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    Josie Hayes, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address1450 3rd Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      University of LeedsPhDSchool of Medicine2015
      University of LeedsMaster of Research in BioinformaticsMolecular and Cellular Biology2004
      University of LeedsBSc GeneticsSchool of Biology2003
      St James's University HospitalClinical Scientist training and registrationYorkshire Regional Cytogenetics Dept2009

      Collapse Overview 
      Collapse Overview
      My long term interests are the improvement of patient management for brain tumors. I have ten years experience as a Clinical Cytogeneticist at St James's University Hospital in Leeds, UK where I pioneered the use of next generation sequencing technologies for detection of copy number alterations in patients with developmental delay. I also coordinated the introduction of next generation sequencing services for oncology mutation detection in non-small cell lung cancer. I obtained my PhD with Prof. D. Westhead at The University of Leeds where I worked with microRNA expression data to predict prognosis and drug response in glioblastoma. Currently I work as a postdoctoral fellow in Prof J. Costello's lab at UCSF where I work on the spatial and temporal genetic changes during the progression of glioma from low grade to high grade.

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hayes J, Thygesen H, Gregory W, Westhead DR, French PJ, Van Den Bent MJ, Lawler SE, Short SC, et al. A validated microRNA profile with predictive potential in glioblastoma patients treated with bevacizumab. Mol Oncol. 2016 Jul 1. PMID: 27396951.
        View in: PubMed
      2. Hayes J, Thygesen H, Droop A, Hughes TA, Westhead D, Lawler SE, Wurdak H, Short SC. Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation. Oncoscience. 2015; 2(3):252-62. PMID: 25897422; PMCID: PMC4394131.
      3. Hayes J, Thygesen H, Tumilson C, Droop A, Boissinot M, Hughes TA, Westhead D, Alder JE, Shaw L, Short SC, Lawler SE. Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature. Mol Oncol. 2015 Mar; 9(3):704-14. PMID: 25499534.
        View in: PubMed
      4. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014 Aug; 20(8):460-9. PMID: 25027972.
        View in: PubMed
      5. Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler S, Abounader R. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res. 2014 Mar 1; 74(5):1541-53. PMID: 24425048; PMCID: PMC3947487.
      6. Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. PMID: 23733246; PMCID: PMC3748913.
      7. Hayes JL, Tzika A, Thygesen H, Berri S, Wood HM, Hewitt S, Pendlebury M, Coates A, Willoughby L, Watson CM, Rabbitts P, Roberts P, Taylor GR. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics. 2013 Sep; 102(3):174-81. PMID: 23598253.
        View in: PubMed
      8. Hope IA, Stevens J, Garner A, Hayes J, Cheo DL, Brasch MA, Vidal M. Feasibility of genome-scale construction of promoter::reporter gene fusions for expression in Caenorhabditis elegans using a multisite gateway recombination system. Genome Res. 2004 Oct; 14(10B):2070-5. PMID: 15489328; PMCID: PMC528922.
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