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    Kaveh Ashrafi, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentPhysiology
    Address600 16th Street, GH
    San Francisco CA 94143
    Phone415-514-4102

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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27):9983-8.
        View in: PubMed
      2. Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA, Ashrafi K. Loss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal Secretions. PLoS Genet. 2014 Jun; 10(6):e1004394.
        View in: PubMed
      3. Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses. PLoS One. 2014; 9(3):e92552.
        View in: PubMed
      4. Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine Signaling Regulates Fat Content through ß-Oxidation in Caenorhabditis elegans. PLoS One. 2014 Jan 22; 9(1):e85874.
        View in: PubMed
      5. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A Regulates Cell Fate duringC. elegans Vulval Development. PLoS Genet. 2013 Dec; 9(12):e1003992.
        View in: PubMed
      6. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding. PLoS Biol. 2013 Nov; 11(11):e1001712.
        View in: PubMed
      7. Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 2013 Oct; 12(5):932-40.
        View in: PubMed
      8. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 3; 16(1):113-21.
        View in: PubMed
      9. Barros AG, Liu J, Lemieux GA, Mullaney BC, Ashrafi K. Analyses of C. elegans fat metabolic pathways. Methods Cell Biol. 2012; 107:383-407.
        View in: PubMed
      10. Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol. 2011 Dec; 9(12):e1001219.
        View in: PubMed
      11. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13.
        View in: PubMed
      12. Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. A stress-responsive system for mitochondrial protein degradation. Mol Cell. 2010 Nov 12; 40(3):465-80.
        View in: PubMed
      13. Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 6; 12(4):398-410.
        View in: PubMed
      14. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8.
        View in: PubMed
      15. Jones KT, Ashrafi K. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Dis Model Mech. 2009 May-Jun; 2(5-6):224-9.
        View in: PubMed
      16. Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 3; 7(3):e60.
        View in: PubMed
      17. Cunningham KA, Ashrafi K. Fat rationing in dauer times. Cell Metab. 2009 Feb; 9(2):113-4.
        View in: PubMed
      18. Mullaney BC, Ashrafi K. C. elegans fat storage and metabolic regulation. Biochim Biophys Acta. 2009 Jun; 1791(6):474-8.
        View in: PubMed
      19. Lee BH, Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet. 2008 Oct; 4(10):e1000213.
        View in: PubMed
      20. Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008 Aug; 8(2):118-31.
        View in: PubMed
      21. Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008 Jun; 7(6):533-44.
        View in: PubMed
      22. Husson SJ, Janssen T, Baggerman G, Bogert B, Kahn-Kirby AH, Ashrafi K, Schoofs L. Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry. J Neurochem. 2007 Jul; 102(1):246-60.
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      23. Ashrafi K. Obesity and the regulation of fat metabolism. WormBook. 2007; 1-20.
        View in: PubMed
      24. Ashrafi K. Mapping out starvation responses. Cell Metab. 2006 Apr; 3(4):235-6.
        View in: PubMed
      25. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003 Jan 16; 421(6920):268-72.
        View in: PubMed
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