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    Leonardo Ramos Ferreira, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      Harvard UniversityPhDMolecular and Cellular Biology2016
      University of CoimbraBScBiochemistry2011

      Collapse Overview 
      Collapse Overview
      Cell-based gene therapies offer unprecedented promise for medicine. One day, it may be possible to cure degenerative diseases consisting of the loss of specialized cellular functions. However, several hurdles must be surpassed to establish cell transplantation therapies. A major one is rejection by the recipient's immune system. This challenge is particularly prominent for autoimmune disorders, such as type 1 diabetes and multiple sclerosis, where the immune system mediates the destruction of self-tissues. Currently, I am a postdoctoral scholar in the Tang and Bluestone laboratories at the Department of Surgery and Diabetes Center at UCSF. I envision that we will be able to use our capacity to engineer the human genome to manipulate our immune system with high precision and efficiency, enabling us to treat devastating illnesses now labeled as incurable. I am highly committed to make this vision become a reality.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5364-9. PMID: 27078102.
        View in: PubMed
      2. Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 2014 Nov 6; 15(5):643-52. PMID: 25517468; PMCID: PMC4269831.
      3. Abreu PL, Ferreira LM, Alpoim MC, Urbano AM. Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer. Biometals. 2014 Jun; 27(3):409-43. PMID: 24664226.
        View in: PubMed
      4. Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA. Genome editing for human gene therapy. Methods Enzymol. 2014; 546:273-95. PMID: 25398345.
        View in: PubMed
      5. Ferreira LM. Gammadelta T cells: innately adaptive immune cells? Int Rev Immunol. 2013 Jun; 32(3):223-48. PMID: 23617235.
        View in: PubMed
      6. Ferreira LM, Mostajo-Radji MA. How induced pluripotent stem cells are redefining personalized medicine. Gene. 2013 May 10; 520(1):1-6. PMID: 23470844.
        View in: PubMed
      7. Ferreira LM, Floriddia EM, Quadrato G, Di Giovanni S. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobiol. 2012 Oct; 46(2):227-41. PMID: 22717989.
        View in: PubMed
      8. Urbano AM, Ferreira LM, Alpoim MC. Molecular and cellular mechanisms of hexavalent chromium-induced lung cancer: an updated perspective. Curr Drug Metab. 2012 Mar; 13(3):284-305. PMID: 22455553.
        View in: PubMed
      9. Ferreira LM, Hebrant A, Dumont JE. Metabolic reprogramming of the tumor. Oncogene. 2012 Sep 6; 31(36):3999-4011. PMID: 22231450.
        View in: PubMed
      10. Urbano AM, Ferreira LM, Cerveira JF, Rodrigues CF, Alpoim MC. . DNA Repair and Human Health (ed. Sonya Vengrova). DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy. 2011; 177-238.
      11. Ferreira LM. Cancer metabolism: the Warburg effect today. Exp Mol Pathol. 2010 Dec; 89(3):372-80. PMID: 20804748.
        View in: PubMed
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