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Josie Hayes, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address1450 3rd Street
San Francisco CA 94158
Phone415-514-1183
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    Collapse Biography 
    Collapse Education and Training
    University of LeedsPhD2015School of Medicine
    University of LeedsMaster of Research in Bioinformatics2004Molecular and Cellular Biology
    University of LeedsBSc Genetics2003School of Biology
    St James's University HospitalClinical Scientist training and registration2009Yorkshire Regional Cytogenetics Dept

    Collapse Overview 
    Collapse Overview
    My long term interests are the improvement of patient management for brain tumors. I have ten years experience as a Clinical Cytogeneticist at St James's University Hospital in Leeds, UK where I pioneered the use of next generation sequencing technologies for detection of copy number alterations in patients with developmental delay. I also coordinated the introduction of next generation sequencing services for oncology mutation detection in non-small cell lung cancer. I obtained my PhD with Prof. D. Westhead at The University of Leeds where I worked with microRNA expression data to predict prognosis and drug response in glioblastoma. Currently I work as a postdoctoral fellow in Prof J. Costello's lab at UCSF where I work on the spatial and temporal genetic changes during the progression of glioma from low grade to high grade.


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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Sep 15. PMID: 28916733.
      View in: PubMed
    2. Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JL, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK. GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance. JCI Insight. 2017 Jan 26; 2(2):e88815. PMID: 28138554.
      View in: PubMed
    3. Hayes J, Thygesen H, Gregory W, Westhead DR, French PJ, Van Den Bent MJ, Lawler SE, Short SC, et al. A validated microRNA profile with predictive potential in glioblastoma patients treated with bevacizumab. Mol Oncol. 2016 Oct; 10(8):1296-304. PMID: 27396951.
      View in: PubMed
    4. Hayes J, Thygesen H, Droop A, Hughes TA, Westhead D, Lawler SE, Wurdak H, Short SC. Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation. Oncoscience. 2015; 2(3):252-62. PMID: 25897422; PMCID: PMC4394131.
    5. Hayes J, Thygesen H, Tumilson C, Droop A, Boissinot M, Hughes TA, Westhead D, Alder JE, Shaw L, Short SC, Lawler SE. Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature. Mol Oncol. 2015 Mar; 9(3):704-14. PMID: 25499534.
      View in: PubMed
    6. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014 Aug; 20(8):460-9. PMID: 25027972.
      View in: PubMed
    7. Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler S, Abounader R. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res. 2014 Mar 01; 74(5):1541-53. PMID: 24425048; PMCID: PMC3947487.
    8. Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. PMID: 23733246; PMCID: PMC3748913.
    9. Hayes JL, Tzika A, Thygesen H, Berri S, Wood HM, Hewitt S, Pendlebury M, Coates A, Willoughby L, Watson CM, Rabbitts P, Roberts P, Taylor GR. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics. 2013 Sep; 102(3):174-81. PMID: 23598253.
      View in: PubMed
    10. Hope IA, Stevens J, Garner A, Hayes J, Cheo DL, Brasch MA, Vidal M. Feasibility of genome-scale construction of promoter::reporter gene fusions for expression in Caenorhabditis elegans using a multisite gateway recombination system. Genome Res. 2004 Oct; 14(10B):2070-5. PMID: 15489328; PMCID: PMC528922.
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