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    Keiichi Kodama, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address550 16th Street, Floor 4
    San Francisco CA 94158
    Phone415-514-0515
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      Collapse Overview
      Our research interests focus on integrating genomics (bioinformatics) to identify diagnostics biomarkers, disease mechanisms and therapeutical drugs for diabetes.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Amor M, Moreno-Viedma V, Sarabi A, Grün NG, Itariu B, Leitner L, Steiner I, Bilban M, Kodama K, Butte AJ, Staffler G, Zeyda M, Stulnig TM, et al. Identification of matrix metalloproteinase-12 as a candidate molecule for prevention and treatment of cardiometabolic disease. Mol Med. 2016 Jun 30; 22. PMID: 27385318.
        View in: PubMed
      2. Kodama K, Zhao Z, Toda K, Yip L, Fuhlbrigge R, Miao D, Fathman CG, Yamada S, Butte AJ, Yu L. Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. Diabetes. 2016 May; 65(5):1341-9. PMID: 26983959.
        View in: PubMed
      3. Liu LF, Kodama K, Wei K, Tolentino LL, Choi O, Engleman EG, Butte AJ, McLaughlin T. The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue. Diabetologia. 2015 Jul; 58(7):1579-86. PMID: 25952479.
        View in: PubMed
      4. Kodama K, Toda K, Morinaga S, Yamada S, Butte AJ. Anti-CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet-induced obese mice. Diabetes. 2015 Mar; 64(3):867-75. PMID: 25294945; PMCID: PMC4392898 [Available on 03/01/16].
      5. Kodama K, Tojjar D, Yamada S, Toda K, Patel CJ, Butte AJ. Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis. Diabetes Care. 2013 Jun; 36(6):1789-96. PMID: 23704681; PMCID: PMC3661854.
      6. Patel CJ, Chen R, Kodama K, Ioannidis JP, Butte AJ. Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet. 2013 May; 132(5):495-508. PMID: 23334806; PMCID: PMC3625410.
      7. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A. 2012 May 1; 109(18):7049-54. PMID: 22499789; PMCID: PMC3344989.
      8. Chen R, Morgan AA, Dudley J, Deshpande T, Li L, Kodama K, Chiang AP, Butte AJ. FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol. 2008; 9(12):R170. PMID: 19061490; PMCID: PMC2646274.
      9. Udayasankar J, Kodama K, Hull RL, Zraika S, Aston-Mourney K, Subramanian SL, Tong J, Faulenbach MV, Vidal J, Kahn SE. Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets. Diabetologia. 2009 Jan; 52(1):145-53. PMID: 19002432.
        View in: PubMed
      10. Kodama K, Butte AJ, Creusot RJ, Su L, Sheng D, Hartnett M, Iwai H, Soares LR, Fathman CG. Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol. 2008 Nov; 129(2):195-201. PMID: 18801706; PMCID: PMC2592195.
      11. Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, Breckpot K, Thielemans K, Gambhir SS, Fathman CG. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol. 2008 May; 127(2):176-87. PMID: 18337172; PMCID: PMC2453076.
      12. Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, Kahn SE. Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care. 2006 Sep; 29(9):2078-83. PMID: 16936156.
        View in: PubMed
      13. Hull RL, Shen ZP, Watts MR, Kodama K, Carr DB, Utzschneider KM, Zraika S, Wang F, Kahn SE. Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide. Diabetes. 2005 Jul; 54(7):2235-44. PMID: 15983227.
        View in: PubMed
      14. Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE. Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia. 2005 Jul; 48(7):1350-8. PMID: 15937671.
        View in: PubMed
      15. Hull RL, Watts MR, Kodama K, Shen ZP, Utzschneider KM, Carr DB, Vidal J, Kahn SE. Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E703-9. PMID: 15899941.
        View in: PubMed
      16. Carr DB, Utzschneider KM, Boyko EJ, Asberry PJ, Hull RL, Kodama K, Callahan HS, Matthys CC, Leonetti DL, Schwartz RS, Kahn SE, Fujimoto WY. A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function. Diabetes. 2005 Feb; 54(2):340-7. PMID: 15677490.
        View in: PubMed
      17. Itoh A, Shimada A, Kodama K, Morimoto J, Suzuki R, Oikawa Y, Irie J, Nakagawa Y, Shigihara T, Kanazawa Y, Okubo Y, Motohashi Y, Maruyama T, Saruta T. GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9. Ann N Y Acad Sci. 2004 Dec; 1037:33-40. PMID: 15699491.
        View in: PubMed
      18. Utzschneider KM, Carr DB, Hull RL, Kodama K, Shofer JB, Retzlaff BM, Knopp RH, Kahn SE. Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes. 2004 Nov; 53(11):2867-72. PMID: 15504967.
        View in: PubMed
      19. Kodama K, Shimada A, Funae O, Morimoto J, Irie J, Shigihara T, Oikawa Y, Tokui M, Watanabe K, Saruta T. Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD mice. Autoimmunity. 2004 Sep-Nov; 37(6-7):481-7. PMID: 15621575.
        View in: PubMed
      20. Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, Brunzell JD, Shofer JB, Fish BE, Knopp RH, Kahn SE. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004 Aug; 53(8):2087-94. PMID: 15277390.
        View in: PubMed
      21. Shimada A, Kodama K, Morimoto J, Oikawa Y, Irie J, Nakagawa Y, Matsubara K, Maruyama T, Saruta T. Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:378-86. PMID: 14679096.
        View in: PubMed
      22. Yamada S, Shimada A, Kodama K, Morimoto J, Suzuki R, Oikawa Y, Irie J, Saruta T. Relationship between beta cell mass of NOD donors and diabetes development of NOD-scid recipients in adoptive transfer system. Ann N Y Acad Sci. 2003 Nov; 1005:211-4. PMID: 14679061.
        View in: PubMed
      23. Yamada S, Irie J, Shimada A, Kodama K, Morimoto J, Suzuki R, Oikawa Y, Saruta T. Assessment of beta cell mass and oxidative peritoneal exudate cells in murine type 1 diabetes using adoptive transfer system. Autoimmunity. 2003 Mar; 36(2):63-70. PMID: 12820687.
        View in: PubMed
      24. Suzuki R, Shimada A, Maruyama T, Funae O, Morimoto J, Kodama K, Oikawa Y, Kasuga A, Matsubara K, Saruta T, Narumi S. T-cell function in anti-GAD65(+)diabetes with residual beta-cell function. J Autoimmun. 2003 Feb; 20(1):83-90. PMID: 12604315.
        View in: PubMed
      25. Shimada A, Oikawa Y, Shigihara T, Senda T, Kodama K. A case of fulminant type 1 diabetes with strong evidence of autoimmunity. Diabetes Care. 2002 Aug; 25(8):1482-3. PMID: 12145259.
        View in: PubMed
      26. Shimada A, Morimoto J, Kodama K, Oikawa Y, Irie J, Nakagawa Y, Narumi S, Saruta T. T-cell-mediated autoimmunity may be involved in fulminant type 1 diabetes. Diabetes Care. 2002 Mar; 25(3):635-6. PMID: 11874969.
        View in: PubMed
      27. Shimada A, Morimoto J, Kodama K, Suzuki R, Oikawa Y, Funae O, Kasuga A, Saruta T, Narumi S. Elevated serum IP-10 levels observed in type 1 diabetes. Diabetes Care. 2001 Mar; 24(3):510-5. PMID: 11289477.
        View in: PubMed
      28. Significance of IGF-1 in type 1 diabetes. Diabetes Frontier. 2000; 11:393-395.
      29. A case of anti-GAD antibody-positive diabetes with idiopathic thrombocytopenic purpura (ITP). J. Japan Diabetes Society. 2000; 43(5):397-402.
      30. A case of diabetes mellitus with pyogenic vertebral osteomyelitis, pyogenic arthritis of knee joint and metastatic bacterial endophthalmitis associated with pneumococcal sepsis. J. Japan Diabetes Society. 2000; 44(3):235-240.
      31. Kodama K, Komatsu H, Sajima Y, Hasegawa N, Ishii K. . A case of esophageal cancer associated with Sweet’s syndrome. Nihon Shokakibyo Gakkai Zasshi. 1999; 96:824-828.
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