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    Liviu Klein, MD, MS

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Avenue
    San Francisco CA 94117
    Phone415-502-8584
    EmailLiviu.Klein@ucsf.edu
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Carol Davila School of MedicineMD Medicine1999
      Northwestern UniversityMSCIGraduate School2005
      University Hospital BucharestResidentInternal Medicine2000
      Advocate Illinois Masonic Medical CenterResidentInternal Medicine2003
      Northwestern UniversityFellowCardiovascular Epidemiology2005
      Northwestern Memorial HospitalFellowCardiovascular Disease2007
      Northwestern Memorial HospitalFellowAdvanced Heart Failure and Transplantation2008
      Northwestern Memorial HospitalFellowClinical Cardiac Electrophysiology2009
      Collapse Awards and Honors
      University of California San Francisco2013Cardiology Faculty Teaching Award
      Northwestern University Feinberg School of Medicine2009Larry Jameson Research Award
      Advocate Illinois Masonic Medical Center2003Outstanding Senior Resident Award

      Collapse Overview 
      Collapse Overview
      CLINICAL INTERESTS
      My clinical interests are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies. I treat patients across the heart failure spectrum, from early diagnosis to heart transplantation.

      RESEARCH INTERESTS
      My research is aimed at understanding the epidemiology of heart failure in women and sudden cardiac death in women with heart failure. In addition, I am developing new diagnostic sensors and therapeutic devices for patients with cardiovascular disease, including patients with heart failure.

      Collapse Interests
      Ventricular assist devices, extracorporeal life support, cardiac resynchronization therapy, implantable hemodynamics monitors, implantable cardioverter defibrillators, heart transplantation, novel heart failure sensors, sudden death.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Awarded Grants
      Collapse Clinical Trials

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Klein L. Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations. JACC Heart Fail. 2016 May; 4(5):345-7. PMID: 27126282.
        View in: PubMed
      2. Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, De Marco T. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. J Card Fail. 2015 Nov; 21(11):924-9. PMID: 26362520.
        View in: PubMed
      3. Rogers SE, Klein L, Perissinotto CM. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890. PMID: 25822770.
        View in: PubMed
      4. Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8. PMID: 25974943.
        View in: PubMed
      5. Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circ Heart Fail. 2015 Jan; 8(1):49-56. PMID: 25398967; PMCID: PMC4303506 [Available on 01/01/16].
      6. Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42. PMID: 25265619; PMCID: PMC4532376 [Available on 07/01/16].
      7. Klein L, Hsia H. Sudden cardiac death in heart failure. Cardiol Clin. 2014 Feb; 32(1):135-44, ix. PMID: 24286584.
        View in: PubMed
      8. Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5188-91. PMID: 25571162; PMCID: PMC4600348.
      9. Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5172-5. PMID: 25571158; PMCID: PMC4605430.
      10. Sridharan L, Klein L. Prognostic factors in patients hospitalized for heart failure. Curr Heart Fail Rep. 2013 Dec; 10(4):380-6. PMID: 24122287.
        View in: PubMed
      11. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart. 2013 Aug; 99(16):1173-8. PMID: 23756655.
        View in: PubMed
      12. Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML. Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials. Circ Arrhythm Electrophysiol. 2012 Dec; 5(6):1108-16. PMID: 23169946.
        View in: PubMed
      13. Klein L. ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF. Ann Intern Med. 2012 Sep 18; 157(6):JC3-2. PMID: 22986394.
        View in: PubMed
      14. Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet. 2012; 8(8):e1002870. PMID: 22912591; PMCID: PMC3415454.
      15. Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV. Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative. Circulation. 2012 Aug 7; 126(6):688-96. PMID: 22753306; PMCID: PMC4618499.
      16. Klein L. Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. PMID: 22250165.
        View in: PubMed
      17. Klein L. Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. PMID: 22250164.
        View in: PubMed
      18. Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L. Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials. J Am Coll Cardiol. 2011 Sep 27; 58(14):1457-64. PMID: 21939829; PMCID: PMC3635103.
      19. Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC. Quality of care and outcomes in women hospitalized for heart failure. Circ Heart Fail. 2011 Sep; 4(5):589-98. PMID: 21862732.
        View in: PubMed
      20. Klein L. Omnes viae Romam ducunt: Asymptomatic cardiac and noncardiac organ system dysfunction leads to heart failure. Circulation. 2011 Jul 5; 124(1):4-6. PMID: 21730317.
        View in: PubMed
      21. Svetlichnaya J, Klein L. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert Rev Cardiovasc Ther. 2011 Jul; 9(7):903-12. PMID: 21809972.
        View in: PubMed
      22. Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N. Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population. ASAIO J. 2011 Jul-Aug; 57(4):254-61. PMID: 21546824.
        View in: PubMed
      23. Shah RU, Tsai V, Klein L, Heidenreich PA. Characteristics and outcomes of very elderly patients after first hospitalization for heart failure. Circ Heart Fail. 2011 May; 4(3):301-7. PMID: 21467294.
        View in: PubMed
      24. Klein L. ACP Journal Club. Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation. Ann Intern Med. 2010 Jan 19; 152(2):JC1-2. PMID: 20083817.
        View in: PubMed
      25. Shah RU, Klein L, Lloyd-Jones DM. Heart failure in women: epidemiology, biology and treatment. Womens Health (Lond Engl). 2009 Sep; 5(5):517-27. PMID: 19702451.
        View in: PubMed
      26. Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF, Califf RM, Gheorghiade M. Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circ Heart Fail. 2008 May; 1(1):25-33. PMID: 19808267.
        View in: PubMed
      27. Klein L, O'connell JB. Thromboembolic risk in the patient with heart failure. Curr Treat Options Cardiovasc Med. 2007 Aug; 9(4):310-7. PMID: 17761116.
        View in: PubMed
      28. Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation. 2007 Feb 27; 115(8):1004-11. PMID: 17283263.
        View in: PubMed
      29. Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005 Dec 20; 112(25):3958-68. PMID: 16365214.
        View in: PubMed
      30. De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M. Hyponatremia in patients with heart failure. Am J Cardiol. 2005 Dec 19; 96(12A):19L-23L. PMID: 16399089.
        View in: PubMed
      31. Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, Adams KF, Califf RM, Gheorghiade M. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation. 2005 May 17; 111(19):2454-60. PMID: 15867182.
        View in: PubMed
      32. Klein L. Posting treatment recommendations to primary care physicians does not improve care for people with myocardial infarction or heart failure. Commentary. Evid Based Cardiovasc Med. 2005 Mar; 9(1):72-5. PMID: 16379994.
        View in: PubMed
      33. Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. Med Clin North Am. 2004 Sep; 88(5):1209-35. PMID: 15331314.
        View in: PubMed
      34. Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation. 2004 Jul; 62(1):35-42. PMID: 15246581.
        View in: PubMed
      35. Klein L, Galvez A, Klein O, Chediak J. Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. Am J Hematol. 2004 Jun; 76(2):176-9. PMID: 15164386.
        View in: PubMed
      36. Klein L, Gattis WA, Borrello F, Wu E, O'Connor CM, Gheorghiade M. Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study. Am J Cardiol. 2004 Apr 22; 93(8A):44A-46A. PMID: 15094106.
        View in: PubMed
      37. Klein L, Gheorghiade M. Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. Am J Med. 2004 Mar 8; 116 Suppl 5A:47S-63S. PMID: 15019863.
        View in: PubMed
      38. Piccini JP, Klein L, Gheorghiade M, Bonow RO. New insights into diastolic heart failure: role of diabetes mellitus. Am J Med. 2004 Mar 8; 116 Suppl 5A:64S-75S. PMID: 15019864.
        View in: PubMed
      39. Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ. Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. Ital Heart J. 2004 Feb; 5(2):160-2. PMID: 15086148.
        View in: PubMed
      40. Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M. Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. Am J Cardiol. 2003 May 8; 91(9A):18F-40F. PMID: 12729848.
        View in: PubMed
      41. Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M. Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. Am Heart J. 2003 Feb; 145(2 Suppl):S3-17. PMID: 12594447.
        View in: PubMed
      42. Klein L, Gheorghiade M. Therapeutic strategies for patients hospitalized with worsening heart failure. Ital Heart J. 2003 Feb; 4(2):71-4. PMID: 12762267.
        View in: PubMed
      43. Borrello F, Beahan M, Klein L, Gheorghiade M. Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period. Rev Cardiovasc Med. 2003; 4 Suppl 3:S13-24. PMID: 14564230.
        View in: PubMed
      44. Gheorghiade M, Gattis WA, Klein L. OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. Eur J Heart Fail. 2003 Jan; 5(1):9-12. PMID: 12559209.
        View in: PubMed
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