Ling Zhan, DDS, PhD

Title(s)Professor, Orofacial Sciences
SchoolSchool of Dentistry
Address707 Parnassus Avenue, #1018
San Francisco CA 94143
Phone415-476-0921
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoP. G. certificate10/2008pediatric dentistry
    University of California, San Franciscovisiting professor10/2003dental caries prevention
    West China University of Medical Sciences, P. R. ChinaPhD06/1997oral biology and dental sciences
    West China University of Medical Sciences, P. R. ChinaDDS06/1992dentistry
    Collapse Awards and Honors
    University of California, San Francisco2000  - 2003Lee Hysan Scholar
    Chinese Ministry of Education2004  - 2004Scientific Advancement Research Award, 1st Prize
    Chinese Association of Medical Science2004  - 2004Scientific Advancement Research Award, 3rd Price
    University of California, San Francisco2008  - 2008The Eric B. Bystrom Pediatric Dentistry Memorial Award
    University of California, San Francisco2016  - 2016Faculty Award for Achievement in Global Oral Health

    Collapse Overview 
    Collapse Overview
    Dr. Ling Zhan is a pediatric dentist who cares for children and adolescents at both the Mission Bay and Parnassus campuses. Her treatment philosophy is very prevention-oriented. She works closely with her patients and their families to identify risk factors for common dental diseases, such as dental caries, and to adopt scientifically-based preventive and treatment regimens to avoid future diseases. Her practice provides routine as well as complex care, including care for children with dental or medical conditions who require treatment under sedation or general anesthesia. She works closely with other dental specialties to treat children with complex dental disease, such as amenogenesis imperfecta.

    In addition to patient care and education, Zhan conducts clinical and translational research projects that are focused on microbiological aspects of tooth decay; oral prevention programs guided by risk assessment; and identification of protocols to prevent or eliminate dental caries in children.

    Zhan completed her pediatric dentistry residency training at UCSF. She is a member of the American Academy of Pediatric Dentistry and a diplomat of the American Board of Pediatric Dentistry.
    Collapse Global Health Equity

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    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis. NPJ Biofilms Microbiomes. 2024 Jan 17; 10(1):3. Kuraji R, Ye C, Zhao C, Gao L, Martinez A, Miyashita Y, Radaic A, Kamarajan P, Le C, Zhan L, Range H, Sunohara M, Numabe Y, Kapila YL. PMID: 38233485; PMCID: PMC10794237.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome. NPJ Biofilms Microbiomes. 2022 06 07; 8(1):45. Gao L, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Rangé H, Sailani MR, Kapila YL. PMID: 35672331; PMCID: PMC9174264.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    3. Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells. PLoS Pathog. 2021 07; 17(7):e1009311. Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL. PMID: 34255809; PMCID: PMC8301614.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    4. Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts. Front Cell Infect Microbiol. 2021; 11:671968. Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL. PMID: 34094999; PMCID: PMC8171266.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. A Comparison of Four Caries Risk Assessment Methods. Front Oral Health. 2021; 2:656558. Featherstone JDB, Crystal YO, Alston P, Chaffee BW, Doméjean S, Rechmann P, Zhan L, Ramos-Gomez F. PMID: 35048004; PMCID: PMC8757708.
      View in: PubMed   Mentions: 5  
    6. Evidence-Based Caries Management for All Ages-Practical Guidelines. Front Oral Health. 2021; 2:657518. Featherstone JDB, Crystal YO, Alston P, Chaffee BW, Doméjean S, Rechmann P, Zhan L, Ramos-Gomez F. PMID: 35048005; PMCID: PMC8757692.
      View in: PubMed   Mentions: 12  
    7. Matching-adjusted indirect comparison of palbociclib versus ribociclib and abemaciclib in hormone receptor-positive/HER2-negative advanced breast cancer. J Comp Eff Res. 2021 04; 10(6):457-467. Rugo HS, Haltner A, Zhan L, Tran A, Bananis E, Hooper B, Mitra D, Cameron C. PMID: 33626934.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin. PLoS Pathog. 2020 10; 16(10):e1008881. Kamarajan P, Ateia I, Shin JM, Fenno JC, Le C, Zhan L, Chang A, Darveau R, Kapila YL. PMID: 33002094; PMCID: PMC7529280.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    9. Modulation of pathogenic oral biofilms towards health with nisin probiotic. J Oral Microbiol. 2020 Aug 24; 12(1):1809302. Radaic A, Ye C, Parks B, Gao L, Kuraji R, Malone E, Kamarajan P, Zhan L, Kapila YL. PMID: 32944159; PMCID: PMC7482728.
      View in: PubMed   Mentions: 24  
    10. Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. NPJ Biofilms Microbiomes. 2020 03 10; 6(1):10. Gao L, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Rangé H, Ho SP, Kapila YL. PMID: 32157085; PMCID: PMC7064479.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    11. Caregivers' Knowledge of Sugar and Control Over Children's Sugar Consumption. Pediatr Dent. 2019 May 15; 41(3):191-199. Kim J, Zhan L, Le T, Cheng J. PMID: 31171070; PMCID: PMC8262768.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Pediatric Caries Risk Assessment as a Predictor of Caries Outcomes. Pediatr Dent. 2017 May 15; 39(3):219-232. Chaffee BW, Featherstone JDB, Zhan L. PMID: 28583247; PMCID: PMC5463572.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    13. Caries Risk Assessment Item Importance: Risk Designation and Caries Status in Children under Age 6. JDR Clin Trans Res. 2016 Jul; 1(2):131-142. Chaffee BW, Featherstone JD, Gansky SA, Cheng J, Zhan L. PMID: 27403458; PMCID: PMC4937437.
      View in: PubMed   Mentions: 9     Fields:    
    14. Oral health education for pediatric nurse practitioner students. J Dent Educ. 2013 May; 77(5):581-90. Golinveaux J, Gerbert B, Cheng J, Duderstadt K, Alkon A, Mullen S, Lin B, Miller A, Zhan L. PMID: 23658403; PMCID: PMC4259151.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    15. Strategic protein target analysis for developing drugs to stop dental caries. Adv Dent Res. 2012 Sep; 24(2):86-93. Horst JA, Pieper U, Sali A, Zhan L, Chopra G, Samudrala R, Featherstone JD. PMID: 22899687; PMCID: PMC3420364.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Clinical efficacy and effects of xylitol wipes on bacterial virulence. Adv Dent Res. 2012 Sep; 24(2):117-22. Zhan L, Featherstone JD, Lo J, Krupansky C, Hoang N, DenBesten P, Huynh T. PMID: 22899693.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Effects of xylitol wipes on cariogenic bacteria and caries in young children. J Dent Res. 2012 Jul; 91(7 Suppl):85S-90S. Zhan L, Cheng J, Chang P, Ngo M, Denbesten PK, Hoover CI, Featherstone JD. PMID: 22699675; PMCID: PMC3383105.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    18. Factors related to maternal transmission of mutans streptococci in high-risk children-pilot study. Pediatr Dent. 2012 Jul-Aug; 34(4):e86-91. Zhan L, Tan S, Den Besten P, Featherstone JD, Hoover CI. PMID: 23014079.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    19. A randomized clinical trial of anticaries therapies targeted according to risk assessment (caries management by risk assessment). Caries Res. 2012; 46(2):118-29. Featherstone JD, White JM, Hoover CI, Rapozo-Hilo M, Weintraub JA, Wilson RS, Zhan L, Gansky SA. PMID: 22472515; PMCID: PMC3362266.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCellsPHPublic Health
    20. Social inequalities in childhood dental caries: the convergent roles of stress, bacteria and disadvantage. Soc Sci Med. 2010 Nov; 71(9):1644-52. Boyce WT, Den Besten PK, Stamperdahl J, Zhan L, Jiang Y, Adler NE, Featherstone JD. PMID: 20870333; PMCID: PMC2954891.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    21. Horizontal transmission of mutans streptococci in children. J Dent Res. 2010 Jan; 89(1):51-5. Doméjean S, Zhan L, DenBesten PK, Stamper J, Boyce WT, Featherstone JD. PMID: 19918090; PMCID: PMC3318045.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    22. Randomized controlled clinical trial on the evaluation of bacteriostatic and cariostatic effects of a novel povidone-iodine/fluoride foam in children with high caries risk. Quintessence Int. 2009 Mar; 40(3):215-23. Xu X, Li JY, Zhou XD, Xie Q, Zhan L, Featherstone JD. PMID: 19417885.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    23. Antibacterial treatment needed for severe early childhood caries. J Public Health Dent. 2006; 66(3):174-9. Zhan L, Featherstone JD, Gansky SA, Hoover CI, Fujino T, Berkowitz RJ, Den Besten PK. PMID: 16913243.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. Cariogenic virulence characteristics of mutans streptococci isolated from caries-active and caries-free adults. J Calif Dent Assoc. 2005 Dec; 33(12):973-80. Khoo G, Zhan L, Hoover C, Featherstone JD. PMID: 16454241.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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