Lucas Schirmer, MD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
DepartmentRegeneration Medicine
Address401 Parnassus Ave.
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of GöttingenM.D.2008School of Medicine
    Technical University of MunichBoard Certification2014Neurology
    Technical University of MunichVenia Legendi2015Neurology
    Collapse Awards and Honors
    National Multiple Sclerosis Society2017  - 2020Postdoctoral Fellowship
    National Multiple Sclerosis Society2017  - 2018Pilot Research Award
    German Research Foundation2015  - 2017Postdoctoral Fellowship
    Genzyme Corporation2013  - 2015Neuroimmunology Fellowship
    German Multiple Sclerosis Society2013Hans Georg Queckenstedt Award
    American Academy of Neurology2013International Scholarship Award
    Technical University of Munich2011Intramural Research Grant (Commission for Clinical Research)
    Multiple Sclerosis International Federation2010Du Pré Grant
    German Society of Neurology2009Felgenhauer Fellowship
    University of Göttingen2009School of Medicine Thesis Award ("summa cum laude")
    German Research Foundation2003  - 2006Graduate Fellowship, European Graduate School 632 “Neuroplasticity: From Molecules to Systems“

    Collapse Overview 
    Collapse Overview
    As a neurologist physician-scientist I focus my research on translational neuroscience working with experimental models and human pathology in a synergistic way. I would like to understand the underlying pathophysiological mechanisms that lead to neurodegeneration, scar formation and unsatisfactory remyelination and work on strategies to foster repair in progressive multiple sclerosis (MS). My clinical interests are focused on several aspects of neuroinflammation and neurooncology with a particular emphasis on MS, glioma, neuroinfectious diseases and spinal cord injury.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH. Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. Glia. 2017 Aug 30. PMID: 28856805.
      View in: PubMed
    2. Wirth M, Schirmer L, Hofauer B, Lenschow M, Loos D, Thuermel K, Knopf A. Head and neck giant cell arteritis: an autoimmune disease with many faces. Acta Otolaryngol. 2017 Sep; 137(9):986-991. PMID: 28440088.
      View in: PubMed
    3. Boeckh-Behrens T, Kleine J, Kaesmacher J, Zimmer C, Schirmer L, Simon S, Poppert H. The CD31 molecule: a possible neuroprotective agent in acute ischemic stroke? Thromb J. 2017; 15:11. PMID: 28413360.
      View in: PubMed
    4. Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017 Apr; 81(4):560-571. PMID: 28253550.
      View in: PubMed
    5. Kaesmacher J, Boeckh-Behrens T, Simon S, Maegerlein C, Kleine JF, Zimmer C, Schirmer L, Poppert H, Huber T. Risk of Thrombus Fragmentation during Endovascular Stroke Treatment. AJNR Am J Neuroradiol. 2017 May; 38(5):991-998. PMID: 28279987.
      View in: PubMed
    6. Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 01 26; 541(7638):481-487. PMID: 28099414.
      View in: PubMed
    7. Schirmer L, Worthington V, Solloch U, Loleit V, Grummel V, Lakdawala N, Grant D, Wassmuth R, Schmidt AH, Gebhardt F, Andlauer TF, Sauter J, Berthele A, Lunn MP, Hemmer B, et al. Higher frequencies of HLA DQB1*05:01 and anti-glycosphingolipid antibodies in a cluster of severe Guillain-Barré syndrome. J Neurol. 2016 Oct; 263(10):2105-13. PMID: 27485170.
      View in: PubMed
    8. Boeckh-Behrens T, Kleine JF, Zimmer C, Neff F, Scheipl F, Pelisek J, Schirmer L, Nguyen K, Karatas D, Poppert H. Thrombus Histology Suggests Cardioembolic Cause in Cryptogenic Stroke. Stroke. 2016 Jul; 47(7):1864-71. PMID: 27197854.
      View in: PubMed
    9. Schirmer L, Wölfel S, Georgi E, Ploner M, Bauer B, Hemmer B. Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis. Open Forum Infect Dis. 2015 Sep; 2(3):ofv124. PMID: 26393235; PMCID: PMC4569839.
    10. Boeckh-Behrens T, Schubert M, Förschler A, Prothmann S, Kreiser K, Zimmer C, Riegger J, Bauer J, Neff F, Kehl V, Pelisek J, Schirmer L, Mehr M, Poppert H. The Impact of Histological Clot Composition in Embolic Stroke. Clin Neuroradiol. 2016 Jun; 26(2):189-97. PMID: 25261075.
      View in: PubMed
    11. Schirmer L, Srivastava R, Kalluri SR, Böttinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer B. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014 Jun; 75(6):810-28. PMID: 24777949.
      View in: PubMed
    12. Schirmer L, Srivastava R, Hemmer B. To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis. Mult Scler. 2014 Mar; 20(3):271-9. PMID: 24589684.
      View in: PubMed
    13. Schirmer L, Rothhammer V, Hemmer B, Korn T. Enriched CD161high CCR6+ ?d T cells in the cerebrospinal fluid of patients with multiple sclerosis. JAMA Neurol. 2013 Mar 01; 70(3):345-51. PMID: 23599932.
      View in: PubMed
    14. Srivastava R, Aslam M, Kalluri SR, Schirmer L, Buck D, Tackenberg B, Rothhammer V, Chan A, Gold R, Berthele A, Bennett JL, Korn T, Hemmer B. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med. 2012 Jul 12; 367(2):115-23. PMID: 22784115.
      View in: PubMed
    15. Schirmer L, Merkler D, König FB, Brück W, Stadelmann C. Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions. Brain Pathol. 2013 Jan; 23(1):2-12. PMID: 22612622.
      View in: PubMed
    16. Lahmer T, Küchle C, Schirmer L, Heemann U, Lutz J, Thürmel K. Kidney transplant after preexisting posterior reversible encephalopathy syndrome induced by Goodpasture's syndrome. Exp Clin Transplant. 2012 Jun; 10(3):299-301. PMID: 22631071.
      View in: PubMed
    17. Sellner J, Schirmer L, Erik Gilhus N, Grisold W, Struhal W. The Open Facilities for Training in European Neurology (OFTEN): an emerging pan-European exchange programme for junior neurologists. Eur J Neurol. 2012 Jun; 19(6):e54-5. PMID: 22448868.
      View in: PubMed
    18. Schirmer L, Seifert CL, Pfeifenbring S, Wunderlich S, Stadelmann C, Hemmer B. Clinicopathological considerations in acute disseminated encephalomyelitis (ADEM): a fulminant case with favorable outcome. J Neurol. 2012 Apr; 259(4):753-5. PMID: 21901482.
      View in: PubMed
    19. Schirmer L, Antel JP, Brück W, Stadelmann C. Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis. Brain Pathol. 2011 Jul; 21(4):428-40. PMID: 21114565.
      View in: PubMed
    20. Sellner J, Schirmer L, Hemmer B, Mühlau M. [Radiologically isolated syndrome: multiple sclerosis based solely on MRI findings?]. Nervenarzt. 2010 Oct; 81(10):1208-17. PMID: 20422146.
      View in: PubMed
    21. Sellner J, Schirmer L, Hemmer B, Mühlau M. The radiologically isolated syndrome: take action when the unexpected is uncovered? J Neurol. 2010 Oct; 257(10):1602-11. PMID: 20503053.
      View in: PubMed
    22. Schirmer L, Albert M, Buss A, Schulz-Schaeffer WJ, Antel JP, Brück W, Stadelmann C. Substantial early, but nonprogressive neuronal loss in multiple sclerosis (MS) spinal cord. Ann Neurol. 2009 Nov; 66(5):698-704. PMID: 19938172.
      View in: PubMed
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