Jonathan Kleen, MD, PhD

TitleResident Physician
SchoolUCSF School of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    1. Kleen JK, Lowenstein DH. Progress in Epilepsy: Latest Waves of Discovery. JAMA Neurol. 2016 Dec 05. PMID: 27918766.
      View in: PubMed
    2. Kleen JK, Levin M. Injection Therapy for Headache and Facial Pain. Oral Maxillofac Surg Clin North Am. 2016 Aug; 28(3):423-34. PMID: 27475516.
      View in: PubMed
    3. Kleen JK, Testorf ME, Roberts DW, Scott RC, Jobst BJ, Holmes GL, Lenck-Santini PP. Oscillation Phase Locking and Late ERP Components of Intracranial Hippocampal Recordings Correlate to Patient Performance in a Working Memory Task. Front Hum Neurosci. 2016; 10:287. PMID: 27378885.
      View in: PubMed
    4. Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Neuro Oncol. 2015 Jun; 17(6):801-9. PMID: 25618892; PMCID: PMC4483125.
    5. Kleen J, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013 Jul 2; 81(1):18-24. PMID: 23685931; PMCID: PMC3770206.
    6. Kleen J, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011 Oct 26; 31(43):15397-406. PMID: 22031886; PMCID: PMC3224083.
    7. Kleen J, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011 Oct; 22(2):214-9. PMID: 21873119; PMCID: PMC3185212.
    8. Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar; 52(3):e12-5. PMID: 21366554; PMCID: PMC3265164.
    9. Kleen J, Holmes GL. Taming TLR4 may ease seizures. Nat Med. 2010 Apr; 16(4):369-70. PMID: 20376038.
      View in: PubMed
    10. Kleen J, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010 Feb; 67(2):250-7. PMID: 20225290; PMCID: PMC2926932.
    11. Kleen J, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008 Dec; 14(12):1309-10. PMID: 19057551.
      View in: PubMed
    12. Kleen J, Sitomer MT, Killeen PR, Conrad CD. Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav Neurosci. 2006 Aug; 120(4):842-51. PMID: 16893290; PMCID: PMC1578508.
    13. Baran SE, Campbell AM, Kleen J, Foltz CH, Wright RL, Diamond DM, Conrad CD. Combination of high fat diet and chronic stress retracts hippocampal dendrites. Neuroreport. 2005 Jan 19; 16(1):39-43. PMID: 15618887; PMCID: PMC1363787.
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