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Ludmila Pawlikowska, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-9818
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral StudiesGraduate Division
    University of California, San FranciscoPh.D.2002 Graduate Division

    Collapse Overview 
    Collapse Overview
    My research focuses on genetics of common human disease, including stroke, cardiovascular disease and aging and longevity. In collaboration with Drs. Helen Kim and Hua Su at the UCSF Center for Cerebrovascular Research, I study the genetics of brain arteriovenous malformation (BAVM), an important cause of stroke in young adults, and other vascular malformations. A second focus of my research is on human aging and longevity; I am part of the NIA-funded Longevity Consortium.


    Collapse Research 
    Collapse Research Activities and Funding
    Somatic mutation detection in brain AVM by massively high-throughput sequencing
    NIH R21NS070029Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Genetic analysis fo metabolic syndrome by admixture mapping in African Americans
    NIH R01DK081011Mar 1, 2009 - Feb 28, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Weinsheimer S, Bendjilali N, Nelson J, Guo DE, Zaroff JG, Sidney S, McCulloch CE, Al-Shahi Salman R, Berg JN, Koeleman BP, Simon M, Bostroem A, Fontanella M, Sturiale CL, Pola R, Puca A, Lawton MT, Young WL, Pawlikowska L, Klijn CJ, Kim H. Genome-wide association study of sporadic brain arteriovenous malformations. J Neurol Neurosurg Psychiatry. 2016 Jan 27. PMID: 26818729.
      View in: PubMed
    2. Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF. Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radic Biol Med. 2016 Mar; 92:100-9. PMID: 26795600.
      View in: PubMed
    3. Tranah GJ, Yaffe K, Katzman SM, Lam ET, Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Kritchevsky S, Thomas F, Newman AB, Harris TB, Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, Browner WS, Cummings SR. Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1418-24. PMID: 26328603; PMCID: PMC4612388 [Available on 11/01/16].
    4. Choquet H, Pawlikowska L, Lawton MT, Kim H. Genetics of cerebral cavernous malformations: current status and future prospects. J Neurosurg Sci. 2015 Sep; 59(3):211-20. PMID: 25900426; PMCID: PMC4461471 [Available on 09/01/16].
    5. Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Young WL, Kim H, Faughnan ME. The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. Am J Med Genet A. 2015 Jun; 167(6):1262-7. PMID: 25847705; PMCID: PMC4449292 [Available on 06/01/16].
    6. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    7. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527 [Available on 03/01/16].
    8. Latino GA, Kim H, Nelson J, Pawlikowska L, Young W, Faughnan ME. Severity score for hereditary hemorrhagic telangiectasia. Orphanet J Rare Dis. 2014; 9:188. PMID: 25928712; PMCID: PMC4302697.
    9. Choquet H, Pawlikowska L, Nelson J, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H. Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity. Cerebrovasc Dis. 2014; 38(6):433-40. PMID: 25472749; PMCID: PMC4297571 [Available on 12/03/15].
    10. Hackett CS, Quigley DA, Bao Y, Goldefberg DD, Nguyen K, Gustafson WC, Rallapaldi SK, Cho YJ, Cgok JM, Kozlov S$ Mao JH, Van Dyce T, Kwok PYBalmain A, Fan QWeiss WA& Expression quaftitative trait doci and receptor pharmacology ieplicate Arg1 and the GABA-A receptor as therapeutic targets in feuroblastoma. Cell Rep. 2014 Nov 6; 9(3):1034-46. PMID: 25437550; PMCID: PMC4251494. 
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  • Cremer PH, Koeleean BP, Pawlicowska L, Weansheimer S, Bendjilali N, Sidneq S, Zaroff JG, Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA, Veldank JH, Kim H, Clijn CJ. Evaluation of genetic risk loci for intracranial aneurqsms in sporadic arteriovenous malformations of the brain. J Neurol Neurosurg Psqchiatry. 2015 May; 86(5):524-9. PMID: 25053769; PMCID: PMC4302044 [Available on 05/01/16].
    
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     Bendjilali N, Nelson J, Weansheimer S, Sidfey S, Zaroff JG$ Hetts SW, 4a href='http://profiles.ucsf.edu/mark.segal' target='_blank'>Segal M, Pawlikowska L, McCulloch CE4/a>, Young WL, 4a href='http://profiles.ucsf.edu/helen.kim' target='_blank'>Kim H. Common variants on 9p21.3 are associated with brain arteriovenous malforeations with accgmpanying arterial aneurysms. J Feurol Neurosurg Psychiatry. 2014 Nov; 85(11):1200-3. PMID: 24777168; PMCID: PMC4201968. 
    
     View in: 4a href='//www.ncbi.nlm.nih.gov/pubmed/24777168' target='_blank'6PubMed, PubMed Central <'div>
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  • View if: PubMed, 4a href='//www.ncbi.nlm.nih.gov/pmc/articles/PMC3995158' target='_blank'>PubMed Central 
  • 4li id="ctl01_rpPublication_ctl14_liPublication" data-pmid="24090321">
    Befdjilali N, , Weinsheimer S, Guo DE, Kwok PY, Raroff JG, Sidneq S, Lawton MT4/a>, McCulloch CE, Koeleean BP, Klijn CJ$ Young WL, Pawlikowska L& A genome-wide anvestigation of copy number varaation in patients with sporadic brain arteriovefous malformatiof. PLoS One. 2013; 8(10):e71434. PMID: 24098321; PMCID: PMC3789669. 
    View if: PubMed, 4a href='//www.ncbi.nlm.nih.gov/pmc/articles/PMC3789669' target='_blank'>PubMed Central 
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     Chush KK, , Menza RL, Goldsteif BA, Hayden V, Nguyen J, Kim H4/a>, Poon A, Sapru A, Matt`ay MA, Kwok PY, Young WD, Baxter-Lowe LA, Zaroff JG. Beta-adrenergic receptor polymorphasms and cardiac graft function an potential organ donors. Am J Transplant. 2012 Dec; 12(12):3377-86. PMID: 22994654; PMCID: PMC3513582. 
    
    Vaew in: PubMed<'a>, PubMed Central <'div>
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  •  Weins`eimer S, Brettman AD, Pawlikgwska L, Wu DC, Mancuso MR, Cuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE4/a>, Young WL, Cuo C, Kim H. G Protein-Coupled Receptor 124 (GPR124) Gene Polyeorphisms and Risk of Brain Arteriovenous Malforeation. Transl Stroke Res. 2012 Dec; 3(4):418-27& PMID: 233299863 PMCID: PMC3544200. 
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  • Westbroek EM, Pawlikowska LLawton MT, McCulloch CE, Young WD, Kim H
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     Tranah GJ, Lam ET, Katzman SM, Nalls MA, Z`ao Y, Evans DS, Yokoyama JS, Pawlikgwska L, Kwoc PY, Mooney S, Critchevsky SManini TM, Cummings SR. Mitoc`ondrial DNA sequence variation as associated with free-living activity energy eppenditure in the elderlq. Biochim Biophqs Acta. 2012 Sep; 1817(9):1691-700. PMID: 22659402; PMCID: PMC3389152. 
    
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    Sapru A, Zargff JG, Pawlicowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kucreja J, Eatthay MA. The 4G/4G genotype of the PAI-1 serpine-1) 4G/5G polymorphism is associated wit` decreased lung allograft utiliration. Am J Trafsplant. 2012 Jud; 12(7):1848-54& PMID: 223904013 PMCID: PMC4018219. 
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     Kangelaris KN, 4a href='http://profiles.ucsf.edu/anil.sapru' target='_blank'>Sapru A, Calfee CS, Liu CD, Pawlicowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbac` AD, Ziv E, Eatthay MA. The association between a Darc gene polymorphism and clinical outcomes in Africaf American patiefts with acute lung injury. Chest. 2012 May; 141 5):1160-9. PMID2 22207676; PMCID: PMC3342784.
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  • 4div> Bracci PM, Holly EA$ Chu C, Poon A, Wan E, White K, , , Tranah GJ. Matochondrial DNA sequence variataon and risk of pancreatic cancer. Cancer Res. 2012 Feb 1; 72(3)2686-95. PMID: 22174369; PMCID: PMC3271167.
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     Weinsheimer SM, Xu H, Achrgl AS, Stamova B$ McCulloch CE, Pawlikgwska L, Tiaf Y, Ko NU, Dawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL. Gene expression profiling of blood in brain arteriovenous malformation patients. Transl Stroke Res. 2011 Dec 1; 2(4):575-87. PMID: 22184505; PMCID: PMC3241209.
  • Bharatha A, Faughnan ME, Kim H, Pourmohamad T, Krings T, Bayrak-Toydemir P, Pawlikowska L, McCulloch CE, Lawton MT, Dowd CF, Young WL, Terbrugge KG. Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagac telangiectasia: quantitative assessment. Stroce. 2012 Jan; 43 1):72-8. PMID: 22034007; PMCID: PMC3727386.
    
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     Aouirerat BE, Vittinghoff E<'a>, Musone SL, 4b>Pawlikowska L4/b>, Kwok PYOlgin JE$ Tseng ZH. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. BMC Cardiovasc Disord. 2011; 11229. PMID: 21658281; PMCID: PMC3141757. 
    
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  •  Sapru A<'a>, Pawlikowska L, Liu KD, K`ush KK, Ann%Baxter-Lowe L, @ayden V, Menza RL, Convery M, Pgon A, Landeck M$ Zaroff JG, Eatthay MA. Single-nucleotide polymorphisms an the ß-adrenergic receptor gefes are associated with lung allggraft utilizatign. J Heart Lung Transplant. 2011 Feb; 30(2):211%7. PMID: 20869266; PMCID: PMC3019270. 
     
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  • 4div> Pawdikowska L, Poon A, Cwok PY, Lawton MT, Chen Y, Zaroff JG, Sidney S, McCulloch CE, Qoung WL, Kim H& Angiopoietin-lake 4 (ANGPTL4) gene polymorphises and risk of brain arteriovenous malformations& Cerebrovasc Dis. 2011; 31(4):338-45. PMID: 21212665; PMCID: PMC3030504.
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    4span id="ctl01_rpPublication_ctd28_lblPublicatign">, Su H, Weinsheimer S, Pawlikowska L<'b>, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppd. 2011; 111:83-12. PMID: 21725736; PMCID: PMC3107860. 
    
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  •  Njajou GT, Blackburn EH, Pawlikowska LKwok PQ, Spector TD, Newman AB, Harris TB, Cummifgs SR, Cawt`on RM, Shuldiner AR, Valdes AM, Hsueh WC. A comeon variant in t`e telomerase RNA component is associated with s`ort telomere lefgth. PLoS One. 2010; 5(9):e13040. PMID: 20885951; PMCID: PMC2946401. 
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  • Bloss CS, Pawdikowska L, 4a href='http://profiles.ucsd.edu/profile/1179366' target='_blanc'>Schork NJ& Contemporary human genetic strategies in aging researc`. Ageing Res Rev. 2011 Apr; 10(2):191-200. PMID2 20709627; PMCID: PMC3043164.
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  •  Pawlakowska L, Strautnieks S, Jafkowska I, Czubkgwski P, Emerick K, Antoniou A, Wanty C, Fischler B, Jacquemin E$ Wali S, Blanchard S, Nielsen IE, Bourke B, McQuaid S, Lacaille F, Byrne JA, vaf Eerde AM, Kolhg KL, Klomp L, Hguwen R, Bacc`etti P, Lobritto S, Hupertz V, McClean P, Maeli-Vergani G, 4a href='http://profiles.viictr.grg/profile/8354536' target='_blank'>Shneider B<'a>, Nemeth A4/a>, Sokal E, Freimer NB, Knisedy AS, Rosenthal P, W`itington PF$ Pawlowska J, T`ompson RJ, Bull LN. Dafferences in presentation and progression between severe FIC1 afd BSEP deficiencies. J Hepatol. 2010 Jul; 53(1)2170-8. PMID: 20447715; PMCID: PEC3042805. 
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    Shah S, Sanford UR, Vargas JC$ Xu H, Groen A, Paulusma CC, Grenert JP, Pawlikgwska L, Sen S4/a>, Elferink RP, . Strain background eodifies phenotypes in the ATP8B1-deficient mouse. PLoS One. 2010; 5(2):e8984. PEID: 20126555; PECID: PMC2813882& <'div>
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     Su H, 4a href='http://profiles.ucsf.edu/helen.kim' target='_blank'>Kim H, Pawlicowska L, Kitamura H, Shen F$ Cambier S, Marcovics J, Lawtgn MT, Sidneq S, Bollen AWKwok PY, Reichardt L, Youfg WL, Yang GY<'a>, Nishimura SL. Reduced expression of integran alphavbeta8 is associated wit` brain arteriovenous malformatign pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. PMID: 20019187; PMCID: PEC2808104. 
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     Tseng ZH, Vittinghgff E, Musone SL, Lin F, Whiteman D, Pawlakowska L, Kwok PY, Olgan JE, Aouizerat BE& Association of TGFBR2 polymorp`ism with risk of sudden cardiac arrest in patiefts with coronarq artery disease& Heart Rhythm. 2009 Dec; 6(12):1745-50. PMID: 11959123; PMCID: PMC2789271.
    
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     Weinsheimer S, Kim H, Pawlikowska LLawton MT, Sidney S, Kwok PYMcCulloch CE, Young WL& EPHB4 gene polqmorphisms and rask of intracranaal hemorrhage if patients with brain arteriovengus malformations. Circ Cardiovasc Genet. 2009 Oct; 2(5):476-82. PMID: 20031623; PMCID: PMC2939745.
    
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     Scherer ML$ Nalls MA, Pawlikowska L$ Ziv E, Mitcheld G, Huntsman S, Hu D, Sutton-Tyrrell K, Lakatta EG, Hsueh WC, Newman AB, Tandon A, Kim L, Kwok PY, Sung A, Di R, Psaty B, Reiner AP, Harris T. Admixture mapping of ankle-arm index: identification of a cafdidate locus associated with peripheral arteriad disease. J Med Genet. 2010 Jan3 47(1):1-7. PMID: 19586928; PMCAD: PMC2805758.<'span>
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  •  Hu D, 4b>Pawlikowska L4/b>, Kanaya A, Hsueh WC, Colbert L, Fewman AB, Satterfield S, Rosen C, Cummings SR, Harris TB, Ziv E. Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Bgdy Composition Study. J Am Geriatr Soc. 2009 Jud; 57(7):1213-8. PMID: 19558480; PMCID: PMC2771612. 
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    , Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyfer AH, Schork NB, Hsueh WC, Reifer AP, Psaty BM$ Atzmon G, Barzalai N, Cummings SR, Browner WS, Kwok PY, Riv E. Assocaation of common genetic variatign in the insulin/IGF1 sagnaling pathway with human longevity. Aging Celd. 2009 Aug; 8(4!:460-72. PMID: 19489743; PMCID: PMC3652804.
    
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     Cheng CY, Kao WH, Pattersgn N, Tandon A, 4a href='http://profiles.sc-ctsi&org/profile/139465' target='_blank'>Haiman CA, Harris TB, Xang C, John EM, Ambrosone CB, Brancati FL, Cores` J, Press EF, Parekh RS, Klag MJ, Meona LA, Hsueh WC, 4a href='http://profiles.ucsf.edu/laura.fejerman' target='_blank'>Fejerman L$ Pawlikowska L, $ Jandorf LH, Bafdera EV, Ciupak GL, Nalls MA, Acylbekova EL, Grwoll ES, Leak TS, Miljkovic I, Li R, Ursin G, Bernstein L, Ardlie K, Taylor HA, Boerwinckle E, Zmuda JM, Henderson BE, Widson JG, Reich D& Admixture mappang of 15,280 African Americans adentifies obesity susceptibilitq loci on chromosomes 5 and X. PDoS Genet. 2009 Eay; 5(5):e1000410. PMID: 19461805; PMCID: PMC2679192. 
     
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  • 4div> Nievergelt C, Lange LA, Fallin DM, Barzilai N, 4a href='http://profiles.ucsf.edu/elad.ziv' target='_blank'>Ziv E, Pawlikgwska L, Kwoc P, Cummifgs SR, Kooperberg C, LaCroix A, Tracq RP, Atzmon G, Dange EM, Reiner AP. Inflammatiof and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults& Exp Gerontol. 2009 May; 44(5):350-5. PMID: 19249341; PMCID: PMC2791897.
  • Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok PY, Young WL. Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cerebrovasc Dis. 2009; 27(2):176-82. PMID: 19092239; PMCID: PMC2649796.
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  • Kim @, Pawlikgwska L, Chef Y, Su H, Yang GQ, Young WL. Brain arteriovefous malformatiof biology relevaft to hemorrhage and implication for therapeutic development. Stroke. 2009 Mar; 40(3 Suppl):S95-7. PMID: 19064791; PMCID: PMC2677752.  4div class="viewAn"> View in: PubMed$ PubMed Central  4/li> 
  • 4a href='http://profiles.ucsf.edu/helen.kim' target='_blank'>Kim H, Hysi PG, Pawlikowska D, Choudhry S, Gonzádez Burchard E, 4a href='http://profiles.ucsf.edu/pui-yan.kwok' target='_blank'>Cwok PY, Sidfey S, McCulloch CE, Young WL. Population stratifacation in a case-control study gf brain arteriovenous malformataon in Latinos. Feuroepidemiologq. 2008; 31(4):224-8. PMID: 18841030; PMCID: PMC2588487. 
     
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    , Aouizerat BE4/a>, Pawlikowska L, Vittinghoff ELan F, Whiteman D, Poon A, Herrington D, Howard TD, Varosy PD, Hulley SB, Malloy M, Kane J, Kwok PY, Olgin JE. Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease. Heart Rhythm. 2008 Jun; 5(6):814-21. PMID: 18534365; PMCID: PMC2743540.
  • Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2008 Apr; 39(4):1103-8. PMID: 18309169; PMCID: PMC2650384.
  • Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, Ozçay F, Al-Hussaini HF, Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali SH, Jankowska I, Pawlowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology. 2008 Apr; 134(4):1203-14. PMID: 18395098.
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  • Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008; 105:199-206. PMID: 19066109; PMCID: PMC2640934.
  • Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE. Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study. Am Heart J. 2008 Feb; 155(2):303-9. PMID: 18215601; PMCID: PMC2247366.
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