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Keith Mostov, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnatomy
Address600 16th St
San Francisco CA 94158
Phone415-476-6048
EmailKeith.Mostov@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    Oxford Rhodes Scholar, Oxford, EnglandNeurobiology
    Rockefeller (Guenter Blobel), New YorkPhDCell Biology
    Cornell Medical, New YorkMDMedicine
    Whitehead - PI , Cambridge MACell Bio

    Collapse Overview 
    Collapse Overview
    Formation and regeneration of epithelial tubes.

    Epithelia are the most common type of tissue in animals. Epithelial cells form sheets of cells that line surfaces and internal cavities. Most internal organs, such as the respiratory, digestive, genito-urinary and vascular systems, consist of a network of tubes that are lined by a single layer of epithelial cells, surrounded by other tissue types, such as muscle, neurons and connective tissue. We are studying how these epithelial tubes form and how they regenerate. We are using as models the tubes in several mammalian organ systems, such as the kidney and digestive system.

    We are particularly interested in how the size of tubes is regulated and how this impacts regeneration. For instance, the mammalian small intestine consists of villi that project into the lumen of the intestine to increase the surface area available to absorb nutrients from the intestinal lumen. In between the villi are crypts, outpouchings of the wall of the small intestine. Epithelial stem cells are located at the base of the crypts. Some daughters of the stem cells differentiate and move up the crypts into the villi and are eventually shed from the tips of the villi. A single crypt stem cell can regenerate an entire crypt-villus structure.

    The small intestine grows enormously in length both in the embryo and after birth, reaching a length of about 6 meters in the adult human. However, the small intestine never regenerates in length, either in the embryo or after birth. If the small intestine is abnormally short for any reason, such as mutation, injury or surgery, it can never recover in length. This is in stark contrast to the ability of a single stem cell in the base of the crypt to regenerate the entire crypt-villus structure. Almost nothing is known about the mechanisms that control the length of the small intestine. We have found multiple genes that control the length of the small intestine and have used them to uncover several signaling pathways that regulate the length of the small intestine. These genes and pathways open the door to therapies to promote regeneration of the length of the small intestine.


    Collapse Research 
    Collapse Research Activities and Funding
    A novel approach to acute kidney injury
    NIH/NIDDK P30 DK079307Aug 1, 2017 - Jul 31, 2019
    Role: Project Leader
    Exploring Design Principles of Cellular Control Circuits
    NIH/NIGMS P50 GM081879Jul 1, 2016 - Jun 30, 2018
    Role: Project Leader
    Control of Epithelial Polarity
    NIH/NIDDK R01DK091530Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Formation of bile ducts in three dimensional culture
    NIH/NIDDK R01DK083330Jun 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Recovery from acute kidney injury
    NIH/NIDDK R01DK074398Apr 1, 2006 - May 31, 2016
    Role: Principal Investigator
    Control of Orientation of Epithelial Polarity
    NIH/NIDDK R01DK067153Apr 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    Multiphoton Microscope Facility for UCSF Mission Bay
    NIH/NCRR S10RR017973Apr 1, 2003 - Mar 31, 2004
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Principal Investigator
    Novel Method for Mucosal Delivery of Protein Drugs
    NIH/NIDDK R01DK058061Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    NOVEL METHOD FOR MUCOSAL GENE DELIVERY
    NIH/NIDDK R21DK055772Apr 15, 1999 - Sep 30, 2001
    Role: Principal Investigator
    Regulation of Transcytosis of Polymeric Immunoglobulins
    NIH/NIAID R01AI036953Sep 30, 1995 - May 31, 2011
    Role: Principal Investigator
    HOST CELL DETERMINANTS IN PSEUDOMONAS PNEUMONIA
    NIH/NHLBI R01HL055980Sep 30, 1995 - Nov 30, 2005
    Role: Principal Investigator
    NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIES
    NIH/NIAID R01AI039161Sep 30, 1995 - Aug 31, 2000
    Role: Principal Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH/NIDDK P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator
    Transport of Immunoglobulins Across Epithelial Cells
    NIH/NIAID R37AI025144Aug 1, 1987 - Jul 31, 2013
    Role: Principal Investigator
    TRANSPORT OF IMMUNOGLOBULINS ACROSS EPITHELIAL CELLS
    NIH/NIAID R01AI025144Aug 1, 1987 - Jul 31, 2002
    Role: Principal Investigator
    RECEPTOR-MEDIATED TRANSPORT OF IGA AND IGM ACROSS CELLS
    NIH/NIAID R23AI021752Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Datta A, Sandilands E, Mostov KE, Bryant DM. Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cell Signal. 2017 Sep 06; 40:91-98. PMID: 28888686.
      View in: PubMed
    2. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK. Developing renal tubules orient cell division via Afadin to position the tubule lumen. Development. 2017 Aug 31. PMID: 28860115.
      View in: PubMed
    3. Ruch TR, Bryant DM, Mostov KE, Engel JN. Par3 Integrates Tiam1 and Phosphatidylinositol 3-Kinase Signaling to Change Apical Membrane Identity. Mol Biol Cell. 2016 Nov 23. PMID: 27881661.
      View in: PubMed
    4. Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH. CD2AP and LMAN2 regulate exosome cargo protein trafficking through the Golgi complex. J Biol Chem. 2016 Oct 20. PMID: 27765817.
      View in: PubMed
    5. Nedvetsky PI, Zhao X, Mathivet T, Aspalter IM, Stanchi F, Metzger RJ, Mostov KE, Gerhardt H. cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner. Development. 2016 Oct 1; 143(19):3582-3590. PMID: 27702786.
      View in: PubMed
    6. Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE. p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway. J Cell Sci. 2015 Dec 1; 128(23):4317-27. PMID: 26483385.
      View in: PubMed
    7. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87. PMID: 25307480; PMCID: PMC4248238.
    8. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. PMID: 25158854; PMCID: PMC4155578.
    9. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43. PMID: 24832456; PMCID: PMC4062193.
    10. Kwon SH, Liu KD, Mostov KE. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. Curr Biol. 2014 Jan 20; 24(2):199-204. PMID: 24412205; PMCID: PMC3938203.
    11. Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A. Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures. J Cell Biol. 2013 Oct 28; 203(2):359-72. PMID: 24145168; PMCID: PMC3812962.
    12. Rousso T, Shewan AM, Mostov KE, Schejter ED, Shilo BZ. Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife. 2013; 2:e00666. PMID: 23853710; PMCID: PMC3707080.
    13. Roignot J, Peng X, Mostov K. Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol. 2013 Feb; 5(2). PMID: 23378592; PMCID: PMC3552506.
    14. Cai L, Mostov KE. Cell height: Tao rising. J Cell Biol. 2012 Dec 24; 199(7):1023-4. PMID: 23266952; PMCID: PMC3529524.
    15. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49. PMID: 22820376; PMCID: PMC3433678.
    16. Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N. Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug; 23(15):2845-55. PMID: 22696678; PMCID: PMC3408412.
    17. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. PMID: 22675028; PMCID: PMC3408423.
    18. Eastburn DJ, Zegers MM, Mostov KE. Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. J Cell Sci. 2012 Sep 1; 125(Pt 17):4147-57. PMID: 22623728; PMCID: PMC3482320.
    19. Su T, Chapin SJ, Bryant DM, Shewan AM, Young K, Mostov KE. Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. J Biol Chem. 2011 Dec 30; 286(52):44921-5. PMID: 22086919; PMCID: PMC3247984.
    20. Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 1; 361(1):68-78. PMID: 22020048; PMCID: PMC3235368.
    21. Shewan A, Eastburn DJ, Mostov K. Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol. 2011 Aug; 3(8):a004796. PMID: 21576256; PMCID: PMC3140688.
    22. Lepanto P, Bryant DM, Rossello J, Datta A, Mostov KE, Kierbel A. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cell Microbiol. 2011 Aug; 13(8):1212-22. PMID: 21615664; PMCID: PMC3813436.
    23. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109. PMID: 21521738; PMCID: PMC3082309.
    24. Engelberg JA, Datta A, Mostov KE, Hunt CA. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol. 2011 Apr; 7(4):e1002030. PMID: 21490722; PMCID: PMC3072361.
    25. Datta A, Bryant DM, Mostov KE. Molecular regulation of lumen morphogenesis. Curr Biol. 2011 Feb 8; 21(3):R126-36. PMID: 21300279; PMCID: PMC3771703.
    26. Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2789-94. PMID: 21282656; PMCID: PMC3041130.
    27. Kwon SH, Nedvetsky PI, Mostov KE. Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis. Curr Biol. 2011 Jan 25; 21(2):161-6. PMID: 21236678; PMCID: PMC3031161.
    28. Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec; 12(12):1143-53. PMID: 21037565; PMCID: PMC3072784.
    29. Bagnat M, Navis A, Herbstreith S, Brand-Arzamendi K, Curado S, Gabriel S, Mostov K, Huisken J, Stainier DY. Cse1l is a negative regulator of CFTR-dependent fluid secretion. Curr Biol. 2010 Oct 26; 20(20):1840-5. PMID: 20933420; PMCID: PMC2963654.
    30. Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, Mostov KE. A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol. 2010 Nov; 12(11):1035-45. PMID: 20890297; PMCID: PMC2975675.
    31. Kim M, O'Brien LE, Kwon SH, Mostov KE. STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis. Mol Biol Cell. 2010 Nov 15; 21(22):3926-33. PMID: 20861313; PMCID: PMC2982126.
    32. Rodriguez-Fraticelli AE, Vergarajauregui S, Eastburn DJ, Datta A, Alonso MA, Mostov K, Martín-Belmonte F. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol. 2010 May 17; 189(4):725-38. PMID: 20479469; PMCID: PMC2872911.
    33. Eastburn DJ, Mostov KE. Laying the foundation for epithelia: insights into polarized basement membrane deposition. EMBO Rep. 2010 May; 11(5):329-30. PMID: 20379219; PMCID: PMC2868545.
    34. Kim SH, Matthay MA, Mostov K, Hunt CA. Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface. 2010 Aug 6; 7(49):1157-70. PMID: 20236957; PMCID: PMC2894878.
    35. Mostov K, Liptsen E, Boutchko R. Medical applications of shortwave FM radar: remote monitoring of cardiac and respiratory motion. Med Phys. 2010 Mar; 37(3):1332-8. PMID: 20384270; PMCID: PMC2847938.
    36. Kim SH, Debnath J, Mostov K, Park S, Hunt CA. A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009; 3:122. PMID: 20043854; PMCID: PMC2814811.
    37. Bucior I, Mostov K, Engel JN. Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium. Infect Immun. 2010 Mar; 78(3):939-53. PMID: 20008530; PMCID: PMC2825949.
    38. Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13; 139(4):660-2. PMID: 19914162; PMCID: PMC2900917.
    39. Kim SH, Park S, Mostov K, Debnath J, Hunt CA. Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009; 6:8. PMID: 19476639; PMCID: PMC2696420.
    40. Luton F, Hexham MJ, Zhang M, Mostov KE. Identification of a cytoplasmic signal for apical transcytosis. Traffic. 2009 Aug; 10(8):1128-42. PMID: 19522755; PMCID: PMC2920487.
    41. Tanimizu N, Miyajima A, Mostov KE. Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell. 2009 May; 20(9):2486-94. PMID: 19297530; PMCID: PMC2675627.
    42. Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA. A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 2009; 4(3):e4819. PMID: 19283073; PMCID: PMC2653231.
    43. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74. PMID: 19116242; PMCID: PMC2660185.
    44. Bryant DM, Mostov KE. From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol. 2008 Nov; 9(11):887-901. PMID: 18946477; PMCID: PMC2921794.
    45. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76. PMID: 18787414; PMCID: PMC2745397.
    46. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9. PMID: 18660750; PMCID: PMC2529350.
    47. Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Ewald A, Werb Z, Alonso MA, Mostov K. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol. 2008 Apr 8; 18(7):507-13. PMID: 18394894; PMCID: PMC2405957.
    48. Martin-Belmonte F, Mostov K. Regulation of cell polarity during epithelial morphogenesis. Curr Opin Cell Biol. 2008 Apr; 20(2):227-34. PMID: 18282696.
      View in: PubMed
    49. Engelberg JA, Kim M, Mostov KE, Hunt CA. In silico simulation of epithelial cell tubulogenesis. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1036-9. PMID: 19162839.
      View in: PubMed
    50. Bryant D, Mostov K. Development: inflationary pressures. Nature. 2007 Oct 4; 449(7162):549-50. PMID: 17914384.
      View in: PubMed
    51. Jacobson C, Mostov K. Catch the KIF5B train to the apical surface. Dev Cell. 2007 Oct; 13(4):457-8. PMID: 17925219.
      View in: PubMed
    52. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
      View in: PubMed
    53. Bagnat M, Cheung ID, Mostov KE, Stainier DY. Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol. 2007 Aug; 9(8):954-60. PMID: 17632505.
      View in: PubMed
    54. Kim M, Datta A, Brakeman P, Yu W, Mostov KE. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J Cell Sci. 2007 Jul 15; 120(Pt 14):2309-17. PMID: 17606986.
      View in: PubMed
    55. Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ. Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells. 2007 Sep; 25(9):2215-23. PMID: 17569786.
      View in: PubMed
    56. Martin-Belmonte F, Mostov K. Phosphoinositides control epithelial development. Cell Cycle. 2007 Aug 15; 6(16):1957-61. PMID: 17712229.
      View in: PubMed
    57. Bryant DM, Kerr MC, Hammond LA, Joseph SR, Mostov KE, Teasdale RD, Stow JL. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci. 2007 May 15; 120(Pt 10):1818-28. PMID: 17502486.
      View in: PubMed
    58. Kierbel A, Gassama-Diagne A, Rocha C, Radoshevich L, Olson J, Mostov K, Engel J. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. J Cell Biol. 2007 Apr 9; 177(1):21-7. PMID: 17403925; PMCID: PMC2064102.
    59. Leroy P, Mostov KE. Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell. 2007 May; 18(5):1943-52. PMID: 17344479; PMCID: PMC1855025.
    60. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
    61. Tanimizu N, Miyajima A, Mostov KE. Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Mol Biol Cell. 2007 Apr; 18(4):1472-9. PMID: 17314404; PMCID: PMC1838984.
    62. Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 2007 Jan 26; 128(2):383-97. PMID: 17254974; PMCID: PMC1865103.
    63. Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. A model of intussusceptive angiogenesis. Novartis Found Symp. 2007; 283:37-42; discussion 42-5, 238-41. PMID: 18300412.
      View in: PubMed
    64. Reiter JF, Mostov K. Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle. Proc Natl Acad Sci U S A. 2006 Dec 5; 103(49):18383-4. PMID: 17132734; PMCID: PMC1693671.
    65. Vergés M, Sebastián I, Mostov KE. Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor. Exp Cell Res. 2007 Feb 15; 313(4):707-18. PMID: 17184770; PMCID: PMC1810347.
    66. Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol. 2006 Sep; 8(9):963-70. PMID: 16921364.
      View in: PubMed
    67. Grant MR, Mostov KE, Tlsty TD, Hunt CA. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol. 2006 Oct 6; 2(10):e129. PMID: 17029556; PMCID: PMC1592363.
    68. Mostov K, Martin-Belmonte F. Developmental biology: the hole picture. Nature. 2006 Jul 27; 442(7101):363-4. PMID: 16871199.
      View in: PubMed
    69. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. PMID: 16697955; PMCID: PMC2925230.
    70. Mostov KE. mTOR is out of control in polycystic kidney disease. Proc Natl Acad Sci U S A. 2006 Apr 4; 103(14):5247-8. PMID: 16567652; PMCID: PMC1459339.
    71. O'Brien LE, Yu W, Tang K, Jou TS, Zegers MM, Mostov KE. Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol. 2006; 406:676-91. PMID: 16472697.
      View in: PubMed
    72. ter Beest MB, Chapin SJ, Avrahami D, Mostov KE. The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells. Mol Biol Cell. 2005 Dec; 16(12):5784-92. PMID: 16207812; PMCID: PMC1289421.
    73. Kierbel A, Gassama-Diagne A, Mostov K, Engel JN. The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization. Mol Biol Cell. 2005 May; 16(5):2577-85. PMID: 15772151; PMCID: PMC1087259.
    74. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30. PMID: 16355541.
      View in: PubMed
    75. Yu W, Datta A, Leroy P, O'Brien LE, Mak G, Jou TS, Matlin KS, Mostov KE, Zegers MM. Beta1-integrin orients epithelial polarity via Rac1 and laminin. Mol Biol Cell. 2005 Feb; 16(2):433-45. PMID: 15574881; PMCID: PMC545874.
    76. Tanimizu N, Saito H, Mostov K, Miyajima A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci. 2004 Dec 15; 117(Pt 26):6425-34. PMID: 15572411.
      View in: PubMed
    77. Vergés M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov KE. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2004 Aug; 6(8):763-9. PMID: 15247922.
      View in: PubMed
    78. O'Brien LE, Tang K, Kats ES, Schutz-Geschwender A, Lipschutz JH, Mostov KE. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell. 2004 Jul; 7(1):21-32. PMID: 15239951.
      View in: PubMed
    79. Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology. 2004 May; 39(5):1415-22. PMID: 15122771.
      View in: PubMed
    80. Kazmierczak BI, Mostov K, Engel JN. Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa. Mol Biol Cell. 2004 Feb; 15(2):411-9. PMID: 14595106; PMCID: PMC329196.
    81. Pollack AL, Apodaca G, Mostov KE. Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C482-94. PMID: 14592813.
      View in: PubMed
    82. Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J. 2003 Aug 15; 22(16):4155-65. PMID: 12912914; PMCID: PMC175788.
    83. Mostov KE. Epithelial polarity and morphogenesis. Methods. 2003 Jul; 30(3):189-90. PMID: 12798132.
      View in: PubMed
    84. Lai JF, Juang SH, Hung YM, Cheng HY, Cheng TL, Mostov KE, Jou TS. An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling. Am J Physiol Cell Physiol. 2003 Sep; 285(3):C711-9. PMID: 12736135.
      View in: PubMed
    85. Mostov K, Su T, ter Beest M. Polarized epithelial membrane traffic: conservation and plasticity. Nat Cell Biol. 2003 Apr; 5(4):287-93. PMID: 12669082.
      View in: PubMed
    86. Zegers MM, O'Brien LE, Yu W, Datta A, Mostov KE. Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol. 2003 Apr; 13(4):169-76. PMID: 12667754.
      View in: PubMed
    87. Lipschutz JH, Lingappa VR, Mostov KE. The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. J Biol Chem. 2003 Jun 6; 278(23):20954-60. PMID: 12665531.
      View in: PubMed
    88. Mostov K, Zegers M. Cell biology: Just mix and patch. Nature. 2003 Mar 20; 422(6929):267-8. PMID: 12646903.
      View in: PubMed
    89. Yu W, O'Brien LE, Wang F, Bourne H, Mostov KE, Zegers MM. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell. 2003 Feb; 14(2):748-63. PMID: 12589067; PMCID: PMC150005.
    90. van Ijzendoorn SC, Mostov KE, Hoekstra D. Role of rab proteins in epithelial membrane traffic. Int Rev Cytol. 2003; 232:59-88. PMID: 14711116.
      View in: PubMed
    91. O'Brien LE, Zegers MM, Mostov KE. Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol. 2002 Jul; 3(7):531-7. PMID: 12094219.
      View in: PubMed
    92. Lipschutz JH, Mostov KE. Exocytosis: the many masters of the exocyst. Curr Biol. 2002 Mar 19; 12(6):R212-4. PMID: 11909549.
      View in: PubMed
    93. van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell. 2002 Feb; 2(2):219-28. PMID: 11832247.
      View in: PubMed
    94. von Zastrow M, Mostov K. Signal transduction. A new thread in an intricate web. Science. 2001 Nov 30; 294(5548):1845-7. PMID: 11729293.
      View in: PubMed
    95. Lipschutz JH, O'Brien LE, Altschuler Y, Avrahami D, Nguyen Y, Tang K, Mostov KE. Analysis of membrane traffic in polarized epithelial cells. Curr Protoc Cell Biol. 2001 Nov; Chapter 15:Unit 15.5. PMID: 18228332.
      View in: PubMed
    96. O'Brien LE, Jou TS, Pollack AL, Zhang Q, Hansen SH, Yurchenco P, Mostov KE. Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat Cell Biol. 2001 Sep; 3(9):831-8. PMID: 11533663.
      View in: PubMed
    97. Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. Am J Physiol Renal Physiol. 2001 May; 280(5):F879-85. PMID: 11292631.
      View in: PubMed
    98. Kazmierczak BI, Jou TS, Mostov K, Engel JN. Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells. Cell Microbiol. 2001 Feb; 3(2):85-98. PMID: 11207623.
      View in: PubMed
    99. Kazmierczak BI, Mostov K, Engel JN. Interaction of bacterial pathogens with polarized epithelium. Annu Rev Microbiol. 2001; 55:407-35. PMID: 11544362.
      View in: PubMed
    100. Lipschutz JH, Guo W, O'Brien LE, Nguyen YH, Novick P, Mostov KE. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Mol Biol Cell. 2000 Dec; 11(12):4259-75. PMID: 11102522; PMCID: PMC15071.
    101. Hansen SH, Zegers MM, Woodrow M, Rodriguez-Viciana P, Chardin P, Mostov KE, McMahon M. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Mol Cell Biol. 2000 Dec; 20(24):9364-75. PMID: 11094087; PMCID: PMC102193.
    102. van Ooij C, Kalman L, Nishijima M, Hanada K, Mostov K, Engel JN. Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis. Cell Microbiol. 2000 Dec; 2(6):627-37. PMID: 11207614.
      View in: PubMed
    103. van Ijzendoorn SC, Mostov KE. Connecting apical endocytosis to the intracellular traffic infrastructure in polarized hepatocytes. Gastroenterology. 2000 Dec; 119(6):1791-4. PMID: 11113104.
      View in: PubMed
    104. Razani B, Altschuler Y, Zhu L, Pestell RG, Mostov KE, Lisanti MP. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry. 2000 Nov 14; 39(45):13916-24. PMID: 11076533.
      View in: PubMed
    105. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 6; 275(40):31255-65. PMID: 10893235.
      View in: PubMed
    106. Zhang JR, Mostov KE, Lamm ME, Nanno M, Shimida S, Ohwaki M, Tuomanen E. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell. 2000 Sep 15; 102(6):827-37. PMID: 11030626.
      View in: PubMed
    107. Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T. Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity. Mol Biol Cell. 2000 Sep; 11(9):3045-60. PMID: 10982399; PMCID: PMC14974.
    108. Mostov KE, Verges M, Altschuler Y. Membrane traffic in polarized epithelial cells. Curr Opin Cell Biol. 2000 Aug; 12(4):483-90. PMID: 10873817.
      View in: PubMed
    109. Zhang W, Razani B, Altschuler Y, Bouzahzah B, Mostov KE, Pestell RG, Lisanti MP. Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1. J Biol Chem. 2000 Jul 7; 275(27):20717-25. PMID: 10748172.
      View in: PubMed
    110. Wang E, Brown PS, Aroeti B, Chapin SJ, Mostov KE, Dunn KW. Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. Traffic. 2000 Jun; 1(6):480-93. PMID: 11208134.
      View in: PubMed
    111. Brown PS, Wang E, Aroeti B, Chapin SJ, Mostov KE, Dunn KW. Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. Traffic. 2000 Feb; 1(2):124-40. PMID: 11208093.
      View in: PubMed
    112. Mostov K, ter Beest MB, Chapin SJ. Catch the mu1B train to the basolateral surface. Cell. 1999 Oct 15; 99(2):121-2. PMID: 10535730.
      View in: PubMed
    113. Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol. 1999 Oct 4; 147(1):7-12. PMID: 10508850; PMCID: PMC2164974.
    114. Luton F, Vergés M, Vaerman JP, Sudol M, Mostov KE. The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo. Mol Cell. 1999 Oct; 4(4):627-32. PMID: 10549294.
      View in: PubMed
    115. Vergés M, Havel RJ, Mostov KE. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10146-51. PMID: 10468577; PMCID: PMC17857.
    116. Comolli JC, Waite LL, Mostov KE, Engel JN. Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. Infect Immun. 1999 Jul; 67(7):3207-14. PMID: 10377092; PMCID: PMC116497.
    117. Luton F, Mostov KE. Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals. Mol Biol Cell. 1999 May; 10(5):1409-27. PMID: 10233153; PMCID: PMC25293.
    118. Altschuler Y, Barbas SM, Terlecky LJ, Tang K, Hardy S, Mostov KE, Schmid SL. Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J Cell Biol. 1998 Dec 28; 143(7):1871-81. PMID: 9864361; PMCID: PMC2175237.
    119. Pollack AL, Runyan RB, Mostov KE. Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev Biol. 1998 Dec 1; 204(1):64-79. PMID: 9851843.
      View in: PubMed
    120. Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J. Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J Autoimmun. 1998 Oct; 11(5):573-80. PMID: 9802945.
      View in: PubMed
    121. Fleiszig SM, Vallas V, Jun CH, Mok L, Balkovetz DF, Roth MG, Mostov KE. Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor. Infect Immun. 1998 Jul; 66(7):3443-6. PMID: 9632620; PMCID: PMC108367.
    122. Weimbs T, Mostov K, Low SH, Hofmann K. A model for structural similarity between different SNARE complexes based on sequence relationships. Trends Cell Biol. 1998 Jul; 8(7):260-2. PMID: 9714596.
      View in: PubMed
    123. Luton F, Cardone MH, Zhang M, Mostov KE. Role of tyrosine phosphorylation in ligand-induced regulation of transcytosis of the polymeric Ig receptor. Mol Biol Cell. 1998 Jul; 9(7):1787-802. PMID: 9658171; PMCID: PMC25419.
    124. Low SH, Chapin SJ, Wimmer C, Whiteheart SW, Kömüves LG, Mostov KE, Weimbs T. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. J Cell Biol. 1998 Jun 29; 141(7):1503-13. PMID: 9647644; PMCID: PMC2133007.
    125. Bose S, Chapin SJ, Seetharam S, Feix J, Mostov KE, Seetharam B. Brefeldin A (BFA) inhibits basolateral membrane (BLM) delivery and dimerization of transcobalamin II receptor in human intestinal epithelial Caco-2 cells. BFA effects on BLM cholesterol content. J Biol Chem. 1998 Jun 26; 273(26):16163-9. PMID: 9632671.
      View in: PubMed
    126. Singer KL, Mostov KE. Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking. Mol Biol Cell. 1998 Apr; 9(4):901-15. PMID: 9529387; PMCID: PMC25316.
    127. Hauser AR, Fleiszig S, Kang PJ, Mostov K, Engel JN. Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells. Infect Immun. 1998 Apr; 66(4):1413-20. PMID: 9529061; PMCID: PMC108068.
    128. Low SH, Roche PA, Anderson HA, van Ijzendoorn SC, Zhang M, Mostov KE, Weimbs T. Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. J Biol Chem. 1998 Feb 6; 273(6):3422-30. PMID: 9452464.
      View in: PubMed
    129. Weimbs T, Low SH, Chapin SJ, Mostov KE. Apical targeting in polarized epithelial cells: There's more afloat than rafts. Trends Cell Biol. 1997 Oct; 7(10):393-9. PMID: 17708988.
      View in: PubMed
    130. Fleiszig SM, Evans DJ, Do N, Vallas V, Shin S, Mostov KE. Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity. Infect Immun. 1997 Jul; 65(7):2861-7. PMID: 9199460; PMCID: PMC175402.
    131. Pollack AL, Barth AI, Altschuler Y, Nelson WJ, Mostov KE. Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis. J Cell Biol. 1997 Jun 30; 137(7):1651-62. PMID: 9199178; PMCID: PMC2137813.
    132. Kang PJ, Hauser AR, Apodaca G, Fleiszig SM, Wiener-Kronish J, Mostov K, Engel JN. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol. 1997 Jun; 24(6):1249-62. PMID: 9218773.
      View in: PubMed
    133. Mostov K, Werb Z. Journey across the osteoclast. Science. 1997 Apr 11; 276(5310):219-20. PMID: 9132944.
      View in: PubMed
    134. Weimbs T, Low SH, Chapin SJ, Mostov KE, Bucher P, Hofmann K. A conserved domain is present in different families of vesicular fusion proteins: a new superfamily. Proc Natl Acad Sci U S A. 1997 Apr 1; 94(7):3046-51. PMID: 9096343; PMCID: PMC20319.
    135. Barth AI, Pollack AL, Altschuler Y, Mostov KE, Nelson WJ. NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J Cell Biol. 1997 Feb 10; 136(3):693-706. PMID: 9024698; PMCID: PMC2134296.
    136. Balkovetz DF, Pollack AL, Mostov KE. Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers. J Biol Chem. 1997 Feb 7; 272(6):3471-7. PMID: 9013593.
      View in: PubMed
    137. Fleiszig SM, Wiener-Kronish JP, Miyazaki H, Vallas V, Mostov KE, Kanada D, Sawa T, Yen TS, Frank DW. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun. 1997 Feb; 65(2):579-86. PMID: 9009316; PMCID: PMC176099.
    138. Low SH, Chapin SJ, Weimbs T, Kömüves LG, Bennett MK, Mostov KE. Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 1996 Dec; 7(12):2007-18. PMID: 8970161; PMCID: PMC276046.
    139. Reich V, Mostov K, Aroeti B. The basolateral sorting signal of the polymeric immunoglobulin receptor contains two functional domains. J Cell Sci. 1996 Aug; 109 ( Pt 8):2133-9. PMID: 8856509.
      View in: PubMed
    140. Enrich C, Apodaca G, Mostov KE. Calmodulin regulates the intracellular trafficking in epithelial cells. Z Gastroenterol. 1996 Jun; 34 Suppl 3:83-5. PMID: 8767473.
      View in: PubMed
    141. Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis. J Cell Biol. 1996 Jun; 133(5):997-1005. PMID: 8655590; PMCID: PMC2120848.
    142. Apodaca G, Cardone MH, Whiteheart SW, DasGupta BR, Mostov KE. Reconstitution of transcytosis in SLO-permeabilized MDCK cells: existence of an NSF-dependent fusion mechanism with the apical surface of MDCK cells. EMBO J. 1996 Apr 1; 15(7):1471-81. PMID: 8612570; PMCID: PMC450054.
    143. Chapin SJ, Enrich C, Aroeti B, Havel RJ, Mostov KE. Calmodulin binds to the basolateral targeting signal of the polymeric immunoglobulin receptor. J Biol Chem. 1996 Jan 19; 271(3):1336-42. PMID: 8576121.
      View in: PubMed
    144. Cardone M, Mostov K. Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor. FEBS Lett. 1995 Nov 27; 376(1-2):74-6. PMID: 8521971.
      View in: PubMed
    145. Song W, Vaerman JP, Mostov KE. Dimeric and tetrameric IgA are transcytosed equally by the polymeric Ig receptor. J Immunol. 1995 Jul 15; 155(2):715-21. PMID: 7608549.
      View in: PubMed
    146. Ma JK, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T. Generation and assembly of secretory antibodies in plants. Science. 1995 May 5; 268(5211):716-9. PMID: 7732380.
      View in: PubMed
    147. Apodaca G, Bomsel M, Lindstedt R, Engel J, Frank D, Mostov KE, Wiener-Kronish J. Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing. Infect Immun. 1995 Apr; 63(4):1541-51. PMID: 7890421; PMCID: PMC173187.
    148. Mostov KE. Regulation of protein traffic in polarized epithelial cells. Histol Histopathol. 1995 Apr; 10(2):423-31. PMID: 7599439.
      View in: PubMed
    149. Mostov KE, Cardone MH. Regulation of protein traffic in polarized epithelial cells. Bioessays. 1995 Feb; 17(2):129-38. PMID: 7748163.
      View in: PubMed
    150. Mostov KE, Altschuler Y, Chapin SJ, Enrich C, Low SH, Luton F, Richman-Eisenstat J, Singer KL, Tang K, Weimbs T. Regulation of protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor model. Cold Spring Harb Symp Quant Biol. 1995; 60:775-81. PMID: 8824452.
      View in: PubMed
    151. Bonzelius F, Herman GA, Cardone MH, Mostov KE, Kelly RB. The polymeric immunoglobulin receptor accumulates in specialized endosomes but not synaptic vesicles within the neurites of transfected neuroendocrine PC12 cells. J Cell Biol. 1994 Dec; 127(6 Pt 1):1603-16. PMID: 7798315; PMCID: PMC2120272.
    152. Song W, Apodaca G, Mostov K. Transcytosis of the polymeric immunoglobulin receptor is regulated in multiple intracellular compartments. J Biol Chem. 1994 Nov 25; 269(47):29474-80. PMID: 7961930.
      View in: PubMed
    153. Apodaca G, Enrich C, Mostov KE. The calmodulin antagonist, W-13, alters transcytosis, recycling, and the morphology of the endocytic pathway in Madin-Darby canine kidney cells. J Biol Chem. 1994 Jul 22; 269(29):19005-13. PMID: 7913467.
      View in: PubMed
    154. Okamoto CT, Song W, Bomsel M, Mostov KE. Rapid internalization of the polymeric immunoglobulin receptor requires phosphorylated serine 726. J Biol Chem. 1994 Jun 3; 269(22):15676-82. PMID: 8195218.
      View in: PubMed
    155. Aroeti B, Mostov KE. Polarized sorting of the polymeric immunoglobulin receptor in the exocytotic and endocytotic pathways is controlled by the same amino acids. EMBO J. 1994 May 15; 13(10):2297-304. PMID: 8194521; PMCID: PMC395093.
    156. Bomsel M, Mostov KE. Both the Gs alpha and beta gamma subunits of the heterotrimeric G protein, Gs, control the sorting of the polymeric immunoglobulin receptor into transcytotic vesicles. Biochem Soc Trans. 1994 May; 22(2):463-8. PMID: 7958347.
      View in: PubMed
    157. Apodaca G, Katz LA, Mostov KE. Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes. J Cell Biol. 1994 Apr; 125(1):67-86. PMID: 8138576; PMCID: PMC2120019.
    158. Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol. 1994 Apr; 125(2):313-20. PMID: 8163548; PMCID: PMC2120024.
    159. Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. J Cell Biol. 1994 Mar; 124(5):717-27. PMID: 8120094; PMCID: PMC2119954.
    160. Song W, Bomsel M, Casanova J, Vaerman JP, Mostov K. Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA. Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1):163-6. PMID: 8278358; PMCID: PMC42906.
    161. Mostov KE. Transepithelial transport of immunoglobulins. Annu Rev Immunol. 1994; 12:63-84. PMID: 8011293.
      View in: PubMed
    162. Bomsel M, Mostov KE. Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor. J Biol Chem. 1993 Dec 5; 268(34):25824-35. PMID: 8245019.
      View in: PubMed
    163. Aroeti B, Kosen PA, Kuntz ID, Cohen FE, Mostov KE. Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. J Cell Biol. 1993 Dec; 123(5):1149-60. PMID: 8245123; PMCID: PMC2119873.
    164. Apodaca G, Mostov KE. Transcytosis of placental alkaline phosphatase-polymeric immunoglobulin receptor fusion proteins is regulated by mutations of Ser664. J Biol Chem. 1993 Nov 5; 268(31):23712-9. PMID: 8226896.
      View in: PubMed
    165. Apodaca G, Aroeti B, Tang K, Mostov KE. Brefeldin-A inhibits the delivery of the polymeric immunoglobulin receptor to the basolateral surface of MDCK cells. J Biol Chem. 1993 Sep 25; 268(27):20380-5. PMID: 8376395.
      View in: PubMed
    166. Lindstedt R, Apodaca G, Barondes SH, Mostov KE, Leffler H. Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway. J Biol Chem. 1993 Jun 5; 268(16):11750-7. PMID: 8505302.
      View in: PubMed
    167. Chang MP, Mallet WG, Mostov KE, Brodsky FM. Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits. EMBO J. 1993 May; 12(5):2169-80. PMID: 8491205; PMCID: PMC413438.
    168. Mostov K. Protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor as a model system. J Cell Sci Suppl. 1993; 17:21-6. PMID: 8144699.
      View in: PubMed
    169. Bomsel M, Mostov K. Role of heterotrimeric G proteins in membrane traffic. Mol Biol Cell. 1992 Dec; 3(12):1317-28. PMID: 1493332; PMCID: PMC275702.
    170. Okamoto CT, Shia SP, Bird C, Mostov K, Roth MG. The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal. J Biol Chem. 1992 May 15; 267(14):9925-32. PMID: 1577823.
      View in: PubMed
    171. Mostov K, Apodaca G, Aroeti B, Okamoto C. Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol. 1992 Feb; 116(3):577-83. PMID: 1730769; PMCID: PMC2289323.
    172. Aroeti B, Casanova J, Okamoto C, Cardone M, Pollack A, Tang K, Mostov K. Polymeric immunoglobulin receptor. Int Rev Cytol. 1992; 137B:157-68. PMID: 1478818.
      View in: PubMed
    173. Casanova JE, Mishumi Y, Ikehara Y, Hubbard AL, Mostov K. Direct apical sorting of rat liver dipeptidylpeptidase IV expressed in Madin-Darby canine kidney cells. J Biol Chem. 1991 Dec 25; 266(36):24428-32. PMID: 1684792.
      View in: PubMed
    174. Mostov K. The polymeric immunoglobulin receptor. Semin Cell Biol. 1991 Dec; 2(6):411-8. PMID: 1813030.
      View in: PubMed
    175. Bomsel M, Mostov K. Sorting of plasma membrane proteins in epithelial cells. Curr Opin Cell Biol. 1991 Aug; 3(4):647-53. PMID: 1772657.
      View in: PubMed
    176. Casanova JE, Apodaca G, Mostov K. An autonomous signal for basolateral sorting in the cytoplasmic domain of the polymeric immunoglobulin receptor. Cell. 1991 Jul 12; 66(1):65-75. PMID: 2070419.
      View in: PubMed
    177. Apodaca G, Bomsel M, Arden J, Breitfeld PP, Tang K, Mostov K. The polymeric immunoglobulin receptor. A model protein to study transcytosis. J Clin Invest. 1991 Jun; 87(6):1877-82. PMID: 2040683; PMCID: PMC296937.
    178. Breitfeld PP, McKinnon WC, Mostov K. Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells. J Cell Biol. 1990 Dec; 111(6 Pt 1):2365-73. PMID: 2277063; PMCID: PMC2116403.
    179. Breitfeld PP, Casanova JE, McKinnon WC, Mostov K. Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic. J Biol Chem. 1990 Aug 15; 265(23):13750-7. PMID: 2380185.
      View in: PubMed
    180. Casanova JE, Breitfeld PP, Ross SA, Mostov K. Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis. Science. 1990 May 11; 248(4956):742-5. PMID: 2110383.
      View in: PubMed
    181. Le Bivic A, Sambuy Y, Mostov K, Rodriguez-Boulan E. Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. J Cell Biol. 1990 May; 110(5):1533-9. PMID: 2335561; PMCID: PMC2200188.
    182. Breitfeld PP, Casanova JE, Simister NE, Ross SA, McKinnon WC, Mostov K. Transepithelial transport of immunoglobulins: a model of protein sorting and transcytosis. Am J Respir Cell Mol Biol. 1989 Oct; 1(4):257-62. PMID: 2696513.
      View in: PubMed
    183. Breitfeld PP, Harris JM, Mostov K. Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells. J Cell Biol. 1989 Aug; 109(2):475-86. PMID: 2760105; PMCID: PMC2115734.
    184. Breitfeld PP, Casanova JE, Simister NE, Ross SA, McKinnon WC, Mostov K. Sorting signals. Curr Opin Cell Biol. 1989 Aug; 1(4):617-23. PMID: 2576381.
      View in: PubMed
    185. Simister NE, Mostov K. An Fc receptor structurally related to MHC class I antigens. Nature. 1989 Jan 12; 337(6203):184-7. PMID: 2911353.
      View in: PubMed
    186. Simister NE, Mostov K. Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:571-80. PMID: 2534798.
      View in: PubMed
    187. Breitfeld PP, Casanova JE, Harris JM, Simister NE, Mostov K. Expression and analysis of the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells using retroviral vectors. Methods Cell Biol. 1989; 32:329-37. PMID: 2532705.
      View in: PubMed
    188. Breitfeld PP, Harris JM, Mostov KE. Cell biology of the IgA receptor in polarized epithelia. Monogr Allergy. 1988; 24:66-70. PMID: 3283534.
      View in: PubMed
    189. Mostov KE, Breitfeld P, Harris JM. An anchor-minus form of the polymeric immunoglobulin receptor is secreted predominantly apically in Madin-Darby canine kidney cells. J Cell Biol. 1987 Nov; 105(5):2031-6. PMID: 3680369; PMCID: PMC2114864.
    190. Mostov KE, de Bruyn Kops A, Deitcher DL. Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis. Cell. 1986 Nov 7; 47(3):359-64. PMID: 3768957.
      View in: PubMed
    191. Mostov KE, Deitcher DL. Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA. Cell. 1986 Aug 15; 46(4):613-21. PMID: 3524859.
      View in: PubMed
    192. Deitcher DL, Mostov KE. Alternate splicing of rabbit polymeric immunoglobulin receptor. Mol Cell Biol. 1986 Jul; 6(7):2712-5. PMID: 3785206; PMCID: PMC367828.
    193. Deitcher DL, Neutra MR, Mostov KE. Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts. J Cell Biol. 1986 Mar; 102(3):911-9. PMID: 3753981; PMCID: PMC2114126.
    194. Mostov KE, Friedlander M, Blobel G. Structure and function of the receptor for polymeric immunoglobulins. Biochem Soc Symp. 1986; 51:113-5. PMID: 3814164.
      View in: PubMed
    195. Mostov KE, Simister NE. Transcytosis. Cell. 1985 Dec; 43(2 Pt 1):389-90. PMID: 4075399.
      View in: PubMed
    196. Mostov KE, Friedlander M, Blobel G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature. 1984 Mar 1-7; 308(5954):37-43. PMID: 6322002.
      View in: PubMed
    197. Anderson DJ, Mostov KE, Blobel G. Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5. Proc Natl Acad Sci U S A. 1983 Dec; 80(23):7249-53. PMID: 6227918; PMCID: PMC390032.
    198. Mostov KE, Blobel G. Transcellular transport of polymeric immunoglobulin by secretory component: a model system for studying intracellular protein sorting. Ann N Y Acad Sci. 1983 Jun 30; 409:441-51. PMID: 6135383.
      View in: PubMed
    199. Mostov KE, Blobel G. Biosynthesis, processing, and function of secretory component. Methods Enzymol. 1983; 98:458-66. PMID: 6669056.
      View in: PubMed
    200. Mostov KE, Blobel G. A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins. J Biol Chem. 1982 Oct 10; 257(19):11816-21. PMID: 7118912.
      View in: PubMed
    201. Hemperly JJ, Mostov KE, Cunningham BA. In vitro translation and processing of a precursor form of favin, a lectin from Vicia faba. J Biol Chem. 1982 Jul 10; 257(13):7903-9. PMID: 7085653.
      View in: PubMed
    202. Mostov KE, DeFoor P, Fleischer S, Blobel G. Co-translational membrane integration of calcium pump protein without signal sequence cleavage. Nature. 1981 Jul 2; 292(5818):87-8. PMID: 6456415.
      View in: PubMed
    203. Mostov KE, Kraehenbuhl JP, Blobel G. Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7257-61. PMID: 6938972; PMCID: PMC350481.
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