Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Luiz Ferrari, DDS, MS, PhD

    TitleAssistant Researcher
    SchoolUCSF School of Dentistry
    DepartmentOral & Maxillofacial Surgery
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94122
    Phone415-476-4902
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil2002 - 2004“Primary Afferent Neuron: A Functional Unit Integrating the Periphery and the Spinal Cord”
      Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil2004 - 2008“Role of Presynaptic Glutamate Receptors NMDA in the Sensitization of the Primary Afferent Neurons”
      SBOT (Brazilian Society of Orthopedics and Traumatology)2005Young Researcher; Project: “Experimental Study of the Lumbar Disc Herniation”
      Postdoctoral National Program of CNPq (National Council of Research, Brazil)2008“Development of New Analgesic Drugs Based in Anti-Hyperalgesic Endogenous Mechanisms and Ionic Chann
      SBOT (Brazilian Society of Orthopedics and Traumatology)2009Experimental Research; Project: “Influence of the Maintenance of the Inflammatory Stimulus Upon the

      Collapse Overview 
      Collapse Overview
      After I got my D.D.S. degree from the School of Dentistry in the University of São Paulo in 1996, I worked in my own office, in Brazil, performing general dentistry, oral surgery and temporomandibular joint dysfunction/orofacial pain treatment. However, to learn and understand more about pain physiology and pharmacology, I went to the Medical School in the University of São Paulo at Ribeirão Preto. There, at the Department of Pharmacology, I got my Masters and Ph.D. in Pharmacology/Neuroscience, researching cellular and molecular mechanisms involved in the generation and maintenance of pain and therapeutic strategies for treatment. I also worked as a Professor of Pharmacology & Therapeutics and Neurophysiology of Pain in the School of Dentistry in University of São Paulo at Ribeirão Preto, and was part of the team of Professors in the Temporomandibular Joint Dysfunction and Orofacial Pain Specialization course for several years, teaching and supervising students of the School of Dentistry in the clinic. Currently, I work in the University of California at San Francisco, as a Research Pharmacologist, investigating the mechanisms involved in the transition from acute to chronic pain, as well as the neural basis of the chronic pain induced by inflammation, stress and as side effect of therapeutic drugs.

      Collapse Interests
      Neuropharmacology and neurophysiology, pain and hyperagesia, molecular mechanisms involved in inflammatory and neuropathic pain, chronic pain, pharmacology of anti-inflammatory and analgesic drugs, temporomandibular joint dysfunctions and orofacial pain mechanisms, temporomandibular joint dysfunctions and orofacial pain therapy

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ferrari LF, Bogen O, Green P, Levine JD. Contribution of Piezo2 to Endothelium-Dependent Pain. Mol Pain. 2015 Jan; 11. PMID: 27655920.
        View in: PubMed
      2. Ferrari LF, Khomula EV, Araldi D, Levine JD. Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat. Sci Rep. 2016; 6:31221. PMID: 27499186.
        View in: PubMed
      3. Araldi D, Ferrari LF, Levine JD. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. 2016 Aug; 157(8):1773-82. PMID: 27075428.
        View in: PubMed
      4. Ferrari LF, Araldi D, Bogen O, Levine JD. Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation. Neuroscience. 2016 Jun 2; 324:390-8. PMID: 26996509.
        View in: PubMed
      5. Araldi D, Ferrari LF, Levine JD. Adenosine-A1 receptor agonist induced hyperalgesic priming type II. Pain. 2016 Mar; 157(3):698-709. PMID: 26588695.
        View in: PubMed
      6. Ferrari LF, Levine JD, Green PG. Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat. Neuroscience. 2016 Mar 11; 317:121-9. PMID: 26779834.
        View in: PubMed
      7. Grava AL, Ferrari LF, Parada CA, Defino HL. EVALUATION OF HYPERALGESIA AND HISTOLOGICAL CHANGES OF DORSAL ROOT GANGLION INDUCED BY NUCLEUS PULPOSUS. Rev Bras Ortop. 2010 Sep-Oct; 45(5):460-7. PMID: 27022595.
        View in: PubMed
      8. de Souza Grava AL, Ferrari LF, Parada CA, Defino HL. PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS. Rev Bras Ortop. 2010 Nov-Dec; 45(6):569-76. PMID: 27026966.
        View in: PubMed
      9. Ferrari LF, Bogen O, Green P, Levine JD. Contribution of Piezo2 to endothelium-dependent pain. Mol Pain. 2015; 11(1):65. PMID: 26497944; PMCID: PMC4619430.
      10. Araldi D, Ferrari LF, Levine JD. Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci. 2015 Sep 9; 35(36):12502-17. PMID: 26354917; PMCID: PMC4563038 [Available on 03/09/16].
      11. Ferrari LF, Araldi D, Levine JD. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 2015 Apr 15; 35(15):6107-16. PMID: 25878283; PMCID: PMC4397607.
      12. Ferrari LF, Bogen O, Reichling DB, Levine JD. Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci. 2015 Jan 14; 35(2):495-507. PMID: 25589745; PMCID: PMC4293406.
      13. Ferrari LF, Lotufo CM, Araldi D, Rodrigues MA, Macedo LP, Ferreira SH, Parada CA. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18363-8. PMID: 25489099; PMCID: PMC4280647.
      14. Joseph EK, Green PG, Ferrari LF, Levine JD. Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat. Neuroscience. 2015 Jan 22; 284:678-84. PMID: 25451284; PMCID: PMC4267916 [Available on 01/22/16].
      15. Ferrari LF, Levine JD. Plasma membrane mechanisms in a preclinical rat model of chronic pain. J Pain. 2015 Jan; 16(1):60-6. PMID: 25451625; PMCID: PMC4274789 [Available on 01/01/16].
      16. Ferrari LF, Bogen O, Levine JD. Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat. J Pain. 2014 Mar; 15(3):312-20. PMID: 24407022; PMCID: PMC3987850.
      17. Gear RW, Bogen O, Ferrari LF, Green PG, Levine JD. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience. 2014 Jan 17; 257:139-48. PMID: 24188792; PMCID: PMC3947912.
      18. Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine JD, Ferrari L, Egli M, Regunathan S. Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav. 2013 Nov; 112:34-41. PMID: 24095683.
        View in: PubMed
      19. Ferrari LF, Bogen O, Levine JD. Role of nociceptor aCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats. J Neurosci. 2013 Jul 3; 33(27):11002-11. PMID: 23825405; PMCID: PMC3718370.
      20. Ferrari LF, Bogen O, Chu C, Levine JD. Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. J Pain. 2013 Jul; 14(7):731-8. PMID: 23664545; PMCID: PMC3700567.
      21. Araldi D, Ferrari LF, Lotufo CM, Vieira AS, Athié MC, Figueiredo JG, Duarte DB, Tambeli CH, Ferreira SH, Parada CA. Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3603-8. PMID: 23401543; PMCID: PMC3587281.
      22. Ferrari LF, Levine E, Levine JD. Role of a novel nociceptor autocrine mechanism in chronic pain. Eur J Neurosci. 2013 May; 37(10):1705-13. PMID: 23379641.
        View in: PubMed
      23. Hendrich J, Alvarez P, Joseph EK, Ferrari LF, Chen X, Levine JD. In vivo and in vitro comparison of female and male nociceptors. J Pain. 2012 Dec; 13(12):1224-31. PMID: 23146406; PMCID: PMC3508307.
      24. Ferrari LF, Levine E, Levine JD. Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy. Neuroscience. 2013 Jan 3; 228:409-17. PMID: 23128028; PMCID: PMC3544550.
      25. Ferrari LF, Bogen O, Alessandri-Haber N, Levine E, Gear RW, Levine JD. Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Neuroscience. 2012 Oct 11; 222:392-403. PMID: 22796071; PMCID: PMC3433493.
      26. de Souza Grava AL, Ferrari LF, Defino HL. Cytokine inhibition and time-related influence of inflammatory stimuli on the hyperalgesia induced by the nucleus pulposus. Eur Spine J. 2012 Mar; 21(3):537-45. PMID: 21947908; PMCID: PMC3296850.
      27. Green PG, Chen X, Alvarez P, Ferrari LF, Levine JD. Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat. Pain. 2011 Nov; 152(11):2549-56. PMID: 21864980; PMCID: PMC3199316.
      28. Ferrari LF, Chum A, Bogen O, Reichling DB, Levine JD. Role of Drp1, a key mitochondrial fission protein, in neuropathic pain. J Neurosci. 2011 Aug 3; 31(31):11404-10. PMID: 21813700; PMCID: PMC3157245.
      29. Alvarez P, Ferrari LF, Levine JD. Muscle pain in models of chemotherapy-induced and alcohol-induced peripheral neuropathy. Ann Neurol. 2011 Jul; 70(1):101-9. PMID: 21786301; PMCID: PMC3145965.
      30. Ferrari LF, Gear RW, Levine JD. Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. J Neurosci. 2010 Oct 13; 30(41):13699-706. PMID: 20943910; PMCID: PMC2970511.
      31. Ferrari LF, Levine JD. Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. Eur J Neurosci. 2010 Sep; 32(5):811-8. PMID: 20726883; PMCID: PMC2974761.
      32. Ferrari LF, Bogen O, Levine JD. Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience. 2010 Feb 3; 165(3):896-901. PMID: 19931357; PMCID: PMC2815163.
      33. Funez MI, Ferrari LF, Duarte DB, Sachs D, Cunha FQ, Lorenzetti BB, Parada CA, Ferreira SH. Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19038-43. PMID: 18799742; PMCID: PMC2614711.
      34. Napimoga MH, Souza GR, Cunha TM, Ferrari LF, Clemente-Napimoga JT, Parada CA, Verri WA, Cunha FQ, Ferreira SH. 15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. J Pharmacol Exp Ther. 2008 Jan; 324(1):313-21. PMID: 17928570.
        View in: PubMed
      35. Ting E, Roveroni RC, Ferrari LF, Lotufo CM, Veiga MC, Parada CA, Tambeli CH. Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats. Life Sci. 2007 Aug 9; 81(9):765-71. PMID: 17706725.
        View in: PubMed
      36. Ferrari LF, Cunha FQ, Parada CA, Ferreira SH. A novel technique to perform direct intraganglionar injections in rats. J Neurosci Methods. 2007 Jan 30; 159(2):236-43. PMID: 16973217.
        View in: PubMed
      37. Ferrari L, Peng N, Halpert JR, Morgan ET. Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes. Mol Pharmacol. 2001 Jul; 60(1):209-16. PMID: 11408616.
        View in: PubMed
      Luiz's Networks
      Related Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Related Authors
      People who share related concepts with this person.
      _
      Back to TOP