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Kirsten Kangelaris, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Phone415-476-4852
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.A.S. in Clinical Research2010 Graduate Division (Advance Training in Clinical Research)

    Collapse Overview 
    Collapse Overview
    Dr. Kangelaris is a hospitalist committed to improving the care of hospitalized adults. Her clinical work includes caring for medical patients on the teaching service at Moffitt-Long hospital and serving as a medical consultant on the inpatient Neurosurgical Surgery service.

    Her research focuses on the role of neutrophils in the development of organ dysfunction in sepsis. Specifically, she studies clinical cohorts of patients with sepsis and the Acute Respiratory Distress Syndrome (ARDS), a common complication of sepsis, using biological markers including genomic, transcriptional and protein biomarkers in order to understand the biological underpinnings of the host response to sepsis and it's complications. The goal of this work is to identify different biological subtypes of risk that can be used to improve treatments and risk stratification in sepsis and ARDS. She is also committed to understanding the epidemiology of early critical illness and expanding cohorts to include non-intensive care unit patients in order to enhance understanding of spectrum of illness in sepsis. Another specific focus relates to understanding genetic and biologic determinants of ARDS observed in African American patients, who suffer increased acute lung injury incidence and mortality.

    Dr. Kangelaris is currently supported by an NHLBI K23 to study chemokine-related pathways of ARDS pathogenesis in African-American patients. She completed medical school, internship and residency in Internal Medicine at the University of Michigan Medical School, and completed a General Medicine Research Fellowship and a Master's of Advanced Studies in Clinical Research at UCSF. She joined faculty in the Division of Hospital Medicine at UCSF in 2010. She is a Fellow of the Society of Hospital Medicine and member of the American Thoracic Society.


    Collapse Research 
    Collapse Research Activities and Funding
    Chemokine-related acute lung injury pathogenesis in African-American patients
    NIH/NHLBI K23HL116800Mar 1, 2013 - Feb 28, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131. PMID: 28593401.
      View in: PubMed
    2. Famous KR, Delucchi K, Ware LB, Kangelaris K, Liu KD, Thompson BT, Calfee CS, et al. Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):331-338. PMID: 27513822.
      View in: PubMed
    3. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e771. PMID: 27428150.
      View in: PubMed
    4. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e769-70. PMID: 27428148.
      View in: PubMed
    5. Patel H, Fang MC, Harrison JD, Auerbach A, Kangelaris K, et al. Implementation and evaluation of a "works-in-progress" session to promote scholarship in an academic hospitalist group. J Hosp Med. 2016 Oct; 11(10):719-723. PMID: 27294477.
      View in: PubMed
    6. Kangelaris K, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. PMID: 26474112; PMCID: PMC4774861 [Available on 01/01/17].
    7. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep; 43(9):1790-7. PMID: 26010690; PMCID: PMC4737582.
    8. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun; 147(6):1539-1548. PMID: 26033126; PMCID: PMC4451708.
    9. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399.
    10. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    11. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527.
    12. Kangelaris KN, Seeley EJ. From storm to suppression in sepsis: are bands the link?*. Crit Care Med. 2014 Sep; 42(9):2135-6. PMID: 25126801.
      View in: PubMed
    13. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. PMID: 25593740; PMCID: PMC4273700.
    14. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40. PMID: 25960880; PMCID: PMC4424730.
    15. Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22. PMID: 24848949; PMCID: PMC4141017.
    16. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014 Feb 18; 4(1):4. PMID: 24533450; PMCID: PMC3931496.
    17. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96. PMID: 24435201; PMCID: PMC3943651.
    18. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):736-42. PMID: 23328529; PMCID: PMC3678110.
    19. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. PMID: 22207676; PMCID: PMC3342784.
    20. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011 Jun 14; 1(1):21. PMID: 21906363; PMCID: PMC3224491.
    21. Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA. Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med. 2010 Oct; 25(10):1030-7. PMID: 20509052; PMCID: PMC2955461.
    22. Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009 May; 24(5):656-64. PMID: 19306050; PMCID: PMC2669873.
    23. Kangelaris KN, Gruber SB. Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer. JAMA. 2007 Jun 06; 297(21):2410-1. PMID: 17545691.
      View in: PubMed
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