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    Kaveh Ashrafi, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentPhysiology
    Address600 16th Street
    San Francisco CA 94158
    Phone415-514-4102
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lemieux GA, Ashrafi K. Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans. Trends Endocrinol Metab. 2016 Aug; 27(8):586-96. PMID: 27289335.
        View in: PubMed
      2. Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015 Nov; 11(11):e1005627. PMID: 26540106; PMCID: PMC4635004.
      3. Lemieux GA, Ashrafi K. Neural Regulatory Pathways of Feeding and Fat in Caenorhabditis elegans. Annu Rev Genet. 2015 Nov 23; 49:413-38. PMID: 26473379.
        View in: PubMed
      4. Lemieux GA, Ashrafi K. Stressing about misplaced fat is a key to longevity. Elife. 2015; 4. PMID: 26287524; PMCID: PMC4541491.
      5. Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 2015 Jan 15; 160(1-2):119-31. PMID: 25594177; PMCID: PMC4334586 [Available on 01/15/16].
      6. Lemieux GA, Ashrafi K. Insights and challenges in using C. elegans for investigation of fat metabolism. Crit Rev Biochem Mol Biol. 2015 Jan-Feb; 50(1):69-84. PMID: 25228063.
        View in: PubMed
      7. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27):9983-8. PMID: 24961373; PMCID: PMC4103324.
      8. Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA, Ashrafi K. Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLoS Genet. 2014 Jun; 10(6):e1004394. PMID: 24921650; PMCID: PMC4055570.
      9. Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One. 2014; 9(3):e92552. PMID: 24651852; PMCID: PMC3961378.
      10. Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine signaling regulates fat content through ß-oxidation in Caenorhabditis elegans. PLoS One. 2014; 9(1):e85874. PMID: 24465759; PMCID: PMC3899111.
      11. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. PLoS Genet. 2013; 9(12):e1003992. PMID: 24348269; PMCID: PMC3861103.
      12. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
      13. Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 2013 Oct; 12(5):932-40. PMID: 23786484; PMCID: PMC3824081.
      14. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 3; 16(1):113-21. PMID: 22768843; PMCID: PMC3413480.
      15. Barros AG, Liu J, Lemieux GA, Mullaney BC, Ashrafi K. Analyses of C. elegans fat metabolic pathways. Methods Cell Biol. 2012; 107:383-407. PMID: 22226531.
        View in: PubMed
      16. Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol. 2011 Dec; 9(12):e1001219. PMID: 22180729; PMCID: PMC3236739.
      17. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
      18. Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. A stress-responsive system for mitochondrial protein degradation. Mol Cell. 2010 Nov 12; 40(3):465-80. PMID: 21070972; PMCID: PMC2998070.
      19. Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 6; 12(4):398-410. PMID: 20889131; PMCID: PMC2992884.
      20. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. PMID: 20338997; PMCID: PMC2865740.
      21. Jones KT, Ashrafi K. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Dis Model Mech. 2009 May-Jun; 2(5-6):224-9. PMID: 19407330; PMCID: PMC2675801.
      22. Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 3; 7(3):e60. PMID: 19260765; PMCID: PMC2650726.
      23. Cunningham KA, Ashrafi K. Fat rationing in dauer times. Cell Metab. 2009 Feb; 9(2):113-4. PMID: 19187769.
        View in: PubMed
      24. Mullaney BC, Ashrafi K. C. elegans fat storage and metabolic regulation. Biochim Biophys Acta. 2009 Jun; 1791(6):474-8. PMID: 19168149; PMCID: PMC2772880.
      25. Lee BH, Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet. 2008 Oct; 4(10):e1000213. PMID: 18846209; PMCID: PMC2556084.
      26. Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008 Aug; 8(2):118-31. PMID: 18680713; PMCID: PMC2556218.
      27. Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008 Jun; 7(6):533-44. PMID: 18522834; PMCID: PMC2495008.
      28. Husson SJ, Janssen T, Baggerman G, Bogert B, Kahn-Kirby AH, Ashrafi K, Schoofs L. Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry. J Neurochem. 2007 Jul; 102(1):246-60. PMID: 17564681.
        View in: PubMed
      29. Ashrafi K. Obesity and the regulation of fat metabolism. WormBook. 2007; 1-20. PMID: 18050496.
        View in: PubMed
      30. Ashrafi K. Mapping out starvation responses. Cell Metab. 2006 Apr; 3(4):235-6. PMID: 16581000.
        View in: PubMed
      31. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003 Jan 16; 421(6920):268-72. PMID: 12529643.
        View in: PubMed
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