Liviu Klein, MD, MS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address505 Parnassus Avenue, #M1178B
San Francisco CA 94117
Phone415-476-2143
ORCID ORCID Icon0000-0002-0547-1480 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Carol Davila School of MedicineMD 1999Medicine
    Northwestern UniversityMSCI2005Graduate School
    University Hospital BucharestResident2000Internal Medicine
    Advocate Illinois Masonic Medical CenterResident2003Internal Medicine
    Northwestern UniversityFellow2005Cardiovascular Epidemiology
    Northwestern Memorial HospitalFellow2007Cardiovascular Disease
    Northwestern Memorial HospitalFellow2008Advanced Heart Failure and Transplantation
    Northwestern Memorial HospitalFellow2009Clinical Cardiac Electrophysiology
    Collapse Awards and Honors
    International Society for Rotary Blood Pumps2016Sezai Innovative Research Award
    University of California San Francisco2013Cardiology Faculty Teaching Award
    Northwestern University Feinberg School of Medicine2009Larry Jameson Research Award
    Advocate Illinois Masonic Medical Center2003Outstanding Senior Resident Award

    Collapse Overview 
    Collapse Overview
    CLINICAL INTERESTS
    My clinical interests are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies. I treat patients across the heart failure spectrum, from early diagnosis to heart transplantation. At UCSF, I am the Director of the Advanced Heart Failure Comprehensive Care Center and the Section Chief of Advanced Heart Failure, Mechanical Circulatory Support, Pulmonary Hypertension and Heart Transplant.

    RESEARCH INTERESTS
    My research is aimed at developing new diagnostic sensors (including implantable hemodynamic sensors), therapeutic devices and artificial intelligence tools for patients with cardiovascular disease, including patients with heart failure. At UCSF, I am the Director of the Cardiology Clinical Research Unit.

    Collapse Research 
    Collapse Research Activities and Funding
    WHISH-2-Prevent Heart Failure Study
    NIH R01HL130591Aug 1, 2016 - May 31, 2021
    Role: Co-Investigator
    Non-invasive biosensors to detect cardiovascular changes in heart failure
    NIH R01HL130619May 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Wearable Cardiomechanics Monitor to Decrease Heart Failure Readmissions
    NIH R56AG048458Sep 30, 2015 - Aug 31, 2016
    Role: Principal Investigator
    CorBand: A novel wearable wrist sensor for heart failure remote monitoring
    NIH R44HL125001Aug 1, 2014 - Jul 31, 2018
    Role: Co-Investigator
    Heart Failure Evaluation in Post-Menopausal Women: The Women's Health Initiative
    NIH R21AG027471Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Featured Content 
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Left atrial to coronary sinus shunting for treatment of heart failure with mildly reduced or preserved ejection fraction: The ALT FLOW Early Feasibility Study 1-year results. Eur J Heart Fail. 2024 Apr 12. Urey MA, Hibbert B, Jorde U, Eckman P, Simard T, Labinaz M, Nazer B, Wiley M, Gupta B, Sauer A, Shah H, Sorajja P, Pineda AM, Missov E, Mahmud E, Kahwash R, Lilly S, Latib A, Murthy S, Fam N, Garcia S, Chung ES, Klein L, Cheng R, Houston BA, Amoroso NS, Chang L, Gafoor S, Chaudhry SP, Hermiller J, Schwartz JG, Aldaia L, Koulogiannis K, Gray WA, Zahr F. PMID: 38606485.
      View in: PubMed   Mentions:
    2. Safety and Performance of the Aortix Device in Acute Decompensated Heart Failure and Cardiorenal Syndrome. JACC Heart Fail. 2023 Nov; 11(11):1565-1575. Cowger JA, Basir MB, Baran DA, Hayward CS, Rangaswami J, Walton A, Tita C, Minear S, Hakemi E, Klein L, Cheng R, Wu R, Mohanty BD, Heuring JJ, Neely E, Shah P, Aortix CRS Pilot Study Investigators. PMID: 37804307.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    3. Corrigendum to "HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support": Journal of Cardiac Failure Vol. 29 No. 4, pp. 479-502. J Card Fail. 2023 Sep; 29(9):1342. Trachtenberg B, Jennings D, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E, Cowger J. PMID: 37414594.
      View in: PubMed   Mentions:    Fields:    
    4. Comment on: Detection and management of HLA sensitization in candidates for adult heart transplantation. J Heart Lung Transplant. 2023 Apr 21. Fiedler AG, Klein L, DeMarco T, Kouretas P, Smith JW. PMID: 37088342.
      View in: PubMed   Mentions:    Fields:    
    5. PROMIS: Physical, Mental and Social Health Outcomes Improve From Before to Early After LVAD Implant: Findings From the Mechanical Circulatory Support: Measures of Adjustment and Quality of Life (MCS A-QOL) Study. J Card Fail. 2023 Oct; 29(10):1398-1411. Hahn EA, Allen LA, Lee CS, Denfeld QE, Stehlik J, Cella D, Lindenfeld J, Teuteberg JJ, McIlvennan CK, Kiernan MS, Beiser DG, Walsh MN, Adler ED, Ruo B, Kirklin JK, Klein L, Bedjeti K, Cummings PD, Burns JL, Vela AM, Grady KL. PMID: 37004864; PMCID: PMC10544687.
      View in: PubMed   Mentions:    Fields:    
    6. HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support. J Card Fail. 2023 04; 29(4):479-502. Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E. PMID: 36828256.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Validity of Patient-Reported Outcomes Measurement Information System Physical, Mental, and Social Health Measures After Left Ventricular Assist Device Implantation and Implications for Patient Care. Circ Cardiovasc Qual Outcomes. 2023 02; 16(2):e008690. Hahn EA, Walsh MN, Allen LA, Lee CS, Denfeld QE, Teuteberg JJ, Beiser DG, McIlvennan CK, Lindenfeld J, Klein L, Adler ED, Stehlik J, Ruo B, Bedjeti K, Cummings PD, Vela AM, Grady KL. PMID: 36752104; PMCID: PMC9940833.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. J Card Fail. 2023 07; 29(7):1017-1028. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. PMID: 36706977; PMCID: PMC10363571.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Rationale and Design of the Proactive-HF Trial for Managing Patients With NYHA Class III Heart Failure by Using the Combined Cordella Pulmonary Artery Sensor and the Cordella Heart Failure System. J Card Fail. 2023 02; 29(2):171-180. Guichard JL, Cowger JA, Chaparro SV, Kiernan MS, Mullens W, Mahr C, Mullin C, Forouzan O, Hiivala NJ, Sauerland A, Leadley K, Klein L. PMID: 36191758.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure. Curr Probl Cardiol. 2022 Dec; 47(12):101364. Fudim M, Shahid I, Emani S, Klein L, Dupuy-McCauley KL, Zieroth S, Mentz RJ. PMID: 35995244.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Estimation of Changes in Intracardiac Hemodynamics Using Wearable Seismocardiography and Machine Learning in Patients With Heart Failure: A Feasibility Study. IEEE Trans Biomed Eng. 2022 08; 69(8):2443-2455. Shandhi MMH, Fan J, Heller JA, Etemadi M, Klein L, Inan OT. PMID: 35100106; PMCID: PMC9347221.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE-HF trial roll-in cohort. Eur J Heart Fail. 2022 08; 24(8):1410-1414. Fudim M, Fail PS, Litwin SE, Shaburishvili T, Goyal P, Hummel SL, Borlaug BA, Mohan RC, Patel RB, Mitter SS, Klein L, Rocha-Singh K, Patel MR, Reddy VY, Burkhoff D, Shah SJ. PMID: 35598154; PMCID: PMC9388552.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    13. Improving clinical trial efficiency using a machine learning-based risk score to enrich study populations. Eur J Heart Fail. 2022 08; 24(8):1418-1426. Jering KS, Campagnari C, Claggett B, Adler E, Klein L, Ahmad FS, Voors AA, Solomon S, Yagil A, Greenberg B. PMID: 35508918; PMCID: PMC9388618.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Blood Pressure Variability and Heart Failure Hospitalization: Results From the Women's Health Initiative. Am J Prev Med. 2022 09; 63(3):410-418. Haring B, Hunt RP, Manson JE, LaMonte MJ, Klein L, Allison MA, Wild RA, Wallace RB, Shadyab AH, Breathett K, Eaton C, Wassertheil-Smoller S, Shimbo D. PMID: 35525685.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Global best practices consensus: Long-term management of patients with hybrid centrifugal flow left ventricular assist device support. J Thorac Cardiovasc Surg. 2022 10; 164(4):1120-1137.e2. Hayward C, Adachi I, Baudart S, Davis E, Feller ED, Kinugawa K, Klein L, Li S, Lorts A, Mahr C, Mathew J, Morshuis M, Müller M, Ono M, Pagani FD, Pappalardo F, Rich J, Robson D, Rosenthal DN, Saeed D, Salerno C, Sauer AJ, Schlöglhofer T, Tops L, VanderPluym C. PMID: 35624053.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Multiple cArdiac seNsors for mAnaGEment of Heart Failure (MANAGE-HF) - Phase I Evaluation of the Integration and Safety of the HeartLogic Multisensor Algorithm in Patients With Heart Failure. J Card Fail. 2022 08; 28(8):1245-1254. Hernandez AF, Albert NM, Allen LA, Ahmed R, Averina V, Boehmer JP, Cowie MR, Chien CV, Galvao M, Klein L, Kwan B, Lam CSP, Ruble SB, Stolen CM, Stein K, MANAGE-HF Study. PMID: 35460884.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    17. Novel Noninvasive Biosensors and Artificial Intelligence for Optimized Heart Failure Management. JACC Basic Transl Sci. 2022 Mar; 7(3):316-318. Neill L, Etemadi M, Klein L, Inan OT. PMID: 35411315; PMCID: PMC8993909.
      View in: PubMed   Mentions: 1  
    18. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. J Oncol Pharm Pract. 2022 Apr; 28(3):729-732. Banerjee R, Lo M, Klein L, Aras M, Logan AC. PMID: 34846217.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Is There a Logic in Using Device-Based Algorithms to Prevent Heart Failure Decompensations? Circ Heart Fail. 2021 10; 14(10):e008770. Klein L. PMID: 34634918.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Long-Term Electrocardiographic and Echocardiographic Progression of Arrhythmogenic Right Ventricular Cardiomyopathy and Their Correlation With Ventricular Tachyarrhythmias. Circ Heart Fail. 2021 09; 14(9):e008121. Kalantarian S, Åström Aneq M, Svetlichnaya J, Sharma S, Vittinghoff E, Klein L, Scheinman MM. PMID: 34550004.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA. Int J Cardiol. 2021 10 01; 340:26-33. Darden D, Ammirati E, Brambatti M, Lin A, Hsu JC, Shah P, Perna E, Cikes M, Gjesdal G, Potena L, Masetti M, Jakus N, Van De Heyning C, De Bock D, Brugts JJ, Russo CF, Veenis JF, Rega F, Cipriani M, Frigerio M, Liviu K, Hong KN, Adler E, Braun OÖ. PMID: 34437934.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Predicting Incident Heart Failure in Women With Machine Learning: The Women's Health Initiative Cohort. Can J Cardiol. 2021 11; 37(11):1708-1714. Tison GH, Avram R, Nah G, Klein L, Howard BV, Allison MA, Casanova R, Blair RH, Breathett K, Foraker RE, Olgin JE, Parikh NI. PMID: 34400272; PMCID: PMC8642266.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia. Womens Health Rep (New Rochelle). 2021; 2(1):97-105. Quesada O, Shandhi MMH, Beach S, Dowling S, Tandon D, Heller J, Etemadi M, Roy S, Gonzalez Velez JM, Inan OT, Klein L. PMID: 33937907; PMCID: PMC8080913.
      View in: PubMed   Mentions: 2  
    24. Two-Year Follow Up of the LATERAL Clinical Trial: A Focus on Adverse Events. Circ Heart Fail. 2021 04; 14(4):e006912. Wieselthaler GM, Klein L, Cheung AW, Danter MR, Strueber M, Mahr C, Mokadam NA, Maltais S, McGee EC. PMID: 33866829; PMCID: PMC8059760.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    25. Effect of preload reducing therapy on right ventricular size and function in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2021 07; 18(7):1186-1191. Kalantarian S, Vittinghoff E, Klein L, Scheinman MM. PMID: 33722762.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women. Circ Heart Fail. 2020 12; 13(12):e007508. LaMonte MJ, Larson JC, Manson JE, Bellettiere J, Lewis CE, LaCroix AZ, Bea JW, Johnson KC, Klein L, Noel CA, Stefanick ML, Wactawski-Wende J, Eaton CB. PMID: 33228398; PMCID: PMC7738397.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African American and Hispanic Women. J Card Fail. 2021 Feb; 27(2):217-223. Breathett K, Kohler LN, Eaton CB, Franceschini N, Garcia L, Klein L, Martin LW, Ochs-Balcom HM, Shadyab AH, Cené CW. PMID: 33232822; PMCID: PMC7880886.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Temporal Associations and Outcomes of Breast Cancer and Heart Failure in Postmenopausal Women. JACC CardioOncol. 2020 Nov; 2(4):567-577. Lam PH, Barac A, Nohria A, Reding KW, Najjar SS, Fonarow GC, Pan K, Sheriff H, Morgan CJ, Chlebowski RT, Klein L, Eaton CB, Howard BV, Ahmed A, Mohammed SF. PMID: 34396268; PMCID: PMC8352239.
      View in: PubMed   Mentions: 1  
    29. Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). Int J Cardiol. 2021 02 01; 324:122-130. Ammirati E, Brambatti M, Braun OÖ, Shah P, Cipriani M, Bui QM, Veenis J, Lee E, Xu R, Hong KN, Van de Heyning CM, Perna E, Timmermans P, Cikes M, Brugts JJ, Veronese G, Minto J, Smith S, Gjesdal G, Gernhofer YK, Partida C, Potena L, Masetti M, Boschi S, Loforte A, Jakus N, Milicic D, Nilsson J, De Bock D, Sterken C, Van den Bossche K, Rega F, Tran H, Singh R, Montomoli J, Mondino M, Greenberg B, Russo CF, Pretorius V, Liviu K, Frigerio M, Adler ED. PMID: 32950592.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Cardiac Function Monitoring for Patients Undergoing Cancer Treatments Using Wearable Seismocardiography: A Proof-of-Concept Study. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:4075-4078. Hasan Shandhi MM, Aras M, Wynn S, Fan J, Heller JA, Etemadi M, Klein L, Inan OT. PMID: 33018894.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Wearable Patch-Based Estimation of Oxygen Uptake and Assessment of Clinical Status during Cardiopulmonary Exercise Testing in Patients With Heart Failure. J Card Fail. 2020 Nov; 26(11):948-958. Shandhi MMH, Hersek S, Fan J, Sander E, De Marco T, Heller JA, Etemadi M, Klein L, Inan OT. PMID: 32473379; PMCID: PMC7704799.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. Detecting Suspected Pump Thrombosis in Left Ventricular Assist Devices via Acoustic Analysis. IEEE J Biomed Health Inform. 2020 07; 24(7):1899-1906. Semiz B, Hersek S, Pouyan MB, Partida C, Blazquez-Arroyo L, Selby V, Wieselthaler G, Rehg JM, Klein L, Inan OT. PMID: 31940570; PMCID: PMC7380556.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Heart-lung transplantation: A viable option for connective tissue diseases. Clin Transplant. 2020 02; 34(2):e13776. Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. PMID: 31867763.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Improving risk prediction in heart failure using machine learning. Eur J Heart Fail. 2020 01; 22(1):139-147. Adler ED, Voors AA, Klein L, Macheret F, Braun OO, Urey MA, Zhu W, Sama I, Tadel M, Campagnari C, Greenberg B, Yagil A. PMID: 31721391.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    35. Menopausal Hormone Therapy and Risks of First Hospitalized Heart Failure and its Subtypes During the Intervention and Extended Postintervention Follow-up of the Women's Health Initiative Randomized Trials. J Card Fail. 2020 Jan; 26(1):2-12. Liu L, Klein L, Eaton C, Panjrath G, Martin LW, Chae CU, Greenland P, Lloyd-Jones DM, Wactawski-Wende J, Manson JE. PMID: 31536806.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis. J Am Heart Assoc. 2019 09 17; 8(18):e010952. Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V. PMID: 31538835; PMCID: PMC6818011.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    37. Classification of Decompensated Heart Failure From Clinical and Home Ballistocardiography. IEEE Trans Biomed Eng. 2020 05; 67(5):1303-1313. Aydemir VB, Nagesh S, Shandhi MMH, Fan J, Klein L, Etemadi M, Heller JA, Inan OT, Rehg JM. PMID: 31425011; PMCID: PMC7271768.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    38. Internal Jugular Vein as Alternative Access for Implantation of a Wireless Pulmonary Artery Pressure Sensor. Circ Heart Fail. 2019 08; 12(8):e006060. Abraham J, McCann P, Wang L, Schnell Heringer A, Paulsen J, Chappell J, Remick J, Westerdahl D, Lewis R, Callis K, Spinelli KJ, Klein L. PMID: 31525097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Atrial arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy: Prevalence, echocardiographic predictors, and treatment. J Cardiovasc Electrophysiol. 2019 10; 30(10):1801-1810. Cardona-Guarache R, Åström-Aneq M, Oesterle A, Asirvatham R, Svetlichnaya J, Marcus GM, Gerstenfeld EP, Klein L, Scheinman MM. PMID: 31310380.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Noninvasive estimation of pulmonary vascular resistance improves portopulmonary hypertension screening in liver transplant candidates. Clin Transplant. 2019 07; 33(7):e13585. DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T. PMID: 31074522.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Evaluation of a lateral thoracotomy implant approach for a centrifugal-flow left ventricular assist device: The LATERAL clinical trial. J Heart Lung Transplant. 2019 04; 38(4):344-351. McGee E, Danter M, Strueber M, Mahr C, Mokadam NA, Wieselthaler G, Klein L, Lee S, Boeve T, Maltais S, Pretorius GV, Adler E, Vassiliades T, Cheung A. PMID: 30945636.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    42. Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies. Open Heart. 2019; 6(1):e000927. Arnaout R, Nah G, Marcus G, Tseng Z, Foster E, Harris IS, Divanji P, Klein L, Gonzalez J, Parikh N. PMID: 30997125; PMCID: PMC6443129.
      View in: PubMed   Mentions: 11     Fields:    
    43. Feasibility and utility of intraoperative epicardial scar characterization during left ventricular assist device implantation. J Cardiovasc Electrophysiol. 2019 02; 30(2):183-192. Moss JD, Oesterle A, Raiman M, Flatley EE, Beaser AD, Jeevanandam V, Klein L, Ota T, Wieselthaler G, Uriel N, Tung R. PMID: 30516301.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    44. Physical Activity and Incidence of Heart Failure in Postmenopausal Women. JACC Heart Fail. 2018 12; 6(12):983-995. LaMonte MJ, Manson JE, Chomistek AK, Larson JC, Lewis CE, Bea JW, Johnson KC, Li W, Klein L, LaCroix AZ, Stefanick ML, Wactawski-Wende J, Eaton CB. PMID: 30196073; PMCID: PMC6275092.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    45. Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Women's Health Initiative. Circ Heart Fail. 2018 05; 11(5):e004642. Breathett K, Leng I, Foraker RE, Abraham WT, Coker L, Whitfield KE, Shumaker S, Manson JE, Eaton CB, Howard BV, Ijioma N, Cené CW, Martin LW, Johnson KC, Klein L. PMID: 29716899; PMCID: PMC5935135.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    46. Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction. Circulation. 2018 04 24; 137(17):1814-1823. Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen NB, Kuller LH, Greenland P, Eaton CB, Gottdiener JS, Lloyd-Jones DM, Berry JD. PMID: 29352072; PMCID: PMC6417883.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    47. Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients. Circ Heart Fail. 2018 01; 11(1):e004313. Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L. PMID: 29330154; PMCID: PMC5769154.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    48. (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure. J Am Coll Cardiol. 2017 10 10; 70(15):1887-1889. Klein L. PMID: 28982502.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    49. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative. J Am Coll Cardiol. 2017 May 23; 69(20):2517-2526. Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI. PMID: 28521890; PMCID: PMC5602586.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    50. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. J Am Coll Cardiol. 2017 Mar 07; 69(9):1129-1142. Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD. PMID: 28254175; PMCID: PMC5848099.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    51. Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis. 2017 Apr; 19(2). Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM. PMID: 28067969; PMCID: PMC5510642.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    52. The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective. Eur J Heart Fail. 2017 05; 19(5):661-669. Cowie MR, Simon M, Klein L, Thokala P. PMID: 28176424; PMCID: PMC5434803.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    53. Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circ Heart Fail. 2016 Oct; 9(10). Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L. PMID: 27682440; PMCID: PMC5111360.
      View in: PubMed   Mentions: 91     Fields:    
    54. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artif Organs. 2016 Oct 10; 39(8):421-430. Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM. PMID: 27646633; PMCID: PMC5067236.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    55. Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations. JACC Heart Fail. 2016 05; 4(5):345-7. Klein L. PMID: 27126282.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    56. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. J Card Fail. 2015 Nov; 21(11):924-9. Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, de Marco T. PMID: 26362520.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890. Rogers SE, Klein L, Perissinotto CM. PMID: 25822770.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    58. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8. Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. PMID: 25974943; PMCID: PMC4643430.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    59. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circ Heart Fail. 2015 Jan; 8(1):49-56. Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. PMID: 25398967; PMCID: PMC4303506.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    60. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42. Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. PMID: 25265619; PMCID: PMC4532376.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    61. Sudden cardiac death in heart failure. Cardiol Clin. 2014 Feb; 32(1):135-44, ix. Klein L, Hsia H. PMID: 24286584.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    62. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5172-5. Wiens A, Etemadi M, Klein L, Roy S, Inan OT. PMID: 25571158; PMCID: PMC4605430.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    63. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5188-91. Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. PMID: 25571162; PMCID: PMC4600348.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    64. Prognostic factors in patients hospitalized for heart failure. Curr Heart Fail Rep. 2013 Dec; 10(4):380-6. Sridharan L, Klein L. PMID: 24122287.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart. 2013 Aug; 99(16):1173-8. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. PMID: 23756655.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    66. Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials. Circ Arrhythm Electrophysiol. 2012 Dec; 5(6):1108-16. Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML. PMID: 23169946.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    67. ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF. Ann Intern Med. 2012 Sep 18; 157(6):JC3-2. Klein L. PMID: 22986394.
      View in: PubMed   Mentions:    Fields:    
    68. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet. 2012; 8(8):e1002870. Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. PMID: 22912591; PMCID: PMC3415454.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    69. Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative. Circulation. 2012 Aug 07; 126(6):688-96. Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV. PMID: 22753306; PMCID: PMC4618499.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    70. Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. Klein L. PMID: 22250164.
      View in: PubMed   Mentions:    Fields:    
    71. Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. Klein L. PMID: 22250165.
      View in: PubMed   Mentions:    Fields:    
    72. Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials. J Am Coll Cardiol. 2011 Sep 27; 58(14):1457-64. Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L. PMID: 21939829; PMCID: PMC3635103.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    73. Quality of care and outcomes in women hospitalized for heart failure. Circ Heart Fail. 2011 Sep; 4(5):589-98. Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC. PMID: 21862732.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    74. Omnes viae Romam ducunt: Asymptomatic cardiac and noncardiac organ system dysfunction leads to heart failure. Circulation. 2011 Jul 05; 124(1):4-6. Klein L. PMID: 21730317.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    75. Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population. ASAIO J. 2011 Jul-Aug; 57(4):254-61. Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N. PMID: 21546824.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert Rev Cardiovasc Ther. 2011 Jul; 9(7):903-12. Svetlichnaya J, Klein L. PMID: 21809972.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    77. Characteristics and outcomes of very elderly patients after first hospitalization for heart failure. Circ Heart Fail. 2011 May; 4(3):301-7. Shah RU, Tsai V, Klein L, Heidenreich PA. PMID: 21467294.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    78. ACP Journal Club. Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation. Ann Intern Med. 2010 Jan 19; 152(2):JC1-2. Klein L. PMID: 20083817.
      View in: PubMed   Mentions:    Fields:    
    79. Heart failure in women: epidemiology, biology and treatment. Womens Health (Lond). 2009 Sep; 5(5):517-27. Shah RU, Klein L, Lloyd-Jones DM. PMID: 19702451.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    80. Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circ Heart Fail. 2008 May; 1(1):25-33. Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF, Califf RM, Gheorghiade M, OPTIME-CHF Investigators. PMID: 19808267.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    81. Thromboembolic risk in the patient with heart failure. Curr Treat Options Cardiovasc Med. 2007 Aug; 9(4):310-7. Klein L, O'connell JB. PMID: 17761116.
      View in: PubMed   Mentions: 2  
    82. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation. 2007 Feb 27; 115(8):1004-11. Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P. PMID: 17283263.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    83. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005 Dec 20; 112(25):3958-68. Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L, International Working Group on Acute Heart Failure Syndromes. PMID: 16365214.
      View in: PubMed   Mentions: 217     Fields:    Translation:Humans
    84. Hyponatremia in patients with heart failure. Am J Cardiol. 2005 Dec 19; 96(12A):19L-23L. De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M. PMID: 16399089.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    85. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation. 2005 May 17; 111(19):2454-60. Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, Adams KF, Califf RM, Gheorghiade M, OPTIME-CHF Investigators. PMID: 15867182.
      View in: PubMed   Mentions: 150     Fields:    Translation:Humans
    86. Posting treatment recommendations to primary care physicians does not improve care for people with myocardial infarction or heart failure. Commentary. Evid Based Cardiovasc Med. 2005 Mar; 9(1):72-5. Klein L. PMID: 16379994.
      View in: PubMed   Mentions:    Fields:    
    87. Coronary artery disease and prevention of heart failure. Med Clin North Am. 2004 Sep; 88(5):1209-35. Klein L, Gheorghiade M. PMID: 15331314.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    88. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation. 2004 Jul; 62(1):35-42. Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF. PMID: 15246581.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    89. Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. Am J Hematol. 2004 Jun; 76(2):176-9. Klein L, Galvez A, Klein O, Chediak J. PMID: 15164386.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    90. Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study. Am J Cardiol. 2004 Apr 22; 93(8A):44A-46A. Klein L, Gattis WA, Borrello F, Wu E, O'Connor CM, Gheorghiade M. PMID: 15094106.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    91. Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. Am J Med. 2004 Mar 08; 116 Suppl 5A:47S-63S. Klein L, Gheorghiade M. PMID: 15019863.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    92. New insights into diastolic heart failure: role of diabetes mellitus. Am J Med. 2004 Mar 08; 116 Suppl 5A:64S-75S. Piccini JP, Klein L, Gheorghiade M, Bonow RO. PMID: 15019864.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    93. Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. Ital Heart J. 2004 Feb; 5(2):160-2. Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ. PMID: 15086148.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. Am J Cardiol. 2003 May 08; 91(9A):18F-40F. Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M. PMID: 12729848.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    95. Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. Am Heart J. 2003 Feb; 145(2 Suppl):S3-17. Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M. PMID: 12594447.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    96. Therapeutic strategies for patients hospitalized with worsening heart failure. Ital Heart J. 2003 Feb; 4(2):71-4. Klein L, Gheorghiade M. PMID: 12762267.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    97. OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. Eur J Heart Fail. 2003 Jan; 5(1):9-12. Gheorghiade M, Gattis WA, Klein L. PMID: 12559209.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    98. Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period. Rev Cardiovasc Med. 2003; 4 Suppl 3:S13-24. Borrello F, Beahan M, Klein L, Gheorghiade M. PMID: 14564230.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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