Lukasz Bugaj, PhD

Address600 16th Street
San Francisco CA 94158
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    1. Bugaj LJ, O'Donoghue GP, Lim WA. Interrogating cellular perception and decision making with optogenetic tools. J Cell Biol. 2017 Jan 02; 216(1):25-28. PMID: 28003330.
      View in: PubMed
    2. Gordley RM, Bugaj LJ, Lim WA. Modular engineering of cellular signaling proteins and networks. Curr Opin Struct Biol. 2016 Aug; 39:106-114. PMID: 27423114.
      View in: PubMed
    3. Yousef H, Conboy MJ, Morgenthaler A, Schlesinger C, Bugaj L, Paliwal P, Greer C, Conboy IM, Schaffer D. Systemic attenuation of the TGF-ß pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 2015 May 20; 6(14):11959-78. PMID: 26003168; PMCID: PMC4494916.
    4. Yousef H, Morgenthaler A, Schlesinger C, Bugaj L, Conboy IM, Schaffer DV. Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis. Stem Cells. 2015 May; 33(5):1577-88. PMID: 25538007; PMCID: PMC4818000.
    5. Bugaj LJ, Spelke DP, Mesuda CK, Varedi M, Kane RS, Schaffer DV. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun. 2015 Apr 22; 6:6898. PMID: 25902152; PMCID: PMC4408875.
    6. Cao J, Arha M, Sudrik C, Bugaj LJ, Schaffer DV, Kane RS. Light-inducible activation of target mRNA translation in mammalian cells. Chem Commun (Camb). 2013 Sep 28; 49(75):8338-40. PMID: 23925486.
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    7. Bugaj LJ, Choksi AT, Mesuda CK, Kane RS, Schaffer DV. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods. 2013 Mar; 10(3):249-52. PMID: 23377377.
      View in: PubMed
    8. Bugaj LJ, Schaffer DV. Bringing next-generation therapeutics to the clinic through synthetic biology. Curr Opin Chem Biol. 2012 Aug; 16(3-4):355-61. PMID: 22609142.
      View in: PubMed
    9. Khan M, Steppan J, Schuleri KH, Schuleri K, Ryoo S, Tuday E, Bugaj L, Santhanam L, Berkowitz T, Nyhan D, Shoukas AA, Berkowitz DE. Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve. Eur J Appl Physiol. 2012 Aug; 112(8):2933-41. PMID: 22160208.
      View in: PubMed
    10. White AR, Ryoo S, Bugaj L, Attarzadeh DO, Thiyagarajan S, Chen K, Attwater S, Abbot B, Li D, Champion HC, Shoukas AA, Nyhan D, Hare JM, Berkowitz DE, Tuday EC. Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway. Eur J Appl Physiol. 2010 Sep; 110(2):395-404. PMID: 20512503.
      View in: PubMed
    11. Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol (1985). 2009 Oct; 107(4):1249-57. PMID: 19661445; PMCID: PMC2763842.
    12. Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4759-64. PMID: 16537391; PMCID: PMC1450243.
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