Katsunobu Hagihara, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
Address513 Parnassus Ave, Med Sci
San Francisco CA 94122
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    1. Ohtoyo M, Machinaga N, Inoue R, Hagihara K, Yuita H, Tamura M, Hashimoto R, Chiba J, Muro F, Watanabe J, Kobayashi Y, Abe K, Kita Y, Nagasaki M, Shimozato T. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19; 23(5):555-60. PMID: 27185637.
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    2. Ogitani Y, Aida T, Hagihara K, Yamaguchi J, Ishii C, Harada N, Soma M, Okamoto H, Oitate M, Arakawa S, Hirai T, Atsumi R, Nakada T, Hayakawa I, Abe Y, Agatsuma T. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15; 22(20):5097-5108. PMID: 27026201.
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    3. Kazui M, Ogura Y, Hagihara K, Kubota K, Kurihara A. Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase. Drug Metab Dispos. 2016 Jan; 44(1):115-23. PMID: 26558823.
      View in: PubMed
    4. Hirasawa M, Hagihara K, Okudaira N, Izumi T. The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01. PLoS One. 2015; 10(6):e0130928. PMID: 26098642; PMCID: PMC4476721.
    5. Kazui M, Hagihara K, Izumi T, Ikeda T, Kurihara A. Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel. Drug Metab Dispos. 2014 Jul; 42(7):1138-45. PMID: 24733788.
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    6. Hagihara K, Kazui M, Kurihara A, Ikeda T, Izumi T. Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate. Drug Metab Dispos. 2012 Sep; 40(9):1854-9. PMID: 22733806.
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    7. Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Izumi T, Ikeda T, Kurihara A. The intestine as an important contributor to prasugrel active metabolite formation in vivo. Drug Metab Dispos. 2011 Apr; 39(4):565-70. PMID: 21189331.
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    8. Hagihara K, Kazui M, Kurihara A, Kubota K, Ikeda T. Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel. Drug Metab Dispos. 2011 Feb; 39(2):208-14. PMID: 21036950.
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    9. Hagihara K, Kazui M, Kurihara A, Iwabuchi H, Ishikawa M, Kobayashi H, Tanaka N, Okazaki O, Farid NA, Ikeda T. Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. Drug Metab Dispos. 2010 Jun; 38(6):898-904. PMID: 20228231.
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    10. Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010 Jan; 38(1):92-9. PMID: 19812348.
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    11. Hagihara K, Kazui M, Kurihara A, Yoshiike M, Honda K, Okazaki O, Farid NA, Ikeda T. A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel. Drug Metab Dispos. 2009 Nov; 37(11):2145-52. PMID: 19704027.
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    12. Nishiya Y, Hagihara K, Ito T, Tajima M, Miura S, Kurihara A, Farid NA, Ikeda T. Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel. Drug Metab Dispos. 2009 Mar; 37(3):589-93. PMID: 19047469.
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    13. Hagihara K, Nishiya Y, Kurihara A, Kazui M, Farid NA, Ikeda T. Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine. Drug Metab Pharmacokinet. 2008; 23(6):412-20. PMID: 19122335.
      View in: PubMed
    14. Kohama Y, Shinoda S, Hagihara K, Hashimoto T, Yamaguchi A, Nakamura A, Tsuchiya T, Tsujikawa K, Yamamoto H. Isolation of proliferation factor of immature T-cell clone in concanavalin A-stimulated splenocyte culture supernatant. Immunology. 2003 Jun; 109(2):209-16. PMID: 12757615; PMCID: PMC1782958.
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