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    Kirk Ehmsen, PhD

    TitleAssistant Researcher
    SchoolUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-8445
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      University of California, San FranciscoPostdoctoral StudiesGraduate Division

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mukherjee S, Wright WD, Ehmsen KT, Heyer WD. The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage. Nucleic Acids Res. 2014 Jun; 42(10):6511-22. PMID: 24744239; PMCID: PMC4041439.
      2. Zhang XP, Janke R, Kingsley J, Luo J, Fasching C, Ehmsen KT, Heyer WD. A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity. PLoS One. 2013; 8(12):e82184. PMID: 24358152; PMCID: PMC3864901.
      3. Schwartz EK, Wright WD, Ehmsen KT, Evans JE, Stahlberg H, Heyer WD. Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair. Mol Cell Biol. 2012 Aug; 32(15):3065-80. PMID: 22645308; PMCID: PMC3434506.
      4. Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol. 2012 May; 32(9):1592-603. PMID: 22354996; PMCID: PMC3347241.
      5. Liu J, Ehmsen KT, Heyer WD, Morrical SW. Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol. 2011 Jun; 46(3):240-70. PMID: 21599536; PMCID: PMC4083101.
      6. Wright WD, Ehmsen KT, Heyer WD. Assays for structure-selective DNA endonucleases. Methods Mol Biol. 2011; 745:345-62. PMID: 21660704; PMCID: PMC4096161.
      7. Heyer WD, Ehmsen KT, Liu J. Regulation of homologous recombination in eukaryotes. Annu Rev Genet. 2010; 44:113-39. PMID: 20690856; PMCID: PMC4114321.
      8. Ehmsen KT, Heyer WD. A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4. Nucleic Acids Res. 2009 Apr; 37(6):2026-36. PMID: 19211663; PMCID: PMC2665226.
      9. Ehmsen KT, Heyer WD. Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res. 2008 Apr; 36(7):2182-95. PMID: 18281703; PMCID: PMC2367710.
      10. Heyer WD, Ehmsen KT, Solinger JA. Holliday junctions in the eukaryotic nucleus: resolution in sight? Trends Biochem Sci. 2003 Oct; 28(10):548-57. PMID: 14559184.
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