, Byfield JE. Irreparable DNA cross-links and mammalian cell lethality with bifunctional alkylating agents. Chem Biol Interact. 1981 Dec; 38(1):75-86.
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      69. Murnane JP, Byfield JE, Chen CT, Wang CH. The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells. Biophys J. 1981 Sep; 35(3):665-76.
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      70. Byfield JE, Murnane J, Ward JF, Calabro-Jones P, Lynch M, Kulhanian F. Mice, men, mustard and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents. Br J Cancer. 1981 May; 43(5):669-83.
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      71. Murnane JP, Byfield JE, Ward JF, Calabro-Jones P. Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents. Nature. 1980 May 29; 285(5763):326-9.
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      72. ALTSCHULE MD, SIEGEL EP, GONCZ RM, MURNANE JP. Effect of pineal extracts on blood glutathione level in psychotic patients. AMA Arch Neurol Psychiatry. 1954 May; 71(5):615-8.
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