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    Luke Davis, JR

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 5
    San Francisco CA 94143
    Phone415-206-4694

       Biography 
       Education and Training
      University of California, San FranciscoM.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research)2008
      University of California, San FranciscoCert Medicine (Advance Training in Clinical Research)2007

       Overview 
       Overview
      My research program focuses on clinical-translational and implementation research on tuberculosis (TB) diagnosis in both high-burden/low-income (Uganda) and low-burden/high-income (San Francisco) settings. I am interested in how diagnostic tests, including tests for monitoring and prediction of treatment outcomes, perform in different clinical and epidemiologic settings, and how they can be integrated into TB evaluation strategies to improve patient and public health outcomes. I am currently involved in the following studies:

      Epidemiologic and Biomarker Research within the Mulago Inpatient Noninvasive Diagnosis (MIND) of Pneumonia Study. This longitudinal cohort study of patients hospitalized with pneumonia at Mulago Hospital in Kampala, Uganda, provides a robust platform for research on diagnosis and pathogenesis of acute respiratory illness in patients with and without HIV. In collaboration with a multidisciplinary team of Ugandan and US researchers, we are studying a variety of diagnostic and treatment response markers in TB and other HIV-related pulmonary infections. Two areas of current focus are biomarker studies using human exosomes and TB transcriptomics.

      TB Biomarker Research in Exosomes. In collaboration with colleagues at Colorado State University and the University of Notre Dame, we are studying whether exosomes, which are small, circulating, host-derived vesicles which concentrate and sequester mycobacterial products in serum and other body fluids, can facilitate identification and development of novel, point-of-care, proteomic and nucleic acid biomarkers for TB diagnosis and treatment monitoring.

      TB Biomarker Research in Host and Pathogen Transcriptomics. In collaboration with colleagues at the University of Colorado-Denver and Stanford University, we are studying whether longitudinal profiling of Mtb RNA in sputum and host RNA in whole blood can help better characterize the biology of Mtb persisters in patients undergoing TB treatment. New insights in this area could provide better biomarkers for treatment monitoring, novel therapeutic targets, and improved models for drug development.

      Implementation Research within the Uganda Tuberculosis Surveillance Project (UTBSP). In partnership with the Uganda National TB and Leprosy Programme and collaborators at Makerere University and Johns Hopkins University, UTBSP is using real-time evaluation and monitoring systems and novel mobile phone technologies to identify barriers to high-quality TB evaluation in a network of rural and urban primary care clinics and their surrounding communities. Current studies include a randomized, controlled trial of novel interventions to improve the effectiveness of household TB contact investigation; a multi-center study of the comparative effectiveness of a novel molecular TB diagnostic assay, GeneXpert MTB/RIF; and a study to improve adherence to guidelines on evaluation and diagnosis of pediatric TB.

      Implementation Research on GeneXpert MTB/RIF Testing at San Francisco General Hospital. We recently completed a series of studies examining the clinical and public health impact and cost-effectiveness of GeneXpert MTB/RIF for rapid TB evaluation in inpatient and outpatient settings in San Francisco. These studies have employed novel methods for describing the impact of new TB diagnostics, and are now informing how we are implementing this technology in our public health system. This project epitomizes how thinking globally can inform quality improvement locally - a process others have coined "reverse innovation" from low-income countries to high-income countries - and illustrates how researchers working in both settings can realize synergies that benefit vulnerable and underserved populations in both settings.

      Working across the TB diagnostic spectrum on biomarker discovery, test development, evaluation, implementation, and dissemination provides a variety of opportunities for collaboration, mentoring, and capacity development. Through a Fogarty AIDS Research Training Grant on TB & Other Pulmonary Complications of HIV with Professor Art Reingold from UC Berkeley, we are supporting training for new and established investigators in Uganda with a goal of building better translational research teams in Uganda. Walimu, an NGO established with U.S. and Ugandan colleagues to improve care of patients with severe acute illness in low-income countries, is another organization focused on implementation, training, and capacity building.

       Interests
      Implementation Science, Socioeconomically marginalized groups, Global populations, Clinic, Hospital, International (public health), Audit and feedback, Team science, TB, HIV/AIDS, Pneumonia, Mentoring junior faculty or trainees, Interdisciplinary research collaboration, Brief implementation science training courses, Works-in-progress seminars

       ORNG Applications 
       Websites
       In The News
       NIH Awarded Grants
       Global Health

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Marquez C, Davis JL, Katamba A, Haguma P, Ochom E, Ayakaka I, Chamie G, Dorsey G, Kamya MR, Charlebois E, Havlir DV, Cattamanchi A. Assessing the quality of tuberculosis evaluation for children with prolonged cough presenting to routine community health care settings in rural Uganda. PLoS One. 2014; 9(8):e105935.
        View in: PubMed
      2. Chaisson LH, Roemer M, Cantu D, Haller B, Millman AJ, Cattamanchi A, Davis JL. Impact of GeneXpert MTB/RIF Assay on Triage of Respiratory Isolation Rooms for Inpatients With Presumed Tuberculosis: A Hypothetical Trial. Clin Infect Dis. 2014 Nov 15; 59(10):1353-60.
        View in: PubMed
      3. Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM. Detection of Mycobacterium tuberculosis Peptides in the Exosomes of Patients with Active and Latent M. tuberculosis Infection Using MRM-MS. PLoS One. 2014; 9(7):e103811.
        View in: PubMed
      4. Davis JL, Kawamura LM, Chaisson LH, Grinsdale J, Benhammou J, Ho C, Babst A, Banouvong H, Metcalfe JZ, Pandori M, Hopewell PC, Cattamanchi A. Impact of GeneXpert MTB/RIF on Patients and Tuberculosis Programs in a Low-Burden Setting. A Hypothetical Trial. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1551-9.
        View in: PubMed
      5. Garcia B, Walter ND, Dolganov G, Coram M, Davis JL, Schoolnik GK, Strong M. A minimum variance method for genome-wide data-driven normalization of quantitative real-time polymerase chain reaction expression data. Anal Biochem. 2014 Aug 1; 458:11-3.
        View in: PubMed
      6. Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV. The Lung Microbiome of Ugandan HIV-Infected Pneumonia Patients Is Compositionally and Functionally Distinct from That of San Franciscan Patients. PLoS One. 2014; 9(4):e95726.
        View in: PubMed
      7. Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A. Point-of-Care C-Reactive Protein Testing to Facilitate Implementation of Isoniazid Preventive Therapy for People Living With HIV. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):551-6.
        View in: PubMed
      8. Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L. Procalcitonin predicts mortality in HIV-infected Ugandan adults with lower respiratory tract infections. Respirology. 2014 Apr; 19(3):382-8.
        View in: PubMed
      9. Yoon C, Davis JL, Cattamanchi A. C-reactive protein and tuberculosis screening: a new trick for an old dog? [Correspondence]. Int J Tuberc Lung Dis. 2013 Dec; 17(12):1656.
        View in: PubMed
      10. Millman AJ, Dowdy DW, Miller CR, Brownell R, Metcalfe JZ, Cattamanchi A, Davis JL. Rapid Molecular Testing for TB to Guide Respiratory Isolation in the U.S.: A Cost-Benefit Analysis. PLoS One. 2013; 8(11):e79669.
        View in: PubMed
      11. Cattamanchi A, Walter ND, Metcalfe JZ, Davis JL. A transcriptional signature for active TB: have we found the needle in the haystack? PLoS Med. 2013 Oct; 10(10):e1001539.
        View in: PubMed
      12. Dowdy DW, Davis JL, den Boon S, Walter ND, Katamba A, Cattamanchi A. Population-level impact of same-day microscopy and Xpert MTB/RIF for tuberculosis diagnosis in Africa. PLoS One. 2013; 8(8):e70485.
        View in: PubMed
      13. Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L. Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda. J Acquir Immune Defic Syndr. 2013 Jun 1; 63(2):189-94.
        View in: PubMed
      14. Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. J Clin Microbiol. 2013 Jun; 51(6):1774-8.
        View in: PubMed
      15. Miller CR, Davis JL, Katamba A, Sserwanga A, Kakeeto S, Kizito F, Cattamanchi A. Sex disparities in tuberculosis suspect evaluation: a cross-sectional analysis in rural Uganda. Int J Tuberc Lung Dis. 2013 Apr; 17(4):480-5.
        View in: PubMed
      16. Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L. Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms. PLoS One. 2012; 7(12):e51545.
        View in: PubMed
      17. Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L. Low prevalence of Pneumocystis pneumonia (PCP) but high prevalence of pneumocystis dihydropteroate synthase (dhps) gene mutations in HIV-infected persons in Uganda. PLoS One. 2012; 7(11):e49991.
        View in: PubMed
      18. Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L. Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda. PLoS One. 2012; 7(11):e48599.
        View in: PubMed
      19. Van Deun A, Cattamanchi A, Davis JL, Ridderhof J. In reply to 'Can LED fluorescence microscopy replace Ziehl-Neelsen microscopy in tuberculosis detection?'. Int J Tuberc Lung Dis. 2012 Nov; 16(11):1558-9.
        View in: PubMed
      20. Davis JL, Cattamanchi A, Cuevas LE, Hopewell PC, Steingart KR. Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 Feb; 13(2):147-54.
        View in: PubMed
      21. Davis JL, Dowdy DW, den Boon S, Walter ND, Katamba A, Cattamanchi A. Test and treat: a new standard for smear-positive tuberculosis. J Acquir Immune Defic Syndr. 2012 Sep 1; 61(1):e6-8.
        View in: PubMed
      22. Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L. Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study. PLoS One. 2012; 7(7):e38888.
        View in: PubMed
      23. Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L. Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients. PLoS One. 2012; 7(6):e39838.
        View in: PubMed
      24. Chang J, Arbeláez P, Switz N, Reber C, Tapley A, Davis JL, Cattamanchi A, Fletcher D, Malik J. Automated tuberculosis diagnosis using fluorescence images from a mobile microscope. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):345-52.
        View in: PubMed
      25. Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L. Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagn Microbiol Infect Dis. 2012 Feb; 72(2):139-43.
        View in: PubMed
      26. Vassall A, van Kampen S, Sohn H, Michael JS, John KR, den Boon S, Davis JL, Whitelaw A, Nicol MP, Gler MT, Khaliqov A, Zamudio C, Perkins MD, Boehme CC, Cobelens F. Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis. PLoS Med. 2011 Nov; 8(11):e1001120.
        View in: PubMed
      27. Worodria W, Anderson J, Cattamanchi A, Davis JL, den Boon S, Andama A, Yoo SD, Joloba M, Huang L, Kato-Maeda M. The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country. PLoS One. 2011; 6(11):e27017.
        View in: PubMed
      28. Kisembo HN, Boon SD, Davis JL, Okello R, Worodria W, Cattamanchi A, Huang L, Kawooya MG. Chest radiographic findings of pulmonary tuberculosis in severely immunocompromised patients with the human immunodeficiency virus. Br J Radiol. 2012 Jun; 85(1014):e130-9.
        View in: PubMed
      29. Yoo SD, Cattamanchi A, Den Boon S, Worodria W, Kisembo H, Huang L, Davis JL. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda. Respirology. 2011 Jul; 16(5):836-41.
        View in: PubMed
      30. Huang L, Cattamanchi A, Davis JL, den Boon S, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H. HIV-associated Pneumocystis pneumonia. Proc Am Thorac Soc. 2011 Jun; 8(3):294-300.
        View in: PubMed
      31. Davis J, Katamba A, Vasquez J, Crawford E, Sserwanga A, Kakeeto S, Kizito F, Dorsey G, den Boon S, Vittinghoff E, Huang L, Adatu F, Kamya MR, Hopewell PC, Cattamanchi A. Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services. Am J Respir Crit Care Med. 2011 Aug 1; 184(3):362-7.
        View in: PubMed
      32. Davis JL, Huang L, Worodria W, Masur H, Cattamanchi A, Huber C, Miller C, Conville PS, Murray P, Kovacs JA. Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study. PLoS One. 2011; 6(1):e16321.
        View in: PubMed
      33. Kyeyune R, den Boon S, Cattamanchi A, Davis JL, Worodria W, Yoo SD, Huang L. Causes of early mortality in HIV-infected TB suspects in an East African referral hospital. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):446-50.
        View in: PubMed
      34. Cattamanchi A, Huang L, Worodria W, den Boon S, Kalema N, Katagira W, Byanyima P, Yoo S, Matovu J, Hopewell PC, Davis JL. Integrated strategies to optimize sputum smear microscopy: a prospective observational study. Am J Respir Crit Care Med. 2011 Feb 15; 183(4):547-51.
        View in: PubMed
      35. Worodria W, Davis JL, Cattamanchi A, Andama A, den Boon S, Yoo SD, Hopewell PC, Huang L. Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients. Eur Respir J. 2010 Aug; 36(2):446-8.
        View in: PubMed
      36. Deok-jong Yoo S, Worodria W, Davis JL, Cattamanchi A, den Boon S, Kyeyune R, Kisembo H, Huang L. The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda. J Acquir Immune Defic Syndr. 2010 Jul; 54(3):269-74.
        View in: PubMed
      37. Cattamanchi A, Davis JL, Pai M, Huang L, Hopewell PC, Steingart KR. Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis? J Clin Microbiol. 2010 Jul; 48(7):2433-9.
        View in: PubMed
      38. Davis JL, Worodria W, Kisembo H, Metcalfe JZ, Cattamanchi A, Kawooya M, Kyeyune R, den Boon S, Powell K, Okello R, Yoo S, Huang L. Clinical and radiographic factors do not accurately diagnose smear-negative tuberculosis in HIV-infected inpatients in Uganda: a cross-sectional study. PLoS One. 2010; 5(3):e9859.
        View in: PubMed
      39. Cattamanchi A, Ssewenyana I, Davis JL, Huang L, Worodria W, den Boon S, Yoo S, Andama A, Hopewell PC, Cao H. Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection. BMC Infect Dis. 2010; 10:75.
        View in: PubMed
      40. Fei MW, Kim EJ, Sant CA, Jarlsberg LG, Davis JL, Swartzman A, Huang L. Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study. Thorax. 2009 Dec; 64(12):1070-6.
        View in: PubMed
      41. Cattamanchi A, Davis JL, Worodria W, den Boon S, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Byanyima P, Andama A, Joloba M, Osmond DH, Hopewell PC, Huang L. Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting. Int J Tuberc Lung Dis. 2009 Sep; 13(9):1130-6.
        View in: PubMed
      42. Andama AO, Cattamanchi A, Davis JL, den Boon S, Worodria W, Huang L. Modified Giemsa method for confirmation of Pneumocystis pneumonia in low-income countries. BMJ Case Rep. 2009; 2009.
        View in: PubMed
      43. Cattamanchi A, Dowdy DW, Davis JL, Worodria W, Yoo S, Joloba M, Matovu J, Hopewell PC, Huang L. Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis. BMC Infect Dis. 2009; 9:53.
        View in: PubMed
      44. Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009 May; 37(5):1574-9.
        View in: PubMed
      45. Shea YR, Davis JL, Huang L, Kovacs JA, Masur H, Mulindwa F, Opus S, Chow Y, Murray PR. High sensitivity and specificity of acid-fast microscopy for diagnosis of pulmonary tuberculosis in an African population with a high prevalence of human immunodeficiency virus. J Clin Microbiol. 2009 May; 47(5):1553-5.
        View in: PubMed
      46. Davis JL, Huang L, Kovacs JA, Masur H, Murray P, Havlir DV, Worodria WO, Charlebois ED, Srikantiah P, Cattamanchi A, Huber C, Shea YR, Chow Y, Fischer SH. Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis. Clin Infect Dis. 2009 Mar 15; 48(6):725-32.
        View in: PubMed
      47. Chakravorty S, Tyagi JS, Cattamanchi A, Davis JL, Worodria W, Yoo S, Huang L. Performance of modified universal sample processing method in a field study in Uganda. J Clin Microbiol. 2009 Feb; 47(2):517-8.
        View in: PubMed
      48. Fei MW, Sant CA, Kim EJ, Swartzman A, Davis JL, Jarlsberg LG, Huang L. Severity and outcomes of Pneumocystis pneumonia in patients newly diagnosed with HIV infection: an observational cohort study. Scand J Infect Dis. 2009; 41(9):672-8.
        View in: PubMed
      49. Powell K, Davis JL, Morris AM, Chi A, Bensley MR, Huang L. Survival for patients With HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy. Chest. 2009 Jan; 135(1):11-7.
        View in: PubMed
      50. Cattamanchi A, Davis JL, Worodria W, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Andama A, Joloba M, Osmond D, Hopewell P, Huang L. Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in Uganda. J Clin Microbiol. 2008 Oct; 46(10):3325-9.
        View in: PubMed
      51. Wang P, Huang L, Davis JL, Swartzman A, Roth B, Stone J, Wu AH. A hydrophilic-interaction chromatography tandem mass spectrometry method for quantitation of serum s-adenosylmethionine in patients infected with human immunodeficiency virus. Clin Chim Acta. 2008 Oct; 396(1-2):86-8.
        View in: PubMed
      52. Davis JL, Morris A, Kallet RH, Powell K, Chi AS, Bensley M, Luce JM, Huang L. Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. Thorax. 2008 Nov; 63(11):988-93.
        View in: PubMed
      53. Davis JL, Fei M, Huang L. Respiratory infection complicating HIV infection. Curr Opin Infect Dis. 2008 Apr; 21(2):184-90.
        View in: PubMed
      54. Davis JL, Welsh DA, Beard CB, Jones JL, Lawrence GG, Fox MR, Crothers K, Morris A, Charbonnet D, Swartzman A, Huang L. Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia. Thorax. 2008 Apr; 63(4):329-34.
        View in: PubMed
      55. Davis JL, Shum AK, Huang L. A 36-year-old man with AIDS and relapsing, nonproductive cough. Chest. 2007 Jun; 131(6):1929-31.
        View in: PubMed
      56. Huang L, Welsh DA, Miller RF, Beard CB, Lawrence GG, Fox M, Swartzman A, Bensley MR, Carbonnet D, Davis JL, Chi A, Yoo BJ, Jones JL. Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia. J Eukaryot Microbiol. 2006; 53 Suppl 1:S114-6.
        View in: PubMed
      57. Davis L, Miller RA. Students' attitudes toward the confidentiality of computerized patient records. Acad Med. 1999 Apr; 74(4):298.
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      58. Davis L, Domm JA, Konikoff MR, Miller RA. Attitudes of first-year medical students toward the confidentiality of computerized patient records. J Am Med Inform Assoc. 1999 Jan-Feb; 6(1):53-60.
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      59. Davis JL, Mendiratta S, May JM. Similarities in the metabolism of alloxan and dehydroascorbate in human erythrocytes. Biochem Pharmacol. 1998 Apr 15; 55(8):1301-7.
        View in: PubMed
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