Luiz Ferrari, DDS, MS, PhD

TitleAssociate Researcher
SchoolUCSF School of Dentistry
DepartmentOral & Maxillofacial Surgery
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Awards and Honors
    Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil2002  - 2004“Primary Afferent Neuron: A Functional Unit Integrating the Periphery and the Spinal Cord”
    Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil2004  - 2008“Role of Presynaptic Glutamate Receptors NMDA in the Sensitization of the Primary Afferent Neurons”
    SBOT (Brazilian Society of Orthopedics and Traumatology)2005Young Researcher; Project: “Experimental Study of the Lumbar Disc Herniation”
    Postdoctoral National Program of CNPq (National Council of Research, Brazil)2008“Development of New Analgesic Drugs Based in Anti-Hyperalgesic Endogenous Mechanisms and Ionic Chann
    SBOT (Brazilian Society of Orthopedics and Traumatology)2009Experimental Research; Project: “Influence of the Maintenance of the Inflammatory Stimulus Upon the

    Collapse Overview 
    Collapse Overview
    After I got my D.D.S. degree from the School of Dentistry in the University of São Paulo in 1996, I worked in my own office, in Brazil, performing general dentistry, oral surgery and temporomandibular joint dysfunction/orofacial pain treatment. However, to learn and understand more about pain physiology and pharmacology, I went to the Medical School in the University of São Paulo at Ribeirão Preto. There, at the Department of Pharmacology, I got my Masters and Ph.D. in Pharmacology/Neuroscience, researching cellular and molecular mechanisms involved in the generation and maintenance of pain and therapeutic strategies for treatment. I also worked as a Professor of Pharmacology & Therapeutics and Neurophysiology of Pain in the School of Dentistry in University of São Paulo at Ribeirão Preto, and was part of the team of Professors in the Temporomandibular Joint Dysfunction and Orofacial Pain Specialization course for several years, teaching and supervising students of the School of Dentistry in the clinic. Currently, I work in the University of California at San Francisco, as a Research Pharmacologist, investigating the mechanisms involved in the transition from acute to chronic pain, as well as the neural basis of the chronic pain induced by inflammation, stress and as side effect of therapeutic drugs.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Araldi D, Khomula EV, Ferrari L, Levine JD. Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals. J Neurosci. 2018 Feb 05. PMID: 29431655.
      View in: PubMed
    2. Araldi D, Ferrari L, Levine JD. Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II). Pain. 2018 Jan 11. PMID: 29447132.
      View in: PubMed
    3. Araldi D, Ferrari LF, Levine JD. Hyperalgesic priming (type II) induced by repeated opioid exposure: maintenance mechanisms. Pain. 2017 Jul; 158(7):1204-1216. PMID: 28306605.
      View in: PubMed
    4. Ferrari LF, Araldi D, Green P, Levine JD. Age-dependent sexual dimorphism in susceptibility to develop chronic pain in the rat. Neuroscience. 2017 Jul 01. PMID: 28676241.
      View in: PubMed
    5. Khomula EV, Ferrari L, Araldi D, Levine JD. Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming. J Neurosci. 2017 Feb 22; 37(8):2032-2044. PMID: 28115480.
      View in: PubMed
    6. Ferrari LF, Araldi D, Levine JD. Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor a in the Rat. J Pain. 2017 May; 18(5):574-582. PMID: 28089711.
      View in: PubMed
    7. Araldi D, Ferrari LF, Green P, Levine JD. Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan. Neuroscience. 2017 Mar 06; 344:394-405. PMID: 28040566.
      View in: PubMed
    8. Ferrari LF, Bogen O, Green P, Levine JD. Contribution of Piezo2 to Endothelium-Dependent Pain. Mol Pain. 2015 Jan; 11. PMID: 27655920.
      View in: PubMed
    9. Ferrari L, Khomula EV, Araldi D, Levine JD. Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat. Sci Rep. 2016 Aug 08; 6:31221. PMID: 27499186; PMCID: PMC4976309.
    10. Araldi D, Ferrari L, Levine JD. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. 2016 08; 157(8):1773-82. PMID: 27075428.
      View in: PubMed
    11. Ferrari L, Araldi D, Bogen O, Levine JD. Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation. Neuroscience. 2016 Jun 02; 324:390-8. PMID: 26996509.
      View in: PubMed
    12. Araldi D, Ferrari L, Levine JD. Adenosine-A1 receptor agonist induced hyperalgesic priming type II. Pain. 2016 Mar; 157(3):698-709. PMID: 26588695.
      View in: PubMed
    13. Ferrari LF, Levine JD, Green PG. Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat. Neuroscience. 2016 Mar 11; 317:121-9. PMID: 26779834; PMCID: PMC4738056 [Available on 03/11/17].
    15. de Souza Grava AL, Ferrari LF, Parada CA, Defino HL. PHARMACOLOGIC TREATMENT OF HYPERALGESIA EXPERIMENTALLY INDUCED BY NUCLEUS PULPOSUS. Rev Bras Ortop. 2010 Nov-Dec; 45(6):569-76. PMID: 27026966; PMCID: PMC4799208.
    16. Ferrari L, Bogen O, Green P, Levine JD. Contribution of Piezo2 to endothelium-dependent pain. Mol Pain. 2015 Oct 24; 11:65. PMID: 26497944; PMCID: PMC4619430.
    17. Araldi D, Ferrari LF, Levine JD. Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci. 2015 Sep 09; 35(36):12502-17. PMID: 26354917; PMCID: PMC4563038.
    18. Ferrari LF, Araldi D, Levine JD. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 2015 Apr 15; 35(15):6107-16. PMID: 25878283; PMCID: PMC4397607.
    19. Ferrari LF, Bogen O, Reichling DB, Levine JD. Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci. 2015 Jan 14; 35(2):495-507. PMID: 25589745; PMCID: PMC4293406.
    20. Ferrari LF, Lotufo CM, Araldi D, Rodrigues MA, Macedo LP, Ferreira SH, Parada CA. Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18363-8. PMID: 25489099; PMCID: PMC4280647.
    21. Joseph EK, Green PG, Ferrari LF, Levine JD. Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat. Neuroscience. 2015 Jan 22; 284:678-84. PMID: 25451284; PMCID: PMC4267916.
    22. Ferrari LF, Levine JD. Plasma membrane mechanisms in a preclinical rat model of chronic pain. J Pain. 2015 Jan; 16(1):60-6. PMID: 25451625; PMCID: PMC4274789.
    23. Ferrari LF, Bogen O, Levine JD. Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat. J Pain. 2014 Mar; 15(3):312-20. PMID: 24407022; PMCID: PMC3987850.
    24. Gear RW, Bogen O, Ferrari LF, Green PG, Levine JD. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience. 2014 Jan 17; 257:139-48. PMID: 24188792; PMCID: PMC3947912.
    25. Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine JD, Ferrari L, Egli M, Regunathan S. Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav. 2013 Nov; 112:34-41. PMID: 24095683; PMCID: PMC4887744.
    26. Ferrari LF, Bogen O, Levine JD. Role of nociceptor aCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats. J Neurosci. 2013 Jul 03; 33(27):11002-11. PMID: 23825405; PMCID: PMC3718370.
    27. Ferrari LF, Bogen O, Chu C, Levine JD. Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. J Pain. 2013 Jul; 14(7):731-8. PMID: 23664545; PMCID: PMC3700567.
    28. Araldi D, Ferrari LF, Lotufo CM, Vieira AS, Athié MC, Figueiredo JG, Duarte DB, Tambeli CH, Ferreira SH, Parada CA. Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3603-8. PMID: 23401543; PMCID: PMC3587281.
    29. Ferrari LF, Levine E, Levine JD. Role of a novel nociceptor autocrine mechanism in chronic pain. Eur J Neurosci. 2013 May; 37(10):1705-13. PMID: 23379641.
      View in: PubMed
    30. Hendrich J, Alvarez P, Joseph EK, Ferrari LF, Chen X, Levine JD. In vivo and in vitro comparison of female and male nociceptors. J Pain. 2012 Dec; 13(12):1224-31. PMID: 23146406; PMCID: PMC3508307.
    31. Ferrari LF, Levine E, Levine JD. Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy. Neuroscience. 2013 Jan 03; 228:409-17. PMID: 23128028; PMCID: PMC3544550.
    32. Ferrari LF, Bogen O, Alessandri-Haber N, Levine E, Gear RW, Levine JD. Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Neuroscience. 2012 Oct 11; 222:392-403. PMID: 22796071; PMCID: PMC3433493.
    33. de Souza Grava AL, Ferrari LF, Defino HL. Cytokine inhibition and time-related influence of inflammatory stimuli on the hyperalgesia induced by the nucleus pulposus. Eur Spine J. 2012 Mar; 21(3):537-45. PMID: 21947908; PMCID: PMC3296850.
    34. Green PG, Chen X, Alvarez P, Ferrari LF, Levine JD. Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat. Pain. 2011 Nov; 152(11):2549-56. PMID: 21864980; PMCID: PMC3199316.
    35. Ferrari LF, Chum A, Bogen O, Reichling DB, Levine JD. Role of Drp1, a key mitochondrial fission protein, in neuropathic pain. J Neurosci. 2011 Aug 03; 31(31):11404-10. PMID: 21813700; PMCID: PMC3157245.
    36. Alvarez P, Ferrari LF, Levine JD. Muscle pain in models of chemotherapy-induced and alcohol-induced peripheral neuropathy. Ann Neurol. 2011 Jul; 70(1):101-9. PMID: 21786301; PMCID: PMC3145965.
    37. Ferrari LF, Gear RW, Levine JD. Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. J Neurosci. 2010 Oct 13; 30(41):13699-706. PMID: 20943910; PMCID: PMC2970511.
    38. Ferrari LF, Levine JD. Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. Eur J Neurosci. 2010 Sep; 32(5):811-8. PMID: 20726883; PMCID: PMC2974761.
    39. Ferrari LF, Bogen O, Levine JD. Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience. 2010 Feb 03; 165(3):896-901. PMID: 19931357; PMCID: PMC2815163.
    40. Funez MI, Ferrari LF, Duarte DB, Sachs D, Cunha FQ, Lorenzetti BB, Parada CA, Ferreira SH. Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19038-43. PMID: 18799742; PMCID: PMC2614711.
    41. Napimoga MH, Souza GR, Cunha TM, Ferrari LF, Clemente-Napimoga JT, Parada CA, Verri WA, Cunha FQ, Ferreira SH. 15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. J Pharmacol Exp Ther. 2008 Jan; 324(1):313-21. PMID: 17928570.
      View in: PubMed
    42. Ting E, Roveroni RC, Ferrari LF, Lotufo CM, Veiga MC, Parada CA, Tambeli CH. Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats. Life Sci. 2007 Aug 09; 81(9):765-71. PMID: 17706725.
      View in: PubMed
    43. Ferrari LF, Cunha FQ, Parada CA, Ferreira SH. A novel technique to perform direct intraganglionar injections in rats. J Neurosci Methods. 2007 Jan 30; 159(2):236-43. PMID: 16973217.
      View in: PubMed
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