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    Liusheng Huang, PhD

    TitleAssociate Researcher
    SchoolUCSF School of Pharmacy
    DepartmentClinical Pharmacy
    Address1001 Potrero Ave, SFGH 100
    San Francisco CA 94110
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      University of California, San FranciscoPostdoctoral StudiesGraduate Division

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sundell K, Jagannathan P, Huang L, Bigira V, Kapisi J, Kakuru MM, Savic R, Kamya MR, Dorsey G, Aweeka F. Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children. Malar J. 2015; 14(1):368. PMID: 26403465; PMCID: PMC4582734.
      2. Parikh S, Fehintola F, Huang L, Olson A, Adedeji WA, Darin KM, Morse GD, Murphy RL, Taiwo BO, Akinyinka OO, Adewole IF, Aweeka FT, Scarsi KK. Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy. Antimicrob Agents Chemother. 2015 Dec; 59(12):7852-6. PMID: 26392500.
        View in: PubMed
      3. Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data. BMC Med. 2015; 13:227. PMID: 26381375; PMCID: PMC4574542.
      4. Haagensen JA, Verotta D, Huang L, Spormann A, Yang K. New in vitro model to study the effect of human simulated antibiotic concentrations on bacterial biofilms. Antimicrob Agents Chemother. 2015 Jul; 59(7):4074-81. PMID: 25918138; PMCID: PMC4468651 [Available on 01/01/16].
      5. Kamya MR, Kapisi J, Bigira V, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Kakuru A, Aweeka FT, Huang L, Jagannathan P, Achan J, Havlir DV, Rosenthal PJ, Dorsey G. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9. PMID: 25493596; PMCID: PMC4487368 [Available on 11/28/15].
      6. Aweeka FT, Hu C, Huang L, Best BM, Stek A, Lizak P, Burchett SK, Read JS, Watts H, Mirochnick M, Capparelli EV. Alteration in cytochrome P450 3A4 activity as measured by a urine cortisol assay in HIV-1-infected pregnant women and relationship to antiretroviral pharmacokinetics. HIV Med. 2015 Mar; 16(3):176-83. PMID: 25407158; PMCID: PMC4320673 [Available on 03/01/16].
      7. Bigira V, Kapisi J, Clark TD, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B, Aweeka FT, Huang L, Achan J, Havlir DV, Rosenthal PJ, Kamya MR, Dorsey G. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med. 2014 Aug; 11(8):e1001689. PMID: 25093754; PMCID: PMC4122345.
      8. Huang L, Haagensen J, Verotta D, Lizak P, Aweeka F, Yang K. Determination of meropenem in bacterial media by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 15; 961:71-6. PMID: 24861874; PMCID: PMC4104812.
      9. Huang L, Lizak P, Dvorak CC, Aweeka F, Long-Boyle J. Simultaneous determination of fludarabine and clofarabine in human plasma by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1; 960:194-9. PMID: 24820973; PMCID: PMC4110960.
      10. Kjellin LL, Dorsey G, Rosenthal PJ, Aweeka F, Huang L. Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Bioanalysis. 2014; 6(23):3081-9. PMID: 25529877; PMCID: PMC4321809.
      11. Huang L, Lizak P, Aweeka F, Long-Boyle J. Determination of intracellular fludarabine triphosphate in human peripheral blood mononuclear cells by LC-MS/MS. J Pharm Biomed Anal. 2013 Dec; 86:198-203. PMID: 24013121; PMCID: PMC3835489.
      12. Huang L, Olson A, Gingrich D, Aweeka FT. Determination of artemether and dihydroartemisinin in human plasma with a new hydrogen peroxide stabilization method. Bioanalysis. 2013 Jun; 5(12):1501-6. PMID: 23795928; PMCID: PMC3879143.
      13. Liu L, Wang L, Huang L, Siu V, Teque F, Aweeka FT, Levy JA. Nevirapine inhibits the anti-HIV activity of CD8+ cells. J Acquir Immune Defic Syndr. 2013 Jun 1; 63(2):184-8. PMID: 23392464; PMCID: PMC3653990.
      14. Gwaza L, Aweeka F, Greenblatt R, Lizak P, Huang L, Guglielmo BJ. Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir. Int J Infect Dis. 2013 Oct; 17(10):e857-61. PMID: 23587599; PMCID: PMC3776002.
      15. Huang L, Parikh S, Rosenthal PJ, Lizak P, Marzan F, Dorsey G, Havlir D, Aweeka FT. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012 Nov 1; 61(3):310-6. PMID: 22918158; PMCID: PMC3511816.
      16. Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S. In vitro metabolism of piperaquine is primarily mediated by CYP3A4. Xenobiotica. 2012 Nov; 42(11):1088-95. PMID: 22671777.
        View in: PubMed
      17. Huang L, Li X, Marzan F, Lizak PS, Aweeka FT. Determination of lumefantrine in small-volume human plasma by LC-MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation. Bioanalysis. 2012 Jan; 4(2):157-66. PMID: 22250798; PMCID: PMC3321395.
      18. Huang L, Lizak PS, Jayewardene AL, Marzan F, Lee MN, Aweeka FT. A modified method for determination of lumefantrine in human plasma by HPLC-UV and combination of protein precipitation and solid-phase extraction: application to a pharmacokinetic study. Anal Chem Insights. 2010; 5:15-23. PMID: 20448843; PMCID: PMC2865164.
      19. Huang L, Jayewardene AL, Li X, Marzan F, Lizak PS, Aweeka FT. Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasma. J Pharm Biomed Anal. 2009 Dec 5; 50(5):959-65. PMID: 19646837; PMCID: PMC3034030.
      20. Huang L, Marzan F, Jayewardene AL, Lizak PS, Li X, Aweeka FT. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15; 877(3):285-90. PMID: 19112051; PMCID: PMC3032609.
      21. Huang L, Ortiz de Montellano PR. Arthromyces ramosus peroxidase produces two chlorinating species. Biochem Biophys Res Commun. 2007 Apr 6; 355(2):581-6. PMID: 17303078; PMCID: PMC1852486.
      22. Huang L, Fernández C, Kerns RJ. Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):419-23. PMID: 17070049.
        View in: PubMed
      23. Huang L, Wojciechowski G, Ortiz de Montellano PR. Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase. J Biol Chem. 2006 Jul 14; 281(28):18983-8. PMID: 16651262.
        View in: PubMed
      24. Huang L, Ortiz de Montellano PR. Heme-protein covalent bonds in peroxidases and resistance to heme modification during halide oxidation. Arch Biochem Biophys. 2006 Feb 1; 446(1):77-83. PMID: 16375846.
        View in: PubMed
      25. Huang L, Kerns RJ. Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins. Bioorg Med Chem. 2006 Apr 1; 14(7):2300-13. PMID: 16314105.
        View in: PubMed
      26. Wojciechowski G, Huang L, Ortiz de Montellano PR. Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking. J Am Chem Soc. 2005 Nov 16; 127(45):15871-9. PMID: 16277530.
        View in: PubMed
      27. Huang L, Wojciechowski G, Ortiz de Montellano PR. Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase. J Am Chem Soc. 2005 Apr 20; 127(15):5345-53. PMID: 15826172.
        View in: PubMed
      28. Huang L, Colas C, Ortiz de Montellano PR. Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation. J Am Chem Soc. 2004 Oct 13; 126(40):12865-73. PMID: 15469283.
        View in: PubMed
      29. Wang J, Niemevz F, Lad L, Huang L, Alvarez DE, Buldain G, Poulos TL, de Montellano PR. Human heme oxygenase oxidation of 5- and 15-phenylhemes. J Biol Chem. 2004 Oct 8; 279(41):42593-604. PMID: 15297453.
        View in: PubMed
      30. Huang L, Tao G, Li L, Chi H. . Computer-aided molecular design of HIV-1 protease dissociative inhibitors. Acta Pharmaceutica Sinica (YaoXueXueBao). 1999; (5):353-357.
      31. Huang L, Yang H. . Method for determination of total mercury in foods by atomic fluorescence spectrometry. J. Chinese Food Hygiene. 1997; (1):3-5.
      32. Yang H, Huang L, Xie B. . Study on the tolerance limit for nitrite in Chinese foods. Hygiene Research. 1995; 24:176-178.
      33. Yang H, Zou Z, Jin C, Yi F, Liang C, Xu X, Wang X, Huang, L. . Monitoring of lead content in foodstuff in China. J. Chinese Preventive Medicine. 1995; 29:96-98.
      34. Yang H, Zou Z, Jin C, Gu W, Liang C, Yi F, Xie B, Huang, L. . A study on cadmium content in foods of six provinces and cities. J. Chinese Prenentive Medicine. 1994; 28:6-8.
      35. Yang H, Han Y, Huang L. . Survey of mercury contamination of food in some areas of China. J. Hygiene Research. 1994; 23:95-96.
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