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Kosaku Shinoda, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
DepartmentDiabetes Center
Address35 Medical Center way
San Fancisco CA 94143
Phone415-476-9736
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    Collapse Biography 
    Collapse Awards and Honors
    National Institutes of Health2016  - 2018Pathway to Independence (K99/R00)
    The Larry L. Hillblom Foundation2016Distinguished Research Scientist
    The Larry L. Hillblom Foundation2015  - 2016Fellowship Grant
    Japan Society for the Promotion of Science2013  - 2015Postdoctoral Fellowship

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Choi SE, Kwon S, Seok S, Xiao Z, Lee KW, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol. 2017 Aug 01; 37(15). PMID: 28533219.
      View in: PubMed
    2. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S, et al. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 Sep 13; 24(3):402-19. PMID: 27568548; PMCID: PMC5023491 [Available on 09/13/17].
    3. Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbe SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab. 2016 Jun 14; 23(6):1200-1206. PMID: 27238638; PMCID: PMC4967557 [Available on 06/14/17].
    4. Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S. A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes. 2016 May; 65(5):1410-23. PMID: 26936964; PMCID: PMC4839206 [Available on 05/01/17].
    5. Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 08; 23(3):454-66. PMID: 26876562; PMCID: PMC4785066 [Available on 03/08/17].
    6. Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S. Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab. 2015 Dec 01; 22(6):997-1008. PMID: 26525534; PMCID: PMC4670581 [Available on 12/01/16].
    7. Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55. PMID: 26496606; PMCID: PMC4656041 [Available on 10/22/16].
    8. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. PMID: 25774848; PMCID: PMC4427356.
    9. Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E315-23. PMID: 25516550.
      View in: PubMed
    10. Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11; 9(5):1584-93. PMID: 25466254; PMCID: PMC4268417.
    11. Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 05; 504(7478):163-7. PMID: 24196706; PMCID: PMC3855638.
    12. Yamada M, Takanashi K, Hamatani T, Hirayama A, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Shinoda K, Soga T, Umezawa A, Kuji N, Yoshimura Y, Tomita M. A medium-chain fatty acid as an alternative energy source in mouse preimplantation development. Sci Rep. 2012; 2:930. PMID: 23226596; PMCID: PMC3514685.
    13. Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L, Hu H, Wang L, Pavlova Z, Gilsanz V, Kajimura S. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012; 7(11):e49452. PMID: 23166672; PMCID: PMC3500293.
    14. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 07; 15(3):395-404. PMID: 22405074; PMCID: PMC3410936.
    15. Shinoda K, Tomita M, Ishihama Y. emPAI Calc--for the estimation of protein abundance from large-scale identification data by liquid chromatography-tandem mass spectrometry. Bioinformatics. 2010 Feb 15; 26(4):576-7. PMID: 20031975.
      View in: PubMed
    16. Shinoda K, Tomita M, Ishihama Y. Aligning LC peaks by converting gradient retention times to retention index of peptides in proteomic experiments. Bioinformatics. 2008 Jul 15; 24(14):1590-5. PMID: 18492686.
      View in: PubMed
    17. Shinoda K, Sugimoto M, Tomita M, Ishihama Y. Informatics for peptide retention properties in proteomic LC-MS. Proteomics. 2008 Feb; 8(4):787-98. PMID: 18214845.
      View in: PubMed
    18. Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y. Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. Mol Cell Proteomics. 2007 Jun; 6(6):1103-9. PMID: 17322306.
      View in: PubMed
    19. Shinoda K, Sugimoto M, Yachie N, Sugiyama N, Masuda T, Robert M, Soga T, Tomita M. Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks. J Proteome Res. 2006 Dec; 5(12):3312-7. PMID: 17137332.
      View in: PubMed
    20. Shinoda K, Yachie N, Masuda T, Sugiyama N, Sugimoto M, Soga T, Tomita M. HybGFS: a hybrid method for genome-fingerprint scanning. BMC Bioinformatics. 2006 Oct 29; 7:479. PMID: 17069662; PMCID: PMC1643838.
    21. Arakawa K, Yamada Y, Shinoda K, Nakayama Y, Tomita M. GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes. BMC Bioinformatics. 2006 Mar 23; 7:168. PMID: 16553966; PMCID: PMC1435936.
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