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    Laurence Cheng, MD, PhD

    TitleAssistant Clinical Professor
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine
      University of WashingtonM.D.School of Medicine2004

      Collapse Overview 
      Collapse Interests
      Cellular and molecular mechanisms underlying allergic inflammation, Immunology, Allergy, Immunoglobulin E (IgE), Basophils, Mast Cells, Hypersensitivity Reactions, Cellular immunology, Microscopy

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ahmed A, Reith W, Puck JM, Cheng LE. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2. PMID: 26271388.
        View in: PubMed
      2. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
      3. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6; 212(4):513-24. PMID: 25779634; PMCID: PMC4387286.
      4. Cheng LE, Cabana MD. Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8. PMID: 25713279; PMCID: PMC4338328 [Available on 03/01/16].
      5. Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2015 Mar; 7(3):a016352. PMID: 25414367.
        View in: PubMed
      6. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
      7. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878; PMCID: PMC3600903.
      8. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. PMID: 23290520; PMCID: PMC3576928.
      9. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. PMID: 21552267; PMCID: PMC3271435.
      10. Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 1; 185(9):5040-7. PMID: 20870945; PMCID: PMC3085987.
      11. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. PMID: 19375390; PMCID: PMC2800791.
      12. Cheng LE, Greenberg PD. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 1; 169(9):4990-7. PMID: 12391213.
        View in: PubMed
      13. Blattman JN, Cheng LE, Greenberg PD. CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2. PMID: 12087413.
        View in: PubMed
      14. Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 3; 195(11):1407-18. PMID: 12045239; PMCID: PMC2193546.
      15. Cheng LE, Ohlén C, Nelson BH, Greenberg PD. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):3001-6. PMID: 11867736; PMCID: PMC122462.
      16. Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75. PMID: 9155013; PMCID: PMC1169790.
      17. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76. PMID: 7565789; PMCID: PMC230888.
      18. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8. PMID: 7739548; PMCID: PMC230498.
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