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Leland Dobbs, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-5995
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel reagents for alveolar type I and type II cells
    NIH RC1HL099820Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Plasticity of Alveolar Epithelial Phenotypic Expression
    NIH R01HL057426Dec 1, 1996 - Feb 28, 2010
    Role: Principal Investigator
    ISOLATION, MARKERS, CULTURE OF HUMAN LUNG TYPE I CELLS
    NIH R01HL041958Dec 1, 1988 - Nov 30, 1993
    Role: Principal Investigator
    HUMAN LUNG SURFACTANT: CELLULAR SOURCE &COMPOSITION
    NIH R01HL034356Sep 30, 1985 - Sep 30, 1989
    Role: Principal Investigator
    Development and Control of Pulmonary alveolar Stability
    NIH P01HL024075Jul 1, 1979 - Dec 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin SE, Barrette AM, Chapin C, Gonzales LW, Gonzalez RF, Dobbs L, Ballard PL. Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice. Physiol Rep. 2015 Dec; 3(12). PMID: 26702074.
      View in: PubMed
    2. Vanderbilt JN, Gonzalez RF, Allen L, Gillespie A, Leaffer D, Dean WB, Chapin C, Dobbs LG. High-efficiency type II cell-enhanced green fluorescent protein expression facilitates cellular identification, tracking, and isolation. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):14-21. PMID: 25692334; PMCID: PMC4566114.
    3. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs L, Ballard PL, Frank JA. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):550-8. PMID: 24787463; PMCID: PMC4189483.
    4. Gonzalez RF, Dobbs L. Isolation and culture of alveolar epithelial Type I and Type II cells from rat lungs. Methods Mol Biol. 2013; 945:145-59. PMID: 23097106; PMCID: PMC3971988.
    5. Gonzalez RF, Allen L, Gonzales L, Ballard PL, Dobbs L. HTII-280, a biomarker specific to the apical plasma membrane of human lung alveolar type II cells. J Histochem Cytochem. 2010 Oct; 58(10):891-901. PMID: 20566753; PMCID: PMC2942742.
    6. Chagnon F, Fournier C, Charette PG, Moleski L, Payet MD, Dobbs L, Lesur O. In vivo intravital endoscopic confocal fluorescence microscopy of normal and acutely injured rat lungs. Lab Invest. 2010 Jun; 90(6):824-34. PMID: 20386539.
      View in: PubMed
    7. Dobbs L, Johnson MD, Vanderbilt J, Allen L, Gonzalez R. The great big alveolar TI cell: evolving concepts and paradigms. Cell Physiol Biochem. 2010; 25(1):55-62. PMID: 20054144.
      View in: PubMed
    8. Gonzalez RF, Allen L, Dobbs L. Rat alveolar type I cells proliferate, express OCT-4, and exhibit phenotypic plasticity in vitro. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1045-55. PMID: 19717550; PMCID: PMC2793185.
    9. Johnson M, Allen L, Dobbs L. Characteristics of Cl- uptake in rat alveolar type I cells. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L816-27. PMID: 19684200; PMCID: PMC2777494.
    10. Vanderbilt JN, Allen L, Gonzalez RF, Tigue Z, Edmondson J, Ansaldi D, Gillespie AM, Dobbs L. Directed expression of transgenes to alveolar type I cells in the mouse. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):253-62. PMID: 18367724; PMCID: PMC2542444.
    11. Dobbs L, Johnson MD. Alveolar epithelial transport in the adult lung. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):283-300. PMID: 17689299.
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    12. Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, Kass D, Martino JM, Bellmeyer A, Albazi JS, Emala C, Lee HT, Dobbs L, Matalon S. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):4083-8. PMID: 17360481; PMCID: PMC1820712.
    13. Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs L, Eaton DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4964-9. PMID: 16549766; PMCID: PMC1458778.
    14. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
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    15. Gonzalez R, Yang YH, Griffin C, Allen L, Tigue Z, Dobbs L. Freshly isolated rat alveolar type I cells, type II cells, and cultured type II cells have distinct molecular phenotypes. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L179-89. PMID: 15447939.
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    16. Dahlin K, Mager EM, Allen L, Tigue Z, Goodglick L, Wadehra M, Dobbs L. Identification of genes differentially expressed in rat alveolar type I cells. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):309-16. PMID: 15205179.
      View in: PubMed
    17. Vanderbilt JN, Mager EM, Allen L, Sawa T, Wiener-Kronish J, Gonzalez R, Dobbs L. CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):661-8. PMID: 12829448.
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    18. Gutierrez JA, Suzara VV, Dobbs L. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):81-7. PMID: 12600831.
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    19. Kitterman JA, Chapin CJ, Vanderbilt JN, Porta NF, Scavo LM, Dobbs L, Ertsey R, Goerke J. Effects of oligohydramnios on lung growth and maturation in the fetal rat. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L431-9. PMID: 11839536.
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    20. Johnson MD, Widdicombe JH, Allen L, Barbry P, Dobbs L. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1966-71. PMID: 11842214; PMCID: PMC122303.
    21. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
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    22. Boylan GM, Pryde JG, Dobbs L, McElroy MC. Identification of a novel antigen on the apical surface of rat alveolar epithelial type II and Clara cells. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1318-26. PMID: 11350813.
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    23. Dobbs L, Gutierrez JA. Mechanical forces modulate alveolar epithelial phenotypic expression. Comp Biochem Physiol A Mol Integr Physiol. 2001 May; 129(1):261-6. PMID: 11369550.
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    24. Ashino Y, Ying X, Dobbs L, Bhattacharya J. [Ca(2+)](i) oscillations regulate type II cell exocytosis in the pulmonary alveolus. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L5-13. PMID: 10893197.
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    25. Newman V, Gonzalez RF, Matthay MA, Dobbs L. A novel alveolar type I cell-specific biochemical marker of human acute lung injury. Am J Respir Crit Care Med. 2000 Mar; 161(3 Pt 1):990-5. PMID: 10712353.
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    26. Wirtz HR, Dobbs L. The effects of mechanical forces on lung functions. Respir Physiol. 2000 Jan; 119(1):1-17. PMID: 10701703.
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    27. Gutierrez JA, Ertsey R, Scavo LM, Collins E, Dobbs L. Mechanical distention modulates alveolar epithelial cell phenotypic expression by transcriptional regulation. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):223-9. PMID: 10423405.
      View in: PubMed
    28. Newman V, Gonzalez R, Matthay M, Dobbs L. HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Chest. 1999 Jul; 116(1 Suppl):35S-36S. PMID: 10424584.
      View in: PubMed
    29. Girod CE, Shin DH, Geraci MW, Warren HB, Dobbs L, Gao B, Rainer JS, Bauer AK, Ikegami M, Shannon JM, Miller YE. Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation. Chest. 1999 Jul; 116(1 Suppl):61S. PMID: 10424594.
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    30. Poulain FR, Akiyama J, Allen L, Brown C, Chang R, Goerke J, Dobbs L, Hawgood S. Ultrastructure of phospholipid mixtures reconstituted with surfactant proteins B and D. Am J Respir Cell Mol Biol. 1999 May; 20(5):1049-58. PMID: 10226076.
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    31. Clark H, Allen L, Collins E, Barr F, Dobbs L, Putz G, Goerke J, Hawgood S. Localization of a candidate surfactant convertase to type II cells, macrophages, and surfactant subfractions. Am J Physiol. 1999 Mar; 276(3 Pt 1):L452-8. PMID: 10070109.
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    32. Dobbs L, Gonzalez RF, Allen L, Froh DK. HTI56, an integral membrane protein specific to human alveolar type I cells. J Histochem Cytochem. 1999 Feb; 47(2):129-37. PMID: 9889249.
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    33. Gonzalez RF, Dobbs L. Purification and analysis of RTI40, a type I alveolar epithelial cell apical membrane protein. Biochim Biophys Acta. 1998 Dec 8; 1429(1):208-16. PMID: 9920397.
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    34. Koslowski R, Dobbs L, Wenzel KW, Schuh D, Müller M, Kasper M. Loss of immunoreactivity for RTI40, a type I cell-specific protein in the alveolar epithelium of rat lungs with bleomycin-induced fibrosis. Eur Respir J. 1998 Dec; 12(6):1397-403. PMID: 9877498.
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    35. Vanderbilt JN, Dobbs L. Characterization of the gene and promoter for RTI40, a differentiation marker of type I alveolar epithelial cells. Am J Respir Cell Mol Biol. 1998 Oct; 19(4):662-71. PMID: 9761764.
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    36. Dobbs L, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2991-6. PMID: 9501203; PMCID: PMC19682.
    37. Gutierrez JA, Gonzalez RF, Dobbs L. Mechanical distension modulates pulmonary alveolar epithelial phenotypic expression in vitro. Am J Physiol. 1998 Feb; 274(2 Pt 1):L196-202. PMID: 9486203.
      View in: PubMed
    38. McElroy MC, Pittet JF, Allen L, Wiener-Kronish JP, Dobbs L. Biochemical detection of type I cell damage after nitrogen dioxide-induced lung injury in rats. Am J Physiol. 1997 Dec; 273(6 Pt 1):L1228-34. PMID: 9435578.
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    39. Pian MS, Dobbs L. Lipoprotein-stimulated surfactant secretion in alveolar type II cells: mediation by heterotrimeric G proteins. Am J Physiol. 1997 Sep; 273(3 Pt 1):L634-9. PMID: 9316499.
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    40. Dobbs L, Pian MS, Maglio M, Dumars S, Allen L. Maintenance of the differentiated type II cell phenotype by culture with an apical air surface. Am J Physiol. 1997 Aug; 273(2 Pt 1):L347-54. PMID: 9277446.
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    41. Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, Minoo P, Koivisto T, Allen L, Dobbs L, Werb Z, Derynck R. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev Biol. 1997 Jun 15; 186(2):224-36. PMID: 9205141.
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    42. McElroy MC, Wiener-Kronish JP, Miyazaki H, Sawa T, Modelska K, Dobbs L, Pittet JF. Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats. Am J Physiol. 1997 Apr; 272(4 Pt 1):L631-8. PMID: 9142935.
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    43. Joe P, Wallen LD, Chapin CJ, Lee CH, Allen L, Han VK, Dobbs L, Hawgood S, Kitterman JA. Effects of mechanical factors on growth and maturation of the lung in fetal sheep. Am J Physiol. 1997 Jan; 272(1 Pt 1):L95-105. PMID: 9038908.
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    44. Pian MS, Dobbs L. Evidence for G beta gamma-mediated cross-talk in primary cultures of lung alveolar cells. Pertussis toxin-sensitive production of cAMP. J Biol Chem. 1995 Mar 31; 270(13):7427-30. PMID: 7706288.
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    45. McElroy MC, Pittet JF, Hashimoto S, Allen L, Wiener-Kronish JP, Dobbs L. A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia. Am J Physiol. 1995 Feb; 268(2 Pt 1):L181-6. PMID: 7864138.
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    46. Rishi AK, Joyce-Brady M, Fisher J, Dobbs L, Floros J, VanderSpek J, Brody JS, Williams MC. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol. 1995 Jan; 167(1):294-306. PMID: 7851650.
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    47. Dobbs L. Alveoli and airways: possible interactions in the pathogenesis of asthma. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 2):S31-2. PMID: 7952588.
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    48. Pian MS, Dobbs L. Activation of G proteins may inhibit or stimulate surfactant secretion in rat alveolar type II cells. Am J Physiol. 1994 Apr; 266(4 Pt 1):L375-81. PMID: 8179014.
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    49. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol (1985). 1993 Oct; 75(4):1661-9. PMID: 8282618.
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    50. Voyno-Yasenetskaya TA, Dobbs L, Erickson SK, Hamilton RL. Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):4256-60. PMID: 8483941; PMCID: PMC46485.
    51. Debs R, Pian M, Gaensler K, Clements J, Friend DS, Dobbs L. Prolonged transgene expression in rodent lung cells. Am J Respir Cell Mol Biol. 1992 Oct; 7(4):406-13. PMID: 1327013.
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    52. Gardner DG, Wirtz H, Dobbs L. Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes. Am J Physiol. 1992 Aug; 263(2 Pt 1):E239-44. PMID: 1381150.
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    53. Voyno-Yasenetskaya TA, Dobbs L, Williams MC. Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells. Am J Physiol. 1991 Oct; 261(4 Suppl):105-9. PMID: 1928448.
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    54. Wright JR, Dobbs L. Regulation of pulmonary surfactant secretion and clearance. Annu Rev Physiol. 1991; 53:395-414. PMID: 2042966.
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    55. Wirtz HR, Dobbs L. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science. 1990 Nov 30; 250(4985):1266-9. PMID: 2173861.
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    56. Williams MC, Dobbs L. Expression of cell-specific markers for alveolar epithelium in fetal rat lung. Am J Respir Cell Mol Biol. 1990 Jun; 2(6):533-42. PMID: 2189457.
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    57. Dobbs L. Isolation and culture of alveolar type II cells. Am J Physiol. 1990 Apr; 258(4 Pt 1):L134-47. PMID: 2185652.
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    58. Dobbs L. Pulmonary surfactant. Annu Rev Med. 1989; 40:431-46. PMID: 2658759.
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    59. Liley HG, Ertsey R, Gonzales LW, Odom MW, Hawgood S, Dobbs L, Ballard PL. Synthesis of surfactant components by cultured type II cells from human lung. Biochim Biophys Acta. 1988 Jul 1; 961(1):86-95. PMID: 3382694.
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    60. Dobbs L, Williams MC, Gonzalez R. Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells. Biochim Biophys Acta. 1988 Jun 30; 970(2):146-56. PMID: 3382696.
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    61. Pian MS, Dobbs L, Düzgünes N. Positive correlation between cytosolic free calcium and surfactant secretion in cultured rat alveolar type II cells. Biochim Biophys Acta. 1988 May 2; 960(1):43-53. PMID: 3358945.
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    62. Wright JR, Wager RE, Hawgood S, Dobbs L, Clements JA. Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells. J Biol Chem. 1987 Feb 25; 262(6):2888-94. PMID: 3818626.
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    63. Dobbs L, Wright JR, Hawgood S, Gonzalez R, Venstrom K, Nellenbogen J. Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells. Proc Natl Acad Sci U S A. 1987 Feb; 84(4):1010-4. PMID: 3469643; PMCID: PMC304351.
    64. Dobbs L, Gonzalez R, Williams MC. An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis. 1986 Jul; 134(1):141-5. PMID: 3637065.
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    65. Dobbs L, Gonzalez RF, Marinari LA, Mescher EJ, Hawgood S. The role of calcium in the secretion of surfactant by rat alveolar type II cells. Biochim Biophys Acta. 1986 Jun 27; 877(2):305-13. PMID: 3013318.
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    66. Dobbs L, Williams MC, Brandt AE. Changes in biochemical characteristics and pattern of lectin binding of alveolar type II cells with time in culture. Biochim Biophys Acta. 1985 Jul 30; 846(1):155-66. PMID: 3839418.
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    67. Mescher EJ, Dobbs L, Mason RJ. Cholera toxin stimulates secretion of saturated phosphatidylcholine and increases cellular cyclic AMP in isolated rat alveolar type II cells. Exp Lung Res. 1983 Nov; 5(3):173-82. PMID: 6317369.
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    68. Dobbs L, Mason RJ, Williams MC, Benson BJ, Sueishi K. Secretion of surfactant by primary cultures of alveolar type II cells isolated from rats. Biochim Biophys Acta. 1982 Oct 14; 713(1):118-27. PMID: 6215948.
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    69. Dobbs L, Geppert EF, Williams MC, Greenleaf RD, Mason RJ. Metabolic properties and ultrastructure of alveolar type II cells isolated with elastase. Biochim Biophys Acta. 1980 Jun 23; 618(3):510-23. PMID: 6901614.
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    70. Mason RJ, Dobbs L. Synthesis of phosphatidylcholine and phosphatidylglycerol by alveolar type II cells in primary culture. J Biol Chem. 1980 Jun 10; 255(11):5101-7. PMID: 7372627.
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    71. Dobbs L, Mason RJ. Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation. J Clin Invest. 1979 Mar; 63(3):378-87. PMID: 34631; PMCID: PMC371964.
    72. Dobbs L, Mason RJ. Stimulation of secretion of disaturated phosphatidylcholine from isolated alveolar type II cells by 12-O-tetradecanoyl-13-phorbol acetate. Am Rev Respir Dis. 1978 Oct; 118(4):705-33. PMID: 581334.
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    73. Mason RJ, Dobbs L, Greenleaf RD, Williams MC. Alveolar type II cells. Fed Proc. 1977 Dec; 36(13):2697-702. PMID: 336407.
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